{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:01:57Z","timestamp":1759683717212,"version":"3.38.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002324","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T21:38:32Z","timestamp":1325194712000},"page":"e1002324","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols"],"prefix":"10.1371","volume":"7","author":[{"given":"Faisal","family":"Naqib","sequence":"first","affiliation":[]},{"given":"Carole A.","family":"Farah","sequence":"additional","affiliation":[]},{"given":"Christopher C.","family":"Pack","sequence":"additional","affiliation":[]},{"given":"Wayne S.","family":"Sossin","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1037\/0033-2909.132.3.354","article-title":"Distributed practice in verbal recall tasks: A review and quantitative synthesis.","volume":"132","author":"NJ Cepeda","year":"2006","journal-title":"Psychol Bull"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cell.2009.09.020","article-title":"It&apos;s all about timing.","volume":"139","author":"GT Philips","year":"2009","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1101\/lm.44802","article-title":"Interaction between amount and pattern of training in the induction of intermediate- and long-term memory for sensitization in aplysia.","volume":"9","author":"MA Sutton","year":"2002","journal-title":"Learn Mem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1067020","article-title":"The molecular biology of memory storage: a dialogue between genes and synapses.","volume":"294","author":"ER Kandel","year":"2001","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1523\/JNEUROSCI.09-12-04200.1989","article-title":"Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock.","volume":"9","author":"DL Glanzman","year":"1989","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1152\/jn.00209.2004","article-title":"Serotonergic modulation in aplysia. I. Distributed serotonergic network persistently activated by sensitizing stimuli.","volume":"92","author":"S Marinesco","year":"2004","journal-title":"J Neurophysiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1101\/lm.5.3.246","article-title":"Differential induction of long-term synaptic facilitation by spaced and massed applications of serotonin at sensory neuron synapses of Aplysia californica.","volume":"5","author":"J Mauelshagen","year":"1998","journal-title":"Learn Mem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"14634","DOI":"10.1073\/pnas.0907502106","article-title":"Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia.","volume":"106","author":"YS Lee","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1471-4159.2010.06986.x","article-title":"Regulation of protein kinase C Apl II by serotonin receptors in Aplysia.","volume":"115","author":"I Nagakura","year":"2010","journal-title":"J Neurochem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0896-6273(00)80660-1","article-title":"Serotonin induces temporally and mechanistically distinct phases of persistent PKA activity in Aplysia sensory neurons.","volume":"21","author":"U Muller","year":"1998","journal-title":"Neuron"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0896-6273(00)81152-6","article-title":"Parallel molecular pathways mediate expression of distinct forms of intermediate-term facilitation at tail sensory-motor synapses in Aplysia.","volume":"26","author":"MA Sutton","year":"2000","journal-title":"Neuron"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1101\/lm.3.5.389","article-title":"An autonomous kinase generated during long-term facilitation in Aplysia is related to the Ca(2+)-independent protein kinase C Apl II.","volume":"3","author":"WS Sossin","year":"1997","journal-title":"Learn Mem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1523\/JNEUROSCI.1533-09.2009","article-title":"PKC differentially translocates during spaced and massed training in Aplysia.","volume":"29","author":"C Farah","year":"2009","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1101\/lm.1949711","article-title":"Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis.","volume":"18","author":"I Jin","year":"2011","journal-title":"Learn Mem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1101\/lm.1.3.189","article-title":"Persistent activation of protein kinase C during the development of long-term facilitation in Aplysia.","volume":"1","author":"WS Sossin","year":"1994","journal-title":"Learn Mem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1101\/lm.44802","article-title":"Interaction between amount and pattern of training in the induction of intermediate-and long-term memory for sensitization in Aplysia.","volume":"9","author":"M Sutton","year":"2002","journal-title":"Learn Mem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.4258-05.2006","article-title":"Two signaling pathways regulate the expression and secretion of a neuropeptide required for long-term facilitation in Aplysia.","volume":"26","author":"JY Hu","year":"2006","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/MCB.00178-08","article-title":"Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons.","volume":"28","author":"C Farah","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1523\/JNEUROSCI.1919-06.2006","article-title":"Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC APL I in the induction of intermediate-term facilitation.","volume":"26","author":"Y Zhao","year":"2006","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1101\/lm.469707","article-title":"Isoform specificity of protein kinase Cs in synaptic plasticity.","volume":"14","author":"WS Sossin","year":"2007","journal-title":"Learn Mem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000258666","article-title":"Evolutionary conservation of the signaling proteins upstream of cyclic AMP-dependent kinase and protein kinase C in gastropod mollusks.","volume":"74","author":"WS Sossin","year":"2009","journal-title":"Brain Behav Evol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(24)01478-9","article-title":"Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.","volume":"53","author":"SS Ferguson","year":"2001","journal-title":"Pharmacol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.neuro.27.070203.144206","article-title":"Desensitization of G protein-coupled receptors and neuronal functions.","volume":"27","author":"RR Gainetdinov","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.pharmtox.48.113006.094830","article-title":"Regulation of GPCRs by endocytic membrane trafficking and its potential implications.","volume":"48","author":"AC Hanyaloglu","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/MCB.00178-08","article-title":"Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons.","volume":"28","author":"CA Farah","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10827-005-6557-0","article-title":"Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in aplysia.","volume":"18","author":"DB Pettigrew","year":"2005","journal-title":"J Comput Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1471-4159.2005.03603.x","article-title":"Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases.","volume":"96","author":"KD Holmes","year":"2006","journal-title":"J Neurochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pharmthera.2005.01.008","article-title":"Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis.","volume":"111","author":"GK Dhami","year":"2006","journal-title":"Pharmacol Ther"},{"key":"ref29","article-title":"Regulation of G Protein-Coupled Receptor Activity, Trafficking and Localization by Gpcr-Interacting Proteins.","author":"AC Magalhaes","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/45816","article-title":"A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.","volume":"401","author":"TT Cao","year":"1999","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"36214","DOI":"10.1074\/jbc.M707263200","article-title":"NHERG1 regulates parathyroid hormone receptor membrane retention without affecting recycling.","volume":"282","author":"B Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1124\/mol.108.054486","article-title":"NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.","volume":"75","author":"B Wang","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature02160","article-title":"Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.","volume":"426","author":"M Ceci","year":"2003","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1128\/MCB.05589-11","article-title":"Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.","volume":"31","author":"M Dobrikov","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"29469","DOI":"10.1074\/jbc.273.45.29469","article-title":"Phosphorylation of eIF4E at a Conserved Serine inAplysia.","volume":"273","author":"JR Dyer","year":"1998","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1471-4159.1998.70020572.x","article-title":"Biochemical pathways by which serotonin regulates translation in the nervous system of Aplysia.","volume":"70","author":"SK Yanow","year":"1998","journal-title":"J Neurochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.7682336","article-title":"Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.","volume":"260","author":"BJ Bacskai","year":"1993","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1523\/JNEUROSCI.02-12-01682.1982","article-title":"Facilitatory transmitter causes a selective and prolonged increase in adenosine 3\u2032:5\u2032-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia.","volume":"2","author":"L Bernier","year":"1982","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.mce.2010.07.010","article-title":"Regulation of GPCR signal networks via membrane trafficking.","volume":"331","author":"F Jean-Alphonse","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1523\/JNEUROSCI.4379-07.2008","article-title":"Dynamics of somatostatin type 2A receptor cargoes in living hippocampal neurons.","volume":"28","author":"B Lelouvier","year":"2008","journal-title":"J Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"29178","DOI":"10.1074\/jbc.M704014200","article-title":"Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors.","volume":"282","author":"D Thompson","year":"2007","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"19203","DOI":"10.1074\/jbc.M701558200","article-title":"Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model.","volume":"282","author":"F Philip","year":"2007","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"15279","DOI":"10.1074\/jbc.275.20.15279","article-title":"Characterization of rapid membrane internalization and recycling.","volume":"275","author":"M Hao","year":"2000","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1021\/bi0359022","article-title":"Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq\/11-coupled receptors.","volume":"43","author":"SJ Mundell","year":"2004","journal-title":"Biochemistry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-12-385952-5.00003-8","article-title":"Role of PDZ Proteins in Regulating Trafficking, Signaling, and Function of GPCRs Means, Motif, and Opportunity.","volume":"62","author":"G Romero","year":"2011","journal-title":"Adv Pharmacol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0896-6273(03)00687-1","article-title":"Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.","volume":"40","author":"M Colledge","year":"2003","journal-title":"Neuron"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"18543","DOI":"10.1074\/jbc.M414112200","article-title":"Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway.","volume":"280","author":"CC Lee","year":"2005","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/sj.onc.1203725","article-title":"The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.","volume":"19","author":"KS Erdmann","year":"2000","journal-title":"Oncogene"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0896-6273(93)90207-8","article-title":"5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of aplysia.","volume":"10","author":"Y Hu","year":"1993","journal-title":"Neuron"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ncb2307","article-title":"Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.","volume":"13","author":"S Boulant","year":"2011","journal-title":"Nat Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1073\/pnas.0707269105","article-title":"Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly.","volume":"105","author":"V Poupon","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2008.05.023","article-title":"Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc\/Arg3.1 essential for mGluR-LTD.","volume":"59","author":"S Park","year":"2008","journal-title":"Neuron"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.cub.2007.10.053","article-title":"The role of rapid, local, postsynaptic protein synthesis in learning-related synaptic facilitation in aplysia.","volume":"17","author":"G Villareal","year":"2007","journal-title":"Curr Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1523\/JNEUROSCI.4947-09.2010","article-title":"Presynaptic and postsynaptic mechanisms of synaptic plasticity and metaplasticity during intermediate-term memory formation in Aplysia.","volume":"30","author":"I Antonov","year":"2010","journal-title":"J Neurosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nn1708","article-title":"AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc.","volume":"9","author":"VR Rao","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"10445","DOI":"10.1523\/JNEUROSCI.2883-07.2007","article-title":"Sustained Arc\/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.","volume":"27","author":"E Messaoudi","year":"2007","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1142\/S0219720007002837","article-title":"Generalized hill function method for modeling molecular processes.","volume":"5","author":"V Likhoshvai","year":"2007","journal-title":"J Bioinform Comput Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/hipo.10086","article-title":"Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP-dependent protein kinase.","volume":"13","author":"NH Woo","year":"2003","journal-title":"Hippocampus"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1152\/jn.2002.87.6.2770","article-title":"Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training.","volume":"87","author":"MT Scharf","year":"2002","journal-title":"J Neurophysiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e1000691","DOI":"10.1371\/journal.pcbi.1000691","article-title":"Temporal sensitivity of protein kinase a activation in late-phase long term potentiation.","volume":"6","author":"M Kim","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.279.5348.227","article-title":"Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.","volume":"279","author":"P De Koninck","year":"1998","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nature00928","article-title":"Protein phosphatase 1 is a molecular constraint on learning and memory.","volume":"418","author":"D Genoux","year":"2002","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(95)90375-5","article-title":"CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila.","volume":"81","author":"JC Yin","year":"1995","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cell.2009.08.033","article-title":"The phosphatase SHP2 regulates the spacing effect for long-term memory induction.","volume":"139","author":"MR Pagani","year":"2009","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1523\/JNEUROSCI.4262-07.2007","article-title":"Transient mitogen-activated protein kinase activation is confined to a narrow temporal window required for the induction of two-trial long-term memory in Aplysia.","volume":"27","author":"GT Philips","year":"2007","journal-title":"J Neurosci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2007.01.050","article-title":"eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.","volume":"129","author":"M Costa-Mattioli","year":"2007","journal-title":"Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1101\/lm.984508","article-title":"Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation.","volume":"15","author":"C Dong","year":"2008","journal-title":"Learn Mem"},{"key":"ref68","doi-asserted-by":"crossref","DOI":"10.1137\/1.9780898717839","article-title":"Finite Difference Methods for Ordinary and Partial Differential Equations","author":"RJ LeVeque","year":"2007"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1523\/JNEUROSCI.21-04-01247.2001","article-title":"Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed Aplysia sensorimotor synapses.","volume":"21","author":"F Manseau","year":"2001","journal-title":"J Neurosci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10827-005-6557-0","article-title":"Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in Aplysia.","volume":"18","author":"D Pettigrew","year":"2005","journal-title":"J Comput Neurosci"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T02:59:59Z","timestamp":1742180399000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002324"}},"subtitle":[],"editor":[{"given":"Jason M.","family":"Haugh","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,12,29]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002324","relation":{},"ISSN":["1553-7358"],"issn-type":[{"type":"electronic","value":"1553-7358"}],"subject":[],"published":{"date-parts":[[2011,12,29]]}}}