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Iakoucheva","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2164-9-S1-S1","article-title":"Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.","volume":"9","author":"CJ Oldfield","year":"2008","journal-title":"BMC Genomics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0968-0004(02)02169-2","article-title":"Intrinsically unstructured proteins.","volume":"27","author":"P Tompa","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2105-9-229","article-title":"A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences.","volume":"9","author":"C Chica","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref54","first-page":"ra39","article-title":"Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.","volume":"2","author":"CS Tan","year":"2009","journal-title":"Sci Signal"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1126\/science.1169375","article-title":"Protein dynamism and evolvability.","volume":"324","author":"N Tokuriki","year":"2009","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"D240","DOI":"10.1093\/nar\/gkm772","article-title":"Phospho.ELM: a database of phosphorylation sites\u2013update 2008.","volume":"36","author":"F Diella","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/pmic.200300772","article-title":"PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation.","volume":"4","author":"PV Hornbeck","year":"2004","journal-title":"Proteomics"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gki070","article-title":"The Universal Protein Resource (UniProt).","volume":"33","author":"A Bairoch","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"D773","DOI":"10.1093\/nar\/gkn701","article-title":"Human Proteinpedia: a unified discovery resource for proteomics research.","volume":"37","author":"K Kandasamy","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"R250","DOI":"10.1186\/gb-2007-8-11-r250","article-title":"PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites.","volume":"8","author":"F Gnad","year":"2007","journal-title":"Genome Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"D767","DOI":"10.1093\/nar\/gkn892","article-title":"Human Protein Reference Database\u20132009 update.","volume":"37","author":"TS Keshava Prasad","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2007.05.052","article-title":"Systematic discovery of in vivo phosphorylation networks.","volume":"129","author":"R Linding","year":"2007","journal-title":"Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molcel.2009.03.007","article-title":"Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.","volume":"34","author":"WM Old","year":"2009","journal-title":"Mol Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1074\/mcp.M800588-MCP200","article-title":"Large-scale proteomics analysis of the human kinome.","volume":"8","author":"FS Oppermann","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"D679","DOI":"10.1093\/nar\/gkm854","article-title":"PepCyber:P\u223cPEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.","volume":"36","author":"W Gong","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"D557","DOI":"10.1093\/nar\/gkl961","article-title":"DOMINO: a database of domain-peptide interactions.","volume":"35","author":"A Ceol","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/bioinformatics\/bti098","article-title":"PDZBase: a protein-protein interaction database for PDZ-domains.","volume":"21","author":"T Beuming","year":"2005","journal-title":"Bioinformatics"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"D300","DOI":"10.1093\/nar\/gkn690","article-title":"3did Update: domain-domain and peptide-mediated interactions of known 3D structure.","volume":"37","author":"A Stein","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1093\/nar\/gkg584","article-title":"Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.","volume":"31","author":"JC Obenauer","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"bap026","DOI":"10.1093\/database\/bap026","article-title":"PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae.","volume":"2010","author":"C Stark","year":"2010","journal-title":"Database (Oxford)"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.1604319","article-title":"Exhaustive matching of the entire protein sequence 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interact with the SH3C domain of Grb2.","volume":"17","author":"M Harkiolaki","year":"2009","journal-title":"Structure"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"18177","DOI":"10.1074\/jbc.M709715200","article-title":"Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.","volume":"283","author":"CH Reynolds","year":"2008","journal-title":"J Biol Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1471-4159.2007.04792.x","article-title":"The binding and phosphorylation of Thr231 is critical for Tau&apos;s hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta.","volume":"103","author":"YT Lin","year":"2007","journal-title":"J Neurochem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0896-6273(00)80207-X","article-title":"Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation.","volume":"17","author":"NA Cohen","year":"1996","journal-title":"Neuron"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1074\/jbc.M107297200","article-title":"G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.","volume":"277","author":"LA Hu","year":"2002","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0896-6273(02)00675-X","article-title":"PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain.","volume":"34","author":"M Tanemoto","year":"2002","journal-title":"Neuron"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/45816","article-title":"A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.","volume":"401","author":"TT Cao","year":"1999","journal-title":"Nature"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"10659","DOI":"10.1074\/jbc.M807643200","article-title":"Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.","volume":"284","author":"B Sulka","year":"2009","journal-title":"J Biol Chem"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1002\/cbic.200700518","article-title":"Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanisms.","volume":"8","author":"P Boisguerin","year":"2007","journal-title":"Chembiochem"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"39994","DOI":"10.1074\/jbc.M110.189449","article-title":"Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand.","volume":"285","author":"D Sengupta","year":"2010","journal-title":"J Biol 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Dev"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"878","DOI":"10.4049\/jimmunol.179.2.878","article-title":"Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.","volume":"179","author":"T Kesti","year":"2007","journal-title":"J Immunol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1074\/jbc.M504163200","article-title":"Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation.","volume":"281","author":"JC Arevalo","year":"2006","journal-title":"J Biol Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"14585","DOI":"10.1021\/bi011247r","article-title":"Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.","volume":"40","author":"F Sotgia","year":"2001","journal-title":"Biochemistry"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1210\/me.2006-0541","article-title":"Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor.","volume":"21","author":"I Uyttendaele","year":"2007","journal-title":"Mol Endocrinol"},{"key":"ref92","first-page":"1249","article-title":"Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.","volume":"10","author":"X Wang","year":"1996","journal-title":"Mol Endocrinol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/pmic.200601006","article-title":"Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.","volume":"7","author":"C Wu","year":"2007","journal-title":"Proteomics"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1074\/jbc.273.15.8867","article-title":"Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.","volume":"273","author":"M Deckert","year":"1998","journal-title":"J Biol Chem"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1111\/j.1742-4658.2006.05535.x","article-title":"Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.","volume":"273","author":"A Sanjay","year":"2006","journal-title":"Febs J"}],"updated-by":[{"DOI":"10.1371\/annotation\/2e21b1b9-46de-4cbe-a2a4-b4598d90d492","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T00:00:00Z","timestamp":1327276800000}}],"container-title":["PLoS Computational 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