{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:40:16Z","timestamp":1784868016690,"version":"3.55.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T00:00:00Z","timestamp":1336608000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002503","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T21:08:34Z","timestamp":1336684114000},"page":"e1002503","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":716,"title":["Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference"],"prefix":"10.1371","volume":"8","author":[{"given":"Feixiong","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery.","volume":"4","author":"AL Hopkins","year":"2008","journal-title":"Nat Chem Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd1346","article-title":"Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.","volume":"3","author":"BL Roth","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/1568026023393796","article-title":"Molecular biology of serotonin receptors structure and function at the molecular level.","volume":"2","author":"WK Kroeze","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs.","volume":"3","author":"TT Ashburn","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.1169920","article-title":"Drug discovery. Repurposing with a difference.","volume":"324","author":"MS Boguski","year":"2009","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature08506","article-title":"Predicting new molecular targets for known drugs.","volume":"462","author":"MJ Keiser","year":"2009","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry.","volume":"25","author":"MJ Keiser","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1021\/pr101009e","article-title":"MIND-BEST: Web Server for Drugs and Target Discovery; Design, Synthesis, and Assay of MAO-B Inhibitors and Theoretical-Experimental Study of G3PDH Protein from Trichomonas gallinae.","volume":"10","author":"H Gonzalez-Diaz","year":"2011","journal-title":"J Proteome Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1002037","DOI":"10.1371\/journal.pcbi.1002037","article-title":"Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir.","volume":"7","author":"L Xie","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"W219","DOI":"10.1093\/nar\/gkl114","article-title":"TarFisDock: a web server for identifying drug targets with docking approach.","volume":"34","author":"H Li","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1002016","DOI":"10.1371\/journal.pcbi.1002016","article-title":"Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome\u2013clozapine-induced agranulocytosis as a case study.","volume":"7","author":"L Yang","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nbt1338","article-title":"Drug-target network.","volume":"25","author":"MA Yildirim","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.1158140","article-title":"Drug target identification using side-effect similarity.","volume":"321","author":"M Campillos","year":"2008","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1073\/pnas.1000138107","article-title":"Discovery of drug mode of action and drug repositioning from transcriptional responses.","volume":"107","author":"F Iorio","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"96ra76","DOI":"10.1126\/scitranslmed.3002648","article-title":"Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.","volume":"3","author":"JT Dudley","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"96ra77","DOI":"10.1126\/scitranslmed.3001318","article-title":"Discovery and preclinical validation of drug indications using compendia of public gene expression data.","volume":"3","author":"M Sirota","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"i232","DOI":"10.1093\/bioinformatics\/btn162","article-title":"Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.","volume":"24","author":"Y Yamanishi","year":"2008","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1073\/pnas.1000488107","article-title":"Solving the apparent diversity-accuracy dilemma of recommender systems.","volume":"107","author":"T Zhou","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"123008","DOI":"10.1088\/1367-2630\/11\/12\/123008","article-title":"Accurate and diverse recommendations via eliminating redundant correlations.","volume":"11","author":"T Zhou","year":"2009","journal-title":"New J Phys"},{"key":"ref20","first-page":"285","article-title":"Item-Based Collaborative Filtering Recommendation Algorithms.","author":"B Sarwar","year":"2001"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1145\/963770.963772","article-title":"Evaluating collaborative filtering recommender systems.","volume":"22","author":"JL Herlocker","year":"2004","journal-title":"ACM T Inform Syst"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nbt0908-983","article-title":"Data completeness\u2013the Achilles heel of drug-target networks.","volume":"26","author":"J Mestres","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"D1035","DOI":"10.1093\/nar\/gkq1126","article-title":"DrugBank 3.0: a comprehensive resource for \u2018omics\u2019 research on drugs.","volume":"39","author":"C Knox","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders.","volume":"33","author":"A Hamosh","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0731-7085(03)00023-2","article-title":"Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection.","volume":"32","author":"L Liu","year":"2003","journal-title":"J Pharm Biomed Anal"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/sj.ijir.3901160","article-title":"Use of oral ketoconazole to prevent postoperative erections following penile surgery.","volume":"16","author":"KC Evans","year":"2004","journal-title":"Int J Impot Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0090-4295(95)80022-0","article-title":"Ketoconazole for prevention of postoperative penile erection.","volume":"45","author":"JA Stock","year":"1995","journal-title":"Urology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"i246","DOI":"10.1093\/bioinformatics\/btq176","article-title":"Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework.","volume":"26","author":"Y Yamanishi","year":"2010","journal-title":"Bioinformatics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e9603","DOI":"10.1371\/journal.pone.0009603","article-title":"Predicting drug-target interaction networks based on functional groups and biological features.","volume":"5","author":"Z He","year":"2010","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/clpt.2009.42","article-title":"Generating genome-scale candidate gene lists for pharmacogenomics.","volume":"86","author":"NT Hansen","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/clpt.2009.103","article-title":"Systematic evaluation of drug-disease relationships to identify leads for novel drug uses.","volume":"86","author":"AP Chiang","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease.","volume":"12","author":"AL Barabasi","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/msb.2008.27","article-title":"Network-based global inference of human disease genes.","volume":"4","author":"X Wu","year":"2008","journal-title":"Mol Syst Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/msb.2011.35","article-title":"Predicting selective drug targets in cancer through metabolic networks.","volume":"7","author":"O Folger","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/msb.2011.26","article-title":"PREDICT: a method for inferring novel drug indications with application to personalized medicine.","volume":"7","author":"A Gottlieb","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jaci.2006.03.010","article-title":"Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism.","volume":"118","author":"A Langlois","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3121\/cmr.2009.824","article-title":"The Effect of an Inhaled Corticosteroid on Glucose Control in Type 2 Diabetes.","volume":"7","author":"JL Faul","year":"2009","journal-title":"Clin Med Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/ci9800211","article-title":"Chemical Similarity Searching.","volume":"38","author":"MB John","year":"1998","journal-title":"J Chem Inf Comput Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ccr.2010.04.023","article-title":"NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.","volume":"17","author":"H Zhou","year":"2010","journal-title":"Cancer Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1074\/jbc.272.6.3406","article-title":"Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.","volume":"272","author":"JM Lehmann","year":"1997","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"14813","DOI":"10.1073\/pnas.0703783104","article-title":"Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment.","volume":"104","author":"S Tiwari-Woodruff","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/331091a0","article-title":"Identification of a new class of steroid hormone receptors.","volume":"331","author":"V Giguere","year":"1988","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1741-7015-5-20","article-title":"Simvastatin is associated with a reduced incidence of dementia and Parkinson&apos;s disease.","volume":"5","author":"B Wolozin","year":"2007","journal-title":"BMC Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/archneur.57.10.1439","article-title":"Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.","volume":"57","author":"B Wolozin","year":"2000","journal-title":"Arch Neurol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1523\/JNEUROSCI.0453-06.2006","article-title":"Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis.","volume":"26","author":"LB Morales","year":"2006","journal-title":"J Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.5414\/CPP42695","article-title":"Inhibitory effect of statins on the proliferation of human breast cancer cells.","volume":"42","author":"AO Muck","year":"2004","journal-title":"Int J Clin Pharmacol Ther"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2174\/0929867053764662","article-title":"Non-steroidal subtype selective estrogens.","volume":"12","author":"GH Veeneman","year":"2005","journal-title":"Curr Med Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1021\/jm100369g","article-title":"Discovery of potent ligands for estrogen receptor beta by structure-based virtual screening.","volume":"53","author":"J Shen","year":"2010","journal-title":"J Med Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkj102","article-title":"From genomics to chemical genomics: new developments in KEGG.","volume":"34","author":"M Kanehisa","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"D431","DOI":"10.1093\/nar\/gkh081","article-title":"BRENDA, the enzyme database: updates and major new developments.","volume":"32","author":"I Schomburg","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"D919","DOI":"10.1093\/nar\/gkm862","article-title":"SuperTarget and Matador: resources for exploring drug-target relationships.","volume":"36","author":"S Gunther","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1021\/ja036030u","article-title":"Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways.","volume":"125","author":"M Hattori","year":"2003","journal-title":"J Am Chem Soc"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0076-6879(02)50957-5","article-title":"Transformation of yeast by lithium acetate\/single-stranded carrier DNA\/polyethylene glycol method.","volume":"350","author":"RD Gietz","year":"2002","journal-title":"Methods Enzymol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jsbmb.2008.03.028","article-title":"Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor beta agonist and induces GLUT4 expression in CHO-K1 cells.","volume":"110","author":"Z Lin","year":"2008","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T12:10:07Z","timestamp":1594123807000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002503"}},"subtitle":[],"editor":[{"given":"Russ B.","family":"Altman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,10]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002503","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,10]]}}}