{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:14:59Z","timestamp":1770884099633,"version":"3.50.1"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:00:00Z","timestamp":1342051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002601","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T20:37:01Z","timestamp":1342211821000},"page":"e1002601","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Nonlinear Dynamic Approach Reveals a Long-Term Stroke Effect on Cerebral Blood Flow Regulation at Multiple Time Scales"],"prefix":"10.1371","volume":"8","author":[{"given":"Kun","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Men-Tzung","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Kang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Novak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"ref1","first-page":"45","article-title":"Cerebral autoregulation.","author":"DW Busija","year":"1993"},{"key":"ref2","first-page":"161","article-title":"Cerebral autoregulation.","volume":"2","author":"OB Paulson","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0163-7258(93)90045-F","article-title":"The effect of carbon dioxide on cerebral arteries.","volume":"59","author":"JA Madden","year":"1993","journal-title":"Pharmacol Ther"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/pr.108.000547","article-title":"Cerebral blood flow regulation by nitric oxide: recent advances.","volume":"61","author":"N Toda","year":"2009","journal-title":"Pharmacol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1161\/01.CIR.0000031798.07790.FE","article-title":"Autonomic neural control of dynamic cerebral autoregulation in humans.","volume":"106","author":"R Zhang","year":"2002","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1152\/japplphysiol.00954.2005","article-title":"Perivascular nerves and the regulation of cerebrovascular tone.","volume":"100","author":"E Hamel","year":"2006","journal-title":"J Appl Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"H1209","DOI":"10.1152\/ajpheart.01047.2006","article-title":"Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell.","volume":"292","author":"S Chien","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.physa.2007.11.052","article-title":"Altered Phase Interactions between Spontaneous Blood Pressure and Flow Fluctuations in Type 2 Diabetes Mellitus: Nonlinear Assessment of Cerebral Autoregulation.","volume":"387","author":"K Hu","year":"2008","journal-title":"Physica A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s00125-008-0958-3","article-title":"A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients.","volume":"51","author":"CM Brown","year":"2008","journal-title":"Diabetologia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/CS20070458","article-title":"Dynamic cerebral autoregulatory capacity is affected early in type 2 diabetes mellitus.","volume":"115","author":"YS Kim","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/hs0202.102376","article-title":"Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke.","volume":"33","author":"S Schwarz","year":"2002","journal-title":"Stroke"},{"key":"ref12","first-page":"467","article-title":"Dynamic cerebral autoregulation and beat-to-beat blood pressure control are impaired in acute ischaemic stroke.","volume":"72","author":"PJ Eames","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000070118","article-title":"Serial changes in static and dynamic cerebral autoregulation after acute ischaemic stroke.","volume":"16","author":"SL Dawson","year":"2003","journal-title":"Cerebrovascular Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10558-007-9045-5","article-title":"Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations.","volume":"8","author":"K Hu","year":"2008","journal-title":"Cardiovasc Eng"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3171\/jns.2003.99.6.0991","article-title":"Asymmetry of pressure autoregulation after traumatic brain injury.","volume":"99","author":"EA Schmidt","year":"2003","journal-title":"J Neurosurgery"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00006123-199707000-00005","article-title":"Continuous assessment of the cerebral vasomotor reactivity in head injury.","volume":"41","author":"M Czosnyka","year":"1997","journal-title":"Neurosurgery"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/neu.2008.0643","article-title":"Nonlinear pressure-flow relationship is able to detect asymmetry of brain blood circulation associated with midline shift.","volume":"26","author":"K Hu","year":"2009","journal-title":"J Neurotrauma"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10558-007-9044-6","article-title":"Cerebral autoregulation: from models to clinical applications.","volume":"8","author":"RB Panerai","year":"2008","journal-title":"Cardiovasc Eng"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ultrasmedbio.2009.01.005","article-title":"Transcranial Doppler assessment of cerebral autoregulation.","volume":"35","author":"J Bellapart","year":"2009","journal-title":"Ultrasound Med Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1080\/01616412.1997.11740873","article-title":"Use of middle cerebral velocity and blood pressure for the analysis of cerebral autoregulation at various frequencies: the coherence index.","volume":"19","author":"CA Giller","year":"1997","journal-title":"Neurol Res"},{"key":"ref21","first-page":"H233","article-title":"Transfer function analysis of dynamic cerebral autoregulation in humans.","volume":"274","author":"R Zhang","year":"1998","journal-title":"Am J Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1113\/jphysiol.2004.066969","article-title":"Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations.","volume":"559","author":"JW Hamner","year":"2004","journal-title":"J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00004647-199803000-00010","article-title":"Frequency domain analysis of cerebral blood flow velocity and its correlation with arterial blood pressure.","volume":"18","author":"TB Kuo","year":"1998","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1098\/rsta.2008.0264","article-title":"Complexity of the human cerebral circulation.","volume":"367","author":"RB Panerai","year":"2009","journal-title":"Philos Transact A Math Phys Eng Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"041107","DOI":"10.1103\/PhysRevE.65.041107","article-title":"Effect of nonstationarities on detrended fluctuation analysis.","volume":"65","author":"Z Chen","year":"2002","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"061924","DOI":"10.1103\/PhysRevE.79.061924","article-title":"Nonlinear phase interaction between nonstationary signals: a comparison study of methods based on Hilbert-Huang and Fourier transforms.","volume":"79","author":"MT Lo","year":"2009","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1073\/pnas.95.9.4816","article-title":"Engineering analysis of biological variables: an example of blood pressure over 1 day.","volume":"95","author":"W Huang","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S1793536909000047","article-title":"Ensemble Empirical Mode Decomposition: a noise-assisted data analysis method.","volume":"1","author":"Z Wu","year":"2009","journal-title":"Adv Adapt Data Anal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1088\/0967-3334\/19\/3\/001","article-title":"Assessment of cerebral pressure autoregulation in humans\u2013a review of measurement methods.","volume":"19","author":"RB Panerai","year":"1998","journal-title":"Physiol Meas"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"785243","DOI":"10.1155\/2008\/785243","article-title":"Multimodal Pressure Flow Analysis: Application of Hilbert Huang Transform in Cerebral Blood Flow Regulation.","volume":"2008","author":"MT Lo","year":"2008","journal-title":"EURASIP J Appl Signal Processing"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.STR.26.6.1014","article-title":"Comparison of static and dynamic cerebral autoregulation measurements.","volume":"26","author":"FP Tiecks","year":"1995","journal-title":"Stroke"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1152\/japplphysiol.90822.2008","article-title":"Dynamic cerebral autoregulation during repeated squat-stand maneuvers.","volume":"106","author":"JA Claassen","year":"2009","journal-title":"J Appl Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1113\/jphysiol.2008.168302","article-title":"Dynamic pressure-flow relationship of the cerebral circulation during acute increase in arterial pressure.","volume":"587","author":"R Zhang","year":"2009","journal-title":"J Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1161\/01.STR.26.10.1801","article-title":"Phase relationship between cerebral blood flow velocity and blood pressure. A clinical test of autoregulation.","volume":"26","author":"RR Diehl","year":"1995","journal-title":"Stroke"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000072564","article-title":"Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity.","volume":"16","author":"TB Kuo","year":"2003","journal-title":"Cerebrovasc Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1088\/0967-3334\/23\/1\/306","article-title":"Assessment of dynamic cerebral autoregulation based on spontaneous fluctuations in arterial blood pressure and intracranial pressure.","volume":"23","author":"RB Panerai","year":"2002","journal-title":"Physiol Meas"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02364625","article-title":"A mathematical study of human intracranial hydrodynamics. Part 1\u2013The cerebrospinal fluid pulse pressure.","volume":"16","author":"M Ursino","year":"1988","journal-title":"Ann Biomed Eng"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R611","DOI":"10.1152\/ajpregu.00285.2001","article-title":"Dynamics of cerebral blood flow regulation explained using a lumped parameter model.","volume":"282","author":"MS Olufsen","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1073\/pnas.89.9.3913","article-title":"Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?","volume":"89","author":"C Iadecola","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1073\/pnas.96.16.9403","article-title":"Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex.","volume":"96","author":"RD Hoge","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/brain\/awg040","article-title":"Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis.","volume":"126","author":"A Hassan","year":"2003","journal-title":"Brain"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.STR.11.3.240","article-title":"Physiological mechanisms controlling cerebral blood flow.","volume":"11","author":"G Mchedlishvili","year":"1980","journal-title":"Stroke"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/01.STR.12.5.598","article-title":"Focal cerebral hyperemia in acute stroke. Incidence, pathophysiology and clinical significance.","volume":"12","author":"TS Olsen","year":"1981","journal-title":"Stroke"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000016060","article-title":"Remote effects of acute ischemic stroke: A xenon CT cerebral blood flow study.","volume":"10","author":"G Rubin","year":"2000","journal-title":"Cerebrovasc Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1097\/00004647-200008000-00001","article-title":"Functional differentiation of multiple perilesional zones after focal cerebral ischemia.","volume":"20","author":"OW Witte","year":"2000","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1097\/HJH.0b013e328330a9a7","article-title":"Autoregulation after ischaemic stroke.","volume":"27","author":"WJ Powers","year":"2009","journal-title":"J Hypertens"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1212\/01.wnl.0000342473.65373.80","article-title":"Vasoreactivity and peri-infarct hyperintensities in stroke.","volume":"72","author":"P Zhao","year":"2009","journal-title":"Neurology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e409","DOI":"10.1161\/circ.113.10.e409","article-title":"Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association\/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline.","volume":"113","author":"RL Sacco","year":"2006","journal-title":"Circulation"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1475-925X-3-39","article-title":"Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension.","volume":"3","author":"V Novak","year":"2004","journal-title":"Biomed Eng Online"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"031915","DOI":"10.1103\/PhysRevE.73.031915","article-title":"Cross-correlation of instantaneous phase increments in pressure-flow fluctuations: applications to cerebral autoregulation.","volume":"73","author":"Z Chen","year":"2006","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1088\/0967-3334\/28\/2\/005","article-title":"Synchronization between arterial blood pressure and cerebral oxyhaemoglobin concentration investigated by wavelet cross-correlation.","volume":"28","author":"AB Rowley","year":"2007","journal-title":"Physiol Meas"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1088\/0967-3334\/31\/10\/001","article-title":"Tracking time-varying cerebral autoregulation in response to changes in respiratory PaCO2.","volume":"31","author":"J Liu","year":"2010","journal-title":"Physiol Meas"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1227\/00006123-199305000-00006","article-title":"Cerebral arterial diameters during changes in blood pressure and CO2 during craniotomy.","volume":"32","author":"CA Giller","year":"1993","journal-title":"Neurosurgery"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.STR.25.4.793","article-title":"Comparison of flow and velocity during dynamic autoregulation testing in humans.","volume":"25","author":"DW Newell","year":"1994","journal-title":"Stroke"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.STR.31.7.1672","article-title":"MRI measures of middle cerebral artery diameter on conscious humans during simulated orthostasis.","volume":"31","author":"JM Serrador","year":"2000","journal-title":"Stroke"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.STR.26.6.1014","article-title":"Comparison of static and dynamic cerebral autoregulation measurements.","volume":"26","author":"FP Tiecks","year":"1995","journal-title":"Stroke"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:15:42Z","timestamp":1588994142000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002601"}},"subtitle":[],"editor":[{"given":"Feilim Mac","family":"Gabhann","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,12]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002601","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,12]]}}}