{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:54:44Z","timestamp":1769345684988,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002739","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T21:06:36Z","timestamp":1351803996000},"page":"e1002739","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Evolution of Associative Learning in Chemical Networks"],"prefix":"10.1371","volume":"8","author":[{"given":"Simon","family":"McGregor","sequence":"first","affiliation":[]},{"given":"Vera","family":"Vasas","sequence":"additional","affiliation":[]},{"given":"Phil","family":"Husbands","sequence":"additional","affiliation":[]},{"given":"Chrisantha","family":"Fernando","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1098\/rsif.2008.0344","article-title":"Molecular circuits for associative learning in single-celled organisms","volume":"6","author":"C Fernando","year":"2008","journal-title":"J Roy Soc Interface"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jtbi.2007.07.004","article-title":"Associative Learning in biochemical networks","volume":"249","author":"N Gandhi","year":"2007","journal-title":"J Theor Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1103\/PhysRevLett.78.1190","article-title":"Chemical kinetics is Turing Universal","volume":"78","author":"MO Magnasco","year":"1997","journal-title":"Phys Rev Lett"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1073\/pnas.88.24.10983","article-title":"Chemical implementation of neural networks and Turing machines","volume":"88","author":"A Hjelmfelt","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e10000084","DOI":"10.1371\/journal.pcbi.1000084","article-title":"Evolution of the Taxis Responses in Virtual Bacteria: Non-Adaptive Dynamics","volume":"4","author":"R Goldstein","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1000206","DOI":"10.1371\/journal.pcbi.1000206","article-title":"Facilitated Variation: How Evolution Learns from Past Environments to Generalize to New Environments","volume":"4","author":"M Parter","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1126\/science.1089118","article-title":"Molecular Networks: The Top-Down View","volume":"26","author":"D Bray","year":"2003","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0006-3495(94)80878-1","article-title":"Computer simulated evolution of a network of cell-signaling molecules","volume":"66","author":"D Bray","year":"1994","journal-title":"Biophys J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1049\/ip-syb:20050096","article-title":"In silico evolution of functional modules in biochemical networks","volume":"153","author":"SR Paladugu","year":"2006","journal-title":"Syst Biol"},{"key":"ref10","unstructured":"Holland JH (1975) Adaptation in Natural and Artificial Systems. Ann Arbor: University of Michigan Press."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Fogel DB (2006) Evolutionary Computation: Toward a New Pholosophy of Machine Intelligence. Piscataway, NJ: Wiley-Interscience.","DOI":"10.1002\/0471749214"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Baeck T, Fogel DB, Michalewicz ZM (1997) Handbook of Evolutionary Computation New York: Taylor and Francis Group.","DOI":"10.1201\/9781420050387"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/1059712307084688","article-title":"The dynamics of associative learning in evolved model circuits","volume":"15","author":"P Phattanasri","year":"2007","journal-title":"Adapt Behav"},{"key":"ref14","unstructured":"Bagley RJ, Farmer JD, Fontana W. (1992) Evolution of a Metabolism. In: Langton CG, Taylor C, Farmer JD, Rasmussen S, editors. Artificial Life II, Proceedings. Santa Fe: Addison-Wesley."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1073\/pnas.91.2.757","article-title":"What would be conserved if \u2018the tape were played twice\u2019?","volume":"91","author":"W Fontana","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jtbi.2007.01.028","article-title":"Natural Selection in Chemical Evolution","volume":"247","author":"C Fernando","year":"2007","journal-title":"J Theor Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.biosystems.2007.05.012","article-title":"The origin of autonomous agents by natural selection","volume":"91","author":"C Fernando","year":"2008","journal-title":"Biosystems"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1186\/1745-6150-7-1","article-title":"Evolution before genes","volume":"7","author":"V Vasas","year":"2012","journal-title":"Biology Direct"},{"key":"ref19","unstructured":"Dayan P, Abbott L (2001) Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems. Cambridge, MA: MIT Press."},{"key":"ref20","unstructured":"Mackintosh NJ (1974) The psychology of animal learning. Oxford, England: Academic Press."},{"key":"ref21","unstructured":"Rescorla RA, Wagner AR (1972) A theory of Pavlovian conditioning: Variations in the effectiveness of reinforcement and nonreinforcement. In: Black AH, Prokasy WF, editors. Classical Conditioning II: Current Research and Theory. Appleton-Century-Crofts. pp. 64\u201399."},{"key":"ref22","unstructured":"Kamin LJ (1969) Predictability, surprise, attention and conditioning. In: Campbell BA, Church RM, editors. Punishment and aversive behavior. New York: Appleton-Century-Crofts. pp. 279\u2013296."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tics.2004.06.005","article-title":"Mechanisms of theory formation in young children","volume":"8","author":"A Gopnik","year":"2004","journal-title":"Trends in Cogn Sci"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Barber D (2012) Bayesian Reasoning and Machine Learning. Cambridge University Press.","DOI":"10.1017\/CBO9780511804779"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1073\/pnas.0608963104","article-title":"Noisy information processing through transcriptional regulation","volume":"104","author":"E Libby","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jcss.2004.04.001","article-title":"On the computational power of recurrent circuits of spiking neurons","volume":"69","author":"W Maass","year":"2004","journal-title":"J Comput Syst Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1162\/089976602760407955","article-title":"Real-Time Computing Without Stable States: A New Framework for Neural Computation Based on Perturbations","volume":"14","author":"W Maass","year":"2002","journal-title":"Neural Comput"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neunet.2007.04.001","article-title":"Introduction to the special issue on echo state networks and liquid state machines","volume":"20","author":"H Jaeger","year":"2007","journal-title":"Neural Netw"},{"key":"ref29","first-page":"245","article-title":"Random projection in dimensionality reduction: Applications to image and text data","author":"E Bingham","year":"2001","journal-title":"Data Min Knowl Discov"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3758\/BF03209695","article-title":"Classical Conditioning in Paramecia","volume":"7","author":"T Hennessey","year":"1979","journal-title":"Anim Learn Behav"},{"key":"ref31","first-page":"683","article-title":"Sensory mechanisms in Paramecium. I. Two cmoponents of the electric response to mechanical stimulation of the anterior surface","volume":"56","author":"R Eckert","year":"1972","journal-title":"J Exp Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1113\/jphysiol.1977.sp011993","article-title":"Localization of Calcium Channels in Paramecium Caudatum","volume":"271","author":"K Dunlap","year":"1977","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/bj2460337","article-title":"Regulation of ciliary adenylate cyclase by Ca2+ in Paramecium","volume":"246","author":"MC Gustin","year":"1987","journal-title":"Biochem J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1073\/pnas.76.12.6675","article-title":"Classical conditioning in <italic>Aplysia californica<\/italic>","volume":"76","author":"ET Walters","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1467-9450.1968.tb00536.x","article-title":"Induced Avoidance Behaviour in the Protozoa Tetrahymena","volume":"9","author":"SR Bergstr\u00f6m","year":"1968","journal-title":"Scand J Psychol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1467-9450.1968.tb00537.x","article-title":"Acquisition of an avoidance reaction to light in the protozoa tetrahymena","volume":"9","author":"SR Bergstr\u00f6m","year":"1968","journal-title":"Scand J Psychol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1744-9081-7-47","article-title":"Learning in a simple biological system: a pilot study of classical conditioning of human macrophages in vitro","volume":"7","author":"G Nilsonne","year":"2011","journal-title":"Behav Brain Funct"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1154456","article-title":"Predictive Behavior Within Microbial Genetic Networks","volume":"320","author":"I Tagkopoulos","year":"2008","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0960-9822(01)00418-3","article-title":"Using artificial evolution and selection to model insect navigation","volume":"11","author":"K Dale","year":"2001","journal-title":"Curr Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature08112","article-title":"Adaptive prediction of environmental changes by microorganisms","volume":"460","author":"A Mitchell","year":"2009","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Harvey I (2011) The Microbial Genetic Algorithm. In: Kampis G, editor. ECAL 2009. Budapest, Hungary: Springer, Heidelberg. pp. 126\u2013133.","DOI":"10.1007\/978-3-642-21314-4_16"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T13:52:41Z","timestamp":1687787561000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002739"}},"subtitle":[],"editor":[{"given":"Abigail","family":"Morrison","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002739","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,1]]}}}