{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:05:15Z","timestamp":1776272715330,"version":"3.50.1"},"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002923","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T14:23:09Z","timestamp":1362147789000},"page":"e1002923","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":157,"title":["Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices"],"prefix":"10.1371","volume":"9","author":[{"given":"Andra\u017e","family":"Sto\u017eer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Gosak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurij","family":"Dolen\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matja\u017e","family":"Perc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Marhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan Slak","family":"Rupnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Koro\u0161ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.physrep.2005.10.009","article-title":"Complex networks: Structure and dynamics","volume":"424","author":"S Boccaletti","year":"2006","journal-title":"Physics Reports"},{"key":"ref2","unstructured":"Newman MEJ, Barab\u00e1si AL, Watts DJ (2006) The Structure And Dynamics of Networks: Princeton University Press."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nphys2188","article-title":"The network takeover","volume":"8","author":"A-L Barabasi","year":"2012","journal-title":"Nat Phys"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nphys2198","article-title":"Complexity","volume":"8","author":"A Trabesinger","year":"2012","journal-title":"Nat Phys"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nphys2162","article-title":"Communities, modules and large-scale structure in networks","volume":"8","author":"MEJ Newman","year":"2012","journal-title":"Nat Phys"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.physrep.2009.11.002","article-title":"Community detection in graphs","volume":"486","author":"S Fortunato","year":"2010","journal-title":"Physics Reports"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/30918","article-title":"Collective dynamics of \u2018small-world\u2019 networks","volume":"393","author":"DJ Watts","year":"1998","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.286.5439.509","article-title":"Emergence of Scaling in Random Networks","volume":"286","author":"A-L Barab\u00e1si","year":"1999","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"11149","DOI":"10.1073\/pnas.200327197","article-title":"Classes of small-world networks","volume":"97","author":"LA Amaral","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1039\/b908681a","article-title":"The powerful law of the power law and other myths in network biology","volume":"5","author":"G Lima-Mendez","year":"2009","journal-title":"Molecular BioSystems"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e24678","DOI":"10.1371\/journal.pone.0024678","article-title":"Development Trends of White Matter Connectivity in the First Years of Life","volume":"6","author":"P-T Yap","year":"2011","journal-title":"PLoS ONE"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1103\/PhysRevLett.84.2758","article-title":"Fast Response and Temporal Coherent Oscillations in Small-World Networks","volume":"84","author":"LF Lago-Fern\u00e1ndez","year":"2000","journal-title":"Physical Review Letters"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/35036627","article-title":"The large-scale organization of metabolic networks","volume":"407","author":"H Jeong","year":"2000","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","article-title":"Network biology: understanding the cell&apos;s functional organization","volume":"5","author":"A-L Barabasi","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature04568","article-title":"Chance and necessity in the evolution of minimal metabolic networks","volume":"440","author":"C P\u00e1l","year":"2006","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1126\/science.1065103","article-title":"Specificity and Stability in Topology of Protein Networks","volume":"296","author":"S Maslov","year":"2002","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35075138","article-title":"Lethality and centrality in protein networks","volume":"411","author":"H Jeong","year":"2001","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.284.5411.92","article-title":"Complexity in Biological Signaling Systems","volume":"284","author":"G Weng","year":"1999","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.283.5400.381","article-title":"Emergent Properties of Networks of Biological Signaling Pathways","volume":"283","author":"Bhalla","year":"1999","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"268702","DOI":"10.1103\/PhysRevLett.89.268702","article-title":"Extreme Self-Organization in Networks Constructed from Gene Expression Data","volume":"89","author":"H Agrawal","year":"2002","journal-title":"Physical Review Letters"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1073\/pnas.0701361104","article-title":"The human disease network","volume":"104","author":"K-I Goh","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tips.2005.02.007","article-title":"The efficiency of multi-target drugs: the network approach might help drug design","volume":"26","author":"P Csermely","year":"2005","journal-title":"Trends in Pharmacological Sciences"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"E Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1073\/pnas.1111738109","article-title":"Simple models of human brain functional networks","volume":"109","author":"PE V\u00e9rtes","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1753-4631-1-3","article-title":"Graph theoretical analysis of complex networks in the brain","volume":"1","author":"C Stam","year":"2007","journal-title":"Nonlinear Biomedical Physics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2003.10.063","article-title":"Functional connectivity patterns of human magnetoencephalographic recordings: a \u2018small-world\u2019 network?","volume":"355","author":"CJ Stam","year":"2004","journal-title":"Neuroscience Letters"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"238103","DOI":"10.1103\/PhysRevLett.97.238103","article-title":"Hierarchical Organization Unveiled by Functional Connectivity in Complex Brain Networks","volume":"97","author":"C Zhou","year":"2006","journal-title":"Physical Review Letters"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"018102","DOI":"10.1103\/PhysRevLett.94.018102","article-title":"Scale-Free Brain Functional Networks","volume":"94","author":"VM Egu\u00edluz","year":"2005","journal-title":"Physical Review Letters"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.clinph.2012.01.011","article-title":"The organization of physiological brain networks","volume":"123","author":"CJ Stam","year":"2012","journal-title":"Clinical Neurophysiology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/ncomms1612","article-title":"Existence of long-lasting experience-dependent plasticity in endocrine cell networks","volume":"3","author":"DJ Hodson","year":"2012","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1365-2826.2010.02052.x","article-title":"Investigating and Modelling Pituitary Endocrine Network Function","volume":"22","author":"DJ Hodson","year":"2010","journal-title":"Journal of Neuroendocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ceca.2011.11.007","article-title":"Coordination of calcium signals by pituitary endocrine cells in situ","volume":"51","author":"DJ Hodson","year":"2012","journal-title":"Cell Calcium"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/JME-11-0035","article-title":"Endocrine cells and blood vessels work in tandem to generate hormone pulses","volume":"47","author":"M Schaeffer","year":"2011","journal-title":"Journal of Molecular Endocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0168-8227(11)70010-9","article-title":"The dual control of insulin secretion by glucose involves triggering and amplifying pathways in \u03b2-cells","volume":"93, Supplement 1","author":"J-C Henquin","year":"2011","journal-title":"Diabetes Research and Clinical Practice"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1098\/rsta.2008.0110","article-title":"Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans","volume":"366","author":"Q Zhang","year":"2008","journal-title":"Philos Transact A Math Phys Eng Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.2337\/db06-0232","article-title":"Cx36-Mediated Coupling Reduces \u03b2-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics","volume":"56","author":"S Speier","year":"2007","journal-title":"Diabetes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"C114","DOI":"10.1152\/ajpcell.1980.238.3.C114","article-title":"Nonrandom distribution of gap junctions between pancreatic beta-cells","volume":"238","author":"P Meda","year":"1980","journal-title":"American Journal of Physiology - Cell Physiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1210\/jcem-41-5-841","article-title":"Cell Contacts in Human Islets of Langerhans","volume":"41","author":"L Orci","year":"1975","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/262502a0","article-title":"Electrophysiological evidence for coupling between [beta] cells of pancreatic islets","volume":"262","author":"HP Meissner","year":"1976","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2337\/diabetes.54.6.1798","article-title":"Loss of Connexin36 Channels Alters \u03b2-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release","volume":"54","author":"MA Ravier","year":"2005","journal-title":"Diabetes"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/S0006-3495(93)81539-X","article-title":"Why pancreatic islets burst but single beta cells do not. The heterogeneity hypothesis","volume":"64","author":"P Smolen","year":"1993","journal-title":"Biophys J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4161\/isl.1.1.8757","article-title":"All together now: Exocytose or fail","volume":"1","author":"M Rupnik","year":"2009","journal-title":"Islets"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00424-003-1097-9","article-title":"A novel approach to in situ characterization of pancreatic \u00df-cells","volume":"446","author":"S Speier","year":"2003","journal-title":"Pfl\u00fcgers Archiv European Journal of Physiology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000274493","article-title":"GnRH-Induced Ca<sup>2+<\/sup>-Signalling Patterns in Mouse Gonadotrophs Recorded from Acute Pituitary Slices in vitro","volume":"91","author":"C S\u00e1nchez-C\u00e1rdenas","year":"2010","journal-title":"Neuroendocrinology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.2337\/db06-0272","article-title":"Glucose Induces Opposite Intracellular Ca<sup>2+<\/sup> Concentration Oscillatory Patterns in Identified \u03b1- and \u03b2-Cells Within Intact Human Islets of Langerhans","volume":"55","author":"I Quesada","year":"2006","journal-title":"Diabetes"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1469-7793.1999.0085z.x","article-title":"Homologous and heterologous asynchronicity between identified \u03b1-, \u03b2- and \u03b4-cells within intact islets of Langerhans in the mouse","volume":"517","author":"A Nadal","year":"1999","journal-title":"J Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"751","DOI":"10.2337\/diabetes.47.5.751","article-title":"Identification of alpha- and beta-cells in intact isolated islets of Langerhans by their characteristic cytoplasmic Ca<sup>2+<\/sup> concentration dynamics and immunocytochemical staining","volume":"47","author":"N Asada","year":"1998","journal-title":"Diabetes"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.2337\/diabetes.48.12.2390","article-title":"Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans","volume":"48","author":"I Quesada","year":"1999","journal-title":"Diabetes"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1113\/jphysiol.1996.sp021361","article-title":"In vivo synchronous membrane potential oscillations in mouse pancreatic beta-cells: lack of co-ordination between islets","volume":"493","author":"M Valdeolmillos","year":"1996","journal-title":"J Physiol"},{"key":"ref50","unstructured":"Glantz S (2005) Primer of Biostatistics. New York: McGraw-Hill Companies, Incorporated. 520 p."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: Uses and interpretations","volume":"52","author":"M Rubinov","year":"2010","journal-title":"NeuroImage"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/35065725","article-title":"Exploring complex networks","volume":"410","author":"SH Strogatz","year":"2001","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1098\/rspb.2005.3354","article-title":"The brainstem reticular formation is a small-world, not scale-free, network","volume":"273","author":"MD Humphries","year":"2006","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1098\/rstb.2000.0553","article-title":"Global relationship between anatomical connectivity and activity propagation in the cerebral cortex","volume":"355","author":"R Kotter","year":"2000","journal-title":"Philosophical Transactions of the Royal Society of London Series B: Biological Sciences"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1098\/rstb.2000.0552","article-title":"Computational analysis of functional connectivity between areas of primate cerebral cortex","volume":"355","author":"KE Stephan","year":"2000","journal-title":"Philosophical Transactions of the Royal Society of London Series B: Biological Sciences"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00550880","article-title":"Widespread synchronous Ca oscillations due to bursting electrical activity in single pancreatic islets","volume":"418","author":"RM Santos","year":"1991","journal-title":"Pfl\u00fcgers Archiv European Journal of Physiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0143-4160(96)90003-2","article-title":"Glucose-induced [Ca<sup>2+<\/sup>]<sub>i<\/sub> oscillations in single human pancreatic islets","volume":"20","author":"F Martin","year":"1996","journal-title":"Cell Calcium"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1469-7793.1998.471bq.x","article-title":"Origin of slow and fast oscillations of Ca2+ in mouse pancreatic islets","volume":"508","author":"Y-J Liu","year":"1998","journal-title":"J Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s00125-002-0883-9","article-title":"Disorganization of cytoplasmic Ca<sup>2+<\/sup> oscillations and pulsatile insulin secretion in islets from <italic>ob\/ob<\/italic> mice","volume":"45","author":"MR Ravier","year":"2002","journal-title":"Diabetologia"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"20713","DOI":"10.1016\/S0021-9258(19)36744-4","article-title":"Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell","volume":"267","author":"P Gilon","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0014-5793(89)81484-X","article-title":"Glucose-induced oscillations of intracellular Ca2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans","volume":"259","author":"M Valdeolmillos","year":"1989","journal-title":"FEBS Letters"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1073\/pnas.0510790103","article-title":"The unique cytoarchitecture of human pancreatic islets has implications for islet cell function","volume":"103","author":"O Cabrera","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4161\/isl.1.2.9480","article-title":"Islet architecture A comparative study","volume":"1","author":"A Kim","year":"2009","journal-title":"Islets"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1529\/biophysj.108.140863","article-title":"Gap junction coupling and calcium waves in the pancreatic islet","volume":"95","author":"RK Benninger","year":"2008","journal-title":"Biophys J"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.2337\/diabetes.48.10.1971","article-title":"Mechanisms of coordination of Ca<sup>2+<\/sup> signals in pancreatic islet cells","volume":"48","author":"F Bertuzzi","year":"1999","journal-title":"Diabetes"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0006-3495(01)76096-1","article-title":"Excitation Wave Propagation as a Possible Mechanism for Signal Transmission in Pancreatic Islets of Langerhans","volume":"80","author":"OV Aslanidi","year":"2001","journal-title":"Biophys J"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/j.clinph.2007.08.010","article-title":"The application of graph theoretical analysis to complex networks in the brain","volume":"118","author":"JC Reijneveld","year":"2007","journal-title":"Clinical Neurophysiology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e983","DOI":"10.1371\/journal.pone.0000983","article-title":"Investigating the Role of Islet Cytoarchitecture in Its Oscillation Using a New \u03b2-Cell Cluster Model","volume":"2","author":"A Nittala","year":"2007","journal-title":"PLoS ONE"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1113\/jphysiol.1997.sp021899","article-title":"Oscillation of gap junction electrical coupling in the mouse pancreatic islets of Langerhans","volume":"498","author":"E Andreu","year":"1997","journal-title":"J Physiol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0006-3495(91)82200-7","article-title":"Biophysical properties of gap junctions between freshly dispersed pairs of mouse pancreatic beta cells","volume":"59","author":"M P\u00e9rez-Armendariz","year":"1991","journal-title":"Biophys J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"E948","DOI":"10.1152\/ajpendo.00216.2004","article-title":"Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse \u03b2-cells","volume":"288","author":"AP Moreno","year":"2005","journal-title":"American Journal of Physiology - Endocrinology And Metabolism"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0006-3495(91)82271-8","article-title":"Model for synchronization of pancreatic beta-cells by gap junction coupling","volume":"59","author":"A Sherman","year":"1991","journal-title":"Biophys J"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"E890","DOI":"10.1152\/ajpendo.00359.2007","article-title":"Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion","volume":"293","author":"R Bertram","year":"2007","journal-title":"American Journal of Physiology - Endocrinology And Metabolism"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1172\/JCI114772","article-title":"Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells","volume":"86","author":"P Meda","year":"1990","journal-title":"The Journal of Clinical Investigation"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00238006","article-title":"Magnitude and Modulation of Pancreatic Beta-Cell Gap Junction Electrical Conductance In-Situ","volume":"146","author":"D Mears","year":"1995","journal-title":"Journal of Membrane Biology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10867-008-9069-0","article-title":"Wave-Block Due to a Threshold Gradient Underlies Limited Coordination in Pancreatic Islets","volume":"34","author":"M Pedersen","year":"2008","journal-title":"Journal of Biological Physics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/B:JOBP.0000046727.28337.f4","article-title":"Homogenization of heterogeneously coupled bistable ODE&apos;s - Applied to excitation waves in pancreatic islets of Langerhans","volume":"30","author":"MG Pedersen","year":"2004","journal-title":"Journal of Biological Physics"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tem.2010.03.003","article-title":"\u2018Giving and taking\u2019: endothelial and \u03b2-cells in the islets of Langerhans","volume":"21","author":"D Eberhard","year":"2010","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tcb.2006.11.005","article-title":"The vascular niche and its basement membrane","volume":"17","author":"G Nikolova","year":"2007","journal-title":"Trends in Cell Biology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nphys1932","article-title":"Dimension of spatially embedded networks","volume":"7","author":"L Daqing","year":"2011","journal-title":"Nat Phys"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T19:52:20Z","timestamp":1644436340000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002923"}},"subtitle":[],"editor":[{"given":"Stanislav","family":"Shvartsman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":80,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002923","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]}}}