{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:55:24Z","timestamp":1783702524821,"version":"3.55.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003122","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T22:29:10Z","timestamp":1372976950000},"page":"e1003122","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Interaction of Motility, Directional Sensing, and Polarity Modules Recreates the Behaviors of Chemotaxing Cells"],"prefix":"10.1371","volume":"9","author":[{"given":"Changji","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Hsiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter N.","family":"Devreotes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ceb.2007.11.011","article-title":"Navigating through models of chemotaxis","volume":"20","author":"PA Iglesias","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"20445","DOI":"10.1074\/jbc.R300010200","article-title":"Eukaryotic chemotaxis: Distinctions between directional sensing and polarization","volume":"278","author":"P Devreotes","year":"2003","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ceb.2009.01.001","article-title":"Calling heads from tails: The role of mathematical modeling in understanding cell polarization","volume":"21","author":"MD Onsum","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1001121","DOI":"10.1371\/journal.pcbi.1001121","article-title":"A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues","volume":"7","author":"A Jilkine","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1002793","DOI":"10.1371\/journal.pcbi.1002793","article-title":"A comparison of computational models for eukaryotic cell shape and motility","volume":"8","author":"WR Holmes","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.112.17.2867","article-title":"Orientation of chemotactic cells and growth cones: Models and mechanisms","volume":"112","author":"H Meinhardt","year":"1999","journal-title":"J Cell Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"158301","DOI":"10.1103\/PhysRevLett.104.158301","article-title":"Transient localized patterns in noise-driven reaction-diffusion systems","volume":"104","author":"I Hecht","year":"2010","journal-title":"Phys Rev Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ceb.2011.11.009","article-title":"Biased excitable networks: How cells direct motion in response to gradients","volume":"24","author":"PA Iglesias","year":"2012","journal-title":"Curr Opin Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e33528","DOI":"10.1371\/journal.pone.0033528","article-title":"An excitable cortex and memory model successfully predicts new pseudopod dynamics","volume":"7","author":"RM Cooper","year":"2012","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1073\/pnas.1011271107","article-title":"Cells navigate with a local-excitation, global-inhibition-biased excitable network","volume":"107","author":"Y Xiong","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1002044","DOI":"10.1371\/journal.pcbi.1002044","article-title":"Activated membrane patches guide chemotactic cell motility","volume":"7","author":"I Hecht","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1000618","DOI":"10.1371\/journal.pbio.1000618","article-title":"Chemotaxis: A feedback-based computational model robustly predicts multiple aspects of real cell behaviour","volume":"9","author":"MP Neilson","year":"2011","journal-title":"PLoS Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0301-4622(99)00146-5","article-title":"Reaction-diffusion waves of actin filament polymerization\/depolymerization in <italic>Dictyostelium<\/italic> pseudopodium extension and cell locomotion","volume":"84","author":"MG Vicker","year":"2000","journal-title":"Biophys Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1529\/biophysj.104.047589","article-title":"Mobile actin clusters and traveling waves in cells recovering from actin depolymerization","volume":"87","author":"G Gerisch","year":"2004","journal-title":"Biophys J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1371\/journal.pbio.0050221","article-title":"An actin-based wave generator organizes cell motility","volume":"5","author":"OD Weiner","year":"2007","journal-title":"PLoS Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e3734","DOI":"10.1371\/journal.pone.0003734","article-title":"Ordered patterns of cell shape and orientational correlation during spontaneous cell migration","volume":"3","author":"YT Maeda","year":"2008","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12399","DOI":"10.1073\/pnas.0908278107","article-title":"Self-organization of the phosphatidylinositol lipids signaling system for random cell migration","volume":"107","author":"Y Arai","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1016\/j.bpj.2008.12.3942","article-title":"The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization","volume":"96","author":"T Bretschneider","year":"2009","journal-title":"Biophys J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bpj.2012.08.004","article-title":"PIP<sub>3<\/sub> waves and PTEN dynamics in the emergence of cell polarity","volume":"103","author":"G Gerisch","year":"2012","journal-title":"Biophys J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/cm.20314","article-title":"Correlated waves of actin filaments and PIP<sub>3<\/sub> in <italic>Dictyostelium<\/italic> cells","volume":"65","author":"Y Asano","year":"2008","journal-title":"Cell Motil Cytoskeleton"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1073\/pnas.1218025110","article-title":"Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells","volume":"110","author":"D Taniguchi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1752-0509-2-68","article-title":"Modeling cellular deformations using the level set formalism","volume":"2","author":"L Yang","year":"2008","journal-title":"BMC Syst Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1016\/j.jcp.2010.06.014","article-title":"The moving boundary node method: A level set-based, finite volume algorithm with applications to cell motility","volume":"229","author":"CW Wolgemuth","year":"2010","journal-title":"J Comput Phys"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ncb1536","article-title":"Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions","volume":"9","author":"N Andrew","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1752-0509-4-33","article-title":"Automated characterization of cell shape changes during amoeboid motility by skeletonization","volume":"4","author":"Y Xiong","year":"2010","journal-title":"BMC Syst Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e5253","DOI":"10.1371\/journal.pone.0005253","article-title":"The ordered extension of pseudopodia by amoeboid cells in the absence of external cues","volume":"4","author":"L Bosgraaf","year":"2009","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.106.2.303","article-title":"A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations","volume":"106","author":"RT Tranquillo","year":"1988","journal-title":"J Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e6842","DOI":"10.1371\/journal.pone.0006842","article-title":"Navigation of chemotactic cells by parallel signaling to pseudopod persistence and orientation","volume":"4","author":"L Bosgraaf","year":"2009","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"28005","DOI":"10.1209\/0295-5075\/90\/28005","article-title":"Quantitative analysis of random ameboid motion","volume":"90","author":"HU Bodeker","year":"2010","journal-title":"Epl"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"046006","DOI":"10.1088\/1478-3975\/8\/4\/046006","article-title":"\u2018Dicty dynamics\u2019: <italic>Dictyostelium<\/italic> motility as persistent random motion","volume":"8","author":"L Li","year":"2011","journal-title":"Phys Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e2648","DOI":"10.1371\/journal.pone.0002648","article-title":"Functional analysis of spontaneous cell movement under different physiological conditions","volume":"3","author":"H Takagi","year":"2008","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1091\/mbc.E03-05-0339","article-title":"Two phases of actin polymerization display different dependencies on PI(3,4,5)P<sub>3<\/sub> accumulation and have unique roles during chemotaxis","volume":"14","author":"L Chen","year":"2003","journal-title":"Mol Biol Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1371\/journal.pcbi.0030036","article-title":"A mathematical model for neutrophil gradient sensing and polarization","volume":"3","author":"M Onsum","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200604113","article-title":"To stabilize neutrophil polarity, PIP<sub>3<\/sub> and Cdc42 augment RhoA activity at the back as well as signals at the front","volume":"174","author":"A Van Keymeulen","year":"2006","journal-title":"Journal of Cell Biology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jtbi.2004.05.024","article-title":"A mechanistic model for eukaryotic gradient sensing: spontaneous and induced phosphoinositide polarization","volume":"231","author":"KK Subramanian","year":"2004","journal-title":"J Theor Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1371\/journal.pcbi.0030108","article-title":"A mass conserved reaction-diffusion system captures properties of cell polarity","volume":"3","author":"M Otsuji","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.febslet.2008.03.029","article-title":"Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity","volume":"582","author":"AB Goryachev","year":"2008","journal-title":"FEBS Lett"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.0911178107","article-title":"External and internal constraints on eukaryotic chemotaxis","volume":"107","author":"D Fuller","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1039\/c0ib00033g","article-title":"Gradient sensing in defined chemotactic fields","volume":"2","author":"M Skoge","year":"2010","journal-title":"Integr Biol (Camb)"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/jcs.113415","article-title":"Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses","volume":"126","author":"K Srinivasan","year":"2013","journal-title":"J Cell Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.92.3.807","article-title":"Cell behavior in <italic>Dictyostelium discoideum<\/italic>: Preaggregation response to localized cyclic AMP pulses","volume":"92","author":"RP Futrelle","year":"1982","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1073\/pnas.0402152101","article-title":"Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton","volume":"101","author":"C Janetopoulos","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1529\/biophysj.104.045484","article-title":"Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P<sub>3<\/sub> response in <italic>Dictyostelium<\/italic> cells","volume":"87","author":"L Ma","year":"2004","journal-title":"Biophys J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1002402","DOI":"10.1371\/journal.pcbi.1002402","article-title":"How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility","volume":"8","author":"AF Maree","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1002366","DOI":"10.1371\/journal.pcbi.1002366","article-title":"Modelling cell polarization driven by synthetic spatially graded Rac activation","volume":"8","author":"WR Holmes","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1083\/jcb.200509028","article-title":"Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts","volume":"171","author":"IC Schneider","year":"2005","journal-title":"J Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev.biophys.093008.131228","article-title":"Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity","volume":"39","author":"KF Swaney","year":"2010","journal-title":"Annu Rev Biophys"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.devcel.2007.03.005","article-title":"PLA2 and PI3K\/PTEN pathways act in parallel to mediate chemotaxis","volume":"12","author":"L Chen","year":"2007","journal-title":"Dev Cell"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cub.2007.04.004","article-title":"Chemotaxis in the absence of PIP<sub>3<\/sub> gradients","volume":"17","author":"O Hoeller","year":"2007","journal-title":"Curr Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/embor.2011.210","article-title":"<italic>Dictyostelium<\/italic> chemotaxis: Essential Ras activation and accessory signalling pathways for amplification","volume":"12","author":"A Kortholt","year":"2011","journal-title":"EMBO Rep"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(02)00745-6","article-title":"Tumor suppressor PTEN mediates sensing of chemoattractant gradients","volume":"109","author":"M Iijima","year":"2002","journal-title":"Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1083\/jcb.201001129","article-title":"Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis","volume":"190","author":"H Cai","year":"2010","journal-title":"J Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.cub.2008.08.069","article-title":"Spatiotemporal regulation of Ras activity provides directional sensing","volume":"18","author":"S Zhang","year":"2008","journal-title":"Curr Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1741-7007-5-53","article-title":"Dynacortin facilitates polarization of chemotaxing cells","volume":"5","author":"C Kabacoff","year":"2007","journal-title":"BMC Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cell.2011.10.050","article-title":"Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration","volume":"148","author":"AR Houk","year":"2012","journal-title":"Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1101\/gad.1694508","article-title":"tsunami, the <italic>Dictyostelium<\/italic> homolog of the Fused kinase, is required for polarization and chemotaxis","volume":"22","author":"L Tang","year":"2008","journal-title":"Genes Dev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1529\/biophysj.106.087353","article-title":"Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells","volume":"92","author":"J Krishnan","year":"2007","journal-title":"Biophys J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1371\/journal.pcbi.0030153","article-title":"An information-theoretic characterization of the optimal gradient sensing response of cells","volume":"3","author":"BW Andrews","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e1002467","DOI":"10.1371\/journal.pcbi.1002467","article-title":"Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression","volume":"8","author":"CC Poirier","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1073\/pnas.0837027100","article-title":"Probing polymerization forces by using actin-propelled lipid vesicles","volume":"100","author":"A Upadhyaya","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1073\/pnas.0607052104","article-title":"Direct measurement of force generation by actin filament polymerization using an optical trap","volume":"104","author":"MJ Footer","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","unstructured":"Picchini U (2007) SDE Toolbox: Simulation and estimation of stochastic differential equations with Matlab, version 1.4.1. Available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/sdetoolbox.sourceforge.net\" xlink:type=\"simple\">http:\/\/sdetoolbox.sourceforge.net<\/ext-link>. Accessed 26 October 2010."},{"key":"ref63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0092-8674(00)81784-5","article-title":"G protein signaling events are activated at the leading edge of chemotactic cells","volume":"95","author":"CA Parent","year":"1998","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1093\/emboj\/18.8.2092","article-title":"Chemoattractant-mediated transient activation and membrane localization of Akt\/PKB is required for efficient chemotaxis to cAMP in <italic>Dictyostelium<\/italic>","volume":"18","author":"R Meili","year":"1999","journal-title":"Embo J"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1091\/mbc.E03-08-0566","article-title":"Uniform cAMP stimulation of <italic>Dictyostelium<\/italic> cells induces localized patches of signal transduction and pseudopodia","volume":"14","author":"M Postma","year":"2003","journal-title":"Mol Biol Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1242\/jcs.01143","article-title":"Sensitization of <italic>Dictyostelium<\/italic> chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches","volume":"117","author":"M Postma","year":"2004","journal-title":"J Cell Sci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"ra2","DOI":"10.1126\/scisignal.2002413","article-title":"Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway","volume":"5","author":"K Takeda","year":"2012","journal-title":"Sci Signal"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1083\/jcb.80.2.300","article-title":"Cyclic 3\u2032,5\u2032 AMP relay in <italic>Dictyostelium discoideum<\/italic>. II. Requirements for the initiation and termination of the response","volume":"80","author":"PN Devreotes","year":"1979","journal-title":"J Cell Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1083\/jcb.82.2.517","article-title":"Sensory adaptation of leukocytes to chemotactic peptides","volume":"82","author":"SH Zigmond","year":"1979","journal-title":"J Cell Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1083\/jcb.96.6.1559","article-title":"Sensory adaptation of <italic>Dictyostelium discoideum<\/italic> cells to chemotactic signals","volume":"96","author":"PJ Van Haastert","year":"1983","journal-title":"J Cell Biol"},{"key":"ref71","first-page":"ra17","article-title":"Diverse sensitivity thresholds in dynamic signaling responses by social amoebae","volume":"5","author":"CJ Wang","year":"2012","journal-title":"Sci Signal"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1073\/pnas.0601909103","article-title":"Cellular asymmetry and individuality in directional sensing","volume":"103","author":"A Samadani","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1088\/1478-3975\/3\/3\/004","article-title":"Morphology matters in immune cell chemotaxis: Membrane asymmetry affects amplification","volume":"3","author":"MD Onsum","year":"2006","journal-title":"Phys Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(82)90340-3","article-title":"Local and spatially coordinated movements in <italic>Dictyostelium discoideum<\/italic> amoebae during chemotaxis","volume":"28","author":"JA Swanson","year":"1982","journal-title":"Cell"},{"key":"ref75","unstructured":"Gerisch G, Malchow D, Huesgen A, Nanjundiah V, Roos W, <etal>et al<\/etal>.. (1975) Cyclic-AMP reception and cell recognition in <italic>Dictyostelium discoideum<\/italic>. In: MacMahon D, Fox CF, editors. Developmental biology: pattern formation, gene regulation. Menlo Park: W. A. Benjamin. pp. 76\u201388."},{"key":"ref76","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jtbi.2008.08.012","article-title":"Stochastic control of spontaneous signal generation for gradient sensing in chemotaxis","volume":"255","author":"H Naoki","year":"2008","journal-title":"J Theor Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1073\/pnas.0601302103","article-title":"Directional sensing in eukaryotic chemotaxis: A balanced inactivation model","volume":"103","author":"H Levine","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-3495(02)75373-3","article-title":"Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils","volume":"82","author":"A Levchenko","year":"2002","journal-title":"Biophys J"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1126\/science.284.5415.765","article-title":"A cell&apos;s sense of direction","volume":"284","author":"CA Parent","year":"1999","journal-title":"Science"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1137\/100815335","article-title":"A computational model of cell polarization and motility coupling mechanics and biochemistry","volume":"9","author":"B Vanderlei","year":"2011","journal-title":"Multiscale Model Simul"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.devcel.2004.12.007","article-title":"A local coupling model and compass parameter for eukaryotic chemotaxis","volume":"8","author":"C Arrieumerlou","year":"2005","journal-title":"Dev Cell"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"e1000874","DOI":"10.1371\/journal.pcbi.1000874","article-title":"A model for a correlated random walk based on the ordered extension of pseudopodia","volume":"6","author":"PJ Van Haastert","year":"2010","journal-title":"PLoS Comput Biol"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T11:28:56Z","timestamp":1645961336000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003122"}},"subtitle":[],"editor":[{"given":"Jason M.","family":"Haugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":82,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003122","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]}}}