{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:33:42Z","timestamp":1770899622268,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003174","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T22:08:53Z","timestamp":1377814133000},"page":"e1003174","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["Conditional Cooperativity of Toxin - Antitoxin Regulation Can Mediate Bistability between Growth and Dormancy"],"prefix":"10.1371","volume":"9","author":[{"given":"Ilaria","family":"Cataudella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Sneppen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenn","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiko","family":"Mitarai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/nar\/gki201","article-title":"Toxin-antitoxin loci are highly abundant in free-living but from host-associated prokaryotes","volume":"33","author":"D Pandey","year":"2005","journal-title":"Nucleic Acids Research"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1073\/pnas.251327898","article-title":"RelE, a global inhibitor of translation, is activated during nutritional stress","volume":"98","author":"SK Christensen","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1365-2958.2008.06313.x","article-title":"Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity","volume":"69","author":"M Overgaard","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jmb.2009.09.006","article-title":"RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB","volume":"394","author":"M Overgaard","year":"2009","journal-title":"J Mol Biol"},{"key":"ref5","first-page":"1641","article-title":"Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity","volume":"20","author":"A B\u00f8gglid","year":"2012","journal-title":"Structure"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1093\/nar\/gks297","article-title":"Conditional cooperativity in toxinantitoxin regulation prevents random toxin activation and promotes fast translational recovery","volume":"40","author":"I Cataudella","year":"2012","journal-title":"Nucleic Acid Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1093\/nar\/gks029","article-title":"Regulation of enteric valbc transcription: induction by vapc toxin dimer breaking","volume":"40","author":"K Winther","year":"2012","journal-title":"Nucleic Acid Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1128\/JB.180.23.6342-6351.1998","article-title":"Corepression of the p1 addiction operon by phd and doc","volume":"180","author":"R Magnuson","year":"1998","journal-title":"J Bacteriol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cell.2010.05.039","article-title":"Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity","volume":"142","author":"A Garcia-Pino","year":"2010","journal-title":"Cell"},{"key":"ref10","first-page":"81","article-title":"Corepression of the p1 addiction operon by phd and doc","volume":"218","author":"R Feyter","year":"1989","journal-title":"Mol Gen Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-1097(03)00856-5","article-title":"Persister cells and tolerance to antimicrobials","volume":"230","author":"I Keren","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1126\/science.1099390","article-title":"Bacterial persistence as a phenotypic switch","volume":"305","author":"NQ Balaban","year":"2010","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1574-6976.2008.00156.x","article-title":"The importance of being persistent: heterogeneity of bacterial populations under antibiotic stress","volume":"33","author":"O Gefen","year":"2009","journal-title":"FEMS Microbiol Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"12541","DOI":"10.1073\/pnas.1004333107","article-title":"Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence","volume":"107","author":"E Rotem","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"13206","DOI":"10.1073\/pnas.1100186108","article-title":"Bacterial persistence by rna endonucleases","volume":"108","author":"E Maisonneuve","year":"2011","journal-title":"Proc Natl Acad Sci US"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-micro-092611-150159","article-title":"Bacterial persisternce and toxin-antitoxin loci","volume":"66","author":"K Gerdes","year":"2012","journal-title":"Ann Rev Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtbi.2008.07.035","article-title":"A molecular model for persister in e. coli","volume":"225","author":"C Lou","year":"2008","journal-title":"J Thor Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2004.06.009","article-title":"The small rna chaperone hfq and multiple small rnas control quorum sensing in vibrio harveyi and vibrio cholerae","volume":"118","author":"D Lenz","year":"2004","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1371\/journal.pbio.0050229","article-title":"Quantitative characteristics of gene regulation by small rna","volume":"5","author":"E Levine","year":"2007","journal-title":"PLoS Comp Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"164171","DOI":"10.1088\/1478-3975\/4\/3\/003","article-title":"Efcient degradation and expression prioritization with small rnas","volume":"4","author":"N Mitarai","year":"2007","journal-title":"Physical Biology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10655","DOI":"10.1073\/pnas.0901466106","article-title":"Dynamic features of gene expression control by small regulatory rnas","volume":"106","author":"N Mitarai","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/msb.2009.30","article-title":"Protein sequestration generates a flexible ultrasensitive response in a genetic network","volume":"5","author":"N Buchler","year":"2009","journal-title":"Molecular Systems Biology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jmb.2009.08.075","article-title":"Modeling of the genetic switch of bacteriophage tp901-1: A heteromer of ci and mor ensures robust bistability","volume":"394","author":"H Nakanishi","year":"2009","journal-title":"J Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/msb.2012.52","article-title":"Sequestration-based bistability enables tuning of the switching boundaries and design of a latch","volume":"8","author":"D Chen","year":"2012","journal-title":"Mol Syst Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jmb.2008.09.071","article-title":"The role of mor and the ci operator sites on the genetic switch of the temperate bacteriophage tp901-1","volume":"384","author":"M Pedersen","year":"2008","journal-title":"J Mol Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.cell.2009.12.001","article-title":"Growth rate-dependent global effects on gene expression in bacteria","volume":"139","author":"S Klumpp","year":"2009","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nchembio.218","article-title":"Emergent bistability by a growth-modulating positive feedback circuit","volume":"5","author":"C Tan","year":"2009","journal-title":"Nature Chemical Biology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1002480","DOI":"10.1371\/journal.pcbi.1002480","article-title":"Mapping the environmental fitness landscape of a synthetic gene circuit","volume":"8","author":"D Nevozhay","year":"2012","journal-title":"PLos Comput Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1534\/genetics.104.035352","article-title":"Bacterial persistence: A model of survival in changing encironment","volume":"169","author":"E Krussel","year":"2005","journal-title":"Genetics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1073\/pnas.0304532101","article-title":"Design of genetic networks with specified functions by evolution in silico","volume":"102","author":"P Francois","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nrmicro2667","article-title":"Non-transcriptional regulatory processes shape transcriptional network dynamics","volume":"9","author":"J Ray","year":"2011","journal-title":"Nature Reviews Microbiology"},{"key":"ref32","unstructured":"Press A WH Teukolsky, Vetterling W, Flannery B (2007) Numerical recipes 3rd edition: The art of scientific computing. Cambridge University Press."}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T20:32:50Z","timestamp":1596400370000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003174"}},"subtitle":[],"editor":[{"given":"Jeffrey J.","family":"Saucerman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003174","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}