{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:30:42Z","timestamp":1775305842755,"version":"3.50.1"},"reference-count":106,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003448","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T21:46:40Z","timestamp":1392328000000},"page":"e1003448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms"],"prefix":"10.1371","volume":"10","author":[{"given":"Alan E.","family":"Bilsland","sequence":"first","affiliation":[]},{"given":"Katrina","family":"Stevenson","sequence":"additional","affiliation":[]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Stacey","family":"Hoare","sequence":"additional","affiliation":[]},{"given":"Claire J.","family":"Cairney","sequence":"additional","affiliation":[]},{"given":"Jon","family":"Roffey","sequence":"additional","affiliation":[]},{"given":"W. Nicol","family":"Keith","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.gene.2012.01.095","article-title":"Regulation of the human catalytic subunit of telomerase (hTERT)","volume":"498","author":"M Daniel","year":"2012","journal-title":"Gene"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.canlet.2012.11.033","article-title":"Cancer omics: From regulatory networks to clinical outcomes","volume":"340","author":"B Tang","year":"2012","journal-title":"Cancer Lett"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e6459","DOI":"10.1371\/journal.pone.0006459","article-title":"Dynamic telomerase gene suppression via network effects of GSK3 inhibition","volume":"4","author":"AE Bilsland","year":"2009","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1038\/onc.2009.238","article-title":"A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT","volume":"28","author":"K Lafferty-Whyte","year":"2009","journal-title":"Oncogene"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"20737","DOI":"10.1074\/jbc.M111.319236","article-title":"Tumor suppressors p53, p63TAalpha, p63TAy, p73alpha, and p73beta use distinct pathways to repress telomerase expression","volume":"287","author":"Y Yao","year":"2012","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1096\/fj.02-0311fje","article-title":"Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells","volume":"16","author":"J Won","year":"2002","journal-title":"Faseb J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/sj.bjc.6605878","article-title":"Wilms&apos; tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways","volume":"103","author":"RT Sitaram","year":"2010","journal-title":"Br J Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1042\/BST0321090","article-title":"Oscillations in transcription factor dynamics: a new way to control gene expression","volume":"32","author":"DE Nelson","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1615\/CritRevOncog.2013007197","article-title":"MicroRNA and Senescence: The Senectome, Integration and Distributed Control","volume":"18","author":"AE Bilsland","year":"2013","journal-title":"Crit Rev Oncog"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"VK Mootha","year":"2003","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1093\/bioinformatics\/bti574","article-title":"goCluster integrates statistical analysis and functional interpretation of microarray expression data","volume":"21","author":"G Wrobel","year":"2005","journal-title":"Bioinformatics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Geard N, Willadsen K (2009) Dynamical approaches to modeling developmental gene regulatory networks. Birth Defects Res C Embryo Today. pp. 131\u2013142.","DOI":"10.1002\/bdrc.20150"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/ncb1994","article-title":"Cell fate decisions are specified by the dynamic ERK interactome","volume":"11","author":"A von Kriegsheim","year":"2009","journal-title":"Nat Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cellsig.2010.10.011","article-title":"Compensatory effects in the PI3K\/PTEN\/AKT signaling network following receptor tyrosine kinase inhibition","volume":"23","author":"A Goltsov","year":"2011","journal-title":"Cell Signal"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"20120071","DOI":"10.1098\/rsfs.2012.0071","article-title":"Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology","volume":"3","author":"N Benson","year":"2013","journal-title":"Interface Focus"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biosystems.2005.09.009","article-title":"An analysis of the class of gene regulatory functions implied by a biochemical model","volume":"84","author":"J Grefenstette","year":"2006","journal-title":"Biosystems"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"14796","DOI":"10.1073\/pnas.2036429100","article-title":"Random Boolean network models and the yeast transcriptional network","volume":"100","author":"S Kauffman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1098\/rsif.2012.0080","article-title":"Digital clocks: simple Boolean models can quantitatively describe circadian systems","volume":"9","author":"OE Akman","year":"2012","journal-title":"J R Soc Interface"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.febslet.2009.02.010","article-title":"Robustness and topology of the yeast cell cycle Boolean network","volume":"583","author":"WB Lee","year":"2009","journal-title":"FEBS Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000595","DOI":"10.1371\/journal.pcbi.1000595","article-title":"ON\/OFF and beyond\u2013a boolean model of apoptosis","volume":"5","author":"R Schlatter","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT promoter mutations in familial and sporadic melanoma","volume":"339","author":"S Horn","year":"2013","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.1229259","article-title":"Highly recurrent TERT promoter mutations in human melanoma","volume":"339","author":"FW Huang","year":"2013","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1073\/pnas.1303607110","article-title":"TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal","volume":"110","author":"PJ Killela","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1593\/neo.05385","article-title":"Properties of a telomerase-specific Cre\/Lox switch for transcriptionally targeted cancer gene therapy","volume":"7","author":"AE Bilsland","year":"2005","journal-title":"Neoplasia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1128\/MCB.25.18.8037-8043.2005","article-title":"Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells","volume":"25","author":"M Takakura","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1158\/0008-5472.CAN-05-0924","article-title":"Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells","volume":"65","author":"L Konnikova","year":"2005","journal-title":"Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.onc.1209011","article-title":"Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms","volume":"25","author":"CJ Anderson","year":"2006","journal-title":"Oncogene"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"31183","DOI":"10.1074\/jbc.M404380200","article-title":"IkappaB kinase alpha and p65\/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation","volume":"279","author":"V Anest","year":"2004","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(88)90143-2","article-title":"The jun proto-oncogene is positively autoregulated by its product, Jun\/AP-1","volume":"55","author":"P Angel","year":"1988","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1158\/0008-5472.CAN-09-2598","article-title":"p53 is a direct transcriptional target of MYCN in neuroblastoma","volume":"70","author":"L Chen","year":"2010","journal-title":"Cancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1128\/MCB.14.7.4380","article-title":"The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator","volume":"14","author":"LI Chen","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/nar\/29.13.2789","article-title":"E2F-1 represses transcription of the human telomerase reverse transcriptase gene","volume":"29","author":"DL Crowe","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11897","DOI":"10.1158\/0008-5472.CAN-06-2497","article-title":"Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer","volume":"66","author":"JN Davis","year":"2006","journal-title":"Cancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1210\/endo.139.4.5870","article-title":"Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation","volume":"139","author":"R Duan","year":"1998","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.immuni.2010.05.003","article-title":"Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis","volume":"32","author":"L Durant","year":"2010","journal-title":"Immunity"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/ATVBAHA.110.219808","article-title":"Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages","volume":"31","author":"F Gizard","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1128\/MCB.25.17.7423-7431.2005","article-title":"p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest","volume":"25","author":"JS Ho","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1158\/0008-5472.CAN-12-0943","article-title":"NLRR1 enhances EGF-mediated MYCN induction in neuroblastoma and accelerates tumor growth in vivo","volume":"72","author":"S Hossain","year":"2012","journal-title":"Cancer Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/me.2010-0424","article-title":"Progesterone receptor activation of extranuclear signaling pathways in regulating p53 expression in vascular endothelial cells","volume":"25","author":"SP Hsu","year":"2011","journal-title":"Mol Endocrinol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/nar\/gkn002","article-title":"Regulation of the MAD1 promoter by G-CSF","volume":"36","author":"K Jiang","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1101\/gad.8.13.1514","article-title":"Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression","volume":"8","author":"DG Johnson","year":"1994","journal-title":"Genes Dev"},{"key":"ref44","first-page":"1239","article-title":"Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription","volume":"6","author":"T Kanaya","year":"2000","journal-title":"Clin Cancer Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1093\/nar\/20.15.4083","article-title":"Repression of the basal c-fos promoter by wild-type p53","volume":"20","author":"N Kley","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/nar\/28.3.669","article-title":"Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)","volume":"28","author":"S Kyo","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/1098-2744(200010)29:2<76::AID-MC4>3.0.CO;2-Y","article-title":"Direct recruitment of N-myc to target gene promoters","volume":"29","author":"SM Mac","year":"2000","journal-title":"Mol Carcinog"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1096\/fj.07-9360com","article-title":"Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development","volume":"22","author":"U Moehren","year":"2008","journal-title":"FASEB J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/bj20021166","article-title":"Transcriptional regulation of the human Sp1 gene promoter by the specificity protein (Sp) family members nuclear factor Y (NF-Y) and E2F","volume":"371","author":"M Nicolas","year":"2003","journal-title":"Biochem J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/sj.onc.1203439","article-title":"Identification of Mad as a repressor of the human telomerase (hTERT) gene","volume":"19","author":"S Oh","year":"2000","journal-title":"Oncogene"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7331","DOI":"10.1073\/pnas.0832317100","article-title":"Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors","volume":"100","author":"TG Oliver","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0014-5793(01)02583-2","article-title":"Alterations in expression of E2F-1 and E2F-responsive genes by RB, p53 and p21(Sdi1\/WAF1\/Cip1) expression","volume":"500","author":"K Ookawa","year":"2001","journal-title":"FEBS Lett"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1038\/sj.onc.1208833","article-title":"Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP","volume":"24","author":"OW Rokhlin","year":"2005","journal-title":"Oncogene"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1128\/MCB.05089-11","article-title":"Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis","volume":"31","author":"T Sengupta","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbagrm.2008.02.006","article-title":"Transcriptional regulation of the 5\u2032-flanking region of the human transcription factor Sp3 gene by NF-1, c-Myb, B-Myb, AP-1 and E2F","volume":"1779","author":"A Tapias","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.4161\/cc.7.18.6671","article-title":"Regulation of Sp1 by cell cycle related proteins","volume":"7","author":"A Tapias","year":"2008","journal-title":"Cell Cycle"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1101\/gad.3.4.527","article-title":"Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter","volume":"3","author":"K Thalmeier","year":"1989","journal-title":"Genes Dev"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.canlet.2004.03.032","article-title":"The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription","volume":"214","author":"Q Wang","year":"2004","journal-title":"Cancer Lett"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1096\/fj.07-8621com","article-title":"Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1","volume":"21","author":"LG Wooten-Blanks","year":"2007","journal-title":"FASEB J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/6010","article-title":"Direct activation of TERT transcription by c-MYC","volume":"21","author":"KJ Wu","year":"1999","journal-title":"Nat Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10142-012-0305-0","article-title":"Subset of genes targeted by transcription factor NF-kappaB in TNFalpha-stimulated human HeLa cells","volume":"13","author":"Y Xing","year":"2013","journal-title":"Funct Integr Genomics"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"15794","DOI":"10.1074\/jbc.M213073200","article-title":"Independent and cooperative activation of chromosomal c-fos promoter by STAT3","volume":"278","author":"E Yang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"17834","DOI":"10.1073\/pnas.0604129103","article-title":"Global mapping of c-Myc binding sites and target gene networks in human B cells","volume":"103","author":"KI Zeller","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1210\/me.2011-1305","article-title":"COUP-TFII is a major regulator of cell cycle and Notch signaling pathways","volume":"26","author":"X Chen","year":"2012","journal-title":"Mol Endocrinol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.freeradbiomed.2013.02.022","article-title":"Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function","volume":"60","author":"K Cho","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/15216540213466","article-title":"E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis B viral X protein (Hbx) on the p53 promoter","volume":"53","author":"M Choi","year":"2002","journal-title":"IUBMB Life"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1158\/1541-7786.MCR-09-0117","article-title":"Mutant p53 (G199V) gains antiapoptotic function through signal transducer and activator of transcription 3 in anaplastic thyroid cancer cells","volume":"7","author":"TH Kim","year":"2009","journal-title":"Mol Cancer Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.18632\/oncotarget.382","article-title":"Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome","volume":"2","author":"PM Neilsen","year":"2011","journal-title":"Oncotarget"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1128\/MCB.25.17.7432-7440.2005","article-title":"Role of Stat3 in regulating p53 expression and function","volume":"25","author":"G Niu","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref70","first-page":"629","article-title":"The Fos and Jun\/AP-1 proteins are involved in the downregulation of Fos transcription","volume":"4","author":"A Schonthal","year":"1989","journal-title":"Oncogene"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1038\/sj.onc.1201363","article-title":"Autoregulation of the human N-myc oncogene is disrupted in amplified but not single-copy neuroblastoma cell lines","volume":"15","author":"LE Sivak","year":"1997","journal-title":"Oncogene"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2004.04.003","article-title":"Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells","volume":"213","author":"H Yuan","year":"2004","journal-title":"Cancer Lett"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jtbi.2007.09.004","article-title":"Robustness and state-space structure of Boolean gene regulatory models","volume":"249","author":"K Willadsen","year":"2007","journal-title":"J Theor Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"36647","DOI":"10.1074\/jbc.M109.019109","article-title":"Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells","volume":"284","author":"J Cho","year":"2009","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1073\/pnas.2133841100","article-title":"Structure and function of the feed-forward loop network motif","volume":"100","author":"S Mangan","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-8733(94)90015-9","article-title":"Betweenness centrality measures for directed graphs","volume":"16","author":"DR White","year":"1994","journal-title":"Social Networks"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0378-8733(91)90017-N","article-title":"Centrality in valued graphs: a measure of betweenness based on network flow","volume":"13","author":"LC Freeman","year":"1991","journal-title":"Social Networks"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.semcdb.2009.07.003","article-title":"Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective","volume":"20","author":"S Huang","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1593\/neo.10180","article-title":"TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression","volume":"12","author":"K Lafferty-Whyte","year":"2010","journal-title":"Neoplasia"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(03)00430-6","article-title":"Multiple tumor suppressor pathways negatively regulate telomerase","volume":"113","author":"SY Lin","year":"2003","journal-title":"Cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1073\/pnas.071043198","article-title":"Switch from Myc\/Max to Mad1\/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells","volume":"98","author":"D Xu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"e56523","DOI":"10.1371\/journal.pone.0056523","article-title":"Balance between noise and information flow maximizes set complexity of network dynamics","volume":"8","author":"T Maki-Marttunen","year":"2013","journal-title":"PLoS One"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"e1002669","DOI":"10.1371\/journal.pcbi.1002669","article-title":"Criticality is an emergent property of genetic networks that exhibit evolvability","volume":"8","author":"C Torres-Sosa","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jtbi.2004.12.016","article-title":"A mathematical model of cellular apoptosis and senescence through the dynamics of telomere loss","volume":"235","author":"N Arkus","year":"2005","journal-title":"J Theor Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"e32117","DOI":"10.1371\/journal.pone.0032117","article-title":"A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations","volume":"7","author":"C Lawless","year":"2012","journal-title":"PLoS One"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.biochi.2007.07.011","article-title":"Targeting telomeres and telomerase","volume":"90","author":"A De Cian","year":"2008","journal-title":"Biochimie"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"021001","DOI":"10.1088\/1478-3975\/9\/2\/021001","article-title":"Single-molecule studies of DNA transcription using atomic force microscopy","volume":"9","author":"DJ Billingsley","year":"2012","journal-title":"Phys Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/cmb.2010.0069","article-title":"Dynamical properties of a boolean model of gene regulatory network with memory","volume":"18","author":"A Graudenzi","year":"2011","journal-title":"J Comput Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"033109","DOI":"10.1063\/1.2962223","article-title":"Evolution of complex dynamics","volume":"18","author":"R Wilds","year":"2008","journal-title":"Chaos"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/157489212798357958","article-title":"Recent patents on anti-telomerase cancer therapy","volume":"7","author":"A Agrawal","year":"2012","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"ref91","unstructured":"Keith WN, Bilsland AE (2008) Targeting telomerase: Therapeutic options for cancer treatment. Telomeres and Telomerase in Ageing, Disease, and Cancer: Springer-Verlag Berlin. pp. 247\u2013283."},{"key":"ref92","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/1471-2164-11-532","article-title":"Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma","volume":"11","author":"K Lafferty-Whyte","year":"2010","journal-title":"BMC Genomics"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1158\/0008-5472.CAN-05-1941","article-title":"Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1\/Sp3","volume":"66","author":"AE Bilsland","year":"2006","journal-title":"Cancer Res"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2407-5-6","article-title":"MDM2 negatively regulates the human telomerase RNA gene promoter","volume":"5","author":"J Zhao","year":"2005","journal-title":"BMC Cancer"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1038\/sj.onc.1209580","article-title":"DNA-binding independent cell death from a minimal proapoptotic region of E2F-1","volume":"25","author":"LA Bell","year":"2006","journal-title":"Oncogene"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/35009130","article-title":"Role of NF-kappaB in p53-mediated programmed cell death","volume":"404","author":"KM Ryan","year":"2000","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1038\/sj.onc.1205851","article-title":"Cell transformation by v-Jun deactivates ERK MAP kinase signalling","volume":"21","author":"EJ Black","year":"2002","journal-title":"Oncogene"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1093\/nar\/gki832","article-title":"Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain","volume":"33","author":"DH Crouch","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1038\/sj.onc.1205663","article-title":"Regulation of FGF8 expression by the androgen receptor in human prostate cancer","volume":"21","author":"VJ Gnanapragasam","year":"2002","journal-title":"Oncogene"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/2191-0855-1-45","article-title":"Modeling formalisms in Systems Biology","volume":"1","author":"D Machado","year":"2011","journal-title":"AMB Express"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2174\/138920209789208237","article-title":"A tutorial on analysis and simulation of boolean gene regulatory network models","volume":"10","author":"Y Xiao","year":"2009","journal-title":"Curr Genomics"},{"key":"ref102","first-page":"89","article-title":"Genomic regulation modeled as a network with basins of attraction","author":"A Wuensche","year":"1998","journal-title":"Pac Symp Biocomput"},{"key":"ref103","first-page":"47","article-title":"Pajek: a program for large network analysis","volume":"21","author":"V Batagelj","year":"1998","journal-title":"Connections"},{"key":"ref104","unstructured":"Borgatti SP, Everett MG, Freeman LC (2002) Ucinet for Windows: software for social network analysis. Harvard, MA: Analytic Technologies. ."},{"key":"ref105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-60761-987-1_18","article-title":"Cytoscape: software for visualization and analysis of biological networks","volume":"696","author":"M Kohl","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"D137","DOI":"10.1093\/nar\/gkl1041","article-title":"TRED: a transcriptional regulatory element database, new entries and other development","volume":"35","author":"C Jiang","year":"2007","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T16:27:20Z","timestamp":1565195240000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003448"}},"subtitle":[],"editor":[{"given":"Satoru","family":"Miyano","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,2,13]]},"references-count":106,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003448","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,13]]}}}