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Mechanisms for the synergistic effects between different acceptor particles in the mobilization of cellular cholesterol","volume":"17","author":"WV Rodrigueza","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.atherosclerosis.2009.10.002","article-title":"HDL superphospholipidation enhances key steps in reverse cholesterol transport","volume":"209","author":"U Tchoua","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1073\/pnas.74.3.837","article-title":"Structure of human serum lipoproteins inferred from compositional analysis","volume":"74","author":"BW Shen","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s11745-012-3703-0","article-title":"Development of a method to measure pre\u2013<italic>\u03b2<\/italic> HDL and <italic>\u03b1<\/italic>\u2013HDL apoA-I enrichment for stable isotopic studies of HDL kinetics","volume":"47","author":"X Li","year":"2012","journal-title":"Lipids"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1021\/bi9919504","article-title":"Role of the kidney in regulating the metabolism of HDL in rabbits: evidence that iodination alters the catabolism of apolipoprotein A-I by the kidney","volume":"39","author":"S Braschi","year":"2000","journal-title":"Biochemistry"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1172\/JCI113266","article-title":"In vivo metabolism of proapolipoprotein A-I in Tangier disease","volume":"80","author":"D Bojanovski","year":"1987","journal-title":"J Clin Invest"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0022-2275(20)35365-7","article-title":"Metabolism of high density lipoprotein subfractions and constituents in Tangier disease following the infusion of high density lipoproteins","volume":"22","author":"EJ Schaefer","year":"1981","journal-title":"J Lipid Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"18847","DOI":"10.1074\/jbc.M109.098434","article-title":"Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteins","volume":"285","author":"G Cavigiolio","year":"2010","journal-title":"J Biol Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0005-2760(92)90077-9","article-title":"Protein transfer between A-I-containing lipoprotein subpopulations: evidence of non-transferable A-I in particles with A-II","volume":"1165","author":"MC Cheung","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1194\/jlr.M002055","article-title":"Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles","volume":"51","author":"S Lund-Katz","year":"2010","journal-title":"J Lipid Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1021\/bi00401a005","article-title":"Early incorporation of cell-derived cholesterol into pre-betamigrating high-density lipoprotein","volume":"27","author":"GR Castro","year":"1988","journal-title":"Biochemistry"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1194\/jlr.M026674","article-title":"Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers","volume":"53","author":"MG Sorci-Thomas","year":"2012","journal-title":"J Lipid Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJM199011013231803","article-title":"Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation","volume":"323","author":"A Inazu","year":"1990","journal-title":"N Engl J Med"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0026-0495(91)90097-G","article-title":"Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates high-density lipoprotein concentration and composition","volume":"40","author":"S Yamashita","year":"1991","journal-title":"Metab Clin Exp"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1194\/jlr.M300198-JLR200","article-title":"Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency","volume":"45","author":"BF Asztalos","year":"2004","journal-title":"J Lipid Res"},{"key":"ref84","unstructured":"Press WH, Teukolsky SA, Vetterling WT, Flannery BP (1992) Numerical recipes in C (2nd ed.): the art of scientific computing. Cambridge, UK: Cambridge University Press."},{"key":"ref85","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1145\/838250.838251","article-title":"The complex-step derivative approximation","volume":"29","author":"JRRA Martins","year":"2003","journal-title":"ACM Trans Math Software"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1039\/b918098b","article-title":"Sloppy models, parameter uncertainty, and the role of experimental design","volume":"6","author":"JF Apgar","year":"2010","journal-title":"Mol Biosyst"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1752-0509-5-112","article-title":"An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability","volume":"5","author":"XN Wei","year":"2011","journal-title":"BMC Syst Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.ATV.20.3.801","article-title":"Apolipoprotein A-I and A-II kinetic parameters as assessed by endogenous labeling with [(2)H(3)]leucine in middle-aged and elderly men and women","volume":"20","author":"W Velez-Carrasco","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/MOL.0b013e32833c1ef6","article-title":"Marked HDL deficiency and premature coronary heart disease","volume":"21","author":"EJ Schaefer","year":"2010","journal-title":"Curr Opin Lipidol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1567-5688(02)00041-7","article-title":"Hugh Sinclair Lecture: the regulation and remodelling of HDL by plasma factors","volume":"Suppl 3","author":"PJ Barter","year":"2002","journal-title":"Atheroscler"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2008.11.146","article-title":"Formation of prebeta1-HDL during lipolysis of triglyceride-rich lipoprotein","volume":"379","author":"O Miyazaki","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0022-2275(20)39962-4","article-title":"Dissociation of lipid-free apolipoprotein A-I from high density lipoproteins","volume":"35","author":"HQ Liang","year":"1994","journal-title":"J Lipid Res"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"26898","DOI":"10.1074\/jbc.M010708200","article-title":"The mechanism of the remodeling of high density lipoproteins by phospholipid transfer protein","volume":"276","author":"N Settasatian","year":"2001","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1004001","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000}}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T18:37:04Z","timestamp":1648579024000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003509"}},"subtitle":[],"editor":[{"given":"Daniel A.","family":"Beard","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":93,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003509","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}