{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:16:00Z","timestamp":1764432960760},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003513","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T20:52:00Z","timestamp":1397163120000},"page":"e1003513","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Dynamics of Cellular Responses to Radiation"],"prefix":"10.1371","volume":"10","author":[{"given":"Dominik","family":"Wodarz","sequence":"first","affiliation":[]},{"given":"Ron","family":"Sorace","sequence":"additional","affiliation":[]},{"given":"Natalia L.","family":"Komarova","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mrfmmm.2004.06.044","article-title":"Phenomena leading to cell survival values which deviate from linear-quadratic models","volume":"568","author":"WM Bonner","year":"2004","journal-title":"Mutat Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00411-006-0078-8","article-title":"Radioadaptive response revisited","volume":"46","author":"S Tapio","year":"2007","journal-title":"Radiat Environ Biophys"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.6695170","article-title":"Adaptive response of human lymphocytes to low concentrations of radioactive thymidine","volume":"223","author":"G Olivieri","year":"1984","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1590\/S1415-47572008000300002","article-title":"Adaptive response': some underlying mechanisms and open questions","volume":"31","author":"EG Dimova","year":"2008","journal-title":"Genetics and Molecular Biology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0006-2952(97)00448-6","article-title":"Adaptive response to DNA-damaging agents: a review of potential mechanisms","volume":"55","author":"C Stecca","year":"1998","journal-title":"Biochemical pharmacology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/10807030009380063","article-title":"The current status of the adaptive response to ionizing radiation in mammalian cells","volume":"6","author":"A Wojcik","year":"2000","journal-title":"Human and Ecological Risk Assessment"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0027-5107(96)00120-0","article-title":"Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells","volume":"358","author":"T Ikushima","year":"1996","journal-title":"Mutat Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.ijrobp.2007.11.071","article-title":"Low-dose hyper-radiosensitivity: past, present, and future","volume":"70","author":"B Marples","year":"2008","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1667\/RR3130","article-title":"Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells","volume":"161","author":"B Marples","year":"2004","journal-title":"Radiat Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0360-3016(00)01471-1","article-title":"Low-dose hypersensitivity: current status and possible mechanisms","volume":"49","author":"MC Joiner","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/09553000110041326","article-title":"Low-dose hypersensitivity after fractionated low-dose irradiation in vitro","volume":"77","author":"SC Short","year":"2001","journal-title":"Int J Radiat Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/095530097143725","article-title":"Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells","volume":"71","author":"B Marples","year":"1997","journal-title":"Int J Radiat Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/09553000500077047","article-title":"Adaptive response: stimulated DNA repair or decreased damage fixation","volume":"81","author":"I Szumiel","year":"2005","journal-title":"International journal of radiation biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2187\/bss.18.247","article-title":"Radiation-induced adaptive responses and bystander effects","volume":"18","author":"H Matsumoto","year":"2004","journal-title":"Biological Sciences in Space"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1191\/0960327104ht423oa","article-title":"Review of radiation-induced bystander effects","volume":"23","author":"AR Snyder","year":"2004","journal-title":"Human & experimental toxicology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/rpd\/ncr169","article-title":"Radiation-induced bystander effects induce radioadaptive response by low-dose radiation","volume":"146","author":"M Ojima","year":"2011","journal-title":"Radiation Protection Dosimetry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1269\/jrr.06084","article-title":"Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects","volume":"48","author":"N Hamada","year":"2007","journal-title":"Journal of radiation research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/095530096145841","article-title":"Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of X-rays","volume":"69","author":"K Ishii","year":"1996","journal-title":"International journal of radiation biology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1667\/RR3044","article-title":"Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts","volume":"160","author":"C Shao","year":"2003","journal-title":"Radiation research"},{"key":"ref20","first-page":"473","article-title":"Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from \u03b1-particle irradiated to nonirradiated cells","volume":"98","author":"EI Azzam","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2307\/3579958","article-title":"Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium","volume":"149","author":"C Mothersill","year":"1998","journal-title":"Radiation research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1667\/0033-7587(2001)155[0387:IORBAN]2.0.CO;2","article-title":"Induction of radioresistance by a nitric oxide-mediated bystander effect","volume":"155","author":"H Matsumoto","year":"2001","journal-title":"Radiation research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1269\/jrr.45.357","article-title":"Oxidative stress, radiation-adaptive responses, and aging","volume":"45","author":"Y Miura","year":"2004","journal-title":"Journal of radiation research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8574","DOI":"10.1158\/0008-5472.CAN-07-1913","article-title":"Nitric oxide radicals choreograph a radioadaptive response","volume":"67","author":"H Matsumoto","year":"2007","journal-title":"Cancer research"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/rpd\/ncq474","article-title":"Adaptive response: modelling and experimental studies","volume":"143","author":"G Esposito","year":"2011","journal-title":"Radiation Protection Dosimetry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0027-5107(96)00122-4","article-title":"Radioadaptive response: An implication for the biological consequences of low dose-rate exposure to radiations","volume":"358","author":"MS Sasaki","year":"1996","journal-title":"Mutation Research\/Fundamental and Molecular Mechanisms of Mutagenesis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1667\/RR3071","article-title":"Quantitative analysis of biological responses to ionizing radiation, including dose, irradiation time, and dose rate","volume":"160","author":"J Magae","year":"2003","journal-title":"Radiation research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00411-007-0146-8","article-title":"Systems biology and its potential role in radiobiology","volume":"47","author":"L Feinendegen","year":"2008","journal-title":"Radiation and environmental biophysics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1667\/0033-7587(2001)155[0402:TBEIRO]2.0.CO;2","article-title":"The bystander effect in radiation oncogenesis: II. A quantitative model","volume":"155","author":"D Brenner","year":"2001","journal-title":"Radiation research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0025-5564(98)10053-6","article-title":"Modeling radioprotective mechanisms in the dose effect relation at low doses and low dose rates of ionizing radiation","volume":"155","author":"CM Fleck","year":"1999","journal-title":"Mathematical Biosciences"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.asr.2007.04.039","article-title":"Effects of low-level chronic irradiation on the radiosensitivity of mammals: Modeling studies","volume":"40","author":"O Smirnova","year":"2007","journal-title":"Advances in Space Research"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/20018091094709","article-title":"A biomathematical modeling approach to explain the phenomenon of radiation hormesis","volume":"7","author":"H Sch\u00f6llnberger","year":"2001","journal-title":"Human and Ecological Risk Assessment"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2203\/dose-response.09-054.Zhao","article-title":"Modeling dose-response at low dose: a systems biology approach for ionization radiation","volume":"8","author":"Y Zhao","year":"2010","journal-title":"Dose-Response"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2203\/dose-response.11-003.Fornalski","article-title":"A Stochastic Markov Model of Cellular Response to Radiation","volume":"9","author":"KW Fornalski","year":"2011","journal-title":"Dose-Response"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1667\/rr0742.1","article-title":"Detrimental and protective bystander effects: a model approach","volume":"168","author":"H Sch\u00f6llnberger","year":"2009","journal-title":"Radiat Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0027-5107(99)00136-0","article-title":"Radioresponsiveness at low doses: Hyper-radiosensitivity and increased radioresistance in mammalian cells","volume":"430","author":"KA Skov","year":"1999","journal-title":"Mutation research"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0027-5107(96)00118-2","article-title":"Hypersensitivity to very-low single radiation doses: its relationship to the adaptive response and induced radioresistance","volume":"358","author":"MC Joiner","year":"1996","journal-title":"Mutat Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2307\/3578255","article-title":"The response of Chinese hamster V79 cells to low radiation doses: Evidence of enhanced sensitivity of the whole cell population","volume":"133","author":"B Marples","year":"1993","journal-title":"Radiation research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/3577233","article-title":"Renal damage in the mouse: the response to very small doses per fraction","volume":"114","author":"M Joiner","year":"1988","journal-title":"Radiation research"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1073\/pnas.0830918100","article-title":"Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses","volume":"100","author":"K Rothkamm","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1667\/RR0776.1","article-title":"Role of apoptosis in low-dose hyper-radiosensitivity","volume":"167","author":"S Krueger","year":"2007","journal-title":"Radiation research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1080\/095530099139908","article-title":"Low dose hypersensitivity in the T98G human glioblastoma cell line","volume":"75","author":"S Short","year":"1999","journal-title":"International journal of radiation biology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1080\/095530099139214","article-title":"The response of human glioma cell lines to low-dose radiation exposure","volume":"75","author":"SC Short","year":"1999","journal-title":"International Journal of Radiation Biology"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T21:02:20Z","timestamp":1540328540000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003513"}},"subtitle":[],"editor":[{"given":"Andrey","family":"Rzhetsky","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,4,10]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003513","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,10]]}}}