{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:04:24Z","timestamp":1775984664476,"version":"3.50.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003520","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T20:22:27Z","timestamp":1400790147000},"page":"e1003520","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["The Changing Geometry of a Fitness Landscape Along an Adaptive Walk"],"prefix":"10.1371","volume":"10","author":[{"given":"Devin","family":"Greene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Crona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/genetics\/16.2.97","article-title":"Evolution in Mendelian populations","volume":"16","author":"S Wright","year":"1931","journal-title":"Genetics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2148-7-60","article-title":"Analysis of epistatic interactions and fitness landscapes using a new geometric approach","volume":"7","author":"N Beerenwinkel","year":"2007","journal-title":"BMC Evolutionary Biology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1203799","article-title":"Diminishing returns epistasis among beneficial mutations decelerates adaptation","volume":"332","author":"HH Chou","year":"2011","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.1203801","article-title":"Negative epistasis between beneficial mutations in an evolving bacterial population","volume":"332","author":"AI Khan","year":"2011","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1111\/evo.12192","article-title":"Selection biases the prevalence and type of epistasis along adaptive trajectories","volume":"67","author":"JA Draghi","year":"2013","journal-title":"Evolution"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1086\/599081","article-title":"Exploring the effect of sex on empirical fitness landscapes","volume":"174 Suppl 1","author":"JAGM De Visser","year":"2009","journal-title":"The American Naturalist"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"e1002134","DOI":"10.1371\/journal.pcbi.1002134","article-title":"Evolutionary Accessibility of Mutational Pathways","volume":"7","author":"J Franke","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtbi.2012.09.028","article-title":"The peaks and geometry of fitness landscapes","volume":"317","author":"K Crona","year":"2013","journal-title":"J Theor Biol"},{"key":"ref9","unstructured":"Crona K (2013) Graphs, polytopes and fitness landscapes. In Recent Advances in the Theory and Application of Fitness Landscapes. A. Engelbrecht and H. Richter, editors. New York: Springer Series in Emergence, Complexity, and Computation. pp. 177\u2013206."},{"key":"ref10","first-page":"1165","article-title":"Sign epistasis and genetic constraint on evolutionary trajectories","volume":"59","author":"DM Weinreich","year":"2005","journal-title":"Evolution"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature05451","article-title":"Empirical fitness landscapes reveal accessible evolutionary paths","volume":"445","author":"FJ Poelwijk","year":"2007","journal-title":"Nature"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jtbi.2010.12.015","article-title":"Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes","volume":"Mar 7; 272","author":"FJ Poelwijk","year":"2011","journal-title":"J Theor Biol"},{"key":"ref13","article-title":"Quantitative analyses of empirical fitness landscapes","author":"IG Szendro","year":"2013","journal-title":"J Stat Mech"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-5193(87)80029-2","article-title":"Towards a general theory of adaptive walks on rugged landscapes","volume":"128","author":"SA Kauffman","year":"1987","journal-title":"J Theor Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-5193(89)80019-0","article-title":"The NK model of rugged fitness landscape and its application to maturation of the immune response","volume":"141","author":"SA Kauffman","year":"1989","journal-title":"J Theor Biol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/jtbi.1996.0189","article-title":"Fitness spectrum among random mutants on Rough Mt. Fuji-type fitness landscape","volume":"182","author":"T Aita","year":"1996","journal-title":"J Theor Biol"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1097-0282(200007)54:1<64::AID-BIP70>3.0.CO;2-R","article-title":"Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin","volume":"54","author":"T Aita","year":"2000","journal-title":"Biopolymers"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0040-5809(83)90014-X","article-title":"A simple stochastic gene substitution model","volume":"23","author":"JH Gillespie","year":"1983","journal-title":"Theor Pop Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.1073\/pnas.81.24.8009","article-title":"The molecular clock may be an episodic clock","volume":"81","author":"JH Gillespie","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/225563a0","article-title":"Natural selection and the concept of protein space","volume":"225","author":"J Maynard Smith","year":"1970","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/j.0014-3820.2002.tb01446.x","article-title":"The population genetics of adaptation: the adaptation of DNA sequences","volume":"56","author":"HA Orr","year":"2002","journal-title":"Evolution"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1073\/pnas.86.16.6191","article-title":"Protein Evolution on Rugged Landscapes","author":"C Macken","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1103\/PhysRevA.46.6714","article-title":"Evolution in a rugged fitness landscape","author":"H Flyvbjerg","year":"1992","journal-title":"Physical Review A"},{"key":"ref24","first-page":"1317","article-title":"Epistasis and shapes of fitness landscapes","volume":"17","author":"N Beerenwinkel","year":"2007","journal-title":"Statistica Sinica"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"e56040","DOI":"10.1371\/journal.pone.0056040","article-title":"Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes","volume":"8","author":"CP Goulart","year":"2013","journal-title":"PLoS ONE"},{"key":"ref26","unstructured":"Crona K, Patterson D, Stack K, Greene D, Goulart C, <etal>et al<\/etal>..(2013) A quantification of theory-data incompatibility for fitness landscapes. arXiv:1303.3842"},{"key":"ref27","unstructured":"R Core Team (2013). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. URL: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\/\" xlink:type=\"simple\">http:\/\/www.R-project.org\/<\/ext-link>."},{"key":"ref28","unstructured":"Soetart, Karline (2013). diagram: Functions for visualising simple graphs (networks), plotting flow diagrams. R package version 1.6.1. URL: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/CRAN.R-project.org\/package=diagram\" xlink:type=\"simple\">http:\/\/CRAN.R-project.org\/package=diagram<\/ext-link>."}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T01:34:30Z","timestamp":1649036070000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003520"}},"subtitle":[],"editor":[{"given":"Rachel B.","family":"Brem","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003520","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}