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Evidence for a slow production pathway and results for normolipidemic subjects","volume":"63","author":"LA Zech","year":"1979","journal-title":"J Clin Invest"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0022-2275(20)41419-1","article-title":"ApoB-75, a truncation of apolipoprotein B associated with familial hypobetalipoproteinemia: genetic and kinetic studies","volume":"33","author":"ES Krul","year":"1992","journal-title":"J Lipid Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0022-2275(20)39765-0","article-title":"Development and application of a multicompartmental model to study very low density lipoprotein subfraction metabolism","volume":"36","author":"CJ Packard","year":"1995","journal-title":"J Lipid Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0022-2275(20)30164-4","article-title":"Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover","volume":"43","author":"BW Patterson","year":"2002","journal-title":"J Lipid Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0022-2275(20)31574-1","article-title":"Distinct patterns of lipoproteins with apoB defined by presence of apoE or apoC-III in hypercholesterolemia and hypertriglyceridemia","volume":"42","author":"H Campos","year":"2001","journal-title":"J Lipid Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/01.ATV.0000203519.25116.54","article-title":"Apolipoproteins C-III and A-V as predictors of very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics","volume":"26","author":"DC Chan","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0022-2275(20)32065-4","article-title":"Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions","volume":"41","author":"CJ Packard","year":"2000","journal-title":"J Lipid Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1194\/jlr.M400108-JLR200","article-title":"A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions","volume":"46","author":"M Adiels","year":"2005","journal-title":"J Lipid Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/ATVBAHA.107.160192","article-title":"Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome","volume":"28","author":"M Adiels","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.atherosclerosis.2012.02.001","article-title":"Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity","volume":"222","author":"M Adiels","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref93","unstructured":"Bhattacharya BS (2011) Mathematical Modelling of Low Density Lipoprotein Metabolism. Intracellular Cholesterol Regulation. Phd thesis, The University of Reading."},{"key":"ref94","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1194\/jlr.M900015-JLR200","article-title":"Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro","volume":"50","author":"LK Potter","year":"2009","journal-title":"J Lipid Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s11538-006-9132-6","article-title":"A dynamical model of lipoprotein metabolism","volume":"69","author":"E August","year":"2007","journal-title":"Bull Math Biol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jtbi.2008.11.016","article-title":"A continuum receptor model of hepatic lipoprotein metabolism","volume":"257","author":"MJ Tindall","year":"2009","journal-title":"J Theor Biol"},{"key":"ref97","unstructured":"Balgi G, Kadambi A, Paterson TS. (2006) methods and models for cholesterol metabolism, wo2006066051."},{"key":"ref98","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/2043-9113-1-29","article-title":"Diagnostic markers based on a computational model of lipoprotein metabolism","volume":"1","author":"DB van Schalkwijk","year":"2011","journal-title":"J Clin Bioinforma"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"e38072","DOI":"10.1371\/journal.pone.0038072","article-title":"Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy","volume":"7","author":"K van Bochove","year":"2012","journal-title":"PLoS One"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1084-9521(02)00169-6","article-title":"Mouse models as tools for dissecting disorders of lipoprotein metabolism","volume":"14","author":"P Marschang","year":"2003","journal-title":"Semin Dev Biol"},{"key":"ref101","doi-asserted-by":"crossref","unstructured":"van de Pas NC (2011) A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man. 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