{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:27:17Z","timestamp":1771360037854,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003601","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T21:13:51Z","timestamp":1399583631000},"page":"e1003601","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus"],"prefix":"10.1371","volume":"10","author":[{"given":"Julian","family":"Tejada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Garcia-Cairasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio C.","family":"Roque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-1211(02)00072-4","article-title":"New insights from the use of pilocarpine and kainate models","volume":"50","author":"JP Leite","year":"2002","journal-title":"Epilepsy Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1126\/science.2449733","article-title":"Synaptic reorganization in the hippocampus induced by abnormal functional activity","volume":"239","author":"T Sutula","year":"1988","journal-title":"Science (New York, NY)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1523\/JNEUROSCI.10-01-00267.1990","article-title":"Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy","volume":"10","author":"CR Houser","year":"1990","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1152\/jn.1999.82.4.1883","article-title":"Mossy Fiber\u2013Granule Cell Synapses in the Normal and Epileptic Rat Dentate Gyrus Studied With Minimal Laser Photostimulation","volume":"82","author":"P Moln\u00e1r","year":"1999","journal-title":"J Neurophysiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1528-1167.2012.03480.x","article-title":"New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction","volume":"53","author":"HE Scharfman","year":"2012","journal-title":"Epilepsia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997","article-title":"Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus","volume":"17","author":"JM Parent","year":"1997","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1523\/JNEUROSCI.3381-10.2011","article-title":"Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion","volume":"31","author":"BL Murphy","year":"2011","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Sloviter R, Bumanglag A, Schwarcz R, Frotscher M (2012) Abnormal dentate gyrus network circuitry in temporal lobe epilepsy. In: Noebels J, Avoli M, Rogawski M, editors. Jasper's Basic Mechanisms of the Epilepsies. Bethesda: National Center for Biotechnology Information. pp. 454\u2013469.","DOI":"10.1093\/med\/9780199746545.003.0034"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","article-title":"Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures","volume":"32","author":"EA Cavalheiro","year":"1991","journal-title":"Epilepsia"},{"key":"ref10","first-page":"499","article-title":"Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes","volume":"89","author":"JH Margerison","year":"1966","journal-title":"Brain"},{"key":"ref11","first-page":"1511","article-title":"Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy","volume":"13","author":"M Isokawa","year":"1993","journal-title":"J Neurosci"},{"key":"ref12","first-page":"758407","article-title":"Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"2011","author":"J Lachos","year":"2011","journal-title":"Epilepsy Res Treat"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1523\/JNEUROSCI.20-16-06144.2000","article-title":"Granule-Like Neurons at the Hilar\/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis","volume":"20","author":"HE Scharfman","year":"2000","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1523\/JNEUROSCI.5508-05.2006","article-title":"Seizures accelerate functional integration of adult-generated granule cells","volume":"26","author":"LS Overstreet-Wadiche","year":"2006","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.eplepsyres.2005.12.003","article-title":"Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses","volume":"69","author":"LA Shapiro","year":"2006","journal-title":"Epilepsy Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2007.06.037","article-title":"Doublecortin-positive newly born granule cells of hippocampus have abnormal apical dendritic morphology in the pilocarpine model of temporal lobe epilepsy","volume":"1165","author":"GM Arisi","year":"2007","journal-title":"Brain Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.1523\/JNEUROSCI.2002-07.2007","article-title":"Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling","volume":"27","author":"S Jessberger","year":"2007","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jnr.21474","article-title":"Loss of synapses in the entorhinal-dentate gyrus pathway following repeated induction of electroshock seizures in the rat","volume":"86","author":"A Cardoso","year":"2008","journal-title":"J Neurosci Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.neuroscience.2011.09.034","article-title":"Contributions of mature granule cells to structural plasticity in temporal lobe epilepsy","volume":"197","author":"VR Santos","year":"2011","journal-title":"Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0079-6123(02)35012-X","article-title":"Seizure-induced neurogenesis: are more new neurons good for an adult brain?","volume":"135","author":"JM Parent","year":"2002","journal-title":"Prog Brain Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.neuron.2006.11.004","article-title":"Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability","volume":"52","author":"K Jakubs","year":"2006","journal-title":"Neuron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1523\/JNEUROSCI.22-14-06052.2002","article-title":"Relations Between Brain Pathology and Temporal Lobe Epilepsy","volume":"22","author":"X Zhang","year":"2002","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1567202043480242","article-title":"Mossy fiber sprouting as a potential therapeutic target for epilepsy","volume":"1","author":"R Koyama","year":"2004","journal-title":"Curr Neurovasc Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0306-4522(99)00358-9","article-title":"Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures","volume":"94","author":"MJ Routbort","year":"1999","journal-title":"Neuroscience"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1152\/jn.01028.2003","article-title":"Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures","volume":"92","author":"SB Bausch","year":"2004","journal-title":"J Neurophysiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1523\/JNEUROSCI.5462-11.2012","article-title":"Pten deletion in adult hippocampal neural stem\/progenitor cells causes cellular abnormalities and alters neurogenesis","volume":"32","author":"A Amiri","year":"2012","journal-title":"J Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2012.08.002","article-title":"Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy","volume":"75","author":"RYK Pun","year":"2012","journal-title":"Neuron"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1152\/jn.00777.2004","article-title":"Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography","volume":"93","author":"V Santhakumar","year":"2005","journal-title":"J Neurophysiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1152\/jn.00950.2006","article-title":"Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data","volume":"97","author":"J Dyhrfjeld-Johnsen","year":"2007","journal-title":"J Neurophysiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1073\/pnas.0801372105","article-title":"Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures","volume":"105","author":"RJ Morgan","year":"2008","journal-title":"Proc NatlAcad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1212\/WNL.59.9_suppl_5.S7","article-title":"Animal models of epileptogenesis","volume":"59","author":"HS White","year":"2002","journal-title":"Neurology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1528-1167.2012.03477.x","article-title":"Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells","volume":"53","author":"CR Houser","year":"2012","journal-title":"Epilepsia"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1098\/rstb.2001.0905","article-title":"Generation, description and storage of dendritic morphology data","volume":"356","author":"GA Ascoli","year":"2001","journal-title":"Phil Trans R Soc B"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fncom.2010.00128","article-title":"An inverse approach for elucidating dendritic function","volume":"4","author":"B Torben-Nielsen","year":"2010","journal-title":"Front Comput Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/cne.902960407","article-title":"Burst generating and regular spiking layer 5 pyramidal neurons of rat neocortex have different morphological features","volume":"296","author":"Y ChagnacAmitai","year":"1990","journal-title":"J Comp Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/382363a0","article-title":"Inuence of dendritic structure on firing pattern in model neocortical neurons","volume":"382","author":"Z Mainen","year":"1996","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0006-8993(02)02488-5","article-title":"Effects of dendritic morphology on CA3 pyramidal cell electrophysiology: a simulation study","volume":"941","author":"JL Krichmar","year":"2002","journal-title":"Brain Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1152\/jn.00829.2011","article-title":"Altered dendritic complexity affects firing properties of cortical layer 2\/3 pyramidal neurons in mice lacking the 5-HT3A receptor","volume":"108","author":"L van der Velden","year":"2012","journal-title":"J Neurophysiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e40726","DOI":"10.1371\/journal.pone.0040726","article-title":"Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable","volume":"7","author":"J Tejada","year":"2012","journal-title":"PLoS ONE"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"P56","DOI":"10.1186\/1471-2202-13-S1-P56","article-title":"Role of morphological changes in newly born granule cells of hippocampus after status epilepticus induced by pilocarpine in hyperexcitability","volume":"13","author":"J Tejada","year":"2012","journal-title":"BMC Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-3806(90)90071-6","article-title":"Dendritic growth and regression in rat dentate granule cells during late postnatal development","volume":"54","author":"LL Rihn","year":"1990","journal-title":"Brain Res Dev Brain Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-0270(98)00091-0","article-title":"An on-line archive of reconstructed hippocampal neurons","volume":"84","author":"RC Cannon","year":"1998","journal-title":"J Neurosci Methods"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/cne.22568","article-title":"Morphometry of hilar ectopic granule cells in the rat","volume":"519","author":"JP Pierce","year":"2011","journal-title":"J Comp Neurol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1523\/JNEUROSCI.4141-11.2012","article-title":"Decrease in tonic inhibition contributes to increase in dentate semilunar granule cell excitability after brain injury","volume":"32","author":"A Gupta","year":"2012","journal-title":"J Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/hipo.450030408","article-title":"Projection of the entorhinal layer II neurons in the rat as revealed by intracellular pressure-injection of neurobiotin","volume":"3","author":"N Tamamaki","year":"1993","journal-title":"Hippocampus"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1152\/physrev.1992.72.suppl_4.S159","article-title":"Matching dendritic neuron models to experimental data","volume":"72","author":"W Rall","year":"1992","journal-title":"Physiol rev"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Morgan RJ, Soltesz I (2010) Microcircuit model of the dentate gyrus in epilepsy. In: Cutsuridis V, Graham B, Cobb S, Vida I, editors. Hippocampal Microcircuits: A Computational Modeler's Resource Book. New York: Springer Series in Computational Neuroscience. pp. 495\u2013525.","DOI":"10.1007\/978-1-4419-0996-1_17"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/107385840100700207","article-title":"NEURON: a tool for neuroscientists","volume":"7","author":"ML Hines","year":"2001","journal-title":"Neuroscientist"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tics.2010.04.003","article-title":"Adult neurogenesis: integrating theories and separating functions","volume":"14","author":"JB Aimone","year":"2010","journal-title":"Trends Cogn Sci"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T09:07:41Z","timestamp":1565428061000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003601"}},"subtitle":[],"editor":[{"given":"Lyle J.","family":"Graham","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,8]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003601","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,8]]}}}