{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:20:25Z","timestamp":1774599625714,"version":"3.50.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003632","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T16:39:50Z","timestamp":1402591190000},"page":"e1003632","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Comparative Analysis of Human Tissue Interactomes Reveals Factors Leading to Tissue-Specific Manifestation of Hereditary Diseases"],"prefix":"10.1371","volume":"10","author":[{"given":"Ruth","family":"Barshir","sequence":"first","affiliation":[]},{"given":"Omer","family":"Shwartz","sequence":"additional","affiliation":[]},{"given":"Ilan Y.","family":"Smoly","sequence":"additional","affiliation":[]},{"given":"Esti","family":"Yeger-Lotem","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"D793","DOI":"10.1093\/nar\/gkn665","article-title":"McKusick&apos;s Online Mendelian Inheritance in Man (OMIM)","volume":"37","author":"J Amberger","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.genom.7.080505.115737","article-title":"Protein misfolding and human disease","volume":"7","author":"N Gregersen","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"20870","DOI":"10.1073\/pnas.0810772105","article-title":"A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes","volume":"105","author":"K Lage","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-0381-1-8","article-title":"Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes","volume":"1","author":"A Reverter","year":"2008","journal-title":"BioData Min"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1741-7007-6-49","article-title":"A comprehensive functional analysis of tissue specificity of human gene expression","volume":"6","author":"Z Dezso","year":"2008","journal-title":"BMC Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/bioinformatics\/btq408","article-title":"Computational analysis of tissue-specific gene networks: application to murine retinal functional studies","volume":"26","author":"J Hu","year":"2010","journal-title":"Bioinformatics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/pr101132h","article-title":"Tissue-specific proteins and functional implications","volume":"10","author":"D Emig","year":"2011","journal-title":"J Proteome Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e25394","DOI":"10.1371\/journal.pone.0025394","article-title":"MicroRNA regulation and tissue-specific protein interaction network","volume":"6","author":"W Zhu","year":"2011","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/msb.2009.17","article-title":"Tissue specificity and the human protein interaction network","volume":"5","author":"A Bossi","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1002694","DOI":"10.1371\/journal.pcbi.1002694","article-title":"Tissue-specific functional networks for prioritizing phenotype and disease genes","volume":"8","author":"Y Guan","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1002690","DOI":"10.1371\/journal.pcbi.1002690","article-title":"Enhancing the Prioritization of Disease-Causing Genes through Tissue Specific Protein Interaction Networks","volume":"8","author":"O Magger","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"AI Su","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1000598","DOI":"10.1371\/journal.pcbi.1000598","article-title":"An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data","volume":"5","author":"D Ramskold","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1074\/mcp.R800013-MCP200","article-title":"A genecentric Human Protein Atlas for expression profiles based on antibodies","volume":"7","author":"L Berglund","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e1001229","DOI":"10.1371\/journal.pbio.1001229","article-title":"Alternative splicing of RNA triplets is often regulated and accelerates proteome evolution","volume":"10","author":"RK Bradley","year":"2012","journal-title":"PLoS Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"D698","DOI":"10.1093\/nar\/gkq1116","article-title":"The BioGRID Interaction Database: 2011 update","volume":"39","author":"C Stark","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"D449","DOI":"10.1093\/nar\/gkh086","article-title":"The Database of Interacting Proteins: 2004 update","volume":"32","author":"L Salwinski","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"D525","DOI":"10.1093\/nar\/gkp878","article-title":"The IntAct molecular interaction database in 2010","volume":"38","author":"B Aranda","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"D532","DOI":"10.1093\/nar\/gkp983","article-title":"MINT, the molecular interaction database: 2009 update","volume":"38","author":"A Ceol","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"S Anders","year":"2010","journal-title":"Genome biology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature750","article-title":"Comparative assessment of large-scale data sets of protein-protein interactions","volume":"417","author":"C von Mering","year":"2002","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","article-title":"Interactome networks and human disease","volume":"144","author":"M Vidal","year":"2011","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"B Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nmeth756","article-title":"Multiple-laboratory comparison of microarray platforms","volume":"2","author":"RA Irizarry","year":"2005","journal-title":"Nat Methods"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nature04209","article-title":"Towards a proteome-scale map of the human protein-protein interaction network","volume":"437","author":"JF Rual","year":"2005","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cell.2009.04.029","article-title":"Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity","volume":"138","author":"T Vavouri","year":"2009","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/msb.2009.80","article-title":"Edgetic perturbation models of human inherited disorders","volume":"5","author":"Q Zhong","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nbt.2106","article-title":"Three-dimensional reconstruction of protein networks provides insight into human genetic disease","volume":"30","author":"X Wang","year":"2012","journal-title":"Nat Biotechnol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/sj.onc.1208190","article-title":"Structural determinants of the BRCA1 : estrogen receptor interaction","volume":"24","author":"YX Ma","year":"2005","journal-title":"Oncogene"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/1471-2407-11-172","article-title":"Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma","volume":"11","author":"I Centeno","year":"2011","journal-title":"BMC Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1158\/1940-6207.CAPR-08-0014","article-title":"Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells","volume":"1","author":"J Zhang","year":"2008","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0898-6568(01)00188-7","article-title":"The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation","volume":"13","author":"JL Ilsley","year":"2001","journal-title":"Cell Signal"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"38048","DOI":"10.1074\/jbc.M005321200","article-title":"Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members","volume":"275","author":"F Sotgia","year":"2000","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.ejhg.5201189","article-title":"Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients","volume":"12","author":"A Fogli","year":"2004","journal-title":"Eur J Hum Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.cell.2010.04.008","article-title":"Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation","volume":"141","author":"J Tcherkezian","year":"2010","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes","volume":"456","author":"ET Wang","year":"2008","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/msb.2011.99","article-title":"Differential network biology","volume":"8","author":"T Ideker","year":"2012","journal-title":"Mol Syst Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R130","DOI":"10.1186\/gb-2009-10-11-r130","article-title":"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources","volume":"10","author":"C Wu","year":"2009","journal-title":"Genome biology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","article-title":"Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification","volume":"21","author":"I Yanai","year":"2005","journal-title":"Bioinformatics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"bar041","DOI":"10.1093\/database\/bar041","article-title":"BioMart Central Portal: an open database network for the biological community","volume":"2011","author":"JM Guberman","year":"2011","journal-title":"Database (Oxford)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"D841","DOI":"10.1093\/nar\/gks1198","article-title":"The TissueNet database of human tissue protein-protein interactions","volume":"41","author":"R Barshir","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkm415","article-title":"DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists","volume":"35","author":"W Huang da","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrc1299","article-title":"A census of human cancer genes","volume":"4","author":"PA Futreal","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1677\/erc.1.00972","article-title":"BRCA1 in hormonal carcinogenesis: basic and clinical research","volume":"12","author":"EM Rosen","year":"2005","journal-title":"Endocr Relat Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1600-0854.2007.00562.x","article-title":"The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR","volume":"8","author":"N Nassoury","year":"2007","journal-title":"Traffic"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1128\/MCB.25.4.1238-1257.2005","article-title":"Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction","volume":"25","author":"S Bai","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.281.5373.108","article-title":"Congenital heart disease caused by mutations in the transcription factor NKX2-5","volume":"281","author":"JJ Schott","year":"1998","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"368938","DOI":"10.1155\/2012\/368938","article-title":"Structure, Expression, and Function of ICAM-5","volume":"2012","author":"H Yang","year":"2012","journal-title":"Comp Funct Genomics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/sj.mp.4001379","article-title":"Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms","volume":"8","author":"EM Hol","year":"2003","journal-title":"Mol Psychiatry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/archneurol.2010.177","article-title":"Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease","volume":"67","author":"K Nishioka","year":"2010","journal-title":"Arch Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1212\/WNL.0b013e31825fdeed","article-title":"Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor","volume":"79","author":"S Thier","year":"2012","journal-title":"Neurology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1210\/jc.2003-031240","article-title":"A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency","volume":"89","author":"RV Correa","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1126\/science.1069094","article-title":"Colorectal cancer in mice genetically deficient in the mucin Muc2","volume":"295","author":"A Velcich","year":"2002","journal-title":"Science"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:42:49Z","timestamp":1540233769000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003632"}},"subtitle":[],"editor":[{"given":"William Stafford","family":"Noble","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,6,12]]},"references-count":53,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003632","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,12]]}}}