{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T09:57:48Z","timestamp":1706003868072},"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003655","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T20:33:24Z","timestamp":1403210004000},"page":"e1003655","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["An Expanded Notch-Delta Model Exhibiting Long-Range Patterning and Incorporating MicroRNA Regulation"],"prefix":"10.1371","volume":"10","author":[{"given":"Jerry S.","family":"Chen","sequence":"first","affiliation":[]},{"given":"Abygail M.","family":"Gumbayan","sequence":"additional","affiliation":[]},{"given":"Robert W.","family":"Zeller","sequence":"additional","affiliation":[]},{"given":"Joseph M.","family":"Mahaffy","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1242\/dev.063610","article-title":"Notch signaling: simplicity in design, versatility in function","volume":"138","author":"ER Andersson","year":"2011","journal-title":"Development"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: Cell fate control and signal integration in development","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"SJ Bray","year":"2006","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1242\/dev.01074","article-title":"Notch signaling: Control of cell communication and cell fate","volume":"131","author":"EC Lai","year":"2004","journal-title":"Development"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrn874","article-title":"Proneural genes and the specification of neural cell types","volume":"3","author":"N Bertrand","year":"2002","journal-title":"Nature Reviews Neuroscience"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1242\/dev.01270","article-title":"Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: Towards a comprehensive understanding of gene networks","volume":"131","author":"KS Imai","year":"2004","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.neuron.2011.02.031","article-title":"Notch in the vertebrate nervous system: An old dog with new tricks","volume":"69","author":"T Pierfelice","year":"2011","journal-title":"Neuron"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1242\/dev.000786","article-title":"The Hes gene family: Repressors and oscillators that orchestrate embryogenesis","volume":"134","author":"R Kageyama","year":"2007","journal-title":"Development"},{"key":"ref9","first-page":"1067","article-title":"Pervasive regulation of <italic>Drosophila<\/italic> Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs","volume":"19","author":"EC Lai","year":"2005","journal-title":"Science Signaling"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1007\/s00018-005-5124-1","article-title":"From skin to nerve: flies, vertebrates and the first helix","volume":"62","author":"XJ Quan","year":"2005","journal-title":"Cellular and Molecular Life Sciences CMLS"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.113.3.657","article-title":"Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of <italic>Drosophila<\/italic>: Implications for notch function","volume":"113","author":"RG Fehon","year":"1991","journal-title":"The Journal of Cell Biology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature08959","article-title":"<italic>Cis<\/italic>-interactions between Notch and Delta generate mutually exclusive signalling states","volume":"465","author":"D Sprinzak","year":"2010","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.122.1.161","article-title":"Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in <italic>Drosophila<\/italic>","volume":"122","author":"P Heitzler","year":"1996","journal-title":"Development"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0092-8674(94)90010-8","article-title":"Reciprocal changes in expression of the receptor <italic>lin<\/italic>-12 and its ligand <italic>lag<\/italic>-2 prior to commitment in a <italic>C. elegans<\/italic> cell fate decision","volume":"79","author":"HA Wilkinson","year":"1994","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1242\/dev.113.4.1395","article-title":"The determination of sense organs in <italic>Drosophila<\/italic>: Effect of the neurogenic mutations in the embryo","volume":"113","author":"A Goriely","year":"1991","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0092-8674(91)90263-X","article-title":"The choice of cell fate in the epidermis of <italic>Drosophila<\/italic>","volume":"64","author":"P Heitzler","year":"1991","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0960-9822(93)90025-J","article-title":"Falling off the knife edge","volume":"3","author":"PW Sternberg","year":"1993","journal-title":"Current biology: CB"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1101\/gad.9.21.2609","article-title":"Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity","volume":"9","author":"AM Bailey","year":"1995","journal-title":"Genes & Development"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1242\/dev.127.16.3441","article-title":"The enhancer of split complex of <italic>Drosophila<\/italic> includes four Notch-regulated members of the bearded gene family","volume":"127","author":"EC Lai","year":"2000","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1006\/jtbi.1996.0233","article-title":"Pattern formation by lateral inhibition with feedback: A mathematical model of Delta-Notch intercellular signalling","volume":"183","author":"JR Collier","year":"1996","journal-title":"Journal of Theoretical Biology"},{"key":"ref21","unstructured":"Marnellos G, Deblandre G, Mjolsness E, Kintner C (2000) Delta-Notch lateral inhibitory patterning in the emergence of ciliated cells in <italic>Xenopus<\/italic>: experimental observations and a gene network model. In: Pacific Symposium on Biocomputing. volume 5, pp. 329\u2013340."},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Ghosh R, Tomlin CJ (2001) Lateral inhibition through Delta-Notch signaling: A piecewise affine hybrid model. In: Hybrid Systems: Computation and Control, Springer. pp. 232\u2013246.","DOI":"10.1007\/3-540-45351-2_21"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1000390","DOI":"10.1371\/journal.pcbi.1000390","article-title":"Computational models of the Notch network elucidate mechanisms of context-dependent signaling","volume":"5","author":"S Agrawal","year":"2009","journal-title":"PLoS Computational Biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e14668","DOI":"10.1371\/journal.pone.0014668","article-title":"Modelling the Delta1\/Notch1 pathway: In search of the mediator (s) of neural stem cell differentiation","volume":"6","author":"A Kiparissides","year":"2011","journal-title":"PLoS ONE"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Goodwin BC (1963) Temporal organization in cells. A dynamic theory of cellular control processes. London and New York: Academic Press.","DOI":"10.5962\/bhl.title.6268"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Kiernan A (2013) Notch signaling during cell fate determination in the inner ear. In: Seminars in Cell &amp; Developmental Biology. Elsevier.","DOI":"10.1016\/j.semcdb.2013.04.002"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1523\/JNEUROSCI.21-13-04712.2001","article-title":"Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear","volume":"21","author":"A Zine","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/dbio.2001.0482","article-title":"<italic>Scabrous<\/italic> modifies epithelial cell adhesion and extends the range of lateral signalling during development of the spaced bristle pattern in <italic>Drosophila<\/italic>","volume":"240","author":"O Renaud","year":"2001","journal-title":"Developmental Biology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0925-4773(02)00381-7","article-title":"Movement of bristle precursors contributes to the spacing pattern in <italic>Drosophila<\/italic>","volume":"119","author":"O Renaud","year":"2002","journal-title":"Mechanisms of Development"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature02157","article-title":"Delta-promoted filopodia mediate long-range lateral inhibition in <italic>Drosophila<\/italic>","volume":"426","author":"C de Joussineau","year":"2003","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.devcel.2010.06.006","article-title":"Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition","volume":"19","author":"M Cohen","year":"2010","journal-title":"Developmental cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1371\/journal.pbio.0040225","article-title":"Formation of the ascidian epidermal sensory neurons: Insights into the origin of the chordate peripheral nervous system","volume":"4","author":"A Pasini","year":"2006","journal-title":"PLoS Biology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1242\/dev.068049","article-title":"miR-124 function during <italic>Ciona intestinalis<\/italic> neuronal development includes extensive interaction with the Notch signaling pathway","volume":"138","author":"JS Chen","year":"2011","journal-title":"Development"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ydbio.2013.03.016","article-title":"Transcriptional regulation of the peripheral nervous system in <italic>Ciona intestinalis<\/italic>","volume":"378","author":"W Joyce Tang","year":"2013","journal-title":"Developmental Biology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1073\/pnas.97.22.11692","article-title":"Notch signaling in the development of the inner ear: Lessons from <italic>Drosophila<\/italic>","volume":"97","author":"M Eddison","year":"2000","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/mcne.2002.1174","article-title":"Interkinetic nuclear movement may provide spatial clues to the regulation of neurogenesis","volume":"21","author":"A Murciano","year":"2002","journal-title":"Molecular and Cellular Neuroscience"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cell.2008.07.017","article-title":"Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient","volume":"134","author":"F Del Bene","year":"2008","journal-title":"Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.hdy.6800874","article-title":"The origin and evolution of stereotyped patterns of macrochaetes on the nota of cyclorraphous Diptera","volume":"97","author":"P Simpson","year":"2006","journal-title":"Heredity"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/43191","article-title":"Fringe modulates Notch-ligand interactions","volume":"387","author":"VM Panin","year":"1997","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/dbio.1999.9536","article-title":"Lateral induction by juxtacrine signaling is a new mechanism for pattern formation","volume":"217","author":"MR Owen","year":"2000","journal-title":"Developmental Biology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"15792","DOI":"10.1073\/pnas.1002827107","article-title":"Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear","volume":"107","author":"BH Hartman","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0025-5564(98)10034-2","article-title":"Mathematical modelling of juxtacrine cell signalling","volume":"153","author":"MR Owen","year":"1998","journal-title":"Mathematical Biosciences"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/bulm.1999.0152","article-title":"Mathematical modelling of juxtacrine patterning","volume":"62","author":"HJ Wearing","year":"2000","journal-title":"Bulletin of Mathematical Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00285-003-0247-1","article-title":"Oscillations and patterns in spatially discrete models for developmental intercellular signalling","volume":"48","author":"SD Webb","year":"2004","journal-title":"Journal of Mathematical Biology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1098\/rstb.1952.0012","article-title":"The chemical basis of morphogenesis","volume":"237","author":"AM Turing","year":"1952","journal-title":"Philosophical Transactions of the Royal Society of London"},{"key":"ref46","unstructured":"Chen J, Zeller R (2009) Regulation of gene expression by the microRNA miR-124 in the developing nervous system of <italic>C. intestinalis<\/italic>. ACSESS Proceedings AP0904."},{"key":"ref47","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nature04336","article-title":"Tunicates and not cephalochordates are the closest living relatives of vertebrates","volume":"439","author":"F Delsuc","year":"2006","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1242\/dev.073833","article-title":"BMP and Delta\/Notch signaling control the development of <italic>Am-phioxus<\/italic> epidermal sensory neurons: insights into the evolution of the peripheral sensory system","volume":"139","author":"TM Lu","year":"2012","journal-title":"Development"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1007\/s00018-010-0403-x","article-title":"The role of bHLH genes in ear development and evolution: Revisiting a 10-year-old hypothesis","volume":"67","author":"B Fritzsch","year":"2010","journal-title":"Cellular and Molecular Life Sciences"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"DP Bartel","year":"2009","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/cne.21247","article-title":"Neurons of the ascidian larval nervous system in <italic>Ciona intestinalis<\/italic>: II. Peripheral nervous system","volume":"501","author":"JH Imai","year":"2007","journal-title":"Journal of Comparative Neurology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1073\/pnas.0308265100","article-title":"Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems","volume":"101","author":"D Angeli","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrn1847","article-title":"Notch signalling in vertebrate neural development","volume":"7","author":"A Louvi","year":"2006","journal-title":"Nature Reviews Neuroscience"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0022-5193(84)90011-0","article-title":"Cellular control models with linked positive and negative feedback and delays. I. The models","volume":"106","author":"J Mahaffy","year":"1984","journal-title":"Journal of Theoretical Biology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1073\/pnas.0307969100","article-title":"The <italic>Arabidopsis<\/italic> double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation","volume":"101","author":"MH Han","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","article-title":"Regulation by <italic>let-7<\/italic> and <italic>lin-4<\/italic> miRNAs results in target mRNA degradation","volume":"122","author":"S Bagga","year":"2005","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","article-title":"Control of translation and mRNA degradation by miRNAs and siRNAs","volume":"20","author":"MA Valencia-Sanchez","year":"2006","journal-title":"Genes & Development"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1073\/pnas.0510928103","article-title":"MicroRNAs direct rapid deadenylation of mRNA","volume":"103","author":"L Wu","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/dev.125.23.4637","article-title":"Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: Evidence from the mind bomb mutant","volume":"125","author":"C Haddon","year":"1998","journal-title":"Development"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1242\/dev.125.3.359","article-title":"Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis","volume":"125","author":"C Haddon","year":"1998","journal-title":"Development"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1242\/dev.126.24.5669","article-title":"The <italic>deltaA<\/italic> gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2","volume":"126","author":"BB Riley","year":"1999","journal-title":"Development"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1242\/dev.01589","article-title":"Two contrasting roles for Notch activity in chick inner ear development: Specification of prosensory patches and lateral inhibition of hair-cell differentiation","volume":"132","author":"N Daudet","year":"2005","journal-title":"Development"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/6804","article-title":"Notch signalling pathway mediates hair cell development in mammalian cochlea","volume":"21","author":"PJ Lanford","year":"1999","journal-title":"Nature Genetics"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Murata J, Ikeda K, Okano H (2012) Notch signaling and the developing inner ear. In: Notch Signaling in Embryology and Cancer, Springer. pp. 161\u2013173.","DOI":"10.1007\/978-1-4614-0899-4_12"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ncb2358","article-title":"Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta\/Notch pathway","volume":"13","author":"B Marcet","year":"2011","journal-title":"Nature Cell Biology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.4161\/cc.10.17.17011","article-title":"MicroRNA-based silencing of Delta\/Notch signaling promotes multiple cilia formation","volume":"10","author":"B Marcet","year":"2011","journal-title":"Cell Cycle"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2006.07.006","article-title":"MicroRNA gene expression in the mouse inner ear","volume":"1111","author":"MD Weston","year":"2006","journal-title":"Brain Research"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2009.02.027","article-title":"Little but loud: Small RNAs have a resounding affect on ear development","volume":"1277","author":"GA Soukup","year":"2009","journal-title":"Brain Research"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/WNR.0b013e328338864b","article-title":"MicroRNA expression in the embryonic mouse inner ear","volume":"21","author":"XR Wang","year":"2010","journal-title":"NeuroReport"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1101\/gad.1937010","article-title":"MicroRNAs and gene regulatory networks: Managing the impact of noise in biological systems","volume":"24","author":"H Herranz","year":"2010","journal-title":"Genes & Development"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"7915","DOI":"10.1073\/pnas.0812446106","article-title":"MicroRNAs are essential for development and function of inner ear hair cells in vertebrates","volume":"106","author":"LM Friedman","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.gep.2009.01.003","article-title":"Expression patterns of miR-96, miR-182 and miR-183 in the developing inner ear","volume":"9","author":"R Sacheli","year":"2009","journal-title":"Gene Expression Patterns"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1101\/gad.1466306","article-title":"MicroRNA-9a ensures the precise specification of sensory organ precursors in <italic>Drosophila<\/italic>","volume":"20","author":"Y Li","year":"2006","journal-title":"Genes & Development"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ydbio.2008.12.036","article-title":"<italic>Drosophila miR-9a<\/italic> regulates wing development via fine-tuning expression of the LIM only factor, dLMO","volume":"327","author":"I Biryukova","year":"2009","journal-title":"Developmental Biology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ng865","article-title":"MicroRNAs are complementary to 3&apos;UTR sequence motifs that mediate negative post-transcriptional regulation","volume":"30","author":"EC Lai","year":"2002","journal-title":"Nature Genetics"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1242\/dev.127.21.4551","article-title":"Hes1 is a negative regulator of inner ear hair cell differentiation","volume":"127","author":"JL Zheng","year":"2000","journal-title":"Development"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/35018575","article-title":"Presenilin is required for proper morphology and function of neurons in <italic>C. elegans<\/italic>","volume":"406","author":"N Wittenburg","year":"2000","journal-title":"Nature"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1534\/genetics.110.117515","article-title":"The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in <italic>Caenorhabditis elegans<\/italic>","volume":"185","author":"WR Shaw","year":"2010","journal-title":"Genetics"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2008.12.037","article-title":"Interaction of notochordderived fibrinogen-like protein with Notch regulates the patterning of the central nervous system of <italic>Ciona intestinalis<\/italic> embryos","volume":"328","author":"S Yamada","year":"2009","journal-title":"Developmental Biology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1523\/JNEUROSCI.2754-07.2007","article-title":"Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis","volume":"27","author":"LM Baye","year":"2007","journal-title":"The Journal of Neuroscience"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0092-8674(00)80149-X","article-title":"Short-range signaling by candidate morphogens of the TGF<italic>\u03b2<\/italic> family and evidence for a relay mechanism of induction","volume":"86","author":"KM Reilly","year":"1996","journal-title":"Cell"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1242\/dev.124.3.589","article-title":"Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, <italic>Ciona intestinalis<\/italic>","volume":"124","author":"JC Corbo","year":"1997","journal-title":"Development"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/dvdy.20644","article-title":"Optimized green fluorescent protein variants provide improved single cell resolution of transgene expression in ascidian embryos","volume":"235","author":"RW Zeller","year":"2006","journal-title":"Developmental Dynamics"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T22:41:22Z","timestamp":1649457682000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003655"}},"subtitle":[],"editor":[{"given":"Qing","family":"Nie","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":83,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003655","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]}}}