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Symonds","year":"2010","journal-title":"Immunol Res"},{"key":"ref6","first-page":"67","article-title":"HIV-1 drug resistance mutations: an updated framework for the second decade of HAART","volume":"10","author":"RW Shafer","year":"2008","journal-title":"AIDS Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.2012.7961","article-title":"Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel","volume":"308","author":"MA Thompson","year":"2012","journal-title":"JAMA: the journal of the American Medical Association"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jhep.2005.11.021","article-title":"Update on HAART in HIV","volume":"44","author":"P Yeni","year":"2006","journal-title":"J Hepatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/jgm.908","article-title":"Gene therapy for HIV infection: what does it need to make 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Allers","year":"2011","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"17372","DOI":"10.1073\/pnas.0608138103","article-title":"Gene transfer in humans using a conditionally replicating lentiviral vector","volume":"103","author":"BL Levine","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jgm.705","article-title":"Long-term survival and concomitant gene expression of ribozyme-transduced CD4+T-lymphocytes in HIV-infected patients","volume":"7","author":"JL Macpherson","year":"2005","journal-title":"J Gene Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1182\/blood.V96.3.785","article-title":"Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects","volume":"96","author":"RT Mitsuyasu","year":"2000","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1089\/hum.2005.16.1065","article-title":"Preferential survival of CD4+T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals","volume":"16","author":"RA Morgan","year":"2005","journal-title":"Hum Gene Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1073\/pnas.95.3.1201","article-title":"Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals","volume":"95","author":"U Ranga","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"132ra153","DOI":"10.1126\/scitranslmed.3003761","article-title":"Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells","volume":"4","author":"J Scholler","year":"2012","journal-title":"Sci Transl 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cells","volume":"15","author":"RT Mitsuyasu","year":"2009","journal-title":"Nat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ymthe.2005.02.024","article-title":"Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells","volume":"12","author":"GM Podsakoff","year":"2005","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e12357","DOI":"10.1371\/journal.pone.0012357","article-title":"Survival of the fittest: positive selection of CD4+T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection","volume":"5","author":"J Kimpel","year":"2010","journal-title":"PLoS One"},{"key":"ref31","unstructured":"ClinicalTrials.gov (2012) Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection. ClinicalTrialsgov Identifier: NCT01734850 Available online under: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01734850\" xlink:type=\"simple\">http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01734850<\/ext-link>."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nbt.1663","article-title":"Human hematopoietic stem\/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo","volume":"28","author":"N Holt","year":"2010","journal-title":"Nat Biotechnol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nbt1410","article-title":"Establishment of HIV-1 resistance in CD4+T cells by genome editing using zinc-finger nucleases","volume":"26","author":"EE Perez","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref34","unstructured":"Ando D, Tebas P, Stein D, Wang S, Lee G, <etal>et al<\/etal>.. (2011) HAART Treatment Interruption Following Adoptive Transfer of Zinc Finger Nuclease (ZFN) CCR5 Modified AutologousCD4 T-cells (SB-728-T) to HIV-infected Subjects Demonstrates Durable Engraftment and Suppression of Viral Load 51th ICAAC, Chicago, IL, September 17\u201320, 2011."},{"key":"ref35","unstructured":"June CH, Tebas P, Stein D, Mitsuyasu R, Lalezari J, <etal>et al<\/etal>.. (2012) Induction of Acquired CCR5 Deficiency with Zinc Finger Nuclease-modified Autologous CD4 T Cells (SB-728-T) Correlates with Increases in CD4 Count and Effects on Viral Load in HIV-infected Subjects. In: Proceedings of the 19th Conference on Retroviruses and Opportunistic Infections; 5\u20138 March 2012; Seattle, Washington, United States. CROI 2012."},{"key":"ref36","unstructured":"Mitsuyasu R, Lalezari J, Deeks S, Wang S, Lee G, <etal>et al<\/etal>.. (2011) Adoptive Transfer of Zinc Finger Nuclease CCR5 Modified Autologous CD4 T-cells (SB-728-T) to Aviremic HIV-infected Subjects with Suboptimal CD4 Counts (200\u2013500 cells\/mm<sup>3<\/sup>) [Abstract H1-375]. In: Proceedings of the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy; 17\u201320 September, 2011; Chicago, Illinois, United States. 51st ICAAC."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1056\/NEJMoa0803154","article-title":"Subgroup analyses of Maraviroc in previously treated R5 HIV-1 infection","volume":"359","author":"G Fatkenheuer","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3851\/IMP1507","article-title":"CCR5 antagonists: host-targeted antiviral agents for the treatment of HIV infection, 4 years on","volume":"20","author":"M Westby","year":"2010","journal-title":"Antiviral chemistry & chemotherapy"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2004.07.021","article-title":"Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and \u00d74 primate immunodeficiency viruses","volume":"328","author":"SM Wolinsky","year":"2004","journal-title":"Virology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"681","DOI":"10.7326\/0003-4819-118-9-199305010-00004","article-title":"Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS","volume":"118","author":"M Koot","year":"1993","journal-title":"Ann Intern Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"8000","DOI":"10.1073\/pnas.0503233102","article-title":"Resting naive CD4+T cells are massively infected and eliminated by \u00d74-tropic simian-human immunodeficiency viruses in macaques","volume":"102","author":"Y Nishimura","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1086\/591623","article-title":"Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the multicenter AIDS cohort study","volume":"198","author":"JC Shepherd","year":"2008","journal-title":"J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/jgm.1401","article-title":"Mathematical modelling of the impact of haematopoietic stem cell-delivered gene therapy for HIV","volume":"11","author":"JM Murray","year":"2009","journal-title":"J Gene Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nm.1932","article-title":"Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells","volume":"15","author":"RT Mitsuyasu","year":"2009","journal-title":"Nat Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/363728a0","article-title":"HIV induces thymus depletion in vivo","volume":"363","author":"ML Bonyhadi","year":"1993","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1182\/blood-2003-09-3333","article-title":"Immune activation set point during early HIV infection predicts subsequent CD4+T-cell changes independent of viral load","volume":"104","author":"SG Deeks","year":"2004","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0025-5564(98)10046-9","article-title":"A model of primary HIV-1 infection","volume":"154","author":"JM Murray","year":"1998","journal-title":"Math Biosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/jtbi.1994.1199","article-title":"Modeling HIV infection of CD4+T-cell subpopulations","volume":"170","author":"P Essunger","year":"1994","journal-title":"J Theor Biol"},{"key":"ref49","first-page":"75","article-title":"HIV diversity, recombination and disease progression: how does fitness &quot;fit&quot; into the puzzle?","volume":"9","author":"DM Tebit","year":"2007","journal-title":"AIDS Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"9006","DOI":"10.1128\/JVI.79.14.9006-9018.2005","article-title":"Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression","volume":"79","author":"RM Troyer","year":"2005","journal-title":"J Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e17956","DOI":"10.1371\/journal.pone.0017956","article-title":"Cumulative viral load and virologic decay patterns after antiretroviral therapy in HIV-infected subjects influence CD4 recovery and AIDS","volume":"6","author":"VC Marconi","year":"2011","journal-title":"PLoS One"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1128\/JVI.80.2.802-809.2006","article-title":"Naive and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy","volume":"80","author":"RM Ribeiro","year":"2006","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e1000467","DOI":"10.1371\/journal.pcbi.1000467","article-title":"Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection","volume":"5","author":"AD Weinberger","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/infdis\/jir714","article-title":"Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission","volume":"205","author":"K Chalmet","year":"2012","journal-title":"J Infect Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.clim.2012.06.004","article-title":"T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals","volume":"144","author":"B Savkovic","year":"2012","journal-title":"Clin Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00002030-199506000-00005","article-title":"Effects of primary HIV-1 infection on subsets of CD4+ and CD8+T lymphocytes","volume":"9","author":"J Zaunders","year":"1995","journal-title":"AIDS"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1600-0609.2008.01052.x","article-title":"Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis","volume":"80","author":"S Huenecke","year":"2008","journal-title":"Eur J Haematol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJM199302043280508","article-title":"New concepts in the immunopathogenesis of human immunodeficiency virus infection","volume":"328","author":"G Pantaleo","year":"1993","journal-title":"N Engl J Med"},{"key":"ref59","unstructured":"Ledger S, Savkovic B, Murray J, Symonds G. (2012) Short-hairpin RNA to CCR5 and its effect on HIV susceptible cultures through the use of a lentiviral vector. In: Proceedings of the 24th Annual Conference of the Australasian Society for HIV Medicine 17\u201319 October, 2012 Melbourne, Victoria, Australia. ASHM 2012."},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/gt.2008.73","article-title":"Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides","volume":"15","author":"RC Zahn","year":"2008","journal-title":"Gene Therapy"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1128\/JVI.78.2.568-575.2004","article-title":"Inhibition of Human Immunodeficiency Virus Type 1 Entry in Cells Expressing gp41-Derived Peptides","volume":"78","author":"M Egelhofer","year":"2004","journal-title":"Journal of Virology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1128\/AAC.00494-09","article-title":"Inhibition of envelope-mediated CD4+T-cell depletion by human immunodeficiency virus attachment inhibitors","volume":"53","author":"L Alexander","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nm0295-129","article-title":"Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes","volume":"1","author":"TH Finkel","year":"1995","journal-title":"Nat Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1128\/JVI.79.10.6299-6311.2005","article-title":"Distinct mechanisms of CD4+ and CD8+T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions","volume":"79","author":"GH Holm","year":"2005","journal-title":"J Virol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1128\/JVI.78.9.4541-4551.2004","article-title":"Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope\/receptor affinity and coreceptor binding site exposure","volume":"78","author":"GH Holm","year":"2004","journal-title":"J Virol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"36404","DOI":"10.1074\/jbc.M111.281659","article-title":"HIV ENV glycoprotein-mediated bystander apoptosis depends on expression of the CCR5 co-receptor at the cell surface and ENV fusogenic activity","volume":"286","author":"A Joshi","year":"2011","journal-title":"J Biol Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1742-4690-7-83","article-title":"In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy","volume":"7","author":"TL Applegate","year":"2010","journal-title":"Retrovirology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e1000883","DOI":"10.1371\/journal.pcbi.1000883","article-title":"Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles","volume":"6","author":"S Aviran","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/BF02458427","article-title":"Gene therapy of T helper cells in HIV infection: mathematical model of the criteria for clinical effect","volume":"59","author":"O Lund","year":"1997","journal-title":"Bull Math Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1440-1711.2003.01191.x","article-title":"Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty","volume":"81","author":"JM Murray","year":"2003","journal-title":"Immunol Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood.V91.8.2672.2672_2672_2678","article-title":"Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo","volume":"91","author":"M Jenkins","year":"1998","journal-title":"Blood"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1097\/00002030-200211220-00005","article-title":"Reconstitution of naive T cells during antiretroviral treatment of HIV- infected adults is dependent on age","volume":"16","author":"J Cohen Stuart","year":"2002","journal-title":"Aids"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"393698","DOI":"10.4061\/2011\/393698","article-title":"Phase I\/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt","volume":"2011","author":"RT Mitsuyasu","year":"2011","journal-title":"Stem cells international"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1128\/JVI.06300-11","article-title":"Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector","volume":"86","author":"JE Walker","year":"2012","journal-title":"J Virol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1182\/blood-2012-07-447250","article-title":"Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV","volume":"121","author":"P Tebas","year":"2013","journal-title":"Blood"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1073\/pnas.92.9.3707","article-title":"In vivo estimates of division and death rates of human T lymphocytes","volume":"92","author":"AR McLean","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1182\/blood-2013-01-482224","article-title":"Positive selection of mC46-expressing CD4+T cells and maintenance of virus specific immunity in a primate AIDS model","volume":"122","author":"PM 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