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Cambridge, UK: Cambridge University Press."},{"key":"ref3","unstructured":"Michod RE, Levin BR (1987) The Evolution of Sex: An Examination of Current Ideas. Michigan: Sinauer Associates. 352 p."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.genet.30.1.261","article-title":"Population genetic perspectives on the evolution of recombination","volume":"30","author":"MW Feldman","year":"1997","journal-title":"Annu Rev Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrg761","article-title":"Resolving the paradox of sex and recombination","volume":"3","author":"SP Otto","year":"2002","journal-title":"Nat Rev Gen"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrg1985","article-title":"The evolution of sex: empirical insights into the roles of epistasis and drift","volume":"8","author":"JAGM de Visser","year":"2007","journal-title":"Nat Rev Gen"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1086\/599084","article-title":"The evolutionary enigma of sex","volume":"174","author":"SP Otto","year":"2009","journal-title":"Amer Nat"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S001667230001569X","article-title":"An experiment on recombination load in Drosophila melanogaster","volume":"25","author":"B Charlesworth","year":"1975","journal-title":"Genet Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0027-5107(64)90047-8","article-title":"The relation of recombination to mutational advance","volume":"106","author":"HJ Muller","year":"1964","journal-title":"Mutat Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/genetics\/78.2.737","article-title":"The Evolutionary Advantage of Recombination","volume":"78","author":"J Felsenstein","year":"1974","journal-title":"Genetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/336435a0","article-title":"Deleterious mutations and the evolution of sexual reproduction","volume":"336","author":"AS Kondrashov","year":"1988","journal-title":"Nature"},{"key":"ref12","first-page":"1","article-title":"A new evolutionary law","volume":"1","author":"L Van Valen","year":"1973","journal-title":"Evol Theor"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Fisher RA (1930) The genetical theory of natural selection. 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New York: JohnWiley&amp; Sons, Ltd."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1098\/rspb.2011.1537","article-title":"The causes of epistasis","volume":"278","author":"JAGM de Visser","year":"2011","journal-title":"Proc R Soc London B"},{"key":"ref22","first-page":"1165","article-title":"Perspective: Sign epistasis and genetic constraint on evolutionary trajectories","volume":"59","author":"DM Weinreich","year":"2005","journal-title":"Evolution"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature05451","article-title":"Empirical fitness landscapes reveal accessible evolutionary paths","volume":"445","author":"FJ Poelwijk","year":"2007","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1002134","DOI":"10.1371\/journal.pcbi.1002134","article-title":"Evolutionary accessibility of mutational pathways","volume":"7","author":"J Franke","year":"2011","journal-title":"PLoS Comput 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epistasis can cause a transition from allele to genotype selection","volume":"106","author":"RA Neher","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Neher RA, Vucelja M, Mezard M, Shraiman BI (2013) Emergence of clones in sexual populations. J Stat Mech Theor Exp: P01008","DOI":"10.1088\/1742-5468\/2013\/01\/P01008"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1097-0282(200007)54:1<64::AID-BIP70>3.0.CO;2-R","article-title":"Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin","volume":"54","author":"T Aita","year":"2000","journal-title":"Biopolymers"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s002850000046","article-title":"Adaptive walks by the fittest among finite random mutants on a Mt. Fuji-type fitness landscape II. Effect of small non-additivity","volume":"41","author":"T Aita","year":"2000","journal-title":"J Math Biol"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Neidhart J, Szendro IG, Krug J (2014) Adaptation in tunably rugged fitness landscapes: The rough Mount Fuji model. Genetics. E-pub ahead of print. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/arxiv.org\/abs\/1402.3065\" xlink:type=\"simple\">http:\/\/arxiv.org\/abs\/1402.3065<\/ext-link>. Accessed 25 August 2014.","DOI":"10.1534\/genetics.114.167668"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tig.2009.01.002","article-title":"From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation","volume":"25","author":"V Mustonen","year":"2009","journal-title":"Trends Genet"},{"key":"ref59","first-page":"625","article-title":"Modification of linkage intensity by natural selection Genetics","volume":"57","author":"M Nei","year":"1967"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/genetics\/134.2.627","article-title":"The Evolution of Multilocus Systems Under Weak Selection","volume":"134","author":"T Nagylaki","year":"1993","journal-title":"Genetics"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1534\/genetics.105.045252","article-title":"Adaptation in Sexuals vs. Asexuals: Clonal Interference and the Fisher-Muller Model","volume":"171(3)","author":"Y Kim","year":"2005","journal-title":"Genetics"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1073\/pnas.83.13.4824","article-title":"An evolutionary reduction principle for genetic modifiers","volume":"83","author":"MW Feldman","year":"1986","journal-title":"Proc Matl Acad Sci"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1098\/rstb.2010.0106","article-title":"Genetic linkage and natural selection","volume":"365","author":"NH Barton","year":"2010","journal-title":"Phil Trans R Soc B"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-5193(89)80019-0","article-title":"The NK Model of rugged fitness landscapes and its application to the maturation of the immune response","volume":"141","author":"S Kauffman","year":"1989","journal-title":"J Theor Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tpb.2009.02.006","article-title":"The rate at which asexual populations cross fitness valleys","volume":"75","author":"DB Weissman","year":"2009","journal-title":"Theor Popul Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0040-5809(71)90022-0","article-title":"Equilibrium studies of two locus haploid populations with recombination","volume":"2","author":"MW Feldman","year":"1971","journal-title":"Theor Pop Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/tpbi.1994.1009","article-title":"Dynamics of the two-locus haploid model","volume":"45","author":"DA Rutschman","year":"1994","journal-title":"Theor Pop Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0040-5809(90)90002-D","article-title":"Dynamics of Polygenic Characters under Selection","volume":"38","author":"M Turelli","year":"1990","journal-title":"Theor Popul Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-5193(87)80029-2","article-title":"Towards a general theory of adaptive walks on rugged landscapes","volume":"128","author":"S Kauffman","year":"1987","journal-title":"J Theor Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0022-5193(71)90058-0","article-title":"What use is sex?","volume":"30","author":"J Maynard Smith","year":"1971","journal-title":"J Theor Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1534\/genetics.113.155135","article-title":"Rate of adaptation in sexuals and asexuals: A solvable model for the Fisher-Muller effect","volume":"195","author":"S-C Park","year":"2013","journal-title":"Genetics"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10955-009-9915-x","article-title":"The speed of evolution in large asexual populations","volume":"138","author":"S-C Park","year":"2010","journal-title":"J Stat Phys"},{"key":"ref73","unstructured":"Park S-C, Krug J (2008) Evolution in random fitness landscapes: the infinite sites model. 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