{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:25:17Z","timestamp":1770510317736,"version":"3.49.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1003842","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T19:06:17Z","timestamp":1411671977000},"page":"e1003842","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["IDEPI: Rapid Prediction of HIV-1 Antibody Epitopes and Other Phenotypic Features from Sequence Data Using a Flexible Machine Learning Platform"],"prefix":"10.1371","volume":"10","author":[{"given":"N. Lance","family":"Hepler","sequence":"first","affiliation":[]},{"given":"Konrad","family":"Scheffler","sequence":"additional","affiliation":[]},{"given":"Steven","family":"Weaver","sequence":"additional","affiliation":[]},{"given":"Ben","family":"Murrell","sequence":"additional","affiliation":[]},{"given":"Douglas D.","family":"Richman","sequence":"additional","affiliation":[]},{"given":"Dennis R.","family":"Burton","sequence":"additional","affiliation":[]},{"given":"Pascal","family":"Poignard","sequence":"additional","affiliation":[]},{"given":"Davey M.","family":"Smith","sequence":"additional","affiliation":[]},{"given":"Sergei L.","family":"Kosakovsky Pond","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2165\/11633630-000000000-00000","article-title":"HIV-1 antiretroviral resistance: scientific principles and clinical applications","volume":"72","author":"MW Tang","year":"2012","journal-title":"Drugs"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1086\/503914","article-title":"Web resources for HIV type 1 genotypic-resistance test interpretation","volume":"42","author":"TF Liu","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e21189","DOI":"10.1371\/journal.pone.0021189","article-title":"Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load","volume":"6","author":"AFY Poon","year":"2011","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1086\/589297","article-title":"Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel","volume":"47","author":"MS Hirsch","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.qai.0000147526.64863.53","article-title":"Comparison of the precision and sensitivity of the Antivirogram and PhenoSense HIV drug susceptibility assays","volume":"38","author":"J Zhang","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e11505","DOI":"10.1371\/journal.pone.0011505","article-title":"Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time","volume":"5","author":"D Frentz","year":"2010","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1186\/1756-0500-5-582","article-title":"Comparison of predicted susceptibility between genotype and virtual phenotype HIV drug resistance interpretation systems among treatment-naive HIV-infected patients in Asia: TASER-M cohort analysis","volume":"5","author":"A Jiamsakul","year":"2012","journal-title":"BMC Res Notes"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13598","DOI":"10.1128\/JVI.01570-07","article-title":"Mapping protease inhibitor resistance to human immunodeficiency virus type 1 sequence polymorphisms within patients","volume":"81","author":"AFY Poon","year":"2007","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1128\/AAC.00574-10","article-title":"HIV-1 protease mutations and protease inhibitor cross-resistance","volume":"54","author":"SY Rhee","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1128\/AAC.05487-11","article-title":"Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility","volume":"56","author":"GL Melikian","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1128\/AAC.06170-11","article-title":"Broad phenotypic crossresistance to elvitegravir in HIV-infected patients failing on raltegravir-containing regimens","volume":"56","author":"C Garrido","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-422X-10-8","article-title":"Quantitative prediction of integrase inhibitor resistance from genotype through consensus linear regression modeling","volume":"10","author":"K Van der Borght","year":"2013","journal-title":"Virol J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1073\/pnas.0907304107","article-title":"Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance","volume":"107","author":"J Zhang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e65115","DOI":"10.1371\/journal.pone.0065115","article-title":"Structure and dynamics of the gp120 V3 loop that confers noncompetitive resistance in R5 HIV-1(JR-FL) to maraviroc","volume":"8","author":"Y Yuan","year":"2013","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/135965350901400315","article-title":"Investigation of expert rule bases, logistic regression, and non-linear machine learning techniques for predicting response to antiretroviral treatment","volume":"14","author":"MCF Prosperi","year":"2009","journal-title":"Antivir Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/bioinformatics\/btt331","article-title":"Multilabel classification for exploiting crossresistance information in HIV-1 drug resistance prediction","volume":"29","author":"D Heider","year":"2013","journal-title":"Bioinformatics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"W286","DOI":"10.1093\/nar\/gkt497","article-title":"SigniSite: Identification of residue-level genotypephenotype correlations in protein multiple sequence alignments","volume":"41","author":"LE Jessen","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0952-7915(97)80110-0","article-title":"Co-receptors for HIV-1 entry","volume":"9","author":"JP Moore","year":"1997","journal-title":"Curr Opin Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jac\/dkp113","article-title":"Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients","volume":"63","author":"L Vandekerckhove","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1570162033485357","article-title":"HIV-1 coreceptor usage, transmission, and disease progression","volume":"1","author":"SM Philpott","year":"2003","journal-title":"Curr HIV Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1128\/JVI.66.2.757-765.1992","article-title":"Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity","volume":"66","author":"JJ de Jong","year":"1992","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/cid\/cir072","article-title":"Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity","volume":"52","author":"TJ Wilkin","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1128\/JCM.01204-10","article-title":"Performance of genotypic algorithms for predicting HIV-1 tropism measured against the enhanced-sensitivity Trofile coreceptor tropism assay","volume":"48","author":"V S\u00e1nchez","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.antiviral.2012.11.002","article-title":"Correlation between genotypic (V3 population sequencing) and phenotypic (Trofile ES) methods of characterizing coreceptor usage of HIV-1 from 200 treatment-na\u00efve HIV patients screened for Study A4001078","volume":"97","author":"S Portsmouth","year":"2013","journal-title":"Antiviral Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1128\/JVI.66.5.3183-3187.1992","article-title":"Phenotypeassociated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule","volume":"66","author":"RA Fouchier","year":"1992","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/088922203762688658","article-title":"A new perspective on V3 phenotype prediction","volume":"19","author":"S Pillai","year":"2003","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1000743","DOI":"10.1371\/journal.pcbi.1000743","article-title":"Prediction of co-receptor usage of HIV-1 from genotype","volume":"6","author":"JN Dybowski","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"13376","DOI":"10.1128\/JVI.77.24.13376-13388.2003","article-title":"Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences","volume":"77","author":"MA Jensen","year":"2003","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/viro.2001.1087","article-title":"Improved success of phenotype prediction of the human immunodeficiency virus type 1 from envelope variable loop 3 sequence using neural networks","volume":"288","author":"W Resch","year":"2001","journal-title":"Virology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/jac\/dkt077","article-title":"Improvement of HIV-1 coreceptor tropism prediction by employing selected nucleotide positions of the env gene in a Bayesian network classifier","volume":"68","author":"F D\u00edez-Fuertes","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e61437","DOI":"10.1371\/journal.pone.0061437","article-title":"Hybrid approach for predicting coreceptor used by HIV-1 from its V3 loop amino acid sequence","volume":"8","author":"R Kumar","year":"2013","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1371\/journal.pcbi.0030058","article-title":"Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage","volume":"3","author":"O Sander","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"F17","DOI":"10.1097\/QAD.0b013e3282ef81ea","article-title":"Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates","volume":"21","author":"AJ Low","year":"2007","journal-title":"AIDS"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/brain\/awl136","article-title":"Genetic attributes of cerebrospinal fluid-derived HIV-1 env","volume":"129","author":"SK Pillai","year":"2006","journal-title":"Brain"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e49538","DOI":"10.1371\/journal.pone.0049538","article-title":"A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia","volume":"7","author":"AG Holman","year":"2012","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e1002209","DOI":"10.1371\/journal.ppat.1002209","article-title":"Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections","volume":"7","author":"S Gnanakaran","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.1194693","article-title":"A boost for HIV vaccine design","volume":"329","author":"DR Burton","year":"2010","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.1178746","article-title":"Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target","volume":"326","author":"LM Walker","year":"2009","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1192819","article-title":"Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01","volume":"329","author":"T Zhou","year":"2010","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature10373","article-title":"Broad neutralization coverage of HIV by multiple highly potent antibodies","volume":"477","author":"LM Walker","year":"2011","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.chom.2012.09.008","article-title":"A Blueprint for HIV Vaccine Discovery","volume":"12","author":"DR Burton","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nsmb.2600","article-title":"Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16","volume":"20","author":"M Pancera","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11200","DOI":"10.1128\/JVI.00790-10","article-title":"Mutation at a single position in the V2 domain of the HIV-1 envelope protein confers neutralization sensitivity to a highly neutralization-resistant virus","volume":"84","author":"SM O'Rourke","year":"2010","journal-title":"J Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1000955","DOI":"10.1371\/journal.pcbi.1000955","article-title":"Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies","volume":"6","author":"S Gnanakaran","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"10598","DOI":"10.1073\/pnas.1309215110","article-title":"Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues","volume":"110","author":"AP West Jr","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1128\/JVI.00984-13","article-title":"Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains","volume":"87","author":"GY Chuang","year":"2013","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e80562","DOI":"10.1371\/journal.pone.0080562","article-title":"Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data","volume":"8","author":"AL Ferguson","year":"2013","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/1743-422X-10-347","article-title":"Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models","volume":"10","author":"M Lacerda","year":"2013","journal-title":"Virol J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jtbi.1996.0213","article-title":"A New Approach to Clustering the Amino Acid","volume":"183","author":"LE Stanfel","year":"1996","journal-title":"Journal of Theoretical Biology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1109\/TPAMI.2005.159","article-title":"Feature selection based on mutual information criteria of max-dependency, max-relevance, and min-redundancy","volume":"27","author":"H Peng","year":"2005","journal-title":"Pattern Analysis and Machine Intelligence, IEEE Transactions on"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bpc.2010.11.004","article-title":"A combined sequence-structure approach for predicting resistance to the non-nucleoside HIV-1 reverse transcriptase inhibitor Nevirapine","volume":"153","author":"VL Ravich","year":"2011","journal-title":"Biophys Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e27812","DOI":"10.1371\/journal.pone.0027812","article-title":"National prevalence and trends of HIV transmitted drug resistance in Mexico","volume":"6","author":"S Avila-R\u00edos","year":"2011","journal-title":"PLoS One"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/001316446002000104","article-title":"A coefficient of agreement for nominal scales","volume":"20","author":"J Cohen","year":"1960","journal-title":"Educational and Psychological Measurement"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/QAD.0b013e3282f5ff71","article-title":"Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance","volume":"22","author":"L Liu","year":"2008","journal-title":"AIDS"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1128\/JVI.75.12.5541-5549.2001","article-title":"Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes","volume":"75","author":"EG Cormier","year":"2001","journal-title":"J Virol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-6405-7-43","article-title":"HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites","volume":"7","author":"AG Holman","year":"2010","journal-title":"AIDS Res Ther"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.7973652","article-title":"Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody","volume":"266","author":"DR Burton","year":"1994","journal-title":"Science"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nri3516","article-title":"Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning","volume":"13","author":"PD Kwong","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1128\/JVI.67.11.6642-6647.1993","article-title":"A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1","volume":"67","author":"T Muster","year":"1993","journal-title":"J Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1371\/journal.pmed.0030255","article-title":"Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype B","volume":"3","author":"ES Gray","year":"2006","journal-title":"PLoS Med"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1118398","article-title":"Structure of a V3-containing HIV-1 gp120 core","volume":"310","author":"Cc Huang","year":"2005","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10696","article-title":"Structure of HIV-1 gp120 V1\/V2 domain with broadly neutralizing antibody PG9","volume":"480","author":"JS McLellan","year":"2011","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e1003342","DOI":"10.1371\/journal.ppat.1003342","article-title":"Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans","volume":"9","author":"JP Julien","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature11544","article-title":"Broad and potent neutralization of HIV-1 by a gp41-specific human antibody","volume":"491","author":"J Huang","year":"2012","journal-title":"Nature"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.1207227","article-title":"Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding","volume":"333","author":"JF Scheid","year":"2011","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1088\/0004-637X\/764\/2\/167","article-title":"Studies in Astronomical Time Series Analysis. VI. Bayesian Block Representations","volume":"764","author":"JD Scargle","year":"2013","journal-title":"The Astrophysical Journal"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1128\/JVI.75.13.5998-6006.2001","article-title":"N-linked glycosylation sites adjacent to and within the V1\/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropism","volume":"75","author":"RA Ogert","year":"2001","journal-title":"J Virol"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T21:48:02Z","timestamp":1650232082000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003842"}},"subtitle":[],"editor":[{"given":"Robert F.","family":"Murphy","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":67,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003842","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,25]]}}}