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New York."},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Kim C-J, Nelson CR (1999) State-Space Models with Regime Switching: Classical and Gibbs-Sampling Approaches with Applications. MIT Press Books 1.","DOI":"10.7551\/mitpress\/6444.001.0001"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Efron B, Tibshirani R (1993) An introduction to the bootstrap. 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