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Disease. Int J Alzheimers Dis, Article ID 535816.","DOI":"10.4061\/2011\/535816"},{"key":"ref46","first-page":"12","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137(1)","author":"R Leech","year":"2013","journal-title":"Brain"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.neuroimage.2011.03.069","article-title":"Weight-conserving characterization of complex functional brain networks","volume":"56","author":"M Rubinov","year":"2011","journal-title":"Neuroimage"},{"key":"ref48","unstructured":"Snow J (1855) On the mode of communication of cholera. London J Churchill, 2."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1245200","article-title":"The hidden geometry of complex, network-driven contagion phenomena","volume":"342","author":"D Brockmann","year":"2013","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tics.2013.09.012","article-title":"Network hubs in the human brain","volume":"17","author":"MP Van den Heuvel","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awu132","article-title":"The hubs of the human connectome are generally implicated in the anatomy of brain disorders","volume":"137(8)","author":"a Crossley N","year":"2014","journal-title":"Brain"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"J Hardy","year":"1992","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrd3505","article-title":"The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics","volume":"10","author":"E Karran","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/mp.2013.19","article-title":"APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study","volume":"19","author":"V Ramanan","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"77sr71","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer's disease: the challenge of the second century","volume":"3","author":"D Holtzman","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance","volume":"3","author":"J Castellano","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/brain\/aws127","article-title":"Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta","volume":"135","author":"R Koffie","year":"2012","journal-title":"Brain"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"E Corder","year":"1993","journal-title":"Science (80)"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/jnnp.2003.030882","article-title":"Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve","volume":"76(1)","author":"L Mosconi","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mp.2011.52","article-title":"APOE and Alzheimer disease: a major gene with semi-dominant inheritance","volume":"16(9)","author":"E Genin","year":"2011","journal-title":"Mol Psychiatry"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"8254","DOI":"10.1523\/JNEUROSCI.0305-12.2012","article-title":"Gender Modulates the APOE E4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels","volume":"32(24)","author":"J Damoiseaux","year":"2012","journal-title":"J Neurosci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"L Farrer","year":"1997","journal-title":"JAMA"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1196\/annals.1297.005","article-title":"The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism","volume":"1019","author":"E Corder","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s11065-009-9118-x","article-title":"Beta-Amyloid Deposition and the Aging Brain","volume":"19(4)","author":"K Rodrigue","year":"2009","journal-title":"Neuropsychol Rev"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment among the elderly","volume":"65","author":"H Aizenstein","year":"2008","journal-title":"Arch Neurol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ana.21212","article-title":"Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease","volume":"63","author":"N Kemppainen","year":"2008","journal-title":"Ann Neurol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000203130","article-title":"Biomarkers in relation to cognitive reserve in patients with mild cognitive impairment\u2014proof of concept","volume":"27","author":"S Rolstad","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","volume":"65","author":"LM Shaw","year":"2009","journal-title":"Ann Neurol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"CR Jack Jr","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"CR Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuron.2008.11.007","article-title":"Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis","volume":"60","author":"S Small","year":"2008","journal-title":"Neuron"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.expneurol.2010.11.003","article-title":"Autophagy and misfolded proteins in neurodegeneration","volume":"238","author":"DJ Metcalf","year":"2012","journal-title":"Exp Neurol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-\u03b2 Induced Neuronal Dysfunction in Alzheimer's Disease: From Synapses toward Neural Networks","volume":"13(7)","author":"J Palop","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref74","first-page":"1","article-title":"Epidemic spreading in networks with nonrandom long-range interactions","volume":"036110","author":"E Estrada","year":"2011","journal-title":"Phys Rev E"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/brain.2012.0122","article-title":"Anatomical Brain Networks on the Prediction of Abnormal Brain States","volume":"3(1)","author":"Y Iturria-medina","year":"2013","journal-title":"Brain Connectivity"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuroimage.2013.05.054","article-title":"Networks of anatomical covariance","volume":"80","author":"A Evans","year":"2013","journal-title":"Neuroimage"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1474-4422(10)70043-0","article-title":"11C-PiB PET assessment of change in fibrillar amyloid-\u03b2 load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study","volume":"9(4)","author":"JO Rinne","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"189ra77","DOI":"10.1126\/scitranslmed.3005615","article-title":"Increased in vivo amyloid-\u03b242 production, exchange, and loss in presenilin mutation carriers","volume":"5","author":"R Potter","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/alzrt187","article-title":"Evidence for impaired amyloid \u03b2 clearance in Alzheimer's disease","volume":"5(4)","author":"K Wildsmith","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bcp.2013.12.020","article-title":"Immunotherapy for Alzheimer's disease","volume":"88","author":"T Wisniewski","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1217697","article-title":"ApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models","volume":"335(6075)","author":"P Cramer","year":"2012","journal-title":"Science"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/nbm.1543","article-title":"Twenty-five pitfalls in the analysis of diffusion MRI data","volume":"23","author":"DK Jones","year":"2010","journal-title":"NMR Biomed"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuroimage.2007.02.012","article-title":"Characterizing brain anatomical connections using diffusion weighted MRI and graph theory","volume":"36","author":"Y Iturria-Medina","year":"2007","journal-title":"Neuroimage"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.neuroimage.2009.12.027","article-title":"Whole-brain anatomical networks: Does the choice of nodes matter","volume":"50","author":"A Zalesky","year":"2010","journal-title":"Neuroimage"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuroimage.2013.04.003","article-title":"Microstructural grey matter parcellation and its relevance for connectome analyses","volume":"80","author":"S Caspers","year":"2013","journal-title":"Neuroimage"},{"key":"ref86","unstructured":"Lotka A (1925) Elements of physical biology. Williams Wilkins, Balt."},{"key":"ref87","first-page":"31","article-title":"Variazioni e fluttuazioni del numero d\u2032individui in specie animali conviventi","volume":"2","author":"V Volterra","year":"1926","journal-title":"Lincei, Mem R Accad Naz dei"},{"key":"ref88"},{"key":"ref89"},{"key":"ref90"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1110\/ps.041266605","article-title":"The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation","volume":"14","author":"P Hortschansky","year":"2005","journal-title":"Protein Sci"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/nimg.1995.1012","article-title":"A Probablistic Atlas of the Human Brain: Theory and Rationale for Its Development","volume":"2","author":"J Mazziotta","year":"1995","journal-title":"Neuroimage"},{"key":"ref93","unstructured":"Gini C (1912) Variability and Mutability. C Cuppini, Bol: 156 pages."},{"key":"ref94","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1073\/pnas.092205999","article-title":"Transmissibility of systemic a myloidosis by a prion-like mechanism","volume":"99(10)","author":"K Lundmark","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref95","first-page":"264","article-title":"Acceleration of murine AA amyloidosis by oral administration of amyloid fibrils extracted from different species","volume":"52(4)","author":"D Cui","year":"2002","journal-title":"Pathol Int"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jalz.2010.03.003","article-title":"The Alzheimer's disease neuroimaging initiative positron emission tomography core","volume":"6","author":"W Jagust","year":"2010","journal-title":"Alzheimers Dement"},{"key":"ref97","doi-asserted-by":"crossref","unstructured":"Evans A, Kamber M, Collins D, Macdonald D (1994) An MRI-based probabilistic atlas of neuroanatomy. S Shorvon, D Fish, F Andermann, G Bydder H Stefan, Ed Magn Reson Scanning Epilepsy, Plenum, New York: 263\u2013274.","DOI":"10.1007\/978-1-4615-2546-2_48"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroimage.2011.06.021","article-title":"NTU-90: a high angular resolution brain atlas constructed by q-space diffeomorphic reconstruction","volume":"58(1)","author":"F Yeh","year":"2011","journal-title":"Neuroimage"},{"key":"ref99","first-page":"336","article-title":"Simultaneous measurement of \u00df-amyloid1-42 in CSF by xMAP technology","volume":"51","author":"A Olsson","year":"2005","journal-title":"Clin Chem"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00401-011-0808-0","article-title":"Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI","volume":"121","author":"L Shaw","year":"2011","journal-title":"Acta Neuropath"},{"key":"ref101","first-page":"119","article-title":"Introduction to Bivariate and Multivariate Analysis","volume":"IL","author":"R Lindeman","year":"1980","journal-title":"Scott, Foresman, Glenview"},{"issue":"1","key":"ref102","article-title":"Relative Importance for Linear Regression in R : The Package relaimpo","volume":"17","author":"U Gr\u00f6mping","year":"2006","journal-title":"J Stat Sofw"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:04:16Z","timestamp":1589018656000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1003956"}},"subtitle":[],"editor":[{"given":"Olaf","family":"Sporns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,20]]},"references-count":102,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1003956","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,20]]}}}