{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T13:30:34Z","timestamp":1775223034250,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004125","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T17:50:56Z","timestamp":1428601856000},"page":"e1004125","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Quantification of Diabetes Comorbidity Risks across Life Using Nation-Wide Big Claims Data"],"prefix":"10.1371","volume":"11","author":[{"given":"Peter","family":"Klimek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kautzky-Willer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Chmiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"Schiller-Fr\u00fchwirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Thurner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"issue":"9786","key":"ref1","first-page":"99","article-title":"The diabetes pandemic","volume":"378","year":"2011"},{"key":"ref2","article-title":"The Epidemiology of Diabetes Mellitus","author":"JM Eko\u00e9","year":"2008"},{"key":"ref3","first-page":"229","article-title":"Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetec subjects with and without prior myocardial infarction","volume":"339","author":"SM Haffner","year":"1998"},{"issue":"13","key":"ref4","first-page":"1422","article-title":"The independent effect of type 2 diabetes mellitus on ischemic heart diesease, stroke and death","volume":"164","author":"T Almdal","year":"2004"},{"issue":"6","key":"ref5","first-page":"1069","article-title":"The prevalence of comorbid depression in adults with diabetes","volume":"24","author":"RJ Anderson","year":"2001"},{"issue":"1","key":"ref6","first-page":"31","article-title":"The role of depression and anxiety in onset of diabetes in a large population-based study","volume":"62","author":"A Engum","year":"2007"},{"key":"ref7","first-page":"584","article-title":"Retinopathy in diabetes","volume":"27","author":"DS Fong","year":"2004"},{"key":"ref8","first-page":"667","article-title":"Diabetes and hypertension","volume":"3","author":"RM Lago","year":"2007"},{"issue":"12","key":"ref9","first-page":"4703","article-title":"Quantification of excess-risk for diabetes when born in times of hunger, in an entire population of a nation, across a century","volume":"110","author":"S Thurner","year":"2013"},{"issue":"1","key":"ref10","first-page":"8","article-title":"Comorbidity measures for use with administrative data","volume":"36","author":"A Elixhauser","year":"1998"},{"key":"ref11","first-page":"101","article-title":"Which chronic diseases and disease combinations are specific to multimorbidity in the elderly?","volume":"11","author":"H Van den Bussche","year":"2011"},{"issue":"4","key":"ref12","first-page":"e1000353","article-title":"A dynamic network approach for the study of human phenotypes","volume":"5","author":"CA Hidalgo","year":"2008"},{"issue":"28","key":"ref13","first-page":"11694","article-title":"Probing genetic overlap among complex human phenotypes","volume":"104","author":"A Rzhetsky","year":"2006"},{"issue":"1","key":"ref14","first-page":"70","article-title":"A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk","volume":"155","author":"DR Blair","year":"2013"},{"key":"ref15","first-page":"140032","article-title":"Building the graph of medicine from millions of clinical narratives","volume":"1","author":"SG Finlayson","year":"2014"},{"key":"ref16","unstructured":"Endel G. Health systems research in Austria: Part 1. <italic>Social Security Online<\/italic> 2011; available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sozialversicherung.at\/mediaDB\/831485_Artikel_Gesundheitssystemforschung-in-Oesterreich_Dr.Endel.pdf\" xlink:type=\"simple\">www.sozialversicherung.at\/mediaDB\/831485_Artikel_Gesundheitssystemforschung-in-Oesterreich_Dr.Endel.pdf<\/ext-link> (in German)."},{"issue":"1","key":"ref17","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995"},{"issue":"4","key":"ref18","first-page":"1033","article-title":"American Diabetes Association. Economic costs of diabetes in the U.S. in 2012","volume":"36","year":"2013"},{"issue":"13","key":"ref19","first-page":"1661","article-title":"The cost of major comorbidity in people with diabetes mellitus","volume":"168","author":"SH Simpson","year":"2003"},{"issue":"3","key":"ref20","first-page":"199","article-title":"The use of automated data to identify complications and comorbidities of diabetes: a validation study","volume":"52","author":"KM Newton","year":"1999"},{"key":"ref21","first-page":"1605","article-title":"Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis","volume":"273","author":"J Everhart","year":"1995"},{"key":"ref22","first-page":"1","article-title":"Next-generation phenotyping of electronic health records","volume":"0","author":"G Hripcsak","year":"2012"},{"key":"ref23","first-page":"1","article-title":"Epidemiology and etiology of Parkinson\u2019s disease: a review of the evidence","volume":"26","author":"K Wirdefeldt","year":"2011"},{"issue":"17","key":"ref24","first-page":"1688","article-title":"Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease","volume":"69","author":"KC Simon","year":"2007"},{"issue":"4","key":"ref25","first-page":"843","article-title":"Type 2 diabetes and the risk of Parkinson\u2019s disease","volume":"30","author":"H Gang","year":"2007"},{"key":"ref26","first-page":"169","article-title":"Insulin and neurodegenerative disease: shared and specific mechanisms","volume":"3","author":"S Craft","year":"2004"},{"issue":"3","key":"ref27","first-page":"220","article-title":"Overweight, obesity, and depression. A systematic review and meta-analysis of longitudinal studies","volume":"67","author":"FS Luppino","year":"2010"},{"issue":"6","key":"ref28","first-page":"1224","article-title":"A measurement of brain metabolites in patients with type 2 diabetes and major depression using magnetic resonance spectroscopy","volume":"32","author":"O Ajilore","year":"2007"},{"issue":"4","key":"ref29","first-page":"715","article-title":"Association between weight perception and psychological distress","volume":"32","author":"E Atlantis","year":"2008"},{"key":"ref30","first-page":"561","article-title":"Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia","volume":"159","author":"MJ Sernyak","year":"2002"},{"issue":"4","key":"ref31","first-page":"217","article-title":"Thyroid gland diseases in adult patients with diabetes mellitus","volume":"30","author":"K Vondra","year":"2005"},{"issue":"10","key":"ref32","first-page":"586","article-title":"Does epilepsy occur more frequently in children with type 1 diabetes?","volume":"44","author":"MA O\u2019Connel","year":"2008"},{"issue":"4","key":"ref33","first-page":"662","article-title":"Association of epilesy and type 1 diabetes mellitus in children and adolescents: is there an increased risk for diabetic ketoacidosis?","volume":"160","author":"E Schober","year":"2012"},{"key":"ref34","first-page":"204","article-title":"An association between type 1 diabetes and idiopathic generalized epilepsy","volume":"59","author":"D McCorry","year":"2006"},{"issue":"1","key":"ref35","first-page":"29","article-title":"Role of diabetes in congestive heart failure: The Framingham study","volume":"34","author":"WB Kannel","year":"1974"},{"issue":"8","key":"ref36","first-page":"1879","article-title":"The incidence of congestive heart failure in type 2 diabetes. An update","volume":"27","author":"GA Nichols","year":"2004"},{"key":"ref37","first-page":"496","article-title":"Obstructive sleep apnea and type 2 diabetes: Interacting epidemics","volume":"133","author":"E Tasali","year":"2008"},{"issue":"12","key":"ref38","first-page":"1590","article-title":"Association of sleep apnea and type II diabetes","volume":"172","author":"KJ Reichmuth","year":"2005"},{"issue":"30","key":"ref39","first-page":"4861","article-title":"Is diabetes mellitus a risk factor for pancreatic cancer?","volume":"19","author":"R Pezzilli","year":"2013"},{"issue":"11","key":"ref40","first-page":"2123","article-title":"Alcohol as a risk factor for type 2 diabetes","volume":"32","author":"DO Baliunas","year":"2009"},{"issue":"3","key":"ref41","first-page":"276","article-title":"Diabetes as a risk factor for cardiac conduction defects: a review","volume":"9","author":"M-R Movahed","year":"2007"},{"issue":"1","key":"ref42","first-page":"65","article-title":"Pulmonary complications of diabetes mellitus. Pneumonia","volume":"9","author":"H Koziel","year":"1995"},{"issue":"11","key":"ref43","first-page":"956","article-title":"Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care","volume":"65","author":"JR Feary","year":"2010"},{"issue":"5","key":"ref44","first-page":"574","article-title":"Lung function, insulin resistance and incidence of cardiovascular disease: a longitudinal cohort study","volume":"253","author":"G Engstr\u00f6m","year":"2003"},{"issue":"5","key":"ref45","first-page":"1108","article-title":"Benign pleural effusions in long-standing diabetes mellitus","volume":"99","author":"BS Chertow","year":"1991"},{"key":"ref46","first-page":"80","article-title":"Urinary tract infections in patients with DM","volume":"113","author":"A Stapleton","year":"2002"},{"key":"ref47","first-page":"1851","article-title":"Type 2 diabetes and risk of developing urinary incontinence","volume":"53","author":"KL Lifford","year":"2005"},{"key":"ref48","first-page":"301","article-title":"Urinary incontinence in elderly women: Findings from the Health, Aging, and Body Composition Study","volume":"104","author":"RA Jackson","year":"2004"},{"issue":"8","key":"ref49","first-page":"675","article-title":"Validity of information on comorbidity derived from ICD-9-CCM administrative data","volume":"40","author":"H Quan","year":"2002"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T15:12:09Z","timestamp":1589037129000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004125"}},"subtitle":[],"editor":[{"given":"Lilia M.","family":"Iakoucheva","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004125","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}