{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:27:09Z","timestamp":1773851229973,"version":"3.50.1"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004137","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T14:25:50Z","timestamp":1427898350000},"page":"e1004137","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":98,"title":["The Neuroglial Potassium Cycle during Neurotransmission: Role of Kir4.1 Channels"],"prefix":"10.1371","volume":"11","author":[{"given":"J\u00e9r\u00e9mie","family":"Sibille","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khanh","family":"Dao Duc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Holcman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rouach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijdevneu.2003.12.008","article-title":"Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development","volume":"22","author":"EA Bushong","year":"2004","journal-title":"Int J Dev Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: astrocytes process and control synaptic information","volume":"32","author":"G Perea","year":"2009","journal-title":"Trends Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mce.2011.08.039","article-title":"Calcium signalling in astroglia","volume":"353","author":"A Verkhratsky","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0896-6273(00)80420-1","article-title":"Synaptic activation of glutamate transporters in hippocampal astrocytes","volume":"19","author":"DE Bergles","year":"1997","journal-title":"Neuron"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0896-6273(00)80551-6","article-title":"Glutamate release monitored with astrocyte transporter currents during LTP","volume":"21","author":"JS Diamond","year":"1998","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1113\/jphysiol.2010.203125","article-title":"Contribution of astrocytic glutamate and GABA uptake to corticostriatal information processing","volume":"589","author":"V Goubard","year":"2011","journal-title":"J Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0896-6273(00)80552-8","article-title":"Monitoring glutamate release during LTP with glial transporter currents","volume":"21","author":"C Luscher","year":"1998","journal-title":"Neuron"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1152\/jn.1989.61.5.939","article-title":"Current-evoked transcellular K+ flux in frog retina","volume":"61","author":"CJ Karwoski","year":"1989","journal-title":"J Neurophysiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/hipo.20344","article-title":"Astrocyte membrane responses and potassium accumulation during neuronal activity","volume":"17","author":"JP Meeks","year":"2007","journal-title":"Hippocampus"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1152\/jn.1966.29.4.788","article-title":"Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia","volume":"29","author":"RK Orkand","year":"1966","journal-title":"J Neurophysiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/glia.22288","article-title":"Artifact versus reality\u2014how astrocytes contribute to synaptic events","volume":"60","author":"M Nedergaard","year":"2012","journal-title":"Glia"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1152\/jn.1966.29.4.768","article-title":"Physiological properties of glial cells in the central nervous system of amphibia","volume":"29","author":"SW Kuffler","year":"1966","journal-title":"J Neurophysiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10827-008-0132-4","article-title":"The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics","volume":"26","author":"JR Cressman Jr.","year":"2009","journal-title":"J Comput Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10588","DOI":"10.1523\/JNEUROSCI.2323-09.2009","article-title":"Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?","volume":"29","author":"Y David","year":"2009","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10827-008-0130-6","article-title":"The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics","volume":"26","author":"G Ullah","year":"2009","journal-title":"J Comput Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jtbi.2005.10.023","article-title":"A mathematical model of ion movements in grey matter during a stroke","volume":"240","author":"MA Dronne","year":"2006","journal-title":"J Theor Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.brainres.2006.12.062","article-title":"Role of astrocytes in grey matter during stroke: a modelling approach","volume":"1138","author":"MA Dronne","year":"2007","journal-title":"Brain Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1582-4934.2006.tb00289.x","article-title":"Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions","volume":"10","author":"AM Butt","year":"2006","journal-title":"J Cell Mol Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0197-0186(99)00137-0","article-title":"Role of astrocytes in the clearance of excess extracellular potassium","volume":"36","author":"W Walz","year":"2000","journal-title":"Neurochem Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/glia.22299","article-title":"Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels","volume":"60","author":"V Bay","year":"2012","journal-title":"Glia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1523\/JNEUROSCI.2078-10.2010","article-title":"Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice","volume":"30","author":"O Chever","year":"2010","journal-title":"J Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11354","DOI":"10.1523\/JNEUROSCI.0723-07.2007","article-title":"Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation","volume":"27","author":"B Djukic","year":"2007","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/glia.21205","article-title":"Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)","volume":"59","author":"NN Haj-Yasein","year":"2011","journal-title":"Glia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/jn.2000.84.1.495","article-title":"Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations","volume":"84","author":"H Kager","year":"2000","journal-title":"J Neurophysiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fncel.2013.00159","article-title":"How do astrocytes shape synaptic transmission? Insights from electrophysiology","volume":"7","author":"G Dallerac","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/jphysiol.2013.261735","article-title":"Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapse","volume":"592","author":"J Sibille","year":"2014","journal-title":"J Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-8993(86)90863-2","article-title":"The effects of moderate changes of extracellular K+ and Ca2+ on synaptic and neural function in the CA1 region of the hippocampal slice","volume":"377","author":"M Balestrino","year":"1986","journal-title":"Brain Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0014-4886(81)90099-6","article-title":"Hippocampal excitability and changes in extracellular potassium","volume":"71","author":"JJ Hablitz","year":"1981","journal-title":"Exp Neurol"},{"key":"ref29","first-page":"35","article-title":"The dependence of hippocampal function on extracellular potassium levels","volume":"4","author":"I Izquierdo","year":"1971","journal-title":"Curr Mod Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0006-8993(90)91110-3","article-title":"Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-D-aspartate receptors in hippocampus","volume":"508","author":"NP Poolos","year":"1990","journal-title":"Brain Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/jn.1987.58.2.404","article-title":"Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus","volume":"58","author":"NP Poolos","year":"1987","journal-title":"J Neurophysiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.2004.062661","article-title":"BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampus","volume":"557","author":"G Raffaelli","year":"2004","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jtbi.2009.01.032","article-title":"The role of extracellular potassium dynamics in the different stages of ictal bursting and spreading depression: a computational study","volume":"258","author":"G Florence","year":"2009","journal-title":"J Theor Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10827-011-0345-9","article-title":"Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms","volume":"32","author":"L Oyehaug","year":"2012","journal-title":"J Comput Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1152\/jn.01378.2005","article-title":"Interneuron and pyramidal cell interplay during in vitro seizure-like events","volume":"95","author":"J Ziburkus","year":"2006","journal-title":"J Neurophysiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1152\/jn.1994.72.6.2853","article-title":"Hippocampal inhibitory neuron activity in the elevated potassium model of epilepsy","volume":"72","author":"CJ McBain","year":"1994","journal-title":"J Neurophysiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.bbamcr.2010.11.006","article-title":"Ca(2+) sources for the exocytotic release of glutamate from astrocytes","volume":"1813","author":"V Parpura","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0169-328X(00)00136-4","article-title":"Localization of the tandem pore domain K+ channel TASK-1 in the rat central nervous system","volume":"80","author":"CH Kindler","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"ref39","article-title":"Glial physiology and pathophysiology","author":"A Verkhrastky","year":"2013"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2007.07.013","article-title":"Two-pore-domain potassium channels contribute to neuronal potassium release and glial potassium buffering in the rat hippocampus","volume":"1173","author":"D Pasler","year":"2007","journal-title":"Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/glia.22629","article-title":"Contributions of the Na(+)\/K(+)-ATPase, NKCC1, and Kir4.1 to hippocampal K(+) clearance and volume responses","volume":"62","author":"BR Larsen","year":"2014","journal-title":"Glia"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e25122","DOI":"10.1371\/journal.pone.0025122","article-title":"Synapse geometry and receptor dynamics modulate synaptic strength","volume":"6","author":"D Freche","year":"2011","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0920-1211(98)00059-X","article-title":"Properties of human glial cells associated with epileptic seizure foci","volume":"32","author":"A Bordey","year":"1998","journal-title":"Epilepsy Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuroscience.2012.06.002","article-title":"Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors","volume":"220","author":"A Das","year":"2012","journal-title":"Neuroscience"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1460-9568.2000.00104.x","article-title":"Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances","volume":"12","author":"S Hinterkeuser","year":"2000","journal-title":"Eur J Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1046\/j.1460-9568.2000.00103.x","article-title":"Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1","volume":"12","author":"A Kivi","year":"2000","journal-title":"Eur J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/glia.10112","article-title":"Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering","volume":"39","author":"P Kofuji","year":"2002","journal-title":"Glia"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.eplepsyres.2004.02.003","article-title":"Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility","volume":"58","author":"RJ Buono","year":"2004","journal-title":"Epilepsy Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.eplepsyres.2009.09.023","article-title":"Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy","volume":"88","author":"K Heuser","year":"2010","journal-title":"Epilepsy Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington\u2019s disease model mice","volume":"17","author":"X Tong","year":"2014","journal-title":"Nat Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMoa1110740","article-title":"Potassium channel KIR4.1 as an immune target in multiple sclerosis","volume":"367","author":"R Srivastava","year":"2012","journal-title":"N Engl J Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4161\/cib.19410","article-title":"Astroglial gap junctions shape neuronal network activity","volume":"5","author":"U Pannasch","year":"2012","journal-title":"Commun Integr Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nn.3662","article-title":"Connexin 30 sets synaptic strength by controlling astroglial synapse invasion","volume":"17","author":"U Pannasch","year":"2014","journal-title":"Nat Neurosci"},{"key":"ref54","first-page":"e4418","article-title":"Dual electrophysiological recordings of synaptically-evoked astroglial and neuronal responses in acute hippocampal slices","author":"U Pannasch","year":"2012","journal-title":"J Vis Exp"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1073\/pnas.94.2.719","article-title":"The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability","volume":"94","author":"MV Tsodyks","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1073\/pnas.95.9.5323","article-title":"Differential signaling via the same axon of neocortical pyramidal neurons","volume":"95","author":"H Markram","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1162\/089976698300017502","article-title":"Neural networks with dynamic synapses","volume":"10","author":"M Tsodyks","year":"1998","journal-title":"Neural Comput"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","article-title":"A quantitative description of membrane current and its application to conduction and excitation in nerve","volume":"117","author":"AL Hodgkin","year":"1952","journal-title":"J Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0301-4622(93)E0104-D","article-title":"The role of the potassium inward rectifier in defining cell membrane potentials in low potassium media, analyzed by computer simulation","volume":"50","author":"van Siegenbeek","year":"1994","journal-title":"Biophys Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1152\/jn.1995.73.1.333","article-title":"Biophysical and pharmacological characterization of inwardly rectifying K+ currents in rat spinal cord astrocytes","volume":"73","author":"CB Ransom","year":"1995","journal-title":"J Neurophysiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/BF01945519","article-title":"Potassium currents in cardiac cells","volume":"43","author":"E Carmeliet","year":"1987","journal-title":"Experientia"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF01870103","article-title":"The anomalous rectification and cation selectivity of the membrane of a starfish egg cell","volume":"18","author":"S Hagiwara","year":"1974","journal-title":"J Membr Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0006-3495(88)83048-0","article-title":"K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells","volume":"54","author":"M Mazzanti","year":"1988","journal-title":"Biophys J"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1113\/jphysiol.1984.sp015088","article-title":"Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart","volume":"347","author":"B Sakmann","year":"1984","journal-title":"J Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1152\/jn.1996.76.1.626","article-title":"Astrocytic inwardly rectifying potassium currents are dependent on external sodium ions","volume":"76","author":"CB Ransom","year":"1996","journal-title":"J Neurophysiol"},{"issue":"70 Suppl","key":"ref66","doi-asserted-by":"crossref","first-page":"S239","DOI":"10.1139\/y92-267","article-title":"K+ ion regulation in retina","author":"A Reichenbach","year":"1992","journal-title":"Can J Physiol Pharmacol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1085\/jgp.87.3.485","article-title":"Na+ and K+ transport at basolateral membranes of epithelial cells. II. K+ efflux and stoichiometry of the Na,K-ATPase","volume":"87","author":"TC Cox","year":"1986","journal-title":"J Gen Physiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"F793","DOI":"10.1152\/ajprenal.2000.279.5.F793","article-title":"Molecular and functional properties of two-pore-domain potassium channels","volume":"279","author":"F Lesage","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"11228","DOI":"10.1523\/JNEUROSCI.0015-14.2014","article-title":"Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission","volume":"34","author":"O Chever","year":"2014","journal-title":"J Neurosci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1126\/science.7569903","article-title":"Regulation of hippocampal transmitter release during development and long-term potentiation","volume":"269","author":"VY Bolshakov","year":"1995","journal-title":"Science"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1113\/jphysiol.1952.sp004716","article-title":"Measurement of current-voltage relations in the membrane of the giant axon of Loligo","volume":"116","author":"AL Hodgkin","year":"1952","journal-title":"J Physiol"},{"key":"ref72","first-page":"369","article-title":"Astroglial connexin 43 sustains glutamatergic synaptic efficacy","author":"O Chever","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1016\/S0006-3495(00)76822-6","article-title":"Spatial buffering of potassium ions in brain extracellular space","volume":"78","author":"KC Chen","year":"2000","journal-title":"Biophys J"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:47:53Z","timestamp":1588974473000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004137"}},"subtitle":[],"editor":[{"given":"Renaud","family":"Jolivet","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":73,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004137","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]}}}