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Bush","year":"1988","journal-title":"Clinical microbiology reviews"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1089\/mdr.1996.2.245","article-title":"The Aeromonas metallo\u2010\u03b2\u2010lactamases: genetics, enzymology, and contribution to drug resistance","volume":"2","author":"GM Rossolini","year":"1996","journal-title":"Microbial drug resistance"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.8.4.557","article-title":"beta-Lactamases in laboratory and clinical resistance","volume":"8","author":"DM Livermore","year":"1995","journal-title":"Clinical Microbiology Reviews"},{"key":"ref51","first-page":"439","article-title":"Clinical significance of beta-lactamase induction and stable derepression in gram-negative rods","volume":"6","author":"D Livermore","year":"1987","journal-title":"European Journal of Clinical Microbiology & Infectious 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Bradford","year":"2001","journal-title":"Clinical microbiology reviews"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/48.suppl_1.5","article-title":"Determination of minimum inhibitory concentrations","volume":"48","author":"JM Andrews","year":"2001","journal-title":"Journal of antimicrobial Chemotherapy"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10928-007-9069-x","article-title":"Mechanism-based pharmacokinetic\u2014pharmacodynamic modeling of antimicrobial drug effects","volume":"34","author":"D Czock","year":"2007","journal-title":"Journal of pharmacokinetics and pharmacodynamics"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1099\/mic.0.040618-0","article-title":"Long-term impacts of antibiotic exposure on the human intestinal microbiota","volume":"156","author":"C Jernberg","year":"2010","journal-title":"Microbiology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/CMR.13.4.615-650.2000","article-title":"Interference of antibacterial agents with phagocyte functions: immunomodulation or \u201cimmuno-fairy tales\u201d?","volume":"13","author":"M-T Labro","year":"2000","journal-title":"Clinical microbiology reviews"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1128\/AAC.01602-07","article-title":"Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity","volume":"52","author":"TP Lodise","year":"2008","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref63","first-page":"05496","article-title":"Profound alterations of intestinal microbiota following a single dose of Clindamycin results in sustained susceptibility to C. difficile-induced colitis","author":"CG Buffie","year":"2011","journal-title":"Infection and 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Charlebois","year":"2014","journal-title":"Physical Review E"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/AAC.30.4.521","article-title":"Antibiotic tolerance among clinical isolates of bacteria","volume":"30","author":"E Tuomanen","year":"1986","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.micro.112408.134306","article-title":"Persister cells","volume":"64","author":"K Lewis","year":"2010","journal-title":"Annual review of microbiology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1126\/science.1099390","article-title":"Bacterial persistence as a phenotypic switch","volume":"305","author":"NQ Balaban","year":"2004","journal-title":"Science"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrmicro1557","article-title":"Persister cells, dormancy and infectious disease","volume":"5","author":"K 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