{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:15:30Z","timestamp":1773954930391,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004373","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T18:14:53Z","timestamp":1438712093000},"page":"e1004373","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker\u2019s Yeast"],"prefix":"10.1371","volume":"11","author":[{"given":"Po-Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis L.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf A.","family":"Hannun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard O.","family":"Voit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: from synthesis to breakdown","volume":"688","author":"CR Gault","year":"2010","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"YA Hannun","year":"2008","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1007\/s00018-007-7076-0","article-title":"The metabolism and function of sphingolipids and glycosphingolipids","volume":"64","author":"S Lahiri","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"30328","DOI":"10.1074\/jbc.M300656200","article-title":"Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined through Gene Expression Profiling","volume":"278","author":"LA Cowart","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2875","article-title":"Sphingosine 1-phosphate and cancer","volume":"10","author":"NJ Pyne","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1194\/jlr.R800080-JLR200","article-title":"Bioactive sphingolipids: metabolism and function","volume":"50","author":"N Bartke","year":"2009","journal-title":"Journal of Lipid Research"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/PL00000836","article-title":"Sphingolipids in mammalian cell signalling","volume":"58","author":"J Ohanian","year":"2001","journal-title":"CMLS, Cell Mol Life Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1388-1981(02)00210-X","article-title":"Sphingolipid functions in Saccharomyces cerevisiae","volume":"1583","author":"RC Dickson","year":"2002","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular and Cell Biology of Lipids"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"30196","DOI":"10.1074\/jbc.272.48.30196","article-title":"Sphingolipids Are Potential Heat Stress Signals inSaccharomyces","volume":"272","author":"RC Dickson","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"42572","DOI":"10.1074\/jbc.M207346200","article-title":"Acute activation of <italic>de novo<\/italic> sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins","volume":"277","author":"GM Jenkins","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/metabo2010221","article-title":"Canonical modeling of the multi-scale regulation of the heat stress response in yeast","volume":"2","author":"LL Fonseca","year":"2012","journal-title":"Metabolites"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1039\/C0MB00102C","article-title":"Complex coordination of multi-scale cellular responses to environmental stress","volume":"7","author":"LL Fonseca","year":"2011","journal-title":"Molecular BioSystems"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1003078","DOI":"10.1371\/journal.pcbi.1003078","article-title":"Coordination of Rapid Sphingolipid Responses to Heat Stress in Yeast","volume":"9","author":"P-W Chen","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"rs14-","DOI":"10.1126\/scisignal.2004515","article-title":"Distinct Signaling Roles of Ceramide Species in Yeast Revealed Through Systematic Perturbation and Systems Biology Analyses","volume":"6","author":"DJ Montefusco","year":"2013","journal-title":"Sci Signal"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17272","DOI":"10.1074\/jbc.M112.444802","article-title":"Identification of C18:1-Phytoceramide as the Candidate Lipid Mediator for Hydroxyurea Resistance in Yeast","volume":"288","author":"N Matmati","year":"2013","journal-title":"Journal of Biological Chemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.chemphyslip.2013.10.006","article-title":"The yeast sphingolipid signaling landscape","volume":"177","author":"DJ Montefusco","year":"2014","journal-title":"Chemistry and Physics of Lipids"},{"key":"ref17","first-page":"60","article-title":"Sphingolipids as Signaling and Regulatory Molecules","author":"J Stiban","year":"2010"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1091\/mbc.12.11.3417","article-title":"Lag1p and Lac1p Are Essential for the Acyl-CoA\u2013dependent Ceramide Synthase Reaction in Saccharomyces cerevisae","volume":"12","author":"S Schorling","year":"2001","journal-title":"Molecular Biology of the Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"31369","DOI":"10.1074\/jbc.M003683200","article-title":"Cloning and Characterization of a Saccharomyces cerevisiae Alkaline Ceramidase with Specificity for Dihydroceramide","volume":"275","author":"C Mao","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"29704","DOI":"10.1074\/jbc.272.47.29704","article-title":"Hydroxylation of Saccharomyces cerevisiae Ceramides Requires Sur2p and Scs7p","volume":"272","author":"D Haak","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"39793","DOI":"10.1074\/jbc.M007721200","article-title":"Identification of ISC1 (YER019w) as Inositol Phosphosphingolipid Phospholipase C inSaccharomyces cerevisiae","volume":"275","author":"H Sawai","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature03232","article-title":"Simulation and validation of modelled sphingolipid metabolism in <italic>Saccharomyces cerevisiae<\/italic>","volume":"433","author":"F Alvarez-Vasquez","year":"2005","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jtbi.2003.08.010","article-title":"Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models","volume":"226","author":"F Alvarez-Vasquez","year":"2004","journal-title":"Journal of Theoretical Biology"},{"key":"ref24","first-page":"365","article-title":"Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions","volume":"25","author":"MA Savageau","year":"1969","journal-title":"Journal of Theoretical Biology"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Voit EO (2013) Biochemical Systems Theory: A Review. ISRN Biomathematics 2013: 53.","DOI":"10.1155\/2013\/897658"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511546334","article-title":"Pathway Analysis and Optimization in Metabolic Engineering","author":"NV Torres","year":"2002"},{"key":"ref27","article-title":"A Practical Guide for Biochemists and Molecular Biologists","author":"EO Voit","year":"2000"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1074\/jbc.273.13.7235","article-title":"Heat-induced elevation of ceramide in <italic>Saccharomyces cerevisiae<\/italic> via <italic>de novo<\/italic> synthesis","volume":"273","author":"GB Wells","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"ref29","first-page":"2655","article-title":"C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p","author":"I Guillas","year":"2001","journal-title":"C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p"},{"key":"ref30","article-title":"A mass spectrometry-based method for the assay of ceramide synthase substrate specificity","author":"KD Luttgeharm","year":"2015","journal-title":"Analytical Biochemistry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/iub.319","article-title":"Mammalian ceramide synthases","volume":"62","author":"M Levy","year":"2010","journal-title":"IUBMB Life"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/msb.2010.3","article-title":"Revealing a signaling role of phytosphingosine-1-phosphate in yeast","volume":"6","author":"LA Cowart","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/bioinformatics\/btn470","article-title":"System estimation from metabolic time-series data","volume":"24","author":"G Goel","year":"2008","journal-title":"Bioinformatics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1467-9868.2007.00610.x","article-title":"Parameter estimation for differential equations: a generalized smoothing approach","volume":"69","author":"JO Ramsay","year":"2007","journal-title":"Journal of the Royal Statistical Society: Series B"},{"key":"ref35","first-page":"95","article-title":"Recent advances in parameter identification techniques for O.D.E","volume":"2","author":"HG Bock","year":"1983","journal-title":"Progress in Scientific Computing"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T10:50:50Z","timestamp":1718016650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004373"}},"subtitle":[],"editor":[{"given":"Jorg","family":"Stelling","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,4]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004373","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,4]]}}}