{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:26:33Z","timestamp":1773411993908,"version":"3.50.1"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004400","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T18:10:37Z","timestamp":1439575837000},"page":"e1004400","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Controlled Measurement and Comparative Analysis of Cellular Components in E. coli Reveals Broad Regulatory Changes in Response to Glucose Starvation"],"prefix":"10.1371","volume":"11","author":[{"given":"John R.","family":"Houser","sequence":"first","affiliation":[]},{"given":"Craig","family":"Barnhart","sequence":"additional","affiliation":[]},{"given":"Daniel R.","family":"Boutz","sequence":"additional","affiliation":[]},{"given":"Sean M.","family":"Carroll","sequence":"additional","affiliation":[]},{"given":"Aurko","family":"Dasgupta","sequence":"additional","affiliation":[]},{"given":"Joshua K.","family":"Michener","sequence":"additional","affiliation":[]},{"given":"Brittany D.","family":"Needham","sequence":"additional","affiliation":[]},{"given":"Ophelia","family":"Papoulas","sequence":"additional","affiliation":[]},{"given":"Viswanadham","family":"Sridhara","sequence":"additional","affiliation":[]},{"given":"Dariya K.","family":"Sydykova","sequence":"additional","affiliation":[]},{"given":"Christopher J.","family":"Marx","sequence":"additional","affiliation":[]},{"given":"M. Stephen","family":"Trent","sequence":"additional","affiliation":[]},{"given":"Jeffrey E.","family":"Barrick","sequence":"additional","affiliation":[]},{"given":"Edward M.","family":"Marcotte","sequence":"additional","affiliation":[]},{"given":"Claus O.","family":"Wilke","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,8,14]]},"reference":[{"key":"ref1","article-title":"Escherichia Coli and Salmonella: Cellular and Molecular Biology","author":"FC Neidhardt","year":"1996"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1093\/nar\/gks680","article-title":"RNAsnap<sup>TM<\/sup>: a rapid, quantitative and inexpensive, method for isolating total RNA from bacteria","volume":"40","author":"MB Stead","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: a revolutionary tool for transcriptomics","volume":"10","author":"Z Wang","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1021\/pr3011843","article-title":"Global Dynamics of the Escherichia coli Proteome and Phosphoproteome During Growth in Minimal Medium","volume":"12","author":"NC Soares","year":"2013","journal-title":"J Proteome Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.dib.2014.08.004","article-title":"Quantitative analysis of the Escherichia coli proteome","volume":"1","author":"JR Wi\u015bniewski","year":"2014","journal-title":"Data Brief"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/BF01935530","article-title":"The starvation-survival state of microorganisms in nature and its relationship to the bioavailable energy","volume":"46","author":"RY Morita","year":"1990","journal-title":"Experientia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrmicro1340","article-title":"Long-term survival during stationary phase: evolution and the GASP phenotype","volume":"4","author":"SE Finkel","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7044","DOI":"10.1128\/JB.185.24.7044-7052.2003","article-title":"The growth advantage in stationary-phase phenotype conferred by rpoS mutations is dependent on the pH and nutrient environment","volume":"185","author":"MJ Farrell","year":"2003","journal-title":"J Bacteriol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1073\/pnas.96.7.4023","article-title":"Evolution of microbial diversity during prolonged starvation","volume":"96","author":"SE Finkel","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1126\/science.7681219","article-title":"Microbial competition: Escherichia coli mutants that take over stationary phase cultures","volume":"259","author":"MM Zambrano","year":"1993","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/gb-2012-13-5-r37","article-title":"Comparative multi-omics systems analysis of Escherichia coli strains B and K-12","volume":"13","author":"SH Yoon","year":"2012","journal-title":"Genome Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1188308","article-title":"Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells","volume":"329","author":"Y Taniguchi","year":"2010","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/msb.2010.47","article-title":"Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models","volume":"6","author":"NE Lewis","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/JB.00034-09","article-title":"Gene expression profiling and the use of genome-scale in silico models of Escherichia coli for analysis: providing context for content","volume":"191","author":"NE Lewis","year":"2009","journal-title":"J Bacteriol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1101\/gr.119370.110","article-title":"Genome-wide detection of novel regulatory RNAs in E. coli","volume":"21","author":"R Raghavan","year":"2011","journal-title":"Genome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"S Anders","year":"2010","journal-title":"Genome Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nbt1270","article-title":"Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation","volume":"25","author":"P Lu","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref18","first-page":"1512","article-title":"Global signatures of protein and mRNA expression levels","volume":"5","author":"R de S Abreu","year":"2009","journal-title":"Mol Biosyst"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between Protein and mRNA Abundance in Yeast","volume":"19","author":"SP Gygi","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"C Vogel","year":"2012","journal-title":"Nat Rev Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/msb.2010.59","article-title":"Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line","volume":"6","author":"C Vogel","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1073\/pnas.0634629100","article-title":"Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae","volume":"100","author":"MP Washburn","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/msb.2011.38","article-title":"Quantification of mRNA and protein and integration with protein turnover in a bacterium","volume":"7","author":"T Maier","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1073\/pnas.1105692108","article-title":"Fundamental relationship between operon organization and gene expression","volume":"108","author":"HN Lim","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1128\/jb.170.10.4484-4492.1988","article-title":"Feedback regulation of the spc operon in Escherichia coli: translational coupling and mRNA processing","volume":"170","author":"LC Mattheakis","year":"1988","journal-title":"J Bacteriol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"15256","DOI":"10.1016\/S0021-9258(18)48168-9","article-title":"Rho-dependent transcriptional polarity in the ilvGMEDA operon of wild-type Escherichia coli K12","volume":"262","author":"RC Wek","year":"1987","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0022-2836(88)90193-3","article-title":"Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli","volume":"203","author":"M Yamada","year":"1988","journal-title":"J Mol Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1003091","DOI":"10.1371\/journal.pcbi.1003091","article-title":"The ability of flux balance analysis to predict evolution of central metabolism scales with the initial distance to the optimum","volume":"9","author":"WR Harcombe","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nprot.2009.58","article-title":"(13)C-based metabolic flux analysis","volume":"4","author":"N Zamboni","year":"2009","journal-title":"Nat Protoc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1471-2105-6-209","article-title":"FiatFlux\u2014a software for metabolic flux analysis from 13C-glucose experiments","volume":"6","author":"N Zamboni","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1093\/emboj\/19.19.5071","article-title":"Transfer of palmitate from phospholipids to lipid A in outer membranes of Gram-negative bacteria","volume":"19","author":"RE Bishop","year":"2000","journal-title":"EMBO J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1128\/.61.4.429-441.1997","article-title":"Cyclopropane ring formation in membrane lipids of bacteria","volume":"61","author":"DW Grogan","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"44966","DOI":"10.1074\/jbc.M404963200","article-title":"Lipid Trafficking Controls Endotoxin Acylation in Outer Membranes of Escherichia coli","volume":"279","author":"W Jia","year":"2004","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrmicro3047","article-title":"Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis","volume":"11","author":"BD Needham","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tim.2005.03.008","article-title":"ppGpp: a global regulator in Escherichia coli","volume":"13","author":"LU Magnusson","year":"2005","journal-title":"Trends Microbiol"},{"key":"ref36","first-page":"6956","article-title":"Protein degradation in Escherichia coli. II. Strain differences in the degradation of protein and nucleic acid resulting from starvation","volume":"246","author":"K Nath","year":"1971","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/S0021-9258(18)63072-8","article-title":"Protein degradation in Escherichia coli. I. Measurement of rapidly and slowly decaying components","volume":"245","author":"K Nath","year":"1970","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1128\/JB.01092-07","article-title":"Transcription profiling of the stringent response in Escherichia coli","volume":"190","author":"T Durfee","year":"2008","journal-title":"J Bacteriol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1000096","DOI":"10.1371\/journal.pbio.1000096","article-title":"Global Functional Atlas of Escherichia coli Encompassing Previously Uncharacterized Proteins","volume":"7","author":"P Hu","year":"2009","journal-title":"PLoS Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1073\/pnas.1105692108","article-title":"Fundamental relationship between operon organization and gene expression","volume":"108","author":"HN Lim","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1021\/ja053899z","article-title":"The Activity of Escherichia coli Cyclopropane Fatty Acid Synthase Depends on the Presence of Bicarbonate","volume":"127","author":"DF Iwig","year":"2005","journal-title":"J Am Chem Soc"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1101\/gr.2250904","article-title":"Reconstruction and Validation of Saccharomyces cerevisiae iND750, a Fully Compartmentalized Genome-Scale Metabolic Model","volume":"14","author":"NC Duarte","year":"2004","journal-title":"Genome Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nbt1401","article-title":"The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli","volume":"26","author":"AM Feist","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/msb4100155","article-title":"A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information","volume":"3","author":"AM Feist","year":"2007","journal-title":"Mol Syst Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ymben.2003.12.002","article-title":"Integration of gene expression data into genome-scale metabolic models","volume":"6","author":"M \u00c5kesson","year":"2004","journal-title":"Metab Eng"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e1000489","DOI":"10.1371\/journal.pcbi.1000489","article-title":"Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production","volume":"5","author":"C Colijn","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e1002781","DOI":"10.1371\/journal.pcbi.1002781","article-title":"Temporal Expression-based Analysis of Metabolism","volume":"8","author":"SB Collins","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e1002688","DOI":"10.1371\/journal.pcbi.1002688","article-title":"Modeling Phenotypic Metabolic Adaptations of Mycobacterium tuberculosis H37Rv under Hypoxia","volume":"8","author":"X Fang","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1752-0509-6-73","article-title":"Improving metabolic flux predictions using absolute gene expression data","volume":"6","author":"D Lee","year":"2012","journal-title":"BMC Syst Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0006-3495(02)73903-9","article-title":"Dynamic Flux Balance Analysis of Diauxic Growth in Escherichia coli","volume":"83","author":"R Mahadevan","year":"2002","journal-title":"Biophys J"},{"key":"ref51","article-title":"Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction","volume":"9","author":"EJ O\u2019Brien","year":"2013","journal-title":"Mol Syst Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1109\/TCBB.2009.55","article-title":"Predicting Metabolic Fluxes Using Gene Expression Differences As Constraints","volume":"8","author":"RJP Van Berlo","year":"2011","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"ref53","article-title":"An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of","volume":"10","author":"J Carrera","year":"2014","journal-title":"Escherichia coli. Mol Syst Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2012.05.044","article-title":"A Whole-Cell Computational Model Predicts Phenotype from Genotype","volume":"150","author":"JR Karr","year":"2012","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"D Risso","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e1005206","DOI":"10.1371\/journal.pgen.1005206","article-title":"Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast","volume":"11","author":"G Cs\u00e1rdi","year":"2015","journal-title":"PLoS Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1086\/285289","article-title":"Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 Generations","volume":"138","author":"RE Lenski","year":"1991","journal-title":"Am Nat"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jmb.2009.09.052","article-title":"Genome Sequences of Escherichia coli B strains REL606 and BL21(DE3)","volume":"394","author":"H Jeong","year":"2009","journal-title":"J Mol Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"D226","DOI":"10.1093\/nar\/gks1005","article-title":"Rfam 11.0: 10 years of RNA families","volume":"41","author":"SW Burge","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3390\/biology1030895","article-title":"FLEXBAR\u2014Flexible Barcode and Adapter Processing for Next-Generation Sequencing Platforms","volume":"1","author":"M Dodt","year":"2012","journal-title":"Biology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"B Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"ref62","unstructured":"Anders S, Pyl PT, Huber W. HTSeq\u2014A Python framework to work with high-throughput sequencing data [Internet]. 2014 Feb. Report No.: 002824. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2014\/02\/20\/002824\" xlink:type=\"simple\">http:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2014\/02\/20\/002824<\/ext-link>"},{"key":"ref63","first-page":"239","article-title":"Bacterial Cell Surfaces","author":"JV Hankins","year":"2013"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2958.2010.07476.x","article-title":"Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments","volume":"79","author":"DK Giles","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/nprot.2008.132","article-title":"Calculating absolute and relative protein abundance from mass spectrometry-based protein expression data","volume":"3","author":"C Vogel","year":"2008","journal-title":"Nat Protoc"},{"key":"ref66","unstructured":"Jones E, Oliphant T, Peterson P. SciPy: Open source scientific tools for Python. In: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.scipy.org\/\" xlink:type=\"simple\">http:\/\/www.scipy.org\/<\/ext-link> [Internet]. 2001 [cited 9 Sep 2014]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.scipy.org\/Citing_SciPy\" xlink:type=\"simple\">http:\/\/www.scipy.org\/Citing_SciPy<\/ext-link>"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1109\/MCSE.2011.37","article-title":"The NumPy Array: A Structure for Efficient Numerical Computation","volume":"13","author":"S van der Walt","year":"2011","journal-title":"Comput Sci Eng"},{"key":"ref68","article-title":"Differential Evolution: A Practical Approach to Global Optimization (Natural Computing Series)","author":"K Price","year":"2005"},{"key":"ref69","first-page":"HL1002","article-title":"Good Parameters for Differential Evolution","author":"MEH Pedersen","year":"2010","journal-title":"Hvass Lab Tech Rep"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"T Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"JA Vizca\u00edno","year":"2014","journal-title":"Nat Biotechnol"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T13:04:58Z","timestamp":1653051898000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004400"}},"subtitle":[],"editor":[{"given":"Christos A.","family":"Ouzounis","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,8,14]]},"references-count":71,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004400","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,14]]}}}