{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:34:13Z","timestamp":1781073253097,"version":"3.54.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004506","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T22:09:49Z","timestamp":1444428589000},"page":"e1004506","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality"],"prefix":"10.1371","volume":"11","author":[{"given":"Alexandra","family":"Jacunski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Tatonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2010.11.024","article-title":"Synthetic lethality: General principles, utility and detection using genetic screens in human cells","volume":"585","author":"SMB Nijman","year":"2011","journal-title":"FEBS Letters"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nature05697","article-title":"Synthetic lethal screen identification of chemosensitizer loci in cancer cells","volume":"446","author":"AW Whitehurst","year":"2007","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1752-0509-3-116","article-title":"Human synthetic lethal inference as potential anti-cancer target gene detection","volume":"3","author":"N Conde-Pueyo","year":"2009","journal-title":"BMC Systems Biology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1158\/0008-5472.CAN-10-2352","article-title":"Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment","volume":"70","author":"N Chan","year":"2010","journal-title":"Cancer Research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.cell.2014.07.027","article-title":"Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality","volume":"158","author":"L Jerby-Arnon","year":"2014","journal-title":"Cell"},{"key":"ref6","article-title":"A comparative genomic approach for identifying synthetic lethal interactions in human cancer","author":"R Deshpande","year":"2013","journal-title":"Cancer Research"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"D8","DOI":"10.1093\/nar\/gks1189","article-title":"Database resources of the National Center for Biotechnology Information","volume":"41","year":"2012","journal-title":"Nucleic Acids Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1101\/gr.714603","article-title":"Parallel evolution by gene duplication in the genomes of two unicellular fungi","volume":"13","author":"AL Hughes","year":"2003","journal-title":"Genome Research"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2000-1-2-reviews1011","article-title":"Where does fission yeast sit on the tree of life?","volume":"1","author":"M Sipiczki","year":"2000","journal-title":"Genome Biology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/clpt.2013.168","article-title":"Connecting the dots: applications of network medicine in pharmacology and disease","volume":"94","author":"A Jacunski","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"A-L Barab\u00e1si","year":"2011","journal-title":"Nature Reviews Genetics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/bfgp\/els032","article-title":"Exploring the human diseasome: the human disease network","volume":"11","author":"KI Goh","year":"2012","journal-title":"Briefings in Functional Genomics"},{"key":"ref13","first-page":"384","article-title":"Meta-analysis of Genomic and Proteomic Features to Predict Synthetic Lethality of Yeast and Human Cancer","author":"M Wu","year":"2013"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1039\/c3mb25589a","article-title":"Identification of synthetic lethal pairs in biological systems through network information centrality","volume":"9","author":"T Kranthi","year":"2013","journal-title":"Mol BioSyst"},{"key":"ref15","article-title":"Pfam: the protein families database","author":"RD Finn","year":"2013","journal-title":"Nucleic acids"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"D535","DOI":"10.1093\/nar\/gkj109","article-title":"BioGRID: a general repository for interaction datasets","volume":"34","author":"C Stark","year":"2006","journal-title":"Nucleic Acids Research"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"L Breiman","year":"2001","journal-title":"Machine learning"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1471-2105-10-213","article-title":"A comparison of random forest and its Gini importance with standard chemometric methods for the feature selection and classification of spectral data","volume":"10","author":"BH Menze","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Hagberg A, Schult D, Swart P (2008) Exploring Network Structure, Dynamics, and Function using NetworkX. Proceedings of the Python in Science Conference (SciPy): 11\u201316. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/conference.scipy.org\/proceedings\/SciPy2008\/paper_2\/\" xlink:type=\"simple\">http:\/\/conference.scipy.org\/proceedings\/SciPy2008\/paper_2\/<\/ext-link>. Accessed 11 November 2013.","DOI":"10.25080\/TCWV9851"},{"key":"ref20","first-page":"449","article-title":"The Population Genetics of Synthetic Lethals","author":"PC Phillips","year":"1998","journal-title":"Genetics Society of America"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/gb-2006-7-11-120","article-title":"How complete are current yeast and human protein-interaction networks?","volume":"7","author":"GT Hart","year":"2006","journal-title":"Genome Biology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"GR Abecasis","year":"2012","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ajhg.2012.08.005","article-title":"Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth","volume":"91","author":"M Fromer","year":"2012","journal-title":"Am J Hum Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng.2303","article-title":"Exome sequencing and the genetic basis of complex traits","volume":"44","author":"A Kiezun","year":"2012","journal-title":"Nat Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ng.2283","article-title":"Extremely low-coverage sequencing and imputation increases power for genome-wide association studies","volume":"44","author":"B Pasaniuc","year":"2012","journal-title":"Nat Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"R135","DOI":"10.1186\/gb-2008-9-9-r135","article-title":"Modeling synthetic lethality","volume":"9","author":"N Le Meur","year":"2008","journal-title":"Genome Biology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1091317","article-title":"Global Mapping of the Yeast Genetic Interaction Network","volume":"303","author":"AHY Tong","year":"2004","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"D277","DOI":"10.1093\/nar\/gkh063","article-title":"The KEGG resource for deciphering the genome","volume":"32","author":"M Kanehisa","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"D646","DOI":"10.1093\/nar\/gkm936","article-title":"CORUM: the comprehensive resource of mammalian protein complexes","volume":"36","author":"A Ruepp","year":"2007","journal-title":"Nucleic Acids Research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nbt1210-1248","article-title":"Towards a knowledge-based Human Protein Atlas","volume":"28","author":"M Uhlen","year":"2010","journal-title":"Nat Biotechnol"},{"key":"ref31","first-page":"196034","article-title":"Syn-lethality: an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies","volume":"2014","author":"X-J Li","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"D472","DOI":"10.1093\/nar\/gkt1102","article-title":"The Reactome pathway knowledgebase","volume":"42","author":"D Croft","year":"2014","journal-title":"Nucleic Acids Research"},{"key":"ref33","first-page":"71","article-title":"In Silico Prediction of Synthetic Lethality by Meta-Analysis of Genetic Interactions, Functions, and Pathways in Yeast and Human Cancer","author":"M Wu","year":"2014","journal-title":"CIN"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrc1691","article-title":"The Concept of Synthetic Lethality in the Context of Anticancer Therapy","volume":"5","author":"WG Kaelin","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.12.006","article-title":"Oxidative stress, insulin signaling, and diabetes","volume":"50","author":"JL Rains","year":"2011","journal-title":"Free Radical Biology and Medicine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/path.2440","article-title":"The Human Protein Atlas\u2014a tool for pathology","volume":"216","author":"F Pont\u00e9n","year":"2008","journal-title":"J Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"D492","DOI":"10.1093\/nar\/gkp858","article-title":"The NCBI BioSystems database","volume":"38","author":"LY Geer","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/nar\/28.1.257","article-title":"SCOP: a Structural Classification of Proteins database","volume":"28","author":"LL Conte","year":"2000","journal-title":"Nucleic Acids Research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"D304","DOI":"10.1093\/nar\/gkt1240","article-title":"SCOPe: Structural Classification of Proteins\u2014extended, integrating SCOP and ASTRAL data and classification of new structures","volume":"42","author":"NK Fox","year":"2013","journal-title":"Nucleic Acids Research"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkp1018","article-title":"The Gene Ontology in 2010: extensions and refinements","volume":"38","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"D54","DOI":"10.1093\/nar\/gki031","article-title":"Entrez Gene: gene-centered information at NCBI","volume":"33","author":"D Maglott","year":"2004","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-0134(199707)28:3<405::AID-PROT10>3.0.CO;2-L","article-title":"Pfam: a comprehensive database of protein domain families based on seed alignments","volume":"28","author":"EL Sonnhammer","year":"1997","journal-title":"Proteins"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"DW Huang","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"DW Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"ref45","article-title":"Network-based global inference of human disease genes","volume":"4","author":"X Wu","year":"2008","journal-title":"Mol Syst Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Research"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1198\/016214501753381814","article-title":"Analysis of Data From Viral DNA Microchips","volume":"96","author":"D Amaratunga","year":"2001","journal-title":"Journal of the American Statistical Association"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/bioinformatics\/btp697","article-title":"DCDB: Drug combination database","volume":"26","author":"Y Liu","year":"2010","journal-title":"Bioinformatics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"X Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1109\/MCSE.2007.55","article-title":"Matplotlib: A 2D Graphics Environment","volume":"9","author":"JD Hunter","year":"2007","journal-title":"Comput Sci Eng"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:11:02Z","timestamp":1748650262000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004506"}},"subtitle":[],"editor":[{"given":"Lilia M.","family":"Iakoucheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,9]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004506","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,9]]}}}