{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:34:19Z","timestamp":1774582459704,"version":"3.50.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004611","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T18:40:33Z","timestamp":1454611233000},"page":"e1004611","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Unbiased Rare Event Sampling in Spatial Stochastic Systems Biology Models Using a Weighted Ensemble of Trajectories"],"prefix":"10.1371","volume":"12","author":[{"given":"Rory M.","family":"Donovan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose-Juan","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin P.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Faeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Dittrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1201\/b18849","article-title":"Statistical Physics of Biomolecules: An Introduction","author":"DM Zuckerman","year":"2010"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.1070919","article-title":"Stochastic gene expression in a single cell","volume":"297","author":"MB Elowitz","year":"2002","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.1216379","article-title":"Using gene expression noise to understand gene regulation","volume":"336","author":"B Munsky","year":"2012","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1003844","DOI":"10.1371\/journal.pcbi.1003844","article-title":"Multi-state modeling of biomolecules","volume":"10","author":"MI Stefan","year":"2014","journal-title":"PLoS computational biology"},{"key":"ref5","unstructured":"Shaw DE, Grossman J, Bank JA, Batson B, Butts JA, et al. (2014) Anton 2: Raising the Bar for Performance and Programmability in a Special-Purpose Molecular Dynamics Supercomputer. In: SC14: International Conference for High Performance Computing, Networking, Storage and Analysis. IEEE, pp. 41\u201353. 10.1109\/SC.2014.9. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dl.acm.org\/citation.cfm?id = 2683593.2683599\" xlink:type=\"simple\">http:\/\/dl.acm.org\/citation.cfm?id = 2683593.2683599<\/ext-link>."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-biophys-042910-155245","article-title":"Biomolecular simulation: a computational microscope for molecular biology","volume":"41","author":"RO Dror","year":"2012","journal-title":"Annual review of biophysics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2012.05.044","article-title":"A whole-cell computational model predicts phenotype from genotype","volume":"150","author":"JR Karr","year":"2012","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0021-9991(77)90121-8","article-title":"Nonphysical sampling distributions in Monte Carlo free-energy estimation: Umbrella sampling","volume":"23","author":"G Torrie","year":"1977","journal-title":"Journal of Computational Physics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jcc.540130812","article-title":"THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method","volume":"13","author":"S Kumar","year":"1992","journal-title":"Journal of Computational Chemistry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"090601","DOI":"10.1103\/PhysRevLett.96.090601","article-title":"Equilibrium Free Energies from Nonequilibrium Metadynamics","volume":"96","author":"G Bussi","year":"2006","journal-title":"Physical Review Letters"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.physa.2004.04.033","article-title":"Investigating rare events by transition interface sampling","volume":"340","author":"D Moroni","year":"2004","journal-title":"Physica A: Statistical Mechanics and its Applications"},{"key":"ref12","first-page":"463102","article-title":"Forward flux sampling for rare event simulations","volume":"21","author":"RJ Allen","year":"2009","journal-title":"Journal of physics: Condensed matter"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0006-3495(96)79552-8","article-title":"Weighted-ensemble Brownian dynamics simulations for protein association reactions","volume":"70","author":"GA Huber","year":"1996","journal-title":"Biophysical journal"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1063\/1.475562","article-title":"Transition path sampling and the calculation of rate constants","volume":"108","author":"C Dellago","year":"1998","journal-title":"The Journal of Chemical Physics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10880","DOI":"10.1063\/1.1738640","article-title":"Computing time scales from reaction coordinates by milestoning","volume":"120","author":"AK Faradjian","year":"2004","journal-title":"The Journal of chemical physics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"154112","DOI":"10.1063\/1.2784118","article-title":"Umbrella sampling for nonequilibrium processes","volume":"127","author":"A Warmflash","year":"2007","journal-title":"The Journal of chemical physics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"054107","DOI":"10.1063\/1.3306345","article-title":"The \u201cweighted ensemble\u201d path sampling method is statistically exact for a broad class of stochastic processes and binning procedures","volume":"132","author":"BW Zhang","year":"2010","journal-title":"The Journal of chemical physics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1103\/PhysRevLett.57.2607","article-title":"Replica Monte Carlo Simulation of Spin-Glasses","volume":"57","author":"RH Swendsen","year":"1986","journal-title":"Physical Review Letters"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0009-2614(97)01198-6","article-title":"Parallel tempering algorithm for conformational studies of biological molecules","volume":"281","author":"UH Hansmann","year":"1997","journal-title":"Chemical Physics Letters"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0009-2614(99)01123-9","article-title":"Replica-exchange molecular dynamics method for protein folding","volume":"314","author":"Y Sugita","year":"1999","journal-title":"Chemical Physics Letters"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"028105","DOI":"10.1103\/PhysRevLett.96.028105","article-title":"Resolution Exchange Simulation","volume":"96","author":"E Lyman","year":"2006","journal-title":"Physical Review Letters"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.physchem.58.032806.104614","article-title":"Protein-folding dynamics: overview of molecular simulation techniques","volume":"58","author":"HA Scheraga","year":"2007","journal-title":"Annual review of physical chemistry"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-biophys-042910-155255","article-title":"Equilibrium sampling in biomolecular simulations","volume":"40","author":"DM Zuckerman","year":"2011","journal-title":"Annual review of biophysics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/ct100626x","article-title":"Efficient Explicit-Solvent Molecular Dynamics Simulations of Molecular Association Kinetics: Methane\/Methane, Na+\/Cl-, Methane\/Benzene, and K+\/18-Crown-6 Ether","volume":"7","author":"MC Zwier","year":"2011","journal-title":"Journal of Chemical Theory and Computation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"18043","DOI":"10.1073\/pnas.0706349104","article-title":"Efficient and verified simulation of a path ensemble for conformational change in a united-residue model of calmodulin","volume":"104","author":"BW Zhang","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1021\/ct100406t","article-title":"Heterogeneous path ensembles for conformational transitions in semi-atomistic models of adenylate kinase","volume":"6","author":"D Bhatt","year":"2010","journal-title":"Journal of chemical theory and computation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"115105","DOI":"10.1063\/1.4821167","article-title":"Efficient stochastic simulation of chemical kinetics networks using a weighted ensemble of trajectories","volume":"139","author":"RM Donovan","year":"2013","journal-title":"The Journal of chemical physics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1021\/ct401065r","article-title":"Simultaneous Computation of Dynamical and Equilibrium Information Using a Weighted Ensemble of Trajectories","volume":"10","author":"E Su\u00e1rez","year":"2014","journal-title":"Journal of Chemical Theory and Computation"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1016\/j.bpj.2013.05.023","article-title":"An excess-calcium-binding-site model predicts neurotransmitter release at the neuromuscular junction","volume":"104","author":"M Dittrich","year":"2013","journal-title":"Biophysical journal"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.physchem.58.032806.104637","article-title":"Stochastic simulation of chemical kinetics","volume":"58","author":"DT Gillespie","year":"2007","journal-title":"Annual review of physical chemistry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nmeth.1546","article-title":"Efficient modeling, simulation and coarse-graining of biological complexity with NFsim","volume":"8","author":"MW Sneddon","year":"2011","journal-title":"Nature methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature02026","article-title":"Global analysis of protein localization in budding yeast","volume":"425","author":"WK Huh","year":"2003","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"D230","DOI":"10.1093\/nar\/gkm950","article-title":"LOCATE: a mammalian protein subcellular localization database","volume":"36","author":"J Sprenger","year":"2008","journal-title":"Nucleic acids research"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1093\/bioinformatics\/btt392","article-title":"Determining the subcellular location of new proteins from microscope images using local features","volume":"29","author":"LP Coelho","year":"2013","journal-title":"Bioinformatics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"044105","DOI":"10.1063\/1.4773892","article-title":"Simulating rare events using a weighted ensemble-based string method","volume":"138","author":"JL Adelman","year":"2013","journal-title":"The Journal of chemical physics"},{"key":"ref36","unstructured":"Hill TL (2004) Free Energy Transduction And Biochemical Cycle Kinetics. Dover Publications, 119 pp. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/books.google.com\/books?id=AqVsAAAACAAJ&pgis=1\" xlink:type=\"simple\">http:\/\/books.google.com\/books?id=AqVsAAAACAAJ&amp;pgis=1<\/ext-link>."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"150113180903008","DOI":"10.1021\/ct5010615","article-title":"WESTPA: An interoperable, highly scalable software package for weighted ensemble simulation and analysis","volume":"11","author":"MC Zwier","year":"2015","journal-title":"Journal of Chemical Theory and Computation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1137\/070692017","article-title":"Fast Monte Carlo Simulation Methods for Biological Reaction-Diffusion Systems in Solution and on Surfaces","volume":"30","author":"RA Kerr","year":"2008","journal-title":"SIAM journal on scientific computing"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/cne.23181","article-title":"Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil","volume":"521","author":"JP Kinney","year":"2013","journal-title":"Journal of Comparative Neurology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"18157","DOI":"10.1523\/JNEUROSCI.3827-12.2012","article-title":"The number and organization of Ca2+ channels in the active zone shapes neurotransmitter release from Schaffer collateral synapses","volume":"32","author":"A Scimemi","year":"2012","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1213\/ANE.0b013e31827ee17f","article-title":"Simulation of the kinetics of neuromuscular block: implications for speed of onset","volume":"117","author":"JP Dilger","year":"2013","journal-title":"Anesthesia and analgesia"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.12688\/f1000research.3720.1","article-title":"Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling","volume":"3","author":"N Fameli","year":"2014","journal-title":"F1000Research"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.bpj.2013.01.049","article-title":"Anomalous diffusion of single particles in cytoplasm","volume":"104","author":"BM Regner","year":"2013","journal-title":"Biophysical journal"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1126\/science.1108239","article-title":"Evidence for ectopic neurotransmission at a neuronal synapse","volume":"309","author":"JS Coggan","year":"2005","journal-title":"Science (New York, NY)"},{"key":"ref45","first-page":"1673","article-title":"Encyclopedia of Computational Neuroscience","author":"TM Bartol","year":"2015"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1073\/pnas.93.12.5747","article-title":"Miniature endplate current rise times less than 100 microseconds from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle","volume":"93","author":"JR Stiles","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref47","first-page":"87","article-title":"Computational Neuroscience: Realistic Modeling for Experimentalists","author":"J Stiles","year":"2001"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-59745-525-1_5","article-title":"Rule-based modeling of biochemical systems with BioNetGen","volume":"500","author":"JR Faeder","year":"2009","journal-title":"Methods in molecular biology"},{"key":"ref49","first-page":"13","article-title":"Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems","volume":"6","author":"LA Chylek","year":"2014","journal-title":"Wiley Interdisciplinary Reviews: Systems Biology and Medicine"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/cyto.a.20487","article-title":"Automated learning of generative models for subcellular location: building blocks for systems biology","volume":"71A","author":"T Zhao","year":"2007","journal-title":"Cytometry"},{"key":"ref51","unstructured":"Rohde GK, Wang W, Peng T, Murphy RF (2008) Deformation-based nonlinear dimension reduction: Applications to nuclear morphometry. In: 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro. IEEE, pp. 500\u2013503. 10.1109\/ISBI.2008.4541042. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ieeexplore.ieee.org\/articleDetails.jsp?arnumber = 4541042\" xlink:type=\"simple\">http:\/\/ieeexplore.ieee.org\/articleDetails.jsp?arnumber = 4541042<\/ext-link>."},{"key":"ref52","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/cyto.a.20506","article-title":"Deformation-based nuclear morphometry: capturing nuclear shape variation in HeLa cells","volume":"73A","author":"GK Rohde","year":"2008","journal-title":"Cytometry"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Peng T, Wang W, Rohde GK, Murphy RF (2009) Instance-Based Generative Biological Shape Modeling. Proceedings \/ IEEE International Symposium on Biomedical Imaging: from nano to macro IEEE International Symposium on Biomedical Imaging 5193141: 690\u2013693.","DOI":"10.1109\/ISBI.2009.5193141"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/cyto.a.20854","article-title":"A generative model of microtubule distributions, and indirect estimation of its parameters from fluorescence microscopy images","volume":"77A","author":"A Shariff","year":"2010","journal-title":"Cytometry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cyto.a.21066","article-title":"Image-derived, three-dimensional generative models of cellular organization","volume":"79A","author":"T Peng","year":"2011","journal-title":"Cytometry"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/bies.201200032","article-title":"Toward the virtual cell: automated approaches to building models of subcellular organization \u201clearned\u201d from microscopy images","volume":"34","author":"TE Buck","year":"2012","journal-title":"BioEssays: news and reviews in molecular, cellular and developmental biology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e50292","DOI":"10.1371\/journal.pone.0050292","article-title":"Estimating microtubule distributions from 2D immunofluorescence microscopy images reveals differences among human cultured cell lines","volume":"7","author":"J Li","year":"2012","journal-title":"PloS one"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-388403-9.00007-2","article-title":"CellOrganizer: Image-derived models of subcellular organization and protein distribution","volume":"110","author":"RF Murphy","year":"2012","journal-title":"Methods in cell biology"},{"key":"ref59","article-title":"GLSVLSI","author":"D Sullivan","year":"2015"},{"key":"ref60","unstructured":"SBML-Spatial Working Group (2015). SBML Spatial Processes Specification. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/sbml.org\/Documents\/Specifications\/SBML_Level_3\/Packages\/spatial\" xlink:type=\"simple\">http:\/\/sbml.org\/Documents\/Specifications\/SBML_Level_3\/Packages\/spatial<\/ext-link>."},{"key":"ref61","unstructured":"Harris La, Hogg JS, Faeder JR (2009) Compartmental rule-based modeling of biochemical systems. Proceedings of the 2009 Winter Simulation Conference (WSC): 908\u2013919."},{"key":"ref62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/273345a0","article-title":"Role of cell shape in growth control","volume":"273","author":"J Folkman","year":"1978","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment","volume":"6","author":"R McBeath","year":"2004","journal-title":"Developmental Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrm1890","article-title":"Local force and geometry sensing regulate cell functions","volume":"7","author":"V Vogel","year":"2006","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1126\/science.1140324","article-title":"Quantitative morphological signatures define local signaling networks regulating cell morphology","volume":"316","author":"C Bakal","year":"2007","journal-title":"Science (New York, NY)"},{"key":"ref66","article-title":"Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks","author":"S Neves","year":"2008","journal-title":"Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.1967.sp008367","article-title":"Co-operative action of calcium ions in transmitter release at the neuromuscular junction","volume":"193","author":"FA Dodge","year":"1967","journal-title":"The Journal of Physiology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.biophys.31.101101.140930","article-title":"Computational cell biology: spatiotemporal simulation of cellular events","volume":"31","author":"BM Slepchenko","year":"2002","journal-title":"Annual review of biophysics and biomolecular structure"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/S0006-3495(02)75248-X","article-title":"A Monte Carlo model reveals independent signaling at central glutamatergic synapses","volume":"83","author":"KM Franks","year":"2002","journal-title":"Biophysical journal"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1093\/bioinformatics\/bti431","article-title":"Stochastic reaction-diffusion simulation with MesoRD","volume":"21","author":"J Hattne","year":"2005","journal-title":"Bioinformatics (Oxford, England)"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e1000705","DOI":"10.1371\/journal.pcbi.1000705","article-title":"Detailed simulations of cell biology with Smoldyn 2.1","volume":"6","author":"SS Andrews","year":"2010","journal-title":"PLoS computational biology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.bpj.2009.11.034","article-title":"Monte Carlo Simulation of Buffered Diffusion into and out of a Model Synapse","volume":"98","author":"JP Dilger","year":"2010","journal-title":"Biophysical Journal"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:11:18Z","timestamp":1718341878000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004611"}},"subtitle":[],"editor":[{"given":"Martin","family":"Meier-Schellersheim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,4]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004611","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,4]]}}}