{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:06:56Z","timestamp":1770415616699,"version":"3.49.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004674","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T18:59:45Z","timestamp":1450810785000},"page":"e1004674","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sources of Variability in a Synthetic Gene Oscillator"],"prefix":"10.1371","volume":"11","author":[{"given":"Alan","family":"Veliz-Cuba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Hirning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam A.","family":"Atanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Vancia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kre\u0161imir","family":"Josi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/genetics\/149.4.1633","article-title":"Stochastic Kinetic Analysis of Developmental Pathway Bifurcation in Phage <italic>\u03bb<\/italic>-Infected Escherichia coli Cells","volume":"149","author":"A Arkin","year":"1998","journal-title":"Genetics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ng869","article-title":"Regulation of noise in the expression of a single gene","volume":"31","author":"E Ozbudak","year":"2002","journal-title":"Nat Genet"},{"issue":"5584","key":"ref3","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.1070919","article-title":"Stochastic Gene Expression in a Single Cell","volume":"297","author":"MB Elowitz","year":"2002","journal-title":"Science"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ng1616","article-title":"Contributions of low molecule number and chromosomal positioning to stochastic gene expression","volume":"37","author":"A Becskei","year":"2005","journal-title":"Nat Genet"},{"issue":"52","key":"ref5","doi-asserted-by":"crossref","first-page":"20705","DOI":"10.1073\/pnas.0808831105","article-title":"Determination of cell fate selection during phage lambda infection","volume":"105","author":"F St-Pierre","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nsmb.2336","article-title":"Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis","volume":"19","author":"Z Hensel","year":"2012","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1534\/genetics.167.1.523","article-title":"Stochastic Gene Expression in Fluctuating Environments","volume":"167","author":"M Thattai","year":"2004","journal-title":"Genetics"},{"issue":"29","key":"ref8","doi-asserted-by":"crossref","first-page":"12167","DOI":"10.1073\/pnas.1018832108","article-title":"Separating intrinsic from extrinsic fluctuations in dynamic biological systems","volume":"108","author":"A Hilfinger","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002010","article-title":"Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study","volume":"7","author":"E Roberts","year":"2011","journal-title":"PLoS Comput Biol"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"e1003161","DOI":"10.1371\/journal.pcbi.1003161","article-title":"Cell-Cycle Dependence of Transcription Dominates Noise in Gene Expression","volume":"9","author":"CJ Zopf","year":"2013","journal-title":"PLoS Comput Biol"},{"issue":"20","key":"ref11","doi-asserted-by":"crossref","first-page":"12795","DOI":"10.1073\/pnas.162041399","article-title":"Intrinsic and extrinsic contributions to stochasticity in gene expression","volume":"99","author":"PS Swain","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5678","key":"ref12","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.1098641","article-title":"Control of Stochasticity in Eukaryotic Gene Expression","volume":"304","author":"JM Raser","year":"2004","journal-title":"Science"},{"issue":"7078","key":"ref13","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nature04281","article-title":"Origins of extrinsic variability in eukaryotic gene expression","volume":"439","author":"D Volfson","year":"2006","journal-title":"Nature"},{"issue":"196","key":"ref14","article-title":"Colored extrinsic fluctuations and stochastic gene expression","volume":"4","author":"V Shahrezaei","year":"2008","journal-title":"Mol Syst Biol"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/ng.281","article-title":"Regulatory activity revealed by dynamic correlations in gene expression noise","volume":"40","author":"MJ Dunlop","year":"2008","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature07389","article-title":"A fast, robust and tunable synthetic gene oscillator","volume":"456","author":"J Stricker","year":"2008","journal-title":"Nature"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1038\/msb4100032","article-title":"Monitoring dynamics of single-cell gene expression over multiple cell cycles","volume":"1","author":"S Cookson","year":"2005","journal-title":"Mol Syst Biol"},{"issue":"25","key":"ref18","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical reactions","volume":"81","author":"DT Gillespie","year":"1977","journal-title":"J Phys Chem"},{"issue":"41","key":"ref19","doi-asserted-by":"crossref","first-page":"14593","DOI":"10.1073\/pnas.0503858102","article-title":"Delay-induced stochastic oscillations in gene regulation","volume":"102","author":"D Bratsun","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1371\/journal.pcbi.0020117","article-title":"Oscillatory Regulation of Hes1: Discrete Stochastic Delay Modelling and Simulation","volume":"2","author":"M Barrio","year":"2006","journal-title":"PLoS Comput Biol"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"124108","DOI":"10.1063\/1.2710253","article-title":"Exact stochastic simulation of coupled chemical reactions with delays","volume":"126","author":"X Cai","year":"2007","journal-title":"J Chem Phys"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"e1002264","DOI":"10.1371\/journal.pcbi.1002264","article-title":"Stochastic delay accelerates signaling in gene networks","volume":"7","author":"K Josi\u0107","year":"2011","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/nar\/25.6.1203","article-title":"Independent and Tight Regulation of Transcriptional Units in <italic>Escherichia Coli<\/italic> Via the LacR\/O, the TetR\/O and AraC\/I1\u2013I2 Regulatory Elements","volume":"25","author":"R Lutz","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1128\/AEM.64.6.2240-2246.1998","article-title":"New Unstable Variants of Green Fluorescent Protein for Studies of Transient Gene Expression in Bacteria","volume":"64","author":"JB Andersen","year":"1998","journal-title":"Appl Environ Microbiol"},{"issue":"5885","key":"ref25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1156951","article-title":"Robust, tunable biological oscillations from interlinked positive and negative feedback loops","volume":"321","author":"TY Tsai","year":"2008","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrg2625","article-title":"Microfluidic devices for measuring gene network dynamics in single cells","volume":"10","author":"MR Bennett","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1073\/pnas.1316298111","article-title":"Engineered temperature compensation in a synthetic genetic clock","volume":"111","author":"F Hussain","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5717","key":"ref28","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1126\/science.1106914","article-title":"Gene Regulation at the Single-Cell Level","volume":"307","author":"N Rosenfeld","year":"2005","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"204108","DOI":"10.1063\/1.4878662","article-title":"Modeling delay in genetic networks: From delay birth-death processes to delay stochastic differential equations","volume":"140","author":"C Gupta","year":"2014","journal-title":"J Chem Phys"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1073\/pnas.1313715111","article-title":"Concerted control of <italic>Escherichia coli<\/italic> cell division","volume":"111","author":"M Osella","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.pbio.0030045","article-title":"Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division","volume":"3","author":"EJ Stewart","year":"2005","journal-title":"PLoS Biol"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1073\/pnas.0708931105","article-title":"Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation","volume":"105","author":"AB Lindner","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6064","key":"ref33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1216166","article-title":"Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility","volume":"335","author":"BB Aldridge","year":"2012","journal-title":"Science"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1128\/JB.06500-11","article-title":"Asymmetric Disposal of Individual Protein Aggregates in <italic>Escherichia coli<\/italic>, One Aggregate at a Time","volume":"194","author":"J Lloyd-Price","year":"2012","journal-title":"J Bacteriol"},{"key":"ref35","first-page":"165","article-title":"Entrainment of a population of synthetic genetic oscillators","volume":"55","author":"O Mondrag\u00f3n-Palomino","year":"2011","journal-title":"Science"},{"issue":"0","key":"ref36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jtbi.2013.02.001","article-title":"Modeling the effect of cell division on genetic oscillators","volume":"325","author":"D Gonze","year":"2013","journal-title":"J Theor Biol"},{"issue":"6767","key":"ref37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35002131","article-title":"Construction of a genetic toggle switch in <italic>Escherichia coli<\/italic>","volume":"403","author":"TS Gardner","year":"2000","journal-title":"Nature"},{"issue":"26","key":"ref38","doi-asserted-by":"crossref","first-page":"10610","DOI":"10.1073\/pnas.1305423110","article-title":"Engineering of regulated stochastic cell fate determination","volume":"110","author":"M Wu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1103\/PhysRevA.32.695","article-title":"Bistability driven by colored noise: Theory and experiment","volume":"32","author":"P Hanggi","year":"1985","journal-title":"Phys Rev A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1103\/PhysRevA.34.4525","article-title":"Uniform convergence to an effective Fokker-Planck equation for weakly colored noise","volume":"34","author":"RF Fox","year":"1986","journal-title":"Phys Rev A"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ab.2011.03.036","article-title":"Kinetic study of de novo chromophore maturation of fluorescent proteins","volume":"414","author":"R Iizuka","year":"2011","journal-title":"Analytical Biochemistry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"068105","DOI":"10.1103\/PhysRevLett.102.068105","article-title":"Delay-Induced Degrade-and-Fire Oscillations in Small Genetic Circuits","volume":"102","author":"W Mather","year":"2009","journal-title":"Phys Rev Lett"},{"key":"ref43","article-title":"North-Holland Personal Library","author":"NG van Kampen","year":"1992"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1049\/sb:20045016","article-title":"Cellular growth and division in the Gillespie algorithm","volume":"1","author":"T Lu","year":"2004","journal-title":"Systems Biology, IEE Proceedings"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1109\/TCSII.2007.892203","article-title":"Phase Diffusion Coefficient for Oscillators Perturbed by Colored Noise","volume":"54","author":"F O\u2019Doherty","year":"2007","journal-title":"Circuits and Systems II: Express Briefs, IEEE Transactions on"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T12:00:58Z","timestamp":1653912058000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004674"}},"subtitle":[],"editor":[{"given":"Gabor","family":"Balazsi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004674","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,22]]}}}