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Recommendations for measures to prevent spreading of influenza and acute respiratory infections on the territory of Perm region. 2015. Available (in Russian) from http:\/\/59.rospotrebnadzor.ru\/c\/document_library\/get_file?uuid=e9eef599-a75b-410d-99d2-7e7fb801f603&groupId=10156<\/ext-link>."},{"issue":"7056","key":"ref39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature04017","article-title":"Strategies for containing an emerging influenza pandemic in Southeast Asia","volume":"437","author":"NM Ferguson","year":"2005","journal-title":"Nature"},{"issue":"5737","key":"ref40","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.1115717","article-title":"Containing Pandemic Influenza at the Source","volume":"309","author":"IM Longini","year":"2005","journal-title":"Science"},{"issue":"7101","key":"ref41","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature04795","article-title":"Strategies for mitigating an influenza pandemic","volume":"442","author":"NM 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Natl Acad Sci"},{"issue":"02","key":"ref48","doi-asserted-by":"crossref","DOI":"10.1017\/S0950268807008369","article-title":"Analyses of the 1957 (Asian) influenza pandemic in the United Kingdom and the impact of school closures","volume":"136","author":"E Vynnycky","year":"2008","journal-title":"Epidemiol Infect"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2334-9-117","article-title":"Age-prioritized use of antivirals during an influenza pandemic","volume":"9","author":"S Merler","year":"2009","journal-title":"BMC Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"RRN1119","DOI":"10.1371\/currents.RRN1119","article-title":"Can Reactive School Closures help critical care provision during the current influenza pandemic?","volume":"1","author":"T House","year":"2009","journal-title":"PLoS 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