{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:55:48Z","timestamp":1772171748170,"version":"3.50.1"},"reference-count":0,"publisher":"Public Library of Science (PLoS)","issue":"5","content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004725","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T16:05:07Z","timestamp":1463069107000},"page":"e1004725","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Towards Increasing the Clinical Relevance of In Silico Methods to Predict Pathogenic Missense Variants"],"prefix":"10.1371","volume":"12","author":[{"given":"David L.","family":"Masica","sequence":"first","affiliation":[]},{"given":"Rachel","family":"Karchin","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2016,5,12]]},"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:26:49Z","timestamp":1589016409000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004725"}},"subtitle":[],"editor":[{"given":"Ruth","family":"Nussinov","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004725","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726444662.793520297","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]}}}