{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:24:45Z","timestamp":1764174285419,"version":"3.37.3"},"reference-count":127,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["090813"],"award-info":[{"award-number":["090813"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1058291"],"award-info":[{"award-number":["1058291"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IIS-0904413"],"award-info":[{"award-number":["IIS-0904413"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CNS-0521433"],"award-info":[{"award-number":["CNS-0521433"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CNS-0723054"],"award-info":[{"award-number":["CNS-0723054"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004858","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T17:36:22Z","timestamp":1462815382000},"page":"e1004858","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":88,"title":["High-Degree Neurons Feed Cortical Computations"],"prefix":"10.1371","volume":"12","author":[{"given":"Nicholas M.","family":"Timme","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-257X","authenticated-orcid":true,"given":"Maxym","family":"Myroshnychenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1559-5556","authenticated-orcid":true,"given":"Sunny","family":"Nigam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Shimono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Chin","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-2195","authenticated-orcid":true,"given":"Pawel","family":"Hottowy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M.","family":"Litke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Beggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1089\/brain.2011.0008","article-title":"Functional and effective connectivity: a review","volume":"1","author":"KJ Friston","year":"2011","journal-title":"Brain Connectivity"},{"key":"ref2","article-title":"Complex brain networks: graph theoretical analysis of structural and function systems","volume":"10","author":"E Bullmore","year":"2009","journal-title":"Nature Reviews Neuroscience"},{"article-title":"Nonnegative decomposition of multivariate information","year":"2010","author":"PL Williams","key":"ref3"},{"article-title":"Generalized measures of information transfer","year":"2011","author":"PL Williams","key":"ref4"},{"key":"ref5","first-page":"1","article-title":"Bits from brains for biologically inspired computing","volume":"2","author":"M Wibral","year":"2014","journal-title":"Frontiers in Robotics and AI"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10827-013-0458-4","article-title":"Synergy, redundancy, and multivariate information measures: an experimentalist's perspective","volume":"36","author":"N Timme","year":"2014","journal-title":"Journal of Computational Neuroscience"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1113\/jphysiol.2003.044784","article-title":"Pyramidal cell communication within local networks in layer 2\/3 of rat neocortex","volume":"551","author":"C Holmgren","year":"2003","journal-title":"Journal of Physiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1073\/pnas.0407088102","article-title":"The neocortical microcircuit as a tabula rasa","volume":"102","author":"N Kalisman","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature03252","article-title":"Excitatory cortical neurons form fine-scale functional networks","volume":"433","author":"Y Yoshimura","year":"2005","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jphysparis.2009.05.006","article-title":"Mofit distribution, dynamical properties, and computational performance of two data-based cortical microcircuit templates","volume":"103","author":"S Haeusler","year":"2009","journal-title":"Journal of Physiology\u2014Paris"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnana.2014.00129","article-title":"Generation of dense statistical connectomes from sparse morphological data","volume":"8","author":"R Egger","year":"2014","journal-title":"Frontiers in Neuroanatomy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1523\/JNEUROSCI.2177-15.2016","article-title":"Rich-club organization in effective connectivity among cortical neurons","volume":"36","author":"S Nigam","year":"2016","journal-title":"Journal of Neuroscience"},{"key":"ref13","article-title":"Highly nonrandom features of synaptic connectivity in local cortical circuits","volume":"3","author":"S Song","year":"2005","journal-title":"PLOS Biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1073\/pnas.1016051108","article-title":"A synaptic organizing principle for cortical neuronal groups","volume":"108","author":"R Perin","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref15","first-page":"1","article-title":"Functional clusters, hubs, and communities in the cortical microconnectome","author":"M Shimono","year":"2014","journal-title":"Cerebral Cortex"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10827-010-0253-4","article-title":"Synaptic information transfer in computer models of neocortical columns","volume":"30","author":"SA Neymotin","year":"2011","journal-title":"Journal of Computational Neuroscience"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuron.2008.12.020","article-title":"The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex","volume":"61","author":"S Lefort","year":"2009","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep00485","article-title":"Optimal spike-based communication in excitable networks with strong-spares and weak-dense links","volume":"2","author":"J Teramae","year":"2012","journal-title":"Scientific Reports"},{"key":"ref19","article-title":"Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input","volume":"8","author":"S Ratte","year":"2014","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1109\/JPROC.2014.2306254","article-title":"Computational implications of lognormally distributed synaptic weights","volume":"102","author":"J Teramae","year":"2014","journal-title":"Proceedings of the IEEE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/cercor\/bhs006","article-title":"Interpyramid spike transmission stabilizes the sparseness of recurrent network activity","volume":"23","author":"Y Ikegaya","year":"2012","journal-title":"Cerebral Cortex"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature14182","article-title":"Functional organization of excitatory synaptic strength in primary visual cortex","volume":"518","author":"L Cossell","year":"2015","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1126\/science.1175509","article-title":"GABAergic hub neurons orchestrate synchrony in developing hippocampal networks","volume":"326","author":"P Bonifazi","year":"2009","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e105324","DOI":"10.1371\/journal.pone.0105324","article-title":"Large-scale, high-resolution multielectrode-array recording depicts functional network differences of cortical and hippocampal cultures","volume":"9","author":"S Ito","year":"2014","journal-title":"PloS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1103\/PhysRevLett.85.461","article-title":"Measuring information transfer","volume":"85","author":"T Schreiber","year":"2000","journal-title":"Physical Review Letters"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006482","article-title":"Evaluation of performance of information theory-based methods and cross-correlation to estimate the functional connectivity in cortical networks","volume":"4","author":"M Garofalo","year":"2009","journal-title":"PloS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10827-010-0271-2","article-title":"Multivariate information-theoretic measures reveal directed information structure and task relevant changes in fMRI connectivity","volume":"30","author":"JT Lizier","year":"2011","journal-title":"Journal of Computational Neuroscience"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10827-010-0262-3","article-title":"Transfer entropy\u2014a model-free measure of effective connectivity for the neurosciences","volume":"30","author":"R Vicente","year":"2011","journal-title":"Journal of Computational Neuroscience"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002653","article-title":"Model-free reconstruction of excitatory neuronal connectivity from calcium imaging signals","volume":"8","author":"O Stetter","year":"2012","journal-title":"PLOS Computational Biology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pbiomolbio.2010.11.006","article-title":"Transfer entropy in magnetoencephalographic data: quantifying information flow in cortical and cerebellar networks","volume":"105","author":"M Wibral","year":"2011","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.7551\/978-0-262-31709-2-ch161","article-title":"Multiple time scales observed in spontaneously evolved neurons on high-density CMOS electrode array","author":"E Matsuda","year":"2013"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11571-012-9239-4","article-title":"Estimating causal interaction between prefrontal cortex and striatum by transfer entropy","volume":"7","author":"C Ma","year":"2013","journal-title":"Cognative Neurodynamics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1152\/jn.01106.2006","article-title":"Evaluating information transfer between auditory cortical neurons","volume":"97","author":"B Gourevitch","year":"2007","journal-title":"Journal of Neurophysiology"},{"key":"ref34","unstructured":"Shimono M, Beggs JM. Spontaneous spike-trains reflect detailed topological properties of the structural neuronal network in vitro cortex. Proceedings of the 21st Annual Conference of the Japanese Neural Network Society; 2011."},{"key":"ref35","article-title":"Mesoscopic neuronal activity and neuronal network architecture. Proceedings of the 34th annual meeting of the","author":"M Shimono","year":"2011","journal-title":"Japan Neuroscience Society"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102833","article-title":"Efficient transfer entropy analysis of non-stationary neural time series","author":"P Wollstadt","year":"2014"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e88940","DOI":"10.1371\/journal.pone.0088940","article-title":"Fast dynamics of cortical functional and effective connectivity during word reading","volume":"9","author":"N Bedo","year":"2014","journal-title":"PloS One"},{"key":"ref38","article-title":"Detecting functional hubs of ictogenic networks","author":"F Zubler","year":"2014","journal-title":"Brain Topography"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10827-010-0236-5","article-title":"Causal relationships between frequency bands of extracellular signals in visual cortex revealed by an information theoretic analysis","volume":"29","author":"M Besserve","year":"2010","journal-title":"Journal of Computational Neuroscience"},{"key":"ref40","article-title":"Functional clusters, hubs and communities in the cortical microconnectome","author":"M Shimono","year":"2014","journal-title":"Cerebral Cortex"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.0701519104","article-title":"Network structure of cerebral cortex shapes functional connectivity on multiple time scales","volume":"104","author":"CJ Honey","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e27431","DOI":"10.1371\/journal.pone.0027431","article-title":"Extending transfer entropy improves identification of effective connectivity in a spiking cortical network model","author":"S Ito","year":"2011","journal-title":"PloS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1371\/journal.pcbi.0020144","article-title":"Mapping information flow in sensorimotor networks","author":"M Lungarella","year":"2006","journal-title":"PLOS Computational Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e115764","DOI":"10.1371\/journal.pone.0115764","article-title":"Multiplex networks of cortical and hippocampal neurons revealed at different timescales","volume":"9","author":"N Timme","year":"2014","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1523\/JNEUROSCI.11-01-00072.1991","article-title":"Synaptic transmission between individual pyramidal neurons of the rat visual cortex in vitro","volume":"11","author":"A Mason","year":"1991","journal-title":"Journal of Neuroscience"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1152\/jn.1994.71.2.437","article-title":"Efferent neurons and suspected interneurons in motor cortex of the awake rabbit: axonal properties, sensory receptive fields, and subthreshold synaptic inputs","volume":"71","author":"HA Swadlow","year":"1994","journal-title":"Journal of Neurophysiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.neuro.28.061604.135703","article-title":"Dendritic computation","volume":"28","author":"M London","year":"2005","journal-title":"Annual Review of Neuroscience"},{"key":"ref48","unstructured":"y Areas BA, Fairhall A, Bialek W (2001) What can a single neuron compute? Advances in Neural Information Processing Systems 13: Proceedings of the 2000 Conference: MIT Press. pp. 75."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature01190","article-title":"Multiplicative computation in a visual neuron sensitive to looming","volume":"420","author":"F Gabbiani","year":"2002","journal-title":"Nature"},{"article-title":"Biophysics of Computation: Information Processing in Single Neurons","year":"1999","author":"C Koch","key":"ref50"},{"article-title":"Single Neuron Computation","year":"1992","author":"T McKenna","key":"ref51"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.conb.2014.01.005","article-title":"Single neuron dynamics and computation","volume":"24","author":"N Brunel","year":"2014","journal-title":"Current Opinion in Neurobiology"},{"key":"ref53","article-title":"Correlated activity supports efficient cotrical processing","volume":"8","author":"CP Hung","year":"2014","journal-title":"Frontiers in Computational Neuroscience"},{"key":"ref54","article-title":"The functional structure of cortical neuronal networks grown in vitro","volume":"75","author":"LMA Bettencourt","year":"2007","journal-title":"Physical Review E"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Lizier JT, Flecker B, Williams PL. Towards a synergy-based approach to measuring information modification; 2013; Singapore. IEEE. pp. 43\u201351.","DOI":"10.1109\/ALIFE.2013.6602430"},{"article-title":"Elements of Information Theory","year":"2006","author":"TM Cover","key":"ref56"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1179850","article-title":"The asynchronous state in cortical circuits","volume":"327","author":"A Renart","year":"2000","journal-title":"Science"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrn2886","article-title":"Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding","volume":"11","author":"A Kumar","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1126\/science.1179867","article-title":"Decorrelated neuronal firing in cortical microcircuits","volume":"327","author":"AS Ecker","year":"2010","journal-title":"Science"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nn.2842","article-title":"Measuring and interpreting neuronal correlations","volume":"14","author":"MR Cohen","year":"2011","journal-title":"Nature Neuroscience"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncir.2011.00008","article-title":"Correlations decrease with propagation of spiking activity in the mouse barrel cortex","volume":"5","author":"GN Ranganathan","year":"2011","journal-title":"Frontiers in Neural Circuits"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrn3061","article-title":"The benefits of noise in neural systems: bridging theory and experiment","volume":"12","author":"MD McDonnell","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neubiorev.2013.02.015","article-title":"Moment-to-moment brain signal variability: A next frontier in human brain mapping?","volume":"37","author":"DD Garrett","year":"2013","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"ref64","article-title":"High degree neurons tend to contribute more and process less information in cortical networks","author":"N Timme","year":"2015","journal-title":"Cosyne"},{"key":"ref65","article-title":"Synergy and redundancy in timescale dependent multiplex networks of hippocampal neurons","author":"N Timme","year":"2014","journal-title":"Neuroscience"},{"key":"ref66","article-title":"Hub neurons contribute more to computation","author":"N Timme","year":"2015","journal-title":"Conference on Complex Systems"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1523\/JNEUROSCI.3359-07.2008","article-title":"A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro","volume":"28","author":"A Tang","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"ref68","doi-asserted-by":"crossref","DOI":"10.1109\/TNS.2004.832706","article-title":"What does the eye tell the brain?: development of a system for the large-scale recording of retinal output activity","volume":"51","author":"AM Litke","year":"2004","journal-title":"IEEE Transactions on Nuclear Science"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0165-0270(02)00367-9","article-title":"Statistical assessment of nonlinear causality: application to epileptic EEG signals","volume":"124","author":"M Chavez","year":"2003","journal-title":"Journal of Neuroscience Methods"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.1223082","article-title":"The pulvinar regulates information transmission between cortical areas based on attention demands","volume":"337","author":"YB Saalmann","year":"2012","journal-title":"Science"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"9849","DOI":"10.1073\/pnas.0308538101","article-title":"Beta oscillations in a large-scale sensorimotor cortical network: directional influences revealed by Granger causality","volume":"101","author":"A Brovelli","year":"2004","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e89443","DOI":"10.1371\/journal.pone.0089443","article-title":"Behavior modulates effective connectivity between cortex and striatum","volume":"9","author":"A Nakhnikian","year":"2014","journal-title":"PloS One"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1113\/jphysiol.2004.073189","article-title":"Directional analysis of cohere oscillatory field potentials in the cerebral cortex and basal ganglia of the rat","volume":"562","author":"A Sharott","year":"2005","journal-title":"Journal of Physiology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1371\/journal.pbio.0060315","article-title":"Identifying neural drivers with functional MRI: an electrophysiological validation","volume":"6","author":"O David","year":"2008","journal-title":"PLOS Biology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10827-008-0126-2","article-title":"Analyzing multiple spike trains with nonparametric granger causality","volume":"27","author":"AG Nedungadi","year":"2009","journal-title":"Journal of Computational Neuroscience"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e1001110","DOI":"10.1371\/journal.pcbi.1001110","article-title":"A granger causality measure for point process models of ensemble neural spiking activity","volume":"7","author":"S Kim","year":"2011","journal-title":"PLOS Computational Biology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1523\/JNEUROSCI.5041-14.2015","article-title":"Copula tregression analysis of simultaneously recorded frontal eye field and inferotemporal spiking activity during object-based working memory","volume":"35","author":"M Hu","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.neuroimage.2010.12.039","article-title":"Network discovery with DCM","volume":"56","author":"KJ Friston","year":"2011","journal-title":"NeuroImage"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neuroimage.2011.03.058","article-title":"Effective connectivity: influence, causality and biophysical modeling","volume":"58","author":"PA Valdes-Sosa","year":"2011","journal-title":"NeuroImage"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"18781","DOI":"10.1523\/JNEUROSCI.4201-12.2013","article-title":"Effective connectivity within human primary visual cortex predicts interindividual diversity in illusory perception","volume":"33","author":"C Song","year":"2013","journal-title":"Journal of Neuroscience"},{"key":"ref81","first-page":"303","article-title":"Causality, feedback and directed information","author":"J Massey","year":"1990","journal-title":"Proc. Int. Symp. Inf. Theory Applic"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10827-010-0247-2","article-title":"Estimating the directed information to infer causal relationships in ensemble neural spike train recordings","volume":"30","author":"CJ Quinn","year":"2011","journal-title":"Journal of Computational Neuroscience"},{"key":"ref83","article-title":"Comparing brain networks of different size and connectivity density using graph theory","volume":"5","author":"BCM van Wijk","year":"2010","journal-title":"PloS One"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3390\/e16042161","article-title":"Quantifying unique information","volume":"16","author":"N Bertschinger","year":"2014","journal-title":"Entropy"},{"key":"ref85","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.86.066211","article-title":"Expanding the transfer entropy to identify information circuits in complex systems","volume":"86","author":"S Stramaglia","year":"2012","journal-title":"Physical Review E"},{"key":"ref86","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.87.012130","article-title":"Bivariate measure of redundant information","volume":"87","author":"M Harder","year":"2013","journal-title":"Physical Review E"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3390\/e16041985","article-title":"Intersection information based on common randomness","volume":"16","author":"V Griffith","year":"2014","journal-title":"Entropy"},{"key":"ref88","doi-asserted-by":"crossref","DOI":"10.1007\/BF02289159","article-title":"Multivariate information transmission","volume":"19","author":"WJ McGill","year":"1954","journal-title":"Psychometrika"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroimage.2008.04.239","article-title":"Population dynamics: variance and the sigmoid activation function","volume":"42","author":"AC Marreiros","year":"2008","journal-title":"NeuroImage"},{"year":"1998","author":"GB Orr","key":"ref90"},{"key":"ref91","first-page":"103","article-title":"When is an integrate-and-fire neuron like a poisson neuron?","author":"CF Stevens","year":"1996","journal-title":"Advances in neural information processing systems"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"025102","DOI":"10.1103\/PhysRevE.64.025102","article-title":"Clustering and preferential attachment in growing networks","volume":"64","author":"MEJ Newman","year":"2001","journal-title":"Physical Review E"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.0501179102","article-title":"Subnets of scale-free networks are not scale-free: sampling properties of networks","volume":"102","author":"MPH Stumpf","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tins.2011.02.007","article-title":"Dissecting functional connectivity of neuronal microcircuits: experimental and theoretical insights","volume":"34","author":"S Feldt","year":"2011","journal-title":"Trends in Neuroscience"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/01621459.1985.10477163","article-title":"Oversmoothed nonparametric density estimates","volume":"80","author":"GR Terrell","year":"1985","journal-title":"Journal of the American Statistical Association"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1469-8986.2011.01273.x","article-title":"Mass univariate analysis of event-related brain potentials\/fields I: A critical tutorial review","volume":"48","author":"DM Groppe","year":"2011","journal-title":"Psychophysiology"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society B"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Y Benjamini","year":"2001","journal-title":"The Annals of Statistics"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"E4931","DOI":"10.1073\/pnas.1304680110","article-title":"Long-period rythmic synchronous firing in a scale-free network","volume":"110","author":"Y Mi","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrn1198","article-title":"The high-conductance state of neocortical neurons in vivo","volume":"4","author":"A Destexhe","year":"2003","journal-title":"Nature Reviews Neuroscience"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"M Rubinov","year":"2010","journal-title":"NeuroImage"},{"key":"ref102","article-title":"Fast algorithm for detecting community structure in networks","volume":"69","author":"MEJ Newman","year":"2004","journal-title":"Physical Review E"},{"key":"ref103","article-title":"Assortative mixing in networks","volume":"89","author":"MEJ Newman","year":"2002","journal-title":"Physical Review Letters"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/30918","article-title":"Collective dynamics of 'small-world' networks","volume":"393","author":"DJ Watts","year":"1998","journal-title":"Nature"},{"key":"ref105","article-title":"Opening bottlenecks on weighted networks by local adaptation to cascade failures","author":"J Alstott","year":"2015","journal-title":"Journal of Complex Networks"},{"key":"ref106","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.100.118703","article-title":"Community structure in directed networks","volume":"100","author":"EA Leicht","year":"2008","journal-title":"Physical Review Letters"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-0270(91)90128-M","article-title":"A simple method for organotypic cultures of nervous tissue","volume":"37","author":"L Stoppini","year":"1991","journal-title":"Journal of Neuroscience Methods"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2174\/1568007054546108","article-title":"Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair","volume":"4","author":"J Noraberg","year":"2005","journal-title":"Current Drug Targets\u2014CNS & Neurological Disorders"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2174\/092986710790820679","article-title":"Organotypic cultures as tool to test long-term effects of chemicals on the nervous system","volume":"17","author":"F Pena","year":"2010","journal-title":"Current Medicinal Chemistry"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/cne.902280310","article-title":"Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentata","volume":"228","author":"J Zimmer","year":"1984","journal-title":"Journal of Comparative Neurology"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0006-8993(98)01101-9","article-title":"Synaptic reorganization in explanted cultures of rat hippocampus","volume":"815","author":"R Gutierrez","year":"1999","journal-title":"Brain Research"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0165-3806(93)90109-N","article-title":"Time course of synaptic development in hippocampal organotypic cultures","volume":"71","author":"D Muller","year":"1993","journal-title":"Developmental Brain Research"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.devbrainres.2005.09.009","article-title":"Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development","volume":"160","author":"JG Mielke","year":"2005","journal-title":"Developmental Brain Research"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1152\/jn.2000.84.6.2918","article-title":"Synaptic connections from multiple subfields contribue to granule cell hyperexcitability in hippocampal slice cultures","volume":"84","author":"SB Bausch","year":"2000","journal-title":"Journal of Neurophysiology"},{"key":"ref115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022040","article-title":"Characterization of cortical neuronal and glial alterations during culture of organotypic whole brain slices from neonatal and mature mice","volume":"6","author":"JA Staal","year":"2011","journal-title":"PloS One"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-3806(93)90108-M","article-title":"Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures","volume":"71","author":"PA Buchs","year":"1993","journal-title":"Developmental Brain Research"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0306-4522(99)00009-3","article-title":"Patterns of spontaneous activity and morphology of interneuron types in organotypic cortex and thalamus-cortex cultures","volume":"92","author":"O Klostermann","year":"1999","journal-title":"Neuroscience"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/neu.480230702","article-title":"Formation and preservation of cortical layers in slice cultures","volume":"23","author":"M Gotz","year":"1992","journal-title":"Journal of Neurobiology"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/346359a0","article-title":"Formation of target-specific neuronal projections in organotypic slice cultures from rat visual cortex","volume":"346","author":"J Bolz","year":"1990","journal-title":"Nature"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(86)91631-8","article-title":"Influence of subcortical neurons on the functional development of cerebral neocortex in tissue culture","volume":"365","author":"AL Leiman","year":"1986","journal-title":"Brain Research"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-3806(96)00163-0","article-title":"Cocultured, but not isolated, cortical explants display normal dendritic development: a long-term quantitative study","volume":"98","author":"RE Baker","year":"1997","journal-title":"Developmental Brain Research"},{"key":"ref122","first-page":"133","article-title":"Optical imaging of neocortical dynamics","author":"BF Grewe","year":"2014"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nmeth.1453","article-title":"High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision","volume":"7","author":"BF Grewe","year":"2010","journal-title":"Nature Methods"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1152\/jn.00084.2008","article-title":"Fast and accurate detection of action potentials from somatic calcium fluctuations","volume":"100","author":"T Sasaki","year":"2008","journal-title":"Journal of Neurophysiology"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1460-9568.2010.07250.x","article-title":"Multi-array silicon probes with integrated optical fibers: light-assisted perturbation and recording of local neural circuits in the behaving animal","volume":"31","author":"S Royer","year":"2010","journal-title":"European Journal of Neuroscience"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nmeth.f.324","article-title":"Optogenetics","volume":"8","author":"K Deisseroth","year":"2011","journal-title":"Nature Methods"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00359-006-0117-6","article-title":"How silent is the brain: is there a "dark matter" problem in neuroscience?","volume":"192","author":"S Shoham","year":"2006","journal-title":"Journal of Comparative Physiology A"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T08:41:03Z","timestamp":1718527263000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004858"}},"subtitle":[],"editor":[{"given":"Jonathan W.","family":"Pillow","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,9]]},"references-count":127,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004858","relation":{},"ISSN":["1553-7358"],"issn-type":[{"type":"electronic","value":"1553-7358"}],"subject":[],"published":{"date-parts":[[2016,5,9]]}}}