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September 2015. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/hiv\/pub\/guidelines\/earlyrelease-arv\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/hiv\/pub\/guidelines\/earlyrelease-arv\/en\/<\/ext-link>."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0140-6736(08)61697-9","article-title":"Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model","volume":"373","author":"RM Granich","year":"2009","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/QAD.0b013e32834e1592","article-title":"Elimination of HIV by test and treat: a phantom of wishful thinking?","volume":"26","author":"ME 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Preliminary analyses of the predicted impacts of various vaccination strategies on the transmission of the hepatitis B virus. In: Proceedings of the conference on the control of hepatitis B: the role of prevention in adolescence. London; 1991. p. 95\u2013130."},{"key":"ref35","article-title":"Sexual health in the Netherlands","year":"2006"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/sextrans-2012-050900","article-title":"Hepatitis B vaccination of men who have sex with men in the Netherlands: should we vaccinate more men, younger men or high-risk men?","volume":"89","author":"M Xiridou","year":"2013","journal-title":"Sexually Transmitted Infections"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S0950268801006562","article-title":"Vaccination against hepatitis B in low endemic countries","volume":"128","author":"M Kretzschmar","year":"2002","journal-title":"Epidemiology & Infection"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.vaccine.2008.12.009","article-title":"Model based analysis of hepatitis B vaccination strategies in the Netherlands","volume":"27","author":"M Kretzschmar","year":"2009","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1086\/590501","article-title":"HIV-1 transmission, by stage of infection","volume":"198","author":"TD Hollingsworth","year":"2008","journal-title":"Journal of Infectious Diseases"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00007435-199605000-00015","article-title":"Sexual mixing patterns of patients attending sexually transmitted diseases clinics","volume":"23","author":"GP Garnett","year":"1996","journal-title":"Sexually Transmitted Diseases"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/360407a0","article-title":"AIDS and sexual behaviour in France","volume":"360","year":"1992","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/360410a0","article-title":"Sexual lifestyles and HIV risk","volume":"360","author":"AM Johnson","year":"1992","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0140-6736(12)60821-6","article-title":"Global epidemiology of HIV infection in men who have sex with men","volume":"380","author":"C Beyrer","year":"2012","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198545996.001.0001","article-title":"Infectious diseases of humans","author":"RM Anderson","year":"1991"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0025-5564(02)00108-6","article-title":"Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission","volume":"180","author":"P van den Driessche","year":"2002","journal-title":"Mathematical Biosciences"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1098\/rsif.2009.0386","article-title":"The construction of next-generation matrices for compartmental epidemic models","volume":"7","author":"O Diekmann","year":"2010","journal-title":"Journal of the Royal Society Interface"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1098\/rsif.2011.0131","article-title":"Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical data","volume":"9","author":"CL Althaus","year":"2012","journal-title":"Journal of the Royal Society Interface"},{"key":"ref48","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). 90\u201390\u201390\u2014An ambitious treatment target to help end the AIDS epidemic; 2014. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unaids.org\/en\/resources\/documents\/2014\/90-90-90\" xlink:type=\"simple\">http:\/\/www.unaids.org\/en\/resources\/documents\/2014\/90-90-90<\/ext-link>."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e1001801","DOI":"10.1371\/journal.pmed.1001801","article-title":"Reassessment of HIV-1 acute phase infectivity: accounting for heterogeneity and study design with simulated cohorts","volume":"12","author":"SE Bellan","year":"2015","journal-title":"PLoS Medicine"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00002030-200501030-00009","article-title":"Investigating the relationship between HIV testing and risk behaviour in Britain: National survey of sexual attitudes and lifestyles 2000","volume":"19","author":"CA McGarrigle","year":"2005","journal-title":"AIDS"},{"issue":"Suppl 1)","key":"ref51","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1086\/425286","article-title":"Reported sexually transmitted disease clinic attendance and sexually transmitted infections in Britain: prevalence, risk factors, and proportionate population burden","volume":"191","author":"KA Fenton","year":"2005","journal-title":"Journal of Infectious Diseases"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/QAD.0b013e32833433fe","article-title":"Examining the promise of HIV elimination by \u2018test and treat\u2019 in hyper-endemic settings","volume":"24","author":"PJ Dodd","year":"2010","journal-title":"AIDS"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/EDE.0b013e3181e6639f","article-title":"HIV transmission by stage of infection and pattern of sexual partnerships","volume":"21","author":"JH Kim","year":"2010","journal-title":"Epidemiology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10461-010-9787-8","article-title":"Concurrent sexual partnerships and primary HIV infection: a critical interaction","volume":"15","author":"JW Eaton","year":"2011","journal-title":"AIDS Behavior"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1007\/s10461-012-0254-6","article-title":"Is concurrency driving HIV transmission in sub-Saharan African sexual networks? 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