{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:16:07Z","timestamp":1768731367896,"version":"3.49.0"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-GM007280"],"award-info":[{"award-number":["T32-GM007280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005014","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T17:39:59Z","timestamp":1469468399000},"page":"e1005014","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes"],"prefix":"10.1371","volume":"12","author":[{"given":"Joshua","family":"Mayourian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben M.","family":"Savizky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Sobie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin D.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"issue":"6 Suppl","key":"ref1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2217\/rme.12.80","article-title":"Key developments in stem cell therapy in cardiology","volume":"7","author":"IH Schulman","year":"2012","journal-title":"Regenerative medicine"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","article-title":"Heart disease and stroke statistics\u20132014 update: a report from the american heart association","volume":"129","author":"AS Go","year":"2014","journal-title":"Circulation"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.114.303180","article-title":"Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial","volume":"114","author":"V Karantalis","year":"2014","journal-title":"Circulation research"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/ejechocard\/jep191","article-title":"Long-term effects of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: 5-year results from the randomized-controlled BOOST trial\u2013an echocardiographic study","volume":"11","author":"A Schaefer","year":"2010","journal-title":"European journal of echocardiography: the journal of the working group on echocardiography of the european society of cardiology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2013.282909","article-title":"Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial","volume":"311","author":"AW Heldman","year":"2014","journal-title":"The journal of the american medical association"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12015-012-9375-6","article-title":"Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms","volume":"9","author":"TJ Cashman","year":"2013","journal-title":"Stem cell reviews"},{"issue":"7181","key":"ref7","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nature06800","article-title":"Stem-cell therapy for cardiac disease","volume":"451","author":"VF Segers","year":"2008","journal-title":"Nature"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ccep.2015.03.012","article-title":"Arrhythmia in stem cell transplantation","volume":"7","author":"SO Almeida","year":"2015","journal-title":"Cardiac electrophysiology clinics"},{"key":"ref9","first-page":"419","article-title":"Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects","volume":"5","author":"NW Smit","year":"2014","journal-title":"Frontiers in physiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.1038\/srep12043","article-title":"Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells","volume":"5","author":"IY Shadrin","year":"2015","journal-title":"Scientific reports"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.stem.2012.02.005","article-title":"Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease","volume":"10","author":"SH Ranganath","year":"2012","journal-title":"Cell stem cell"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jacc.2005.07.055","article-title":"Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures","volume":"46","author":"SL Beeres","year":"2005","journal-title":"Journal of the american college of cardiology"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cardiores.2006.07.016","article-title":"Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling","volume":"72","author":"DA Pijnappels","year":"2006","journal-title":"Cardiovascular research"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1046\/j.1540-8167.2003.03124.x","article-title":"Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a swine model of myocardial infarction","volume":"14","author":"HN Pak","year":"2003","journal-title":"Journal of cardiovascular electrophysiology"},{"issue":"Pt 3","key":"ref15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1113\/jphysiol.2003.058719","article-title":"Human mesenchymal stem cells make cardiac connexins and form functional gap junctions","volume":"555","author":"V Valiunas","year":"2004","journal-title":"The journal of physiology"},{"issue":"15","key":"ref16","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.105.593038","article-title":"Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model","volume":"113","author":"MG Chang","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijcard.2005.07.036","article-title":"Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties","volume":"111","author":"MJ Price","year":"2006","journal-title":"International journal of cardiology"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCRESAHA.116.303614","article-title":"Use of mesenchymal stem cells for therapy of cardiac disease","volume":"116","author":"V Karantalis","year":"2015","journal-title":"Circulation research"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"H1573","DOI":"10.1152\/ajpheart.00794.2003","article-title":"A model for human ventricular tissue","volume":"286","author":"KH ten Tusscher","year":"2004","journal-title":"American journal of physiology\u2014heart and circulatory physiology"},{"issue":"23","key":"ref20","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1088\/0031-9155\/51\/23\/014","article-title":"Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions","volume":"51","author":"KH ten Tusscher","year":"2006","journal-title":"Physics in medicine and biology"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"e1002061","DOI":"10.1371\/journal.pcbi.1002061","article-title":"Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation","volume":"7","author":"T O\u2019Hara","year":"2011","journal-title":"PLoS computational biology"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1529\/biophysj.106.101410","article-title":"A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts","volume":"92","author":"KA MacCannell","year":"2007","journal-title":"Biophysical journal"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10439-007-9405-8","article-title":"Electrophysiological modeling of fibroblasts and their interaction with myocytes","volume":"36","author":"FB Sachse","year":"2008","journal-title":"Annals of biomedical engineering"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"H2040","DOI":"10.1152\/ajpheart.01298.2007","article-title":"Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model","volume":"294","author":"V Jacquemet","year":"2008","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.hrthm.2009.08.003","article-title":"Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study","volume":"6","author":"Y Xie","year":"2009","journal-title":"Heart rhythm: the official journal of the Heart Rhythm Society"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1634\/stemcells.2004-0213","article-title":"Characterization of ionic currents in human mesenchymal stem cells from bone marrow","volume":"23","author":"GR Li","year":"2005","journal-title":"Stem cells (Dayton, Ohio)"},{"issue":"Pt 3","key":"ref27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1113\/jphysiol.2003.055806","article-title":"Electrophysiological properties of human mesenchymal stem cells","volume":"554","author":"JF Heubach","year":"2004","journal-title":"The journal of physiology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4252\/wjsc.v3.i3.19","article-title":"Functional ion channels in stem cells","volume":"3","author":"GR Li","year":"2011","journal-title":"World journal of stem cells"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0143-4160(03)00069-1","article-title":"Calcium oscillations regulated by sodium-calcium exchanger and plasma membrane calcium pump induce fluctuations of membrane currents and potentials in human mesenchymal stem cells","volume":"34","author":"S Kawano","year":"2003","journal-title":"Cell calcium"},{"key":"ref30","article-title":"Spiking neuron models: Single neurons, populations, plasticity","author":"G Wolfram","year":"2002"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"e90024","DOI":"10.1371\/journal.pone.0090024","article-title":"Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain","volume":"9","author":"LC Schlichter","year":"2014","journal-title":"PloS one"},{"issue":"7083","key":"ref32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature04710","article-title":"hERG potassium channels and cardiac arrhythmia","volume":"440","author":"MC Sanguinetti","year":"2006","journal-title":"Nature"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1073\/pnas.0636603100","article-title":"Structural basis of two-stage voltage-dependent activation in K+ channels","volume":"100","author":"WR Silverman","year":"2003","journal-title":"Proceedings of the national academy of sciences of the United States of America"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S0033583506004227","article-title":"Computational biology in the study of cardiac ion channels and cell electrophysiology","volume":"39","author":"Y Rudy","year":"2006","journal-title":"Quarterly reviews of biophysics"},{"key":"ref35","article-title":"Ion channels of excitable membranes","author":"B Hille","year":"2001","journal-title":"Mass"},{"key":"ref36","article-title":"Methods in neuronal modeling: from ions to networks","author":"C Koch","year":"1998"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","article-title":"A quantitative description of membrane current and its application to conduction and excitation in nerve","volume":"117","author":"AL Hodgkin","year":"1952","journal-title":"The journal of physiology"},{"issue":"1896","key":"ref38","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1098\/rsta.2008.0283","article-title":"Mathematical models of the electrical action potential of Purkinje fibre cells","volume":"367","author":"P Stewart","year":"2009","journal-title":"Philosophical transactions A: mathematical, physical, and engineering sciences"},{"issue":"6","key":"ref39","first-page":"1061","article-title":"Sustained depolarization-induced outward current in human atrial myocytes","volume":"73","author":"Z Wang","year":"1993","journal-title":"Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents. Circulation research"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.RES.82.1.63","article-title":"Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization","volume":"82","author":"A Nygren","year":"1998","journal-title":"Circulation research"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1113\/jphysiol.1977.sp011853","article-title":"Reconstruction of the action potential of ventricular myocardial fibres","volume":"268","author":"GW Beeler","year":"1977","journal-title":"The journal of physiology"},{"key":"ref42","article-title":"Bioelectricity: A Quantitative Approach","author":"R Plonsey","year":"2007"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"e103273","DOI":"10.1371\/journal.pone.0103273","article-title":"Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 2D simulation study","volume":"9","author":"JF Gomez","year":"2014","journal-title":"PloS one"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1109\/TBME.2012.2188291","article-title":"Modulation of spiral-wave dynamics and spontaneous activity in a fibroblast\/myocyte heterocellular tissue\u2013a computational study","volume":"59","author":"A Greisas","year":"2012","journal-title":"IEEE transactions on bio-medical engineering"},{"issue":"14","key":"ref45","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.102.14.1664","article-title":"Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue","volume":"102","author":"Z Qu","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bpj.2008.10.056","article-title":"Parameter sensitivity analysis in electrophysiological models using multivariable regression","volume":"96","author":"EA Sobie","year":"2009","journal-title":"Biophysical journal"},{"issue":"9","key":"ref47","doi-asserted-by":"crossref","first-page":"e1000914","DOI":"10.1371\/journal.pcbi.1000914","article-title":"Regression analysis for constraining free parameters in electrophysiological models of cardiac cells","volume":"6","author":"AX Sarkar","year":"2010","journal-title":"PLoS computational biology"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"e1003543","DOI":"10.1371\/journal.pcbi.1003543","article-title":"Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence","volume":"10","author":"MA Cummins","year":"2014","journal-title":"PLoS computational biology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1475-925X-4-11","article-title":"Dispersion of cardiac action potential duration and the initiation of re-entry: a computational study","volume":"4","author":"RH Clayton","year":"2005","journal-title":"Biomedical engineering online"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.RES.84.11.1318","article-title":"Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties","volume":"84","author":"JM Cao","year":"1999","journal-title":"Circulation research"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1063\/1.1503941","article-title":"Stability conditions for the traveling pulse: Modifying the restitution hypothesis","volume":"12","author":"E Cytrynbaum","year":"2002","journal-title":"Chaos (Woodbury, NY)"},{"issue":"20","key":"ref52","doi-asserted-by":"crossref","first-page":"208101","DOI":"10.1103\/PhysRevLett.88.208101","article-title":"Instability and spatiotemporal dynamics of alternans in paced cardiac tissue","volume":"88","author":"B Echebarria","year":"2002","journal-title":"Physical review letters"},{"issue":"1 Pt 2","key":"ref53","first-page":"H269","article-title":"Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study","volume":"276","author":"Z Qu","year":"1999","journal-title":"The American journal of physiology"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/CIRCEP.111.000215","article-title":"Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures","volume":"6","author":"SFA Askar","year":"2013","journal-title":"Circulation Arrhythmia and electrophysiology"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.yjmcc.2012.03.008","article-title":"Excitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells","volume":"52","author":"J DeSantiago","year":"2012","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"4","key":"ref56","first-page":"H600","article-title":"Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling","volume":"304","author":"S Mureli","year":"2013","journal-title":"American journal of physiology: heart and circulatory physiology"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1369\/jhc.2008.952507","article-title":"Histopathological study of healing after allogenic mesenchymal stem cell delivery in myocardial infarction in dogs","volume":"57","author":"DC Vela","year":"2009","journal-title":"The journal of histochemistry and cytochemistry: official journal of the histochemistry society"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"685","DOI":"10.5966\/sctm.2014-0198","article-title":"Tracking fusion of human mesenchymal stem cells after transplantation to the heart","volume":"4","author":"BT Freeman","year":"2015","journal-title":"Stem cells translational medicine"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/01.CIR.67.6.1356","article-title":"Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations","volume":"67","author":"CS Kuo","year":"1983","journal-title":"Circulation"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0735-1097(02)02008-9","article-title":"Upstream stimulation versus downstream stimulation: arrhythmogenesis based on repolarization dispersion in the human heart","volume":"40","author":"F Bode","year":"2002","journal-title":"Journal of the american college of cardiology"},{"issue":"Suppl","key":"ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jelectrocard.2003.09.001","article-title":"Cellular basis for ST-segment changes observed during ischemia","volume":"36","author":"JM Di Diego","year":"2003","journal-title":"Journal of electrocardiology"},{"issue":"5","key":"ref62","first-page":"790","article-title":"Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes","volume":"76","author":"RA Bouchard","year":"1995","journal-title":"Action potential voltage-clamp measurements. Circulation research"},{"issue":"3","key":"ref63","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.RES.24.3.409","article-title":"Inotropic effects of electric currents","volume":"24","author":"EH Wood","year":"1969","journal-title":"Circulation research"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0079-6107(73)90008-4","article-title":"Excitation-contraction coupling in heart muscle: membrane control of development of tension","volume":"27","author":"M Morad","year":"1973","journal-title":"Progress in biophysics and molecular biology"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/cvr\/11.3.210","article-title":"On the relationship between action potential duration and tension in cat papillary muscle","volume":"11","author":"DG Allen","year":"1977","journal-title":"Cardiovascular research"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1748-1716.1979.tb06419.x","article-title":"Relationships between peak force, action potential duration and stimulus interval in rabbit myocardium","volume":"106","author":"B Wohlfart","year":"1979","journal-title":"Acta physiologica Scandinavica."},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0022-2828(86)80291-7","article-title":"The negative correlation between action potential duration and force of contraction during restitution in rat myocardium","volume":"18","author":"VJ Schouten","year":"1986","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"3","key":"ref68","first-page":"272","article-title":"Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy","volume":"59","author":"FS Angeli","year":"2009","journal-title":"Comparative medicine"},{"issue":"5","key":"ref69","first-page":"345","article-title":"Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether a-gogo K+ channel","volume":"7","author":"H Ouadid-Ahidouch","year":"2001","journal-title":"Receptors and channels"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1098-1136(200003)30:1<39::AID-GLIA5>3.0.CO;2-S","article-title":"Changes in ion channel expression accompany cell cycle progression of spinal cord astrocytes","volume":"30","author":"SN MacFarlane","year":"2000","journal-title":"Glia"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbrc.2004.02.041","article-title":"Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells","volume":"316","author":"H Ouadid-Ahidouch","year":"2004","journal-title":"Biochemical and biophysical research communications"},{"issue":"5","key":"ref72","doi-asserted-by":"crossref","first-page":"058101","DOI":"10.1103\/PhysRevLett.88.058101","article-title":"Spiral wave generation in heterogeneous excitable media","volume":"88","author":"G Bub","year":"2002","journal-title":"Physical review letters"},{"issue":"4","key":"ref73","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/01.RES.0000031957.70034.89","article-title":"Cardiac microstructure: implications for electrical propagation and defibrillation in the heart","volume":"91","author":"DA Hooks","year":"2002","journal-title":"Circulation research"},{"issue":"8","key":"ref74","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/CIRCRESAHA.107.153858","article-title":"Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure","volume":"101","author":"K Tanaka","year":"2007","journal-title":"Circulation research"},{"issue":"6 Pt 1","key":"ref75","doi-asserted-by":"crossref","first-page":"062902","DOI":"10.1103\/PhysRevE.68.062902","article-title":"Influence of nonexcitable cells on spiral breakup in two-dimensional and three-dimensional excitable media","volume":"68","author":"KHWJ ten Tusscher","year":"2003","journal-title":"Physical review E, Statistical, nonlinear, and soft matter physics"},{"issue":"Suppl 6","key":"ref76","doi-asserted-by":"crossref","first-page":"vi38","DOI":"10.1093\/europace\/eum206","article-title":"Influence of diffuse fibrosis on wave propagation in human ventricular tissue","volume":"9","author":"KHWJ Ten Tusscher","year":"2007","journal-title":"Europace: European pacing, arrhythmias, and cardiac electrophysiology: journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1540-8167.2005.30490.x","article-title":"Numerical simulation of paced electrogram fractionation: relating clinical observations to changes in fibrosis and action potential duration","volume":"16","author":"I Turner","year":"2005","journal-title":"Journal of cardiovascular electrophysiology"},{"issue":"12","key":"ref78","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.1432-2277.2008.00742.x","article-title":"Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure","volume":"21","author":"L Li","year":"2008","journal-title":"Transplant international: official journal of the European Society for Organ Transplantation"},{"issue":"3","key":"ref79","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijcard.2010.07.025","article-title":"Mesenchymal stem cell injection ameliorates the inducibility of ventricular arrhythmias after myocardial infarction in rats","volume":"152","author":"D Wang","year":"2011","journal-title":"International journal of cardiology"},{"issue":"5","key":"ref80","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3892\/mmr.2013.1348","article-title":"Mesenchymal stem cells overexpressing integrin-linked kinase attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions","volume":"7","author":"Q Mao","year":"2013","journal-title":"Molecular medicine reports"},{"issue":"15\u201316","key":"ref81","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1089\/ten.tea.2014.0036","article-title":"Xenotransplantation of Bone Marrow-Derived Human Mesenchymal Stem Cell Sheets Attenuates Left Ventricular Remodeling in a Porcine Ischemic Cardiomyopathy Model","volume":"21","author":"M Kawamura","year":"2015","journal-title":"Tissue engineering Part A"},{"issue":"6","key":"ref82","doi-asserted-by":"crossref","first-page":"H2332","DOI":"10.1152\/ajpheart.00747.2003","article-title":"Suppression of alternans and conduction blocks despite steep APD restitution: electrotonic, memory, and conduction velocity restitution effects","volume":"286","author":"EM Cherry","year":"2004","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"8","key":"ref83","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1161\/01.RES.0000125629.72053.95","article-title":"Role of calcium cycling versus restitution in the mechanism of repolarization alternans","volume":"94","author":"EJ Pruvot","year":"2004","journal-title":"Circulation research"},{"issue":"Suppl","key":"ref84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-0736(99)90077-8","article-title":"Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome","volume":"32","author":"W Shimizu","year":"1999","journal-title":"Journal of electrocardiology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1196\/annals.1380.029","article-title":"Modeling cardiac ischemia","volume":"1080","author":"B Rodr\u00edguez","year":"2006","journal-title":"Annals of the New York academy of sciences"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:25:40Z","timestamp":1589034340000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005014"}},"subtitle":[],"editor":[{"given":"Jeffrey J.","family":"Saucerman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":85,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005014","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]}}}