{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:10:50Z","timestamp":1768745450221,"version":"3.49.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/J00958X\/1"],"award-info":[{"award-number":["EP\/J00958X\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/14\/5\/30533"],"award-info":[{"award-number":["FS\/14\/5\/30533"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005270","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T13:52:15Z","timestamp":1488462735000},"page":"e1005270","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs: A computational study"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-0965","authenticated-orcid":true,"given":"Erick A. Perez","family":"Alday","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-8508","authenticated-orcid":true,"given":"Michael A.","family":"Colman","sequence":"additional","affiliation":[]},{"given":"Philip","family":"Langley","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-5807","authenticated-orcid":false,"given":"Henggui","family":"Zhang","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"issue":"18","key":"ref1","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.108.821306","article-title":"Atrial Fibrillation and Heart Failure Treatment Considerations for a Dual Epidemic","volume":"119","author":"E Anter","year":"2009","journal-title":"Circulation"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"EJ Benjamin","year":"1998","journal-title":"Circulation"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/01.CIR.95.5.1231","article-title":"Configuration of Unipolar Atrial Electrograms During Electrically Induced Atrial Fibrillation in Humans","volume":"95","author":"KTS Konings","year":"1997","journal-title":"Circulation"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1540-8167.2012.02332.x","article-title":"Clinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation","volume":"23","author":"SM Narayan","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"8","key":"ref5","first-page":"S2","article-title":"Mechanisms of atrial fibrillation: mother rotors or multiple daughter wavelets, or both?","volume":"9","author":"J J","year":"1998","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"19","key":"ref6","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/eurheartj\/ehm316","article-title":"European guidelines on cardiovascular disease prevention in clinical practice: executive summary","volume":"28","author":"I Graham","year":"2007","journal-title":"Eur Heart J"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrcardio.2014.118","article-title":"Global epidemiology of atrial fibrillation","volume":"11","author":"F Rahman","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"H34","DOI":"10.1016\/S1520-765X(03)90021-6","article-title":"Radiofrequency ablation for atrial fibrillation","volume":"5","author":"P Jais","year":"2003","journal-title":"Eur Heart J-Suppl"},{"issue":"21","key":"ref9","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1001\/jama.293.21.2634","article-title":"Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: a randomized trial","volume":"293","author":"OM Wazni","year":"2005","journal-title":"Jama"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"e004549","DOI":"10.1161\/JAHA.112.004549","article-title":"Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis","volume":"2","author":"AN Ganesan","year":"2013","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0002-9149(02)02350-0","article-title":"Biatrial multisite mapping of atrial premature complexes triggering onset of atrial fibrillation","volume":"89","author":"C Schmitt","year":"2002","journal-title":"Am J Cardiol"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/CIRCRESAHA.112.279315","article-title":"Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates in Humans","volume":"112","author":"Y Rudy","year":"2013","journal-title":"Circ Res"},{"issue":"20","key":"ref13","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1053\/euhj.2002.3168","article-title":"Ablation of post-surgical intra-atrial reentrant tachycardia. Predilection target sites and mapping approach","volume":"23","author":"W Ann\u00e9","year":"2002","journal-title":"Eur Heart J"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1109\/10.108129","article-title":"The use of temporal information in the regularization of the inverse problem of electrocardiography","volume":"39","author":"HS Oster","year":"1992","journal-title":"IEEE Trans Biomed Eng"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/europace\/eut393","article-title":"An electrocardiography algorithm combined with clinical features could localize the origins of focal atrial tachycardias in adjacent structures","volume":"16","author":"J-S Uhm","year":"2014","journal-title":"Europace"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1540-8159.2010.02980.x","article-title":"An algorithm to predict the site of origin of focal atrial tachycardia","volume":"34","author":"Z-Y QIAN","year":"2011","journal-title":"Pacing Clin Electrophysiol"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1109\/TBME.2011.2161305","article-title":"Correlation between P-wave morphology and origin of atrial focal tachycardia\u2014insights from realistic models of the human atria and torso","volume":"58","author":"MA Colman","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"issue":"1","key":"ref18","article-title":"A New Algorithm to Diagnose Atrial Ectopic Origin from Multi Lead ECG Systems\u2014Insights from 3D Virtual Human Atria and Torso","volume":"11","author":"EAP Alday","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"ref19","unstructured":"Perez Alday E, Colman M, Langley P, Zhang H, others. Spatial refinement of a new algorithm to identify focus of atrial ectopic activity from 64-lead ECGs. In: Computing in Cardiology Conference (CinC), 2014 [Internet]. IEEE; 2014 [cited 2015 Sep 30]. p. 501\u20134. Available from: http:\/\/ieeexplore.ieee.org\/xpls\/abs_all.jsp?arnumber=7043089<\/ext-link>"},{"key":"ref20","unstructured":"Perez Alday E, Colman MA, Butters TD, Higham J, Giacopelli D, Langley P, et al. Diagnosis of atrial ectopic origin from the body surface ECG: Insights from 3D virtual human atria and torso. In: Computing in Cardiology Conference (CinC), 2013 [Internet]. IEEE; 2013 [cited 2015 Sep 25]. p. 1075\u20138. Available from: http:\/\/ieeexplore.ieee.org\/xpls\/abs_all.jsp?arnumber=6713567<\/ext-link>"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pbiomolbio.2011.06.011","article-title":"3D virtual human atria: A computational platform for studying clinical atrial fibrillation","volume":"107","author":"OV Aslanidi","year":"2011","journal-title":"Prog Biophys Mol Biol"},{"issue":"Pt 17","key":"ref22","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1113\/jphysiol.2013.254987","article-title":"Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria","volume":"591","author":"MA Colman","year":"2013","journal-title":"J Physiol"},{"issue":"4","key":"ref23","first-page":"438","article-title":"Frequency analysis of the fibrillatory activity from surface ECG lead V1 and intracardiac recordings: implications for mapping of AF","volume":"10","author":"N-W Hsu","year":"2008","journal-title":"Eur Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1063\/1.166307","article-title":"Reentrant waves and their elimination in a model of mammalian ventricular tissue","volume":"8","author":"VN Biktashev","year":"1998","journal-title":"Chaos Woodbury N"},{"issue":"10","key":"ref25","first-page":"1524","article-title":"Effects of human atrial ionic remodelling by \u03b2-blocker therapy on mechanisms of atrial fibrillation: a computer simulation","volume":"16","author":"SR Kharche","year":"2014","journal-title":"Eur Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1109\/TBME.1980.326742","article-title":"Implementing a Consistency Criterion in Numerical Solution of the Bioelectric Forward Problem","volume":"BME-27","author":"Y Salu","year":"1980","journal-title":"IEEE Trans Biomed Eng"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1540-8159.2012.03428.x","article-title":"Spatial pattern of P waves in paroxysmal atrial fibrillation patients in sinus rhythm and controls","volume":"35","author":"D Giacopelli","year":"2012","journal-title":"Pacing Clin Electrophysiol PACE"},{"issue":"10 Suppl","key":"ref28","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1046\/j.1540.8167.90305.x","article-title":"Frequency measures obtained from the surface electrocardiogram in atrial fibrillation research and clinical decision-making","volume":"14","author":"A Bollmann","year":"2003","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.hrthm.2007.04.021","article-title":"Automated detection and characterization of complex fractionated atrial electrograms in human left atrium during atrial fibrillation","volume":"4","author":"D Scherr","year":"2007","journal-title":"Heart Rhythm"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.hrthm.2013.09.007","article-title":"Localized rotational activation in the left atrium during human atrial fibrillation: relationship to complex fractionated atrial electrograms and low-voltage zones","volume":"10","author":"B Ghoraani","year":"2013","journal-title":"Heart Rhythm"},{"issue":"3","key":"ref31","article-title":"Non-Invasive Estimation Of Left Atrial Dominant Frequency In Atrial Fibrillation From Different Electrode Sites: Insight From Body Surface Potential Mapping","volume":"7","author":"M Bojarnejad","year":"2014","journal-title":"JAFIB J Atr Fibrillation"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.hrthm.2014.05.013","article-title":"Body surface localization of left and right atrial high-frequency rotors in atrial fibrillation patients: A clinical-computational study","volume":"11","author":"M Rodrigo","year":"2014","journal-title":"Heart Rhythm"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/europace\/eut376","article-title":"Computational mapping in atrial fibrillation: how the integration of signal-derived maps may guide the localization of critical sources","volume":"16","author":"F Ravelli","year":"2014","journal-title":"Europace"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1540-8167.2012.02335.x","article-title":"Stability of complex fractionated atrial electrograms: a systematic review","volume":"23","author":"DH Lau","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1540-8167.2007.01034.x","article-title":"The effect of electrogram duration on quantification of complex fractionated atrial electrograms and dominant frequency","volume":"19","author":"MK Stiles","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.jacc.2005.01.042","article-title":"Focal Atrial Tachycardia From the Ostium of the Coronary Sinus","volume":"45","author":"PM Kistler","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1540-8167.2008.01356.x","article-title":"Noninvasive mapping of human atrial fibrillation","volume":"20","author":"MS Guillem","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref38","article-title":"Hands-on Ablation: The Experts\u2019 Approach","author":"A Al-ahmad","year":"2013"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/eurheartj\/ehi834","article-title":"Radiofrequency ablation of arrhythmias guided by non-fluoroscopic catheter location: a prospective randomized trial","volume":"27","author":"MJ Earley","year":"2006","journal-title":"Eur Heart J"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T13:17:52Z","timestamp":1540300672000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005270"}},"subtitle":[],"editor":[{"given":"Alexander V","family":"Panfilov","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005270","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}