{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:58:24Z","timestamp":1772171904421,"version":"3.50.1"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","award":["ASTF 285-2015"],"award-info":[{"award-number":["ASTF 285-2015"]}],"id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005297","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T13:25:02Z","timestamp":1484054702000},"page":"e1005297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Systematic Analysis of Transcriptional and Post-transcriptional Regulation of Metabolism in Yeast"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9967-5205","authenticated-orcid":true,"given":"Emanuel","family":"Gon\u00e7alves","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-699X","authenticated-orcid":false,"given":"Zrinka","family":"Raguz Nakic","sequence":"additional","affiliation":[]},{"given":"Mattia","family":"Zampieri","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-0431","authenticated-orcid":true,"given":"Omar","family":"Wagih","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-278X","authenticated-orcid":true,"given":"David","family":"Ochoa","sequence":"additional","affiliation":[]},{"given":"Uwe","family":"Sauer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-7703","authenticated-orcid":false,"given":"Pedro","family":"Beltrao","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-8976","authenticated-orcid":true,"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrmicro3238","article-title":"Coordination of microbial metabolism","volume":"12","author":"V Chubukov","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nbt1492","article-title":"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology","volume":"26","author":"MJ Herrg\u00e5rd","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"15753","DOI":"10.1073\/pnas.0707476104","article-title":"The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels","volume":"104","author":"P Daran-Lapujade","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","first-page":"rs4","article-title":"Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast","volume":"3","author":"B Bodenmiller","year":"2010","journal-title":"Sci Signal. AAAS"},{"key":"ref5","first-page":"740","article-title":"Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors","volume":"157","author":"P Kemmeren","year":"2014","journal-title":"Cell. Elsevier Inc."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"rs6","DOI":"10.1126\/scisignal.2005602","article-title":"Large-scale functional analysis of the roles of phosphorylation in yeast metabolic pathways","volume":"7","author":"JC Schulz","year":"2014","journal-title":"Sci Signal. AAAS"},{"key":"ref7","article-title":"Regulation of yeast central metabolism by enzyme phosphorylation","volume":"8","author":"AP Oliveira","year":"2012","journal-title":"Mol Syst Biol. Nature Publishing Group"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1003572","DOI":"10.1371\/journal.pcbi.1003572","article-title":"Contribution of network connectivity in determining the relationship between gene expression and metabolite concentration changes","volume":"10","author":"A Zelezniak","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1073\/pnas.0406811102","article-title":"Uncovering transcriptional regulation of metabolism by using metabolic network topology","volume":"102","author":"KR Patil","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cels.2015.09.008","article-title":"Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data","volume":"1","author":"L Gerosa","year":"2015","journal-title":"Cell Systems. Elsevier"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"802","DOI":"10.15252\/msb.20145475","article-title":"Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome","volume":"11","author":"AP Oliveira","year":"2015","journal-title":"Mol Syst Biol. EMBO Press"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"rs4","DOI":"10.1126\/scisignal.2005768","article-title":"Dynamic phosphoproteomics reveals TORC1-dependent regulation of yeast nucleotide and amino acid biosynthesis","volume":"8","author":"AP Oliveira","year":"2015","journal-title":"Sci Signal. AAAS"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1074\/jbc.M309578200","article-title":"Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study","volume":"279","author":"P Daran-Lapujade","year":"2004","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e1003580","DOI":"10.1371\/journal.pcbi.1003580","article-title":"Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism","volume":"10","author":"D Machado","year":"2014","journal-title":"PLoS Comput Biol. Public Library of Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.celrep.2014.07.021","article-title":"Reconstruction of insulin signal flow from phosphoproteome and metabolome data","volume":"8","author":"K Yugi","year":"2014","journal-title":"Cell Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1101\/gr.136838.111","article-title":"Understanding transcriptional regulation by integrative analysis of transcription factor binding data","volume":"22","author":"C Cheng","year":"2012","journal-title":"Genome Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"i401","DOI":"10.1093\/bioinformatics\/btu446","article-title":"Estimating the activity of transcription factors by the effect on their target genes","volume":"30","author":"T Schacht","year":"2014","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"rs6","DOI":"10.1126\/scisignal.2003573","article-title":"Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells","volume":"6","author":"P Casado","year":"2013","journal-title":"Sci Signal"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/bioinformatics\/btv699","article-title":"IKAP: A heuristic framework for inference of kinase activities from Phosphoproteomics data","volume":"32","author":"M Mischnik","year":"2016","journal-title":"Bioinformatics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1534\/genetics.111.133629","article-title":"The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development","volume":"189","author":"S Br\u00fcckner","year":"2011","journal-title":"Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1534\/genetics.112.140863","article-title":"Response to hyperosmotic stress","volume":"192","author":"H Saito","year":"2012","journal-title":"Genetics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"767","DOI":"10.15252\/msb.20145112","article-title":"Phosphoproteomic analyses reveal novel cross-modulation mechanisms between two signaling pathways in yeast","volume":"10","author":"S Vaga","year":"2014","journal-title":"Mol Syst Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molcel.2005.06.005","article-title":"The Protein Kinase Kin4 Inhibits Exit from Mitosis in Response to Spindle Position Defects","volume":"19","author":"KE D\u2019Aquino","year":"2005","journal-title":"Mol Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1021\/ac100101d","article-title":"Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites","volume":"82","author":"JM Buescher","year":"2010","journal-title":"Anal Chem. American Chemical Society"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1021\/ac201267k","article-title":"High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection\u2013Time-of-Flight Mass Spectrometry","volume":"83","author":"T Fuhrer","year":"2011","journal-title":"Anal Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1752-0509-3-37","article-title":"Connecting extracellular metabolomic measurements to intracellular flux states in yeast","volume":"3","author":"ML Mo","year":"2009","journal-title":"BMC Syst Biol. BioMed Central Ltd"},{"key":"ref27","article-title":"Metabolite concentrations, fluxes and free energies imply efficient enzyme usage","author":"JO Park","year":"2016","journal-title":"Nat Chem Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.celrep.2015.01.052","article-title":"A cell-signaling network temporally resolves specific versus promiscuous phosphorylation","volume":"10","author":"E Kanshin","year":"2015","journal-title":"Cell Rep"},{"key":"ref29","article-title":"Oscillatory stress stimulation uncovers an Achilles\u2019 heel of the yeast MAPK signaling network","author":"A Mitchell","year":"2015","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1128\/MMBR.66.2.300-372.2002","article-title":"Osmotic stress signaling and osmoadaptation in yeasts","volume":"66","author":"S Hohmann","year":"2002","journal-title":"Microbiol Mol Biol Rev. Am Soc Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"130008","DOI":"10.1098\/rsob.130008","article-title":"Mate and fuse: how yeast cells do it","volume":"3","author":"L Merlini","year":"2013","journal-title":"Open Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.peptides.2004.10.002","article-title":"A walk-through of the yeast mating pheromone response pathway","volume":"26","author":"L Bardwell","year":"2005","journal-title":"Peptides"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2012.05.036","article-title":"Systematic functional prioritization of protein posttranslational modifications","volume":"150","author":"P Beltrao","year":"2012","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"bat026","DOI":"10.1093\/database\/bat026","article-title":"The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update","volume":"2013","author":"I Sadowski","year":"2013","journal-title":"Database"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"888","DOI":"10.15252\/msb.20167295","article-title":"An atlas of human kinase regulation","volume":"12","author":"D Ochoa","year":"2016","journal-title":"Mol Syst Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/45287","article-title":"The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors","volume":"402","author":"T Beck","year":"1999","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1093\/emboj\/17.23.6924","article-title":"The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease","volume":"17","author":"A Schmidt","year":"1998","journal-title":"EMBO J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S1097-2765(03)00485-4","article-title":"TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0","volume":"12","author":"I Pedruzzi","year":"2003","journal-title":"Mol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cell.2004.11.047","article-title":"TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1","volume":"119","author":"DE Martin","year":"2004","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"732","DOI":"10.15252\/msb.20145172","article-title":"Cell cycle population effects in perturbation studies","volume":"10","author":"E O\u2019Duibhir","year":"2014","journal-title":"Mol Syst Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1091\/mbc.E07-08-0779","article-title":"Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast","volume":"19","author":"MJ Brauer","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1128\/MCB.8.7.2690","article-title":"LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence","volume":"8","author":"P Friden","year":"1988","journal-title":"Mol Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s004380000347","article-title":"Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2","volume":"264","author":"PS Nielsen","year":"2001","journal-title":"Mol Gen Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2016.09.007","article-title":"Functional Metabolomics Describes the Yeast Biosynthetic Regulome","volume":"167","author":"M M\u00fclleder","year":"2016","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1128\/MCB.20.3.892-899.2000","article-title":"The regulator of the yeast proline utilization pathway is differentially phosphorylated in response to the quality of the nitrogen source","volume":"20","author":"HL Huang","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/MCB.11.1.564","article-title":"Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo","volume":"11","author":"JD Axelrod","year":"1991","journal-title":"Mol Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1128\/MCB.9.11.4706","article-title":"The Saccharomyces cerevisiae PUT3 activator protein associates with proline-specific upstream activation sequences","volume":"9","author":"AH Siddiqui","year":"1989","journal-title":"Mol Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"D470","DOI":"10.1093\/nar\/gku1204","article-title":"The BioGRID interaction database: 2015 update","volume":"43","author":"A Chatr-Aryamontri","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot088880","article-title":"Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions","volume":"2016","author":"R Oughtred","year":"2016","journal-title":"Cold Spring Harb Protoc"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.top080754","article-title":"BioGRID: A Resource for Studying Biological Interactions in Yeast","volume":"2016","author":"R Oughtred","year":"2016","journal-title":"Cold Spring Harb Protoc"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8\u2014a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"LJ Jensen","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1534\/genetics.114.168252","article-title":"Global regulation of a differentiation MAPK pathway in yeast","volume":"198","author":"CA Chavel","year":"2014","journal-title":"Genetics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/1574-6976.12065","article-title":"Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae","volume":"38","author":"M Conrad","year":"2014","journal-title":"FEMS Microbiol Rev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1534\/genetics.111.135731","article-title":"Nutritional control of growth and development in yeast","volume":"192","author":"JR Broach","year":"2012","journal-title":"Genetics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1747-1028-1-3","article-title":"Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae","volume":"1","author":"E Swinnen","year":"2006","journal-title":"Cell Div"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1101\/gr.3672305","article-title":"The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species","volume":"15","author":"KP Byrne","year":"2005","journal-title":"Genome Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"D142","DOI":"10.1093\/nar\/gkt997","article-title":"JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles","volume":"42","author":"A Mathelier","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrg1315","article-title":"Applied bioinformatics for the identification of regulatory elements","volume":"5","author":"WW Wasserman","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ng2012","article-title":"Genetic reconstruction of a functional transcriptional regulatory network","volume":"39","author":"Z Hu","year":"2007","journal-title":"Nat Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"12045","DOI":"10.1073\/pnas.0605140103","article-title":"Identifying transcription factor functions and targets by phenotypic activation","volume":"103","author":"G Chua","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature02800","article-title":"Transcriptional regulatory code of a eukaryotic genome","volume":"431","author":"CT Harbison","year":"2004","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.cell.2011.11.013","article-title":"Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution","volume":"147","author":"HS Rhee","year":"2011","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1128\/MCB.25.6.2138-2146.2005","article-title":"Combined global localization analysis and transcriptome data identify genes that are directly coregulated by Adr1 and Cat8","volume":"25","author":"C Tachibana","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.molcel.2011.01.015","article-title":"A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces","volume":"41","author":"BJ Venters","year":"2011","journal-title":"Mol Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"D311","DOI":"10.1093\/nar\/gkh033","article-title":"Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms","volume":"32","author":"KR Christie","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref67","first-page":"2825","article-title":"Scikit-learn: Machine Learning in Python","volume":"12","author":"F Pedregosa","year":"2011","journal-title":"J Mach Learn Res. JMLR.org"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1109\/MCSE.2007.55","article-title":"Matplotlib: A 2D Graphics Environment","volume":"9","author":"JD Hunter","year":"2007","journal-title":"Computing in Science Engineering. AIP Publishing"},{"key":"ref69","unstructured":"Waskom M, Botvinnik O, Hobson P, Cole JB, Halchenko Y, Hoyer S, et al. seaborn: v0.5.0 (November 2014) [Internet]. ZENODO; 2014."}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T15:33:13Z","timestamp":1539963193000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005297"}},"subtitle":[],"editor":[{"given":"Kiran Raosaheb","family":"Patil","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,1,10]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005297","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/057398","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,10]]}}}