{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:53:42Z","timestamp":1768820022958,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005320","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000}}],"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000086","name":"Directorate for Mathematical and Physical Sciences","doi-asserted-by":"publisher","award":["DMS1562078"],"award-info":[{"award-number":["DMS1562078"]}],"id":[{"id":"10.13039\/100000086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM107264"],"award-info":[{"award-number":["R01GM107264"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P50GM76516"],"award-info":[{"award-number":["P50GM76516"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000086","name":"Directorate for Mathematical and Physical Sciences","doi-asserted-by":"publisher","award":["DMS1562176"],"award-info":[{"award-number":["DMS1562176"]}],"id":[{"id":"10.13039\/100000086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005320","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T19:25:42Z","timestamp":1485199542000},"page":"e1005320","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst"],"prefix":"10.1371","volume":"13","author":[{"given":"William R.","family":"Holmes","sequence":"first","affiliation":[]},{"given":"Nabora Soledad","family":"Reyes de Mochel","sequence":"additional","affiliation":[]},{"given":"Qixuan","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Huijing","family":"Du","sequence":"additional","affiliation":[]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Chiang","sequence":"additional","affiliation":[]},{"given":"Olivier","family":"Cinquin","sequence":"additional","affiliation":[]},{"given":"Ken","family":"Cho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-3368","authenticated-orcid":true,"given":"Qing","family":"Nie","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"H.B. Wang","year":"2006","journal-title":"Nature Reviews Genetics"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1242\/dev.017178","article-title":"Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse","volume":"136","author":"J. Rossant","year":"2009","journal-title":"Development"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1242\/dev.128.6.839","article-title":"Specification of embryonic axes begins before cleavage in normal mouse development","volume":"128","author":"R.L. Gardner","year":"2001","journal-title":"Development"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.mod.2004.11.014","article-title":"Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo","volume":"122","author":"K. Piotrowska-Nitsche","year":"2005","journal-title":"Mechanisms of Development"},{"issue":"19","key":"ref5","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1101\/gad.486108","article-title":"Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo","volume":"22","author":"A. Jedrusik","year":"2008","journal-title":"Genes Dev"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0092-8674(81)90502-X","article-title":"The foundation of two distinct cell lineages within the mouse morula","volume":"24","author":"M.H. Johnson","year":"1981","journal-title":"Cell"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0092-8674(03)00392-1","article-title":"Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells","volume":"113","author":"I. Chambers","year":"2003","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/msb.2012.65","article-title":"An Oct4-Sall4-Nanog network controls developmental progression in the pre-implantation mouse embryo","volume":"9","author":"M.H. Tan","year":"2013","journal-title":"Mol Syst Biol"},{"issue":"23","key":"ref9","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1242\/dev.003798","article-title":"Stochastic patterning in the mouse pre-implantation embryo","volume":"134","author":"J.E. Dietrich","year":"2007","journal-title":"Development"},{"issue":"6819","key":"ref10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/35054069","article-title":"Role for sperm in spatial patterning of the early mouse embryo","volume":"409","author":"K. Piotrowska","year":"2001","journal-title":"Nature"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1242\/dev.00725","article-title":"Analysis of cell lineage in two- and four-cell mouse embryos","volume":"130","author":"T. Fujimori","year":"2003","journal-title":"Development"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2016.01.047","article-title":"Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.","volume":"165","author":"M. Goolam","year":"2016","journal-title":"Cell"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cell.2016.02.032","article-title":"Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo","volume":"165","author":"M.D. White","year":"2016","journal-title":"Cell"},{"issue":"20","key":"ref14","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1242\/dev.123950","article-title":"Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq","volume":"142","author":"J. Shi","year":"2015","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-59745-471-1_15","article-title":"Aggregation chimeras: combining ES cells, diploid, and tetraploid embryos","volume":"530","author":"M. Tanaka","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"4695","key":"ref16","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/1841286a0","article-title":"Experiments on the Development of Isolated Blastomeres of Mouse Eggs","volume":"184","author":"A.K. Tarkowski","year":"1959","journal-title":"Nature"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jez.1401570210","article-title":"Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (T12\/T12)-Normal Mosaics","volume":"157","author":"B. Mintz","year":"1964","journal-title":"Journal of Experimental Zoology"},{"issue":"3807","key":"ref18","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.158.3807.1484","article-title":"Intrinsic Immunological Tolerance in Allophenic Mice","volume":"158","author":"B. Mintz","year":"1967","journal-title":"Science"},{"issue":"477","key":"ref19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/190857a0","article-title":"Mouse Chimaeras Developed from Fused Eggs","volume":"190","author":"A.K. Tarkowski","year":"1961","journal-title":"Nature"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.014316","article-title":"Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric\/asymmetric divisions","volume":"135","author":"M. Bischoff","year":"2008","journal-title":"Development"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1242\/dev.103267","article-title":"Limited predictive value of blastomere angle of division in trophectoderm and inner cell mass specification","volume":"141","author":"T. Watanabe","year":"2014","journal-title":"Development"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/dvg.22049","article-title":"Generation and live imaging of an endogenous Cdx2 reporter mouse line","volume":"50","author":"K. McDole","year":"2012","journal-title":"Genesis"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cub.2012.10.054","article-title":"Developmental bias in cleavage-stage mouse blastomeres","volume":"23","author":"I. Tabansky","year":"2013","journal-title":"Curr Biol"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/bdrc.20038","article-title":"The case for prepatterning in the mouse","volume":"75","author":"R.L. Gardner","year":"2005","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.celrep.2013.01.006","article-title":"Asymmetric localization of Cdx2 mRNA during the first cell-fate decision in early mouse development","volume":"3","author":"M. Skamagki","year":"2013","journal-title":"Cell Rep"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ncb2154","article-title":"Oct4 kinetics predict cell lineage patterning in the early mammalian embryo","volume":"13","author":"N. Plachta","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"21","key":"ref27","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1242\/dev.086025","article-title":"Maternal Cdx2 is dispensable for mouse development","volume":"139","author":"S. Blij","year":"2012","journal-title":"Development"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.devcel.2013.05.004","article-title":"Oct4 Cell-Autonomously Promotes Primitive Endoderm Development in the Mouse Blastocyst","volume":"25","author":"T. Frum","year":"2013","journal-title":"Developmental Cell"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)81769-9","article-title":"Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4","volume":"95","author":"J. Nichols","year":"1998","journal-title":"Cell"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0012-1606(83)90019-2","article-title":"Cell interactions influence the fate of mouse blastomeres undergoing the transition from the 16- to the 32-cell stage","volume":"95","author":"M.H. Johnson","year":"1983","journal-title":"Dev Biol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0012-1606(80)90395-4","article-title":"Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives","volume":"76","author":"J. Rossant","year":"1980","journal-title":"Dev Biol"},{"issue":"Pt 3","key":"ref32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/jcs.01666","article-title":"Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo","volume":"118","author":"B. Plusa","year":"2005","journal-title":"J Cell Sci"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jez.1402030315","article-title":"Trophoblast Regeneration by Inner Cell Masses Isolated from Cultured Mouse Embryos","volume":"203","author":"A.I. Spindle","year":"1978","journal-title":"Journal of Experimental Zoology"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0012-1606(79)90022-8","article-title":"Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivo","volume":"70","author":"J. Rossant","year":"1979","journal-title":"Dev Biol"},{"issue":"19","key":"ref35","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1073\/pnas.1201595109","article-title":"Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment","volume":"109","author":"P. Home","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass","volume":"16","author":"N. Nishioka","year":"2009","journal-title":"Dev Cell"},{"issue":"3\u20134","key":"ref37","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.mod.2007.11.002","article-title":"Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos","volume":"125","author":"N. Nishioka","year":"2008","journal-title":"Mechanisms of Development"},{"issue":"13","key":"ref38","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.cub.2013.05.014","article-title":"Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos","volume":"23","author":"Y. Hirate","year":"2013","journal-title":"Current Biology"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1242\/dev.014555","article-title":"Computer simulation of emerging asymmetry in the mouse blastocyst","volume":"135","author":"H. Honda","year":"2008","journal-title":"Development"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003478","article-title":"A Computational Model for Understanding Stem Cell, Trophectoderm and Endoderm Lineage Determination","volume":"3","author":"V. Chickarmane","year":"2008","journal-title":"Plos One"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1371\/journal.pcbi.0020123","article-title":"Transcriptional dynamics of the embryonic stem cell switch","volume":"2","author":"V. Chickarmane","year":"2006","journal-title":"Plos Computational Biology"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"e1001128","DOI":"10.1371\/journal.pcbi.1001128","article-title":"Simulating the mammalian blastocyst\u2014molecular and mechanical interactions pattern the embryo","volume":"7","author":"P. Krupinski","year":"2011","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ng1807","article-title":"Noise in protein expression scales with natural protein abundance","volume":"38","author":"A. Bar-Even","year":"2006","journal-title":"Nature Genetics"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1021\/sb400044g","article-title":"Noise Attenuation in the ON and OFF States of Biological Switches","volume":"2","author":"M. Chen","year":"2013","journal-title":"Acs Synthetic Biology"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2013.09.060","article-title":"Feedback Control of Gene Expression Variability in the Caenorhabditis elegans Wnt Pathway","volume":"155","author":"N. Ji","year":"2013","journal-title":"Cell"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.70.051916","article-title":"Many-body theory of chemotactic cell-cell interactions","volume":"70","author":"T.J. Newman","year":"2004","journal-title":"Physical Review E"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3934\/mbe.2005.2.613","article-title":"Modeling Multicellular Systems Using Subcellular Elements","volume":"2","author":"T.J. Newman","year":"2005","journal-title":"Mathematical Biosciences and Engineering"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0070-2153(07)81005-2","article-title":"Grid-Free Models of Multicellular Systems, with an Application to Large-Scale Vortices Accompanying Primitive Streak Formation","volume":"81","author":"T.J. Newman","year":"2008","journal-title":"Current Topics in Developmental Biology"},{"issue":"99","key":"ref49","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2014.0631","article-title":"Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation","volume":"11","author":"A. Gord","year":"2014","journal-title":"Journal of the Royal Society Interface"},{"issue":"21","key":"ref50","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1101\/gad.1831909","article-title":"Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells","volume":"23","author":"P. Yuan","year":"2009","journal-title":"Genes Dev"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1242\/dev.01801","article-title":"Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst","volume":"132","author":"D. Strumpf","year":"2005","journal-title":"Development"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ydbio.2007.10.054","article-title":"Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo","volume":"313","author":"A. Ralston","year":"2008","journal-title":"Dev Biol"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1242\/dev.038828","article-title":"Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2","volume":"137","author":"A. Ralston","year":"2010","journal-title":"Development"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cell.2005.08.040","article-title":"Interaction between Oct3\/4 and Cdx2 determines trophectoderm differentiation","volume":"123","author":"H. Niwa","year":"2005","journal-title":"Cell"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2005.08.020","article-title":"Core transcriptional regulatory circuitry in human embryonic stem cells","volume":"122","author":"L.A. Boyer","year":"2005","journal-title":"Cell"},{"key":"ref56","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3251","article-title":"Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms","volume":"4","author":"C.Y. Leung","year":"2013","journal-title":"Nature Communications"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2010.11.012","article-title":"The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-beta-SMAD Pathway","volume":"19","author":"X. Varelas","year":"2010","journal-title":"Developmental Cell"},{"issue":"9","key":"ref58","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/cr.2009.79","article-title":"Cross-regulation of the Nanog and Cdx2 promoters","volume":"19","author":"L. Chen","year":"2009","journal-title":"Cell Res"},{"issue":"18","key":"ref59","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1111\/j.1742-4658.2012.08623.x","article-title":"The regulatory circuits for hysteretic switching in cellular signal transduction pathways","volume":"279","author":"J.R. Kim","year":"2012","journal-title":"Febs Journal"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1063\/1.481811","article-title":"The chemical Langevin equation","volume":"113","author":"D.T. Gillespie","year":"2000","journal-title":"Journal of Chemical Physics"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.devcel.2015.07.004","article-title":"Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo","volume":"34","author":"C.R. Samarage","year":"2015","journal-title":"Dev Cell"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.stem.2008.07.027","article-title":"Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States","volume":"3","author":"K. Hayashi","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"78","key":"ref63","doi-asserted-by":"crossref","first-page":"20120525","DOI":"10.1098\/rsif.2012.0525","article-title":"Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations","volume":"10","author":"Y. Luo","year":"2013","journal-title":"Journal of the Royal Society Interface"},{"key":"ref64","doi-asserted-by":"crossref","DOI":"10.1038\/msb.2012.45","article-title":"Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain","volume":"8","author":"L. Zhang","year":"2012","journal-title":"Molecular Systems Biology"},{"issue":"10","key":"ref65","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nrm2766","article-title":"Systems biology of stem cell fate and cellular reprogramming","volume":"10","author":"B.D. Macarthur","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.devcel.2010.02.012","article-title":"Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst","volume":"18","author":"G. Guo","year":"2010","journal-title":"Dev Cell"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1073\/pnas.92.3.855","article-title":"A Targeted Mutation in the Mouse E-Cadherin Gene Results in Defective Preimplantation Development","volume":"92","author":"D. Riethmacher","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(83)90095-8","article-title":"The Calcium-Dependent Cell-Cell Adhesion System Regulates Inner Cell Mass Formation and Cell-Surface Polarization in Early Mouse Development","volume":"35","author":"Y. Shirayoshi","year":"1983","journal-title":"Cell"},{"issue":"5","key":"ref69","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/bies.200800189","article-title":"Reprogramming cell fates: reconciling rarity with robustness","volume":"31","author":"S. Huang","year":"2009","journal-title":"Bioessays"},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ydbio.2007.02.036","article-title":"Bifurcation dynamics in lineage-commitment in bipotent progenitor cells","volume":"305","author":"S. Huang","year":"2007","journal-title":"Developmental Biology"},{"issue":"20","key":"ref71","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1242\/dev.050195","article-title":"Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin","volume":"137","author":"R.O. Stephenson","year":"2010","journal-title":"Development"},{"issue":"14","key":"ref72","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1242\/dev.107276","article-title":"Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo","volume":"141","author":"S. Anani","year":"2014","journal-title":"Development"},{"issue":"12","key":"ref73","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/ncb2875","article-title":"Cadherin-dependent filopodia control preimplantation embryo compaction","volume":"15","author":"J.C. Fierro-Gonzalez","year":"2013","journal-title":"Nat Cell Biol"},{"issue":"7616","key":"ref74","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature18958","article-title":"Asymmetric division of contractile domains couples cell positioning and fate specification","volume":"536","author":"J.L. Maitre","year":"2016","journal-title":"Nature"},{"issue":"7","key":"ref75","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.cell.2006.12.011","article-title":"Keeping the noise down in ES cells","volume":"127","author":"T.P. Zwaka","year":"2006","journal-title":"Cell"},{"issue":"7","key":"ref76","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.cell.2006.10.045","article-title":"The proteasome restricts permissive transcription at tissue-specific gene loci in embryonic stem cells","volume":"127","author":"H. Szutorisz","year":"2006","journal-title":"Cell"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1399-0004.2005.00478.x","article-title":"Genetic regulation of stem cell origins in the mouse embryo","volume":"68","author":"A. Ralston","year":"2005","journal-title":"Clinical Genetics"},{"issue":"5","key":"ref78","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1365-2184.2008.00542.x","article-title":"Identification of osteo-adipo progenitor cells in fat tissue","volume":"41","author":"Y.F. Lin","year":"2008","journal-title":"Cell Proliferation"},{"issue":"11","key":"ref79","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/ncb2603","article-title":"Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity","volume":"14","author":"B.D. MacArthur","year":"2012","journal-title":"Nature Cell Biology"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.celrep.2014.05.053","article-title":"Transcription Factors Modulate c-Fos Transcriptional Bursts","volume":"8","author":"A. Senecal","year":"2014","journal-title":"Cell Rep"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005320","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T15:40:31Z","timestamp":1658504431000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005320"}},"subtitle":[],"editor":[{"given":"Santiago","family":"Schnell","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005320","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1005320","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}