{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:43:03Z","timestamp":1774366983261,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC IVC ESCT 5337 2012"],"award-info":[{"award-number":["PTDC IVC ESCT 5337 2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["DFRH WIIA 60 2011"],"award-info":[{"award-number":["DFRH WIIA 60 2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Curie Actions","award":["DFRH WIIA 60 2011"],"award-info":[{"award-number":["DFRH WIIA 60 2011"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005330","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T13:36:41Z","timestamp":1486129001000},"page":"e1005330","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Early and Real-Time Detection of Seasonal Influenza Onset"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-7452","authenticated-orcid":true,"given":"Miguel","family":"Won","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Marques-Pita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-0362","authenticated-orcid":false,"given":"Carlota","family":"Louro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6654-2126","authenticated-orcid":true,"given":"Joana","family":"Gon\u00e7alves-S\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"ref1","unstructured":"WHO. Influenza (Seasonal) Fact Sheet N\u00b0 211. Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/fs211\/en\/<\/ext-link> [cited 17 February 2016]"},{"issue":"7","key":"ref2","first-page":"761","article-title":"Excess pneumonia and influenza associated hospitalization during influenza epidemics in the United States, 1970-78","volume":"76","author":"WILLIAM H Barker","year":"1986","journal-title":"Journal of Public Health"},{"issue":"27","key":"ref3","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1016\/j.vaccine.2007.03.046","article-title":"The annual impact of seasonal influenza in the US: measuring disease burden and costs","volume":"25","author":"Noelle-Angelique M. Molinari","year":"2007","journal-title":"Vaccine"},{"key":"ref4","unstructured":"ECDC. European Influenza Surveillance Network (EISN). Available from: http:\/\/ecdc.europa.eu\/en\/healthtopics\/influenza\/EISN\/Pages\/index.aspx<\/ext-link> [cited 17 February 2016]."},{"key":"ref5","unstructured":"ECDC. Sentinel surveillance. Available from: http:\/\/ecdc.europa.eu\/en\/healthtopics\/influenza\/surveillance\/Pages\/sentinel_surveillance.aspx<\/ext-link> [cited 17 February 2016]."},{"key":"ref6","unstructured":"Influenzanet. Available from: http:\/\/www.influenzanet.eu\/<\/ext-link>[cited 17 February 2016]."},{"issue":"7232","key":"ref7","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/nature07634","article-title":"Detecting influenza epidemics using search engine query data","volume":"457","author":"J Ginsberg","year":"2009","journal-title":"Nature"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"e1004239","DOI":"10.1371\/journal.pcbi.1004239","article-title":"Forecasting the 2013\u20132014 Influenza Season Using Wikipedia","volume":"11","author":"KS Hickmann","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"10","key":"ref9","article-title":"Combining Search, Social Media, and Traditional Data Sources to Improve Influenza Surveillance","volume":"11","author":"Mauricio Santillana","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"e94130","DOI":"10.1371\/journal.pone.0094130","article-title":"Influenza Forecasting in Human Populations: A Scoping Review","volume":"9","author":"JP Chretien","year":"2014","journal-title":"PLoS ONE"},{"key":"ref11","unstructured":"ECDC. Factsheet for the general public. Available from: http:\/\/ecdc.europa.eu\/en\/healthtopics\/seasonal_influenza\/basic_facts\/pages\/factsheet_general_public.aspx<\/ext-link> [cited 27 October 2016]."},{"issue":"50","key":"ref12","doi-asserted-by":"crossref","first-page":"20425","DOI":"10.1073\/pnas.1208772109","article-title":"Forecasting seasonal outbreaks of influenza","volume":"109","author":"Jeffrey Shaman","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"26","key":"ref13","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1002\/sim.4336","article-title":"A statistical model for hospital admissions caused by seasonal diseases","volume":"30","author":"David Mori\u00f1a","year":"2011","journal-title":"Statistics in medicine"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jtbi.2009.02.017","article-title":"Variational data assimilation with epidemic models","volume":"258","author":"C. J. Rhodes","year":"2009","journal-title":"Journal of theoretical biology"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1472-6947-12-112","article-title":"Sequential detection of influenza epidemics by the Kolmogorov-Smirnov test","volume":"12","author":"Pau Closas","year":"2012","journal-title":"BMC medical informatics and decision making"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/ije\/dyl162","article-title":"Methods for monitoring influenza surveillance data","volume":"35","author":"Benjamin J. Cowling","year":"2006","journal-title":"International journal of epidemiology"},{"issue":"22","key":"ref17","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1002\/sim.3320","article-title":"Bayesian Markov switching models for the early detection of influenza epidemics","volume":"27","author":"Miguel A. Martinez-Beneito","year":"2008","journal-title":"Statistics in medicine"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"e1000316","DOI":"10.1371\/journal.pbio.1000316","article-title":"Absolute humidity and the seasonal onset of influenza in the continental United States","volume":"8","author":"Jeffrey Shaman","year":"2010","journal-title":"PLoS Biol"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"e12948","DOI":"10.1371\/journal.pone.0012948","article-title":"Social network sensors for early detection of contagious outbreaks","volume":"5","author":"Nicholas A. Christakis","year":"2010","journal-title":"PloS one"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.2196\/jmir.2102","article-title":"FluBreaks: early epidemic detection from Google flu trends","volume":"14","author":"Fahad Pervaiz","year":"2012","journal-title":"Journal of medical Internet research"},{"key":"ref21","unstructured":"Sa\u00fade 24. Available from: http:\/\/www.saude24.pt\/<\/ext-link> [cited 17 February 2016]."},{"key":"ref22","unstructured":"ECDC. Data access. Available from: http:\/\/ecdc.europa.eu\/en\/activities\/surveillance\/Pages\/data-access.aspx<\/ext-link>."},{"key":"ref23","unstructured":"Google. Available from: https:\/\/trends.google.com\/trends\/<\/ext-link> [cited 3 Setember 2015]."},{"key":"ref24","unstructured":"ECDC. Influenza case definitions. Available from: http:\/\/ecdc.europa.eu\/en\/healthtopics\/influenza\/surveillance\/Pages\/influenza_case_definitions.aspx<\/ext-link> [cited 17 February 2016]."},{"key":"ref25","unstructured":"Google Translate. Available from: https:\/\/translate.google.com<\/ext-link> [cited 3 Setember 2015]."},{"key":"ref26","unstructured":"Wikipedia. Available from: https:\/\/www.wikipedia.org\/<\/ext-link> [cited 3 Setember 2015]."},{"key":"ref27","unstructured":"FluNet. Available from: http:\/\/gamapserver.who.int\/GlobalAtlas\/home.asp<\/ext-link>[cited 3 December 2015]."},{"key":"ref28","unstructured":"ECDC. Indicators of influenza activity. Available from: http:\/\/ecdc.europa.eu\/en\/healthtopics\/influenza\/surveillance\/Pages\/indicators_influenza.aspx<\/ext-link> [cited 17 February 2016]."},{"key":"ref29","article-title":"Mathematica","year":"2015"},{"issue":"772","key":"ref30","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1098\/rspa.1927.0118","article-title":"A Contribution to the Mathematical Theory of Epidemics","volume":"115","author":"WO Kermack","year":"1927","journal-title":"Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences"},{"key":"ref31","article-title":"The elements of statistical learning: data mining, inference, and prediction","author":"Trevor, J. Hastie","year":"2011"},{"issue":"14 March","key":"ref32","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.1248506","article-title":"The Parable of Google Flu: Traps in Big Data Analysis","volume":"343","author":"D Lazer","year":"2014","journal-title":"Science"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"e1003256","DOI":"10.1371\/journal.pcbi.1003256","article-title":"Reassessing Google Flu Trends Data for Detection of Seasonal and Pandemic Influenza: A Comparative Epidemiological Study at Three Geographic Scales","volume":"9","author":"Donald R. Olson","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"ref34","article-title":"Applying a human factors approach to improve usability of a decision support system in tele-nursing","author":"Amina Tariq","year":"2016","journal-title":"Collegian"},{"issue":"2","key":"ref35","first-page":"127","article-title":"Use of NHS Direct calls for surveillance of influenza\u2013a second year\u2019s experience","volume":"5","author":"D. L. Cooper","year":"2002","journal-title":"Communicable disease and public health\/PHLS"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T03:42:06Z","timestamp":1540266126000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005330"}},"subtitle":[],"editor":[{"given":"Matthew (Matt)","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,3]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005330","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,3]]}}}