{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:52:49Z","timestamp":1772733169566,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005406","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01-GM110310"],"award-info":[{"award-number":["R01-GM110310"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P50 GM103297"],"award-info":[{"award-number":["P50 GM103297"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["PHY-1427654"],"award-info":[{"award-number":["PHY-1427654"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF-CHE-1614101"],"award-info":[{"award-number":["NSF-CHE-1614101"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["CPRIT - grant R1110"],"award-info":[{"award-number":["CPRIT - grant R1110"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005406","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T13:24:50Z","timestamp":1488374690000},"page":"e1005406","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["A magnesium-induced triplex pre-organizes the SAM-II riboswitch"],"prefix":"10.1371","volume":"13","author":[{"given":"Susmita","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-6391","authenticated-orcid":false,"given":"Ryan L.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7501-4229","authenticated-orcid":false,"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-3689","authenticated-orcid":true,"given":"Regan","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Kwaku","family":"Dayie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-0388","authenticated-orcid":true,"given":"Jos\u00e9 N.","family":"Onuchic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karissa Y.","family":"Sanbonmatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm.3981","article-title":"The emerging role of lncRNAs in cancer","volume":"21","author":"M Huarte","year":"2015","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.biophys.37.032807.130000","article-title":"Riboswitches: Emerging Themes in RNA Structure and Function","volume":"37","author":"RK Montange","year":"2008","journal-title":"Annu Rev Biophys"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.biochem.78.070507.135656","article-title":"The Structural and Functional Diversity of Metabolite-Binding Riboswitches","volume":"78","author":"A Roth","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/bs.mie.2014.10.062","article-title":"Using simulations and kinetic network models to reveal the dynamics and functions of riboswitches","volume":"553","author":"JC Lin","year":"2015","journal-title":"Methods Enzymol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nrg2172","article-title":"Ribozymes, riboswitches and beyond: regulation of gene expression without proteins","volume":"8","author":"A Serganov","year":"2007","journal-title":"Nature Reviews Genetics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nsb967","article-title":"An mRNA structure that controls gene expression by binding S-adenosylmethionine","volume":"10","author":"WC Winkler","year":"2003","journal-title":"Nature Structural Biology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R70","DOI":"10.1186\/gb-2005-6-8-r70","article-title":"Genome Biology","volume":"6","author":"KA Corbino","year":"2005","journal-title":"Genome Biology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/j.febslet.2005.03.074","article-title":"Roles of Mg2+ in TPP-dependent riboswitch","volume":"579","author":"T Yamauchi","year":"2005","journal-title":"FEBS Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jmb.2006.10.022","article-title":"Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae","volume":"365","author":"J Lipfert","year":"2007","journal-title":"J Mol Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"E4956","DOI":"10.1073\/pnas.1525082113","article-title":"Kinetic and thermodynamic framework for P4-P6 RNA reveals tertiary motif modularity and modulation of the folding preferred pathway","volume":"113","author":"N Bisaria","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1042\/BST20140268","article-title":"Probing the kinetic and thermodynamic consequences of the tetraloop\/tetraloop receptor monovalent ion-binding site in P4-P6 RNA by smFRET","volume":"43","author":"N Bisaria","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jmb.2004.08.080","article-title":"Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations","volume":"343","author":"K Takamoto","year":"2004","journal-title":"J Mol Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"ncomms11768","DOI":"10.1038\/ncomms11768","article-title":"Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch","volume":"7","author":"Y Xue","year":"2016","journal-title":"Nat Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/tpj.12540","article-title":"Small molecules that interact with RNA: riboswitch-based gene control and its involvement in metabolic regulation in plants and algae","volume":"79","author":"SE Bocobza","year":"2014","journal-title":"Plant J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.jmb.2015.03.009","article-title":"Unwinding the mechanisms of a DEAD-box RNA helicase in cancer","volume":"427","author":"R Russell","year":"2015","journal-title":"J Mol Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature03037","article-title":"Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine","volume":"432","author":"RT Batey","year":"2004","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1261\/rna.2341610","article-title":"Structural basis for recognition of S-adenosylhomocysteine by riboswitches","volume":"16","author":"AL Edwards","year":"2010","journal-title":"RNA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"22347","DOI":"10.1074\/jbc.C800120200","article-title":"Crystal structure of the lysine riboswitch regulatory mRNA element","volume":"283","author":"AD Garst","year":"2008","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1101\/sqb.2006.71.015","article-title":"Structural Studies of the Purine and SAM Binding Riboswitches","volume":"71","author":"SD Gilbert","year":"2006","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nsmb.1371","article-title":"Structure of the SAM-II riboswitch bound to S-adenosylmethionine","volume":"15","author":"SD Gilbert","year":"2008","journal-title":"Nat Struct Mol Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1073\/pnas.1218062110","article-title":"Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution","volume":"110","author":"A Haller","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nchembio.562","article-title":"Conformational capture of the SAM-II riboswitch","volume":"7","author":"A Haller","year":"2011","journal-title":"Nature Chemical Biology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1093\/nar\/gkq1096","article-title":"Tertiary contacts control switching of the SAM-I riboswitch","volume":"39","author":"SP Hennelly","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"ref24","first-page":"25","article-title":"Methods in Molecular Biology","author":"B Heppell","year":"2009"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.chembiol.2006.06.010","article-title":"Folding of the Adenine Riboswitch","volume":"13","author":"J-F Lemay","year":"2006","journal-title":"Chemistry & Biology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nature04819","article-title":"Structure of the S-adenosylmethionine riboswitch regulatory mRNA element","volume":"441","author":"RK Montange","year":"2006","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.str.2010.04.006","article-title":"Free State Conformational Sampling of the SAM-I Riboswitch Aptamer Domain","volume":"18","author":"CD Stoddard","year":"2010","journal-title":"Structure"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1093\/nar\/gkr238","article-title":"Structure and dynamics of the deoxyguanosine-sensing riboswitch studied by NMR-spectroscopy","volume":"39","author":"A Wacker","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"17349","DOI":"10.1073\/pnas.0906625106","article-title":"Assembly mechanisms of RNA pseudoknots are determined by the stabilities of constituent secondary structures","volume":"106","author":"SS Cho","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1073\/pnas.0408314102","article-title":"Mechanical unfolding of RNA hairpins","volume":"102","author":"C Hyeon","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"L7","DOI":"10.1016\/j.bpj.2008.10.033","article-title":"Nonlocal Helix Formation Is Key to Understanding S-Adenosylmethionine-1 Riboswitch Function","volume":"96","author":"PC Whitford","year":"2009","journal-title":"Biophysical Journal"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jtbi.2014.10.022","article-title":"Folding of SAM-II riboswitch explored by replica-exchange molecular dynamics simulation","volume":"365","author":"X Xue","year":"2015","journal-title":"Journal of Theoretical Biology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"284a","DOI":"10.1016\/j.bpj.2013.11.1665","article-title":"Role of Magnesium Ions and Ligand Stacking in the Adenine Riboswitch Folding","volume":"106","author":"F Di Palma","year":"2014","journal-title":"Biophysical Journal"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1261\/rna.5205404","article-title":"A guide to ions and RNA structure","volume":"10","author":"DE Draper","year":"2004","journal-title":"RNA"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"12456","DOI":"10.1073\/pnas.221234598","article-title":"A thermodynamic framework for Mg2+ binding to RNA","volume":"98","author":"VK Misra","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.1021\/ja301454u","article-title":"Magnesium Fluctuations Modulate RNA Dynamics in the SAM-I Riboswitch","volume":"134","author":"RL Hayes","year":"2012","journal-title":"J Am Chem Soc"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.bpj.2014.01.042","article-title":"Reduced Model Captures Mg2+-RNA Interaction Free Energy of Riboswitches","volume":"106","author":"Ryan L Hayes","year":"2014","journal-title":"Biophysical Journal"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.114.258105","article-title":"Generalized Manning Condensation Model Captures the RNA Ion Atmosphere","volume":"114","author":"RL Hayes","year":"2015","journal-title":"Phys Rev Lett"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jmb.2009.08.062","article-title":"Analysis of Riboswitch Structure and Function by an Energy Landscape Framework","volume":"393","author":"G Quarta","year":"2009","journal-title":"Journal of Molecular Biology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1093\/nar\/gkr1154","article-title":"Multiple conformations of SAM-II riboswitch detected with SAXS and NMR spectroscopy","volume":"40","author":"B Chen","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1261\/rna.028779.111","article-title":"Atomic-level insights into metabolite recognition and specificity of the SAM-II riboswitch","volume":"18","author":"U Doshi","year":"2011","journal-title":"RNA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1073\/pnas.0609956104","article-title":"S-adenosylmethionine directly inhibits binding of 30S ribosomal subunits to the SMK box translational riboswitch RNA","volume":"104","author":"RT Fuchs","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jmb.2011.04.039","article-title":"Variable Sequences outside the Sam-Binding Core Critically Influence the Conformational Dynamics of the SAM-III\/SMK Box Riboswitch","volume":"409","author":"C Lu","year":"2011","journal-title":"Journal of Molecular Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1365-2958.2010.07410.x","article-title":"The SAM-responsive SMK box is a reversible riboswitch","volume":"78","author":"AM Smith","year":"2010","journal-title":"Molecular Microbiology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"14075","DOI":"10.1021\/jacs.5b09740","article-title":"Mg 2+ Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection","volume":"137","author":"KC Suddala","year":"2015","journal-title":"J Am Chem Soc"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/nar\/gks978","article-title":"The expression platform and the aptamer: cooperativity between Mg2+ and ligand in the SAM-I riboswitch","volume":"41","author":"SP Hennelly","year":"2012","journal-title":"Nucleic Acids Research"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1002\/anie.201509997","article-title":"SAM-II Riboswitch Samples at least Two Conformations in Solution in the Absence of Ligand: Implications for Recognition","volume":"55","author":"B Chen","year":"2016","journal-title":"Angewandte Chemie International Edition"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4149\/gpb_2009_02_174","article-title":"Structure and flexibility within proteins as identified through small angle X-ray scattering","volume":"28","author":"M Pelikan","year":"2009","journal-title":"General Physiology and Biophysics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"W540","DOI":"10.1093\/nar\/gkq461","article-title":"FoXS: a web server for rapid computation and fitting of SAXS profiles","volume":"38","author":"D Schneidman-Duhovny","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ceb.2013.08.005","article-title":"Long non-coding RNAs: modulators of nuclear structure and function","volume":"26","author":"JH Bergmann","year":"2014","journal-title":"Current Opinion in Cell Biology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"19202","DOI":"10.1073\/pnas.1217338109","article-title":"Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MENbeta noncoding RNAs","volume":"109","author":"JA Brown","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/wrna.1194","article-title":"The emerging role of triple helices in RNA biology","volume":"5","author":"NK Conrad","year":"2014","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1101\/gad.204438.112","article-title":"A triple helix stabilizes the 3 ' ends of long noncoding RNAs that lack poly(A) tails","volume":"26","author":"JE Wilusz","year":"2012","journal-title":"Genes & Development"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1093\/nar\/gkl963","article-title":"The interaction networks of structured RNAs","volume":"34","author":"A Lescoute","year":"2006","journal-title":"Nucleic Acids Research"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1093\/nar\/gkp486","article-title":"Molecular dynamics simulation study of the binding of purine bases to the aptamer domain of the guanine sensing riboswitch","volume":"37","author":"A Villa","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1146\/annurev-biochem-060409-092720","article-title":"Understanding Nucleic Acid-Ion Interactions","volume":"Vol 83","author":"J Lipfert","year":"2014","journal-title":"Annual Review of Biochemistry"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.scient.2011.09.015","article-title":"On the binding of Mg2+, Ca2+, Zn2+ and Cu+ metal cations to 2 '-deoxyguanosine: Changes on sugar puckering and strength of the N-glycosidic bond","volume":"18","author":"MS Ahmadi","year":"2011","journal-title":"Scientia Iranica"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkv1289","article-title":"Automated physics-based design of synthetic riboswitches from diverse RNA aptamers","volume":"44","author":"A Espah Borujeni","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1039\/C3CP55275F","article-title":"From structure to function: the convergence of structure based models and co-evolutionary information","volume":"16","author":"B Jana","year":"2014","journal-title":"Physical Chemistry Chemical Physics"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1021\/jp300852d","article-title":"The shadow map: a general contact definition for capturing the dynamics of biomolecular folding and function","volume":"116","author":"JK Noel","year":"2012","journal-title":"Journal of Physical Chemistry B"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"W657","DOI":"10.1093\/nar\/gkq498","article-title":"SMOG@ctbp: simplified deployment of structure-based models in GROMACS","volume":"38","author":"JK Noel","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.physchem.48.1.545","article-title":"Theory of protein folding: the energy landscape perspective","volume":"48","author":"JN Onuchic","year":"1997","journal-title":"Annu Rev Phys Chem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.biochi.2014.12.007","article-title":"Evolution, energy landscapes and the paradoxes of protein folding","volume":"119","author":"PG Wolynes","year":"2015","journal-title":"Biochimie"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0033583500002031","article-title":"The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides","volume":"11","author":"GS Manning","year":"1978","journal-title":"Q Rev Biophys"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0009-2614(74)80109-0","article-title":"Monte-Carlo Free-Energy Estimates Using Non-Boltzmann Sampling\u2014Application to Subcritical Lennard-Jones Fluid","volume":"28","author":"GM Torrie","year":"1974","journal-title":"Chemical Physics Letters"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jcc.540130812","article-title":"The Weighted Histogram Analysis Method for Free-Energy Calculations on Biomolecules .1. The Method","volume":"13","author":"S Kumar","year":"1992","journal-title":"Journal of Computational Chemistry"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e2735","DOI":"10.1371\/journal.pntd.0002735","article-title":"Relationships between IgE\/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP\/RAL-2 protein family","volume":"8","author":"MF Garcia-Mayoral","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/nar\/gkm072","article-title":"Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis","volume":"35","author":"AY Kobitski","year":"2007","journal-title":"Nucleic Acids Research"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005406","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T08:07:06Z","timestamp":1540282026000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005406"}},"subtitle":[],"editor":[{"given":"Peter M","family":"Kasson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":68,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005406","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1005406","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}