{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:37:16Z","timestamp":1777286236453,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005424","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000}}],"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-SC0008701"],"award-info":[{"award-number":["DE-SC0008701"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U01-GM102098"],"award-info":[{"award-number":["U01-GM102098"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01-GM057089"],"award-info":[{"award-number":["R01-GM057089"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005424","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T13:34:36Z","timestamp":1488807276000},"page":"e1005424","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biomarkers are used to predict quantitative metabolite concentration profiles in human red blood cells"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-509X","authenticated-orcid":true,"given":"James T.","family":"Yurkovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-7643","authenticated-orcid":true,"given":"Laurence","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard O.","family":"Palsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/trf.12804","article-title":"An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies","volume":"55","author":"A D\u2019Alessandro","year":"2015","journal-title":"Transfusion"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11306-016-1094-6","article-title":"Metabolomics enables precision medicine: \u201cA White Paper, Community Perspective\u201d","volume":"12","author":"RD Beger","year":"2016","journal-title":"Metabolomics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpba.2014.12.020","article-title":"Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery","volume":"107","author":"S Patel","year":"2015","journal-title":"J Pharm Biomed Anal"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"e6386","DOI":"10.1371\/journal.pone.0006386","article-title":"Metabolomics reveals metabolic biomarkers of Crohn\u2019s disease","volume":"4","author":"J Jansson","year":"2009","journal-title":"PLoS One"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s00204-015-1519-4","article-title":"Translational biomarkers of acetaminophen-induced acute liver injury","volume":"89","author":"RD Beger","year":"2015","journal-title":"Arch Toxicol"},{"key":"ref6","article-title":"Biomarkers defining the metabolic age of red blood cells during cold storage","author":"G Paglia","year":"2016","journal-title":"Blood"},{"issue":"11 Pt B","key":"ref7","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1016\/j.bbagen.2016.07.007","article-title":"Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study","volume":"1860","author":"K O\u2019Shea","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/trf.13442","article-title":"Metabolomics in transfusion medicine","volume":"56","author":"T Nemkov","year":"2016","journal-title":"Transfusion"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11306-014-0721-3","article-title":"Prediction of intracellular metabolic states from extracellular metabolomic data","volume":"11","author":"MK Aurich","year":"2015","journal-title":"Metabolomics"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/trf.13460","article-title":"Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes","volume":"56","author":"A Bordbar","year":"2016","journal-title":"Transfusion"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1111\/trf.13740","article-title":"Metabolic fate of adenine in red blood cells during storage in SAGM solution","volume":"56","author":"G Paglia","year":"2016","journal-title":"Transfusion"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tmrv.2014.01.003","article-title":"Metabolomics of ADSOL (AS-1) red blood cell storage","volume":"28","author":"JD Roback","year":"2014","journal-title":"Transfus Med Rev"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/trf.12975","article-title":"Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome","volume":"55","author":"A D\u2019Alessandro","year":"2015","journal-title":"Transfusion"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4612-1768-8_11","article-title":"System Identification: Theory for the User","author":"L Ljung","year":"1998"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1115\/1.2896160","article-title":"A Frequency Domain Identification Scheme for Flexible Structure Control","volume":"112","author":"AP Tzes","year":"1990","journal-title":"J Dyn Syst Meas Control"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1109\/TAC.1965.1098181","article-title":"A technique for the identification of linear systems","volume":"10","author":"K Steiglitz","year":"1965","journal-title":"IEEE Trans Automat Contr"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/aic.690320602","article-title":"Adaptive control strategies for process control: A survey","volume":"32","author":"DE Seborg","year":"1986","journal-title":"AIChE J"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4338\/ACI-2015-09-RA-0127","article-title":"Time Series Analysis for Forecasting Hospital Census: Application to the Neonatal Intensive Care Unit","volume":"7","author":"M Capan","year":"2016","journal-title":"Appl Clin Inform"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nbt1330","article-title":"Ensemble modeling for analysis of cell signaling dynamics","volume":"25","author":"L Kuepfer","year":"2007","journal-title":"Nature Biotechnology"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijforecast.2006.03.001","article-title":"Another look at measures of forecast accuracy","volume":"22","author":"RJ Hyndman","year":"2006","journal-title":"Int J Forecast"},{"key":"ref21","article-title":"Red blood cell storage: the story so far","author":"A D\u2019Alessandro","year":"2010","journal-title":"Blood Transfusion"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1537-2995.2011.03100.x","article-title":"Storage lesion: role of red blood cell breakdown","volume":"51","author":"DB Kim-Shapiro","year":"2011","journal-title":"Transfusion"},{"issue":"1","key":"ref23","first-page":"100","article-title":"Stored blood: how old is too old?","volume":"127","author":"JS Lee","year":"2017","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1172\/JCI90837","article-title":"Prolonged red cell storage before transfusion increases extravascular hemolysis","volume":"127","author":"F Rapido","year":"2017","journal-title":"The Journal of Clinical Investigation"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005424","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T17:10:02Z","timestamp":1540314602000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005424"}},"subtitle":[],"editor":[{"given":"Jens","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,6]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005424","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1005424","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,6]]}}}