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tachycardia. II. The role of nonuniform recovery of excitability in the occurrence of unidirectional block, as studied with multiple microelectrodes","volume":"39","author":"MA Allessie","year":"1976","journal-title":"Circ Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1161\/01.RES.65.6.1612","article-title":"Interaction of inhomogeneities of repolarization with anisotropic propagation in dog atria. A mechanism for both preventing and initiating reentry","volume":"65","author":"MS Spach","year":"1989","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0008-6363(02)00258-4","article-title":"Electrical, contractile and structural remodeling during atrial fibrillation","volume":"54","author":"M Allessie","year":"2002","journal-title":"Cardiovasc Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/01.CIR.92.2.164","article-title":"Characterization of Inwardly Rectifying K<sup>+<\/sup> Channel in Human Cardiac Myocytes","volume":"92","author":"S Koumi","year":"1995","journal-title":"Circulation"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1073\/pnas.0708153105","article-title":"The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel","volume":"105","author":"AA Rodr\u00edguez-Menchaca","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000233241","article-title":"Chloroquine Blocks a Mutant Kir2.1 Channel Responsible for Short QT Syndrome and Normalizes Repolarization Properties in silico","volume":"24","author":"A Lopez-Izquierdo","year":"2009","journal-title":"Cell Physiol Biochem"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Tob\u00f3n C, Duarte M, Duque JE, Becerra MA, Arango SS, Cardona K, et al. 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Antiarrhythmic Effects of the Combination of Ranolazine and Chronic Amiodarone in Canine AtriaCLINICAL PERSPECTIVE","volume":"3","author":"S Sicouri","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jacc.2010.08.600","article-title":"Synergistic Effect of the Combination of Ranolazine and Dronedarone to Suppress Atrial Fibrillation","volume":"56","author":"A Burashnikov","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/CIRCEP.115.002856","article-title":"The HARMONY Trial","volume":"8","author":"JA Reiffel","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1161\/CIRCULATIONAHA.115.018016","article-title":"Potassium Channel Blockade Enhances Atrial Fibrillation\u2013Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade","volume":"132","author":"M Aguilar","year":"2015","journal-title":"Circulation"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e1004011","DOI":"10.1371\/journal.pcbi.1004011","article-title":"Disrupted Calcium Release as a Mechanism for Atrial Alternans Associated with Human Atrial Fibrillation","volume":"10","author":"KC Chang","year":"2014","journal-title":"PLOS Comput Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yjmcc.2009.09.019","article-title":"A novel computational model of the human ventricular action potential and Ca transient","volume":"48","author":"E Grandi","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.RES.73.2.276","article-title":"Delayed rectifier outward current and repolarization in human atrial myocytes","volume":"73","author":"Z Wang","year":"1993","journal-title":"Circ 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