{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:32:48Z","timestamp":1784122368211,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005609","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000}}],"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["618091 (SAGE)"],"award-info":[{"award-number":["618091 (SAGE)"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005609","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T17:24:54Z","timestamp":1500398694000},"page":"e1005609","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Stress-induced mutagenesis: Stress diversity facilitates the persistence of mutator genes"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-8004","authenticated-orcid":true,"given":"Marta","family":"Luka\u010di\u0161inov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-824X","authenticated-orcid":true,"given":"Sebastian","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-3953","authenticated-orcid":true,"given":"Tiago","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/genetics\/117.3.559","article-title":"Selection, Generalized Transmission and the Evolution of Modifier Genes. I. The Reduction Principle","volume":"117","author":"L Altenberg","year":"1987","journal-title":"Genetics"},{"issue":"6634","key":"ref2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/42696","article-title":"Role of mutator alleles in adaptive evolution","volume":"387","author":"F Taddei","year":"1997","journal-title":"Nature"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0923-2508(00)01163-3","article-title":"Second-order selection in bacterial evolution: selection acting on mutation and recombination rates in the course of adaptation","volume":"152","author":"O Tenaillon","year":"2001","journal-title":"Research in Microbiology"},{"issue":"5624","key":"ref4","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.1082240","article-title":"Stress-induced mutagenesis in bacteria","volume":"300","author":"I Bjedov","year":"2003","journal-title":"Science"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1371\/journal.pbio.0030176","article-title":"Inhibition of mutation and combating the evolution of antibiotic resistance","volume":"3","author":"RT Cirz","year":"2005","journal-title":"PLoS Biology"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/jac\/dkq496","article-title":"Effect of recA inactivation on mutagenesis of <italic>Escherichia coli<\/italic> exposed to sublethal concentrations of antimicrobials","volume":"66","author":"T Do Thi","year":"2011","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-cancerbio-050216-121919","article-title":"Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance","volume":"1","author":"Devon M Fitzgerald","year":"2017","journal-title":"Annual Review of Cancer Biology"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.molcel.2005.07.025","article-title":"A Switch from High-Fidelity to Error-Prone DNA Double-Strand Break Repair Underlies Stress-Induced Mutation","volume":"19","author":"RG Ponder","year":"2005","journal-title":"Molecular Cell"},{"issue":"5783","key":"ref9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1127912","article-title":"Antibiotic stress induces genetic transformability in the human pathogen <italic>Streptococcus pneumoniae<\/italic>","volume":"313","author":"M Prudhomme","year":"2006","journal-title":"Science"},{"issue":"24","key":"ref10","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1016\/j.cub.2005.10.074","article-title":"Exposure to host resistance mechanisms drives evolution of bacterial virulence in plants","volume":"15","author":"AR Pitman","year":"2005","journal-title":"Current Biology"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1371\/journal.pbio.0060030","article-title":"Increased transmission of mutations by low-condition females: evidence for condition-dependent DNA repair","volume":"6","author":"AF Agrawal","year":"2008","journal-title":"PLoS Biology"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10409230701507773","article-title":"Adaptive mutation in <italic>Saccharomyces cerevisiae<\/italic>","volume":"42","author":"E Heidenreich","year":"2007","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"issue":"1816","key":"ref13","doi-asserted-by":"crossref","first-page":"20150885","DOI":"10.1098\/rspb.2015.0885","article-title":"The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic","volume":"282","author":"C Torres-Barcel\u00f3","year":"2015","journal-title":"Proc R Soc Lond B"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrg3415","article-title":"Evaluating evolutionary models of stress-induced mutagenesis in bacteria","volume":"14","author":"RC MacLean","year":"2013","journal-title":"Nature Reviews Genetics"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/35080556","article-title":"Evolving responsively: adaptive mutation","volume":"2","author":"SM Rosenberg","year":"2001","journal-title":"Nature Reviews Genetics"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1111\/j.1558-5646.2012.01576.x","article-title":"The evolution of stress-induced hypermutation in asexual populations","volume":"66","author":"Y Ram","year":"2012","journal-title":"Evolution"},{"issue":"22","key":"ref17","doi-asserted-by":"crossref","first-page":"12106","DOI":"10.1073\/pnas.94.22.12106","article-title":"Evaluating treatment protocols to prevent antibiotic resistance","volume":"94","author":"S Bonhoeffer","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7136","key":"ref18","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nature05685","article-title":"Antibiotic interactions that select against resistance","volume":"446","author":"R Chait","year":"2007","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2015.05.008","article-title":"Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution","volume":"27","author":"T Bollenbach","year":"2015","journal-title":"Current Opinion in Microbiology"},{"issue":"6634","key":"ref20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/42701","article-title":"Evolution of high mutation rates in experimental populations of E. coli","volume":"387","author":"PD Sniegowski","year":"1997","journal-title":"Nature"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/genetics\/121.1.163","article-title":"Evolutionarily stable mutation rate in a periodically changing environment","volume":"121","author":"K Ishii","year":"1989","journal-title":"Genetics"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/genetics\/164.3.843","article-title":"The Evolution of Mutator Genes in Bacterial Populations: The Roles of Environmental Change and Timing","volume":"164","author":"MM Tanaka","year":"2003","journal-title":"Genetics"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1046\/j.1420-9101.2002.00464.x","article-title":"Genetic loads under fitness-dependent mutation rates","volume":"15","author":"AF Agrawal","year":"2002","journal-title":"Journal of Evolutionary Biology"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.tim.2004.04.002","article-title":"Evolutionary significance of stress-induced mutagenesis in bacteria","volume":"12","author":"O Tenaillon","year":"2004","journal-title":"Trends in Microbiology"},{"issue":"6112","key":"ref25","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1226683","article-title":"Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks","volume":"338","author":"AAMA Mamun","year":"2012","journal-title":"Science"},{"issue":"5767","key":"ref26","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1126\/science.1122469","article-title":"An equivalence principle for the incorporation of favorable mutations in asexual populations","volume":"311","author":"M Hegreness","year":"2006","journal-title":"Science"},{"key":"ref27","article-title":"The mathematical theory of selection, recombination, and mutation","volume":"vol. 228","author":"R B\u00fcrger","year":"2000"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"e4036","DOI":"10.1371\/journal.pone.0004036","article-title":"The impact of different antibiotic regimens on the emergence of antimicrobial-resistant bacteria","volume":"3","author":"EMC D\u2019Agata","year":"2008","journal-title":"PLoS One"},{"issue":"17","key":"ref29","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1128\/AEM.01078-12","article-title":"Multidrug therapy and evolution of antibiotic resistance: when order matters","volume":"78","author":"GG Perron","year":"2012","journal-title":"Applied and Environmental Microbiology"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"e1002783","DOI":"10.1371\/journal.pgen.1002783","article-title":"Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme","volume":"8","author":"MF Schenk","year":"2012","journal-title":"PLOS Genet"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1369-5274(99)00005-3","article-title":"The biological cost of antibiotic resistance","volume":"2","author":"DI Andersson","year":"1999","journal-title":"Current Opinion in Microbiology"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/apt.12325","article-title":"A new method for determining gastric acid output using a wireless pH-sensing capsule","volume":"37","author":"DH Weinstein","year":"2013","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)80412-2","article-title":"Innate Immunity: The Virtues of a Nonclonal System of Recognition","volume":"91","author":"R Medzhitov","year":"1997","journal-title":"Cell"},{"issue":"1816","key":"ref34","doi-asserted-by":"crossref","first-page":"20150885","DOI":"10.1098\/rspb.2015.0885","article-title":"The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic","volume":"282","author":"C Torres-Barcel\u00f3","year":"2015","journal-title":"Proc R Soc B"},{"issue":"40","key":"ref35","doi-asserted-by":"crossref","first-page":"14494","DOI":"10.1073\/pnas.1409800111","article-title":"Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance","volume":"111","author":"S Kim","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"e1004493","DOI":"10.1371\/journal.pcbi.1004493","article-title":"Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance","volume":"11","author":"D Nichol","year":"2015","journal-title":"PLoS Computational Biology"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/eva.12330","article-title":"Temporal variation in antibiotic environments slows down resistance evolution in pathogenic <italic>Pseudomonas aeruginosa<\/italic>","volume":"8","author":"R Roemhild","year":"2015","journal-title":"Evolutionary Applications"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/AAC.11.5.852","article-title":"Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from <italic>Streptomyces clavuligerus<\/italic>","volume":"11","author":"C Reading","year":"1977","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"36","key":"ref39","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1073\/pnas.0402298101","article-title":"Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals","volume":"101","author":"CT Bergstrom","year":"2004","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6268","key":"ref40","doi-asserted-by":"crossref","first-page":"aad3292","DOI":"10.1126\/science.aad3292","article-title":"Multidrug evolutionary strategies to reverse antibiotic resistance","volume":"351","author":"M Baym","year":"2016","journal-title":"Science"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.chembiol.2016.02.010","article-title":"RecA inhibitors potentiate antibiotic activity and block evolution of antibiotic resistance","volume":"23","author":"MK Alam","year":"2016","journal-title":"Cell Chemical Biology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1741-7015-10-89","article-title":"Implications of Stress-Induced Genetic Variation for Minimizing Multidrug Resistance in Bacteria","volume":"10","author":"U Obolski","year":"2012","journal-title":"BMC Medicine"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005609","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T03:47:38Z","timestamp":1659239258000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005609"}},"subtitle":[],"editor":[{"given":"Claus O.","family":"Wilke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,18]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005609","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1005609","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,18]]}}}