{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:03:13Z","timestamp":1772172193926,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005731","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/I001875\/1"],"award-info":[{"award-number":["BB\/I001875\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/I001875\/1"],"award-info":[{"award-number":["BB\/I001875\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biotechnology and Biological Sciences Research Council (GB)","award":["BB\/I001875\/1"],"award-info":[{"award-number":["BB\/I001875\/1"]}]},{"name":"Biotechnology and Biological Sciences Research Council (GB)","award":["BB\/I001875\/1"],"award-info":[{"award-number":["BB\/I001875\/1"]}]},{"name":"Biotechnology and Biological Sciences Research Council (GB)","award":["BB\/I001875\/1"],"award-info":[{"award-number":["BB\/I001875\/1"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M012174\/1"],"award-info":[{"award-number":["MR\/M012174\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005731","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T13:23:46Z","timestamp":1505741026000},"page":"e1005731","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Reconstructing promoter activity from Lux bioluminescent reporters"],"prefix":"10.1371","volume":"13","author":[{"given":"Mudassar","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-3871","authenticated-orcid":true,"given":"Anna M. L.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saara N. A.","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-5235","authenticated-orcid":true,"given":"Ishan","family":"Ajmera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-8526","authenticated-orcid":true,"given":"Peter A.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Kypraios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-8079","authenticated-orcid":true,"given":"Dov J.","family":"Stekel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.ge.28.120194.001001","article-title":"Genetics of bacterial bioluminescence","volume":"28","author":"E Meighan","year":"1994","journal-title":"Annu Rev Genet"},{"key":"ref2","first-page":"37","article-title":"Biochemistry and genetics of bacterial bioluminescence","volume":"144","author":"P Dunlap","year":"2014","journal-title":"Advances in Biochemical Engineering and Biotechnology"},{"issue":"27","key":"ref3","doi-asserted-by":"crossref","first-page":"16581","DOI":"10.1016\/S0021-9258(17)46262-4","article-title":"Nucleotide sequence, expression, and properties of luciferase coded by <italic>lux<\/italic> genes from a terrestrial bacterium","volume":"265","author":"R Szittner","year":"1990","journal-title":"The Journal of Biological Chemistry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/s120100732","article-title":"The evolution of the bacterial luciferase gene cassette (lux) as a real-time bioreporter","volume":"12","author":"D Close","year":"2012","journal-title":"Sensors"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1128\/JB.186.4.1065-1077.2004","article-title":"Real-time monitoring of intracellular <italic>Staphylococcus aureus<\/italic> replication","volume":"186","author":"S Qazi","year":"2004","journal-title":"Journal of Bacteriology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ng1348","article-title":"Just-in-time transcription program in metabolic pathways","volume":"36","author":"A Zaslaver","year":"2004","journal-title":"Nature Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e12441","DOI":"10.1371\/journal.pone.0012441","article-title":"Autonomous bioluminescent expression of the bacterial luciferase gene cassette (lux) in a mammalian cell line","volume":"5","author":"D Close","year":"2010","journal-title":"PLoS One"},{"key":"ref8","first-page":"52","article-title":"Novel aspects of the acid response network of <italic>Escherichia coli K-12<\/italic> are revealed by a study of transcriptional dynamics","volume":"24","author":"C Brutesco","year":"2017","journal-title":"Environ Sci Pollut Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1007\/s00253-015-7229-2","article-title":"A stable luciferase reporter plasmid for in vivo imaging in murine models of <italic>Staphylococcus aureus<\/italic> infections","volume":"100","author":"M Bacconi","year":"2016","journal-title":"Appl Microbial Biotechnol"},{"issue":"16","key":"ref10","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1128\/AEM.01346-16","article-title":"A modular, Tn7-based system for making bioluminescent or fluorescent <italic>Salmonella<\/italic> and <italic>Escherichia coli<\/italic> strains","volume":"82","author":"D Shivak","year":"2016","journal-title":"Appl Environ Microbien"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-3515-4_7","article-title":"In vivo bioluminescence imaging of intratumoral bacteria","volume":"1409","author":"M Cronin","year":"2016","journal-title":"Methods Mol Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1126\/science.249.4970.778","article-title":"Rapid, sensitive bioluminescent reporter technology for naphthalene exposure and biodegradation","volume":"249","author":"J King","year":"1990","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/bit.20708","article-title":"<italic>In situ<\/italic> measurement of bioluminescence and fluorescence in an integrated microbioreactor","volume":"93","author":"A Zanzotto","year":"2006","journal-title":"Biotechnology and Bioengineering"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/IAI.74.2.910-919.2006","article-title":"N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in <italic>Staphylococcus aureus<\/italic>","volume":"74","author":"S Qazi","year":"2006","journal-title":"Infection and Immunity"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jmb.2010.06.054","article-title":"Novel aspects of the acid response network of <italic>Escherichia coli K-12<\/italic> are revealed by a study of transcriptional dynamics","volume":"401","author":"N Burton","year":"2010","journal-title":"Journal of Molecular Biology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ecoenv.2013.06.013","article-title":"Bioluminescence enhancement through an added washing protocol enabling a greater sensitivity to carbofuran toxicity","volume":"96","author":"K Jia","year":"2013","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1039\/B812094C","article-title":"Mathematical model of the Lux luminescence system in the terrestrial bacterium P<italic>hotorhabdus luminescens<\/italic>","volume":"5","author":"P Welham","year":"2009","journal-title":"Molecular Biosystems"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/bi900003t","article-title":"Crystal structure of the bacterial luciferase\/flavin complex provides insight into the function of the beta subunit","volume":"48","author":"Z Campbell","year":"2009","journal-title":"Biochemistry"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1021\/j150544a010","article-title":"A schematic method of deriving the rate laws for enzyme-catalyzed reactions","volume":"60","author":"E King","year":"1956","journal-title":"J Phys Chem"},{"issue":"106","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2015.0069","article-title":"The dynamic balanace of import and export of zinc in <italic>Escherichia coli<\/italic> suggests a heterogeneous population response to stress","volume":"12","author":"H Takahashi","year":"2015","journal-title":"Journal of the Royal Society Interface"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"e111176","DOI":"10.1371\/journal.pone.0111176","article-title":"Analysis of occludin trafficking, demonstrating continuous endocytosis, degradation, recycling and biosynthetic secretory trafficking","volume":"9","author":"S Fletcher","year":"2014","journal-title":"PLoS ONE"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9258(18)32563-8","article-title":"Purification of the acyl coenzyme A reductase component from a complex responsible for the reduction of fatty acids in bioluminescent bacteria. Properties and acyltransferase activity","volume":"258","author":"A Rodriguez","year":"1983","journal-title":"The Journal of Biological Chemistry"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1139\/o85-138","article-title":"ATP turnover by the fatty acid reductase complex of <italic>Photobacterium phosphoreum<\/italic>","volume":"63","author":"A Rodriguez","year":"1985","journal-title":"Canadian Journal of Biochemistry and Cell Biology"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1128\/IAI.69.11.7074-7082.2001","article-title":"<italic>agr<\/italic> expression precedes escape of internalised <italic>Staphylococcus aureus<\/italic> from the host endosome","volume":"69","author":"S Qazi","year":"2001","journal-title":"Infection and Immunity"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11693-006-9001-5","article-title":"A destabilized bacterial luciferase for dynamic gene expression studies","volume":"1","author":"M Allen","year":"2007","journal-title":"Systems and Synthetic Biology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1128\/AAC.00528-15","article-title":"Bioluminescence for assessing drug potency against nonreplicating <italic>Mycobacterium tuberculosis<\/italic>","volume":"59","author":"A Vocat","year":"2015","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1472-6750-9-41","article-title":"A suite of recombinant luminescent bacterial strains for the quantification of bioavailable heavy metals and toxicity testing","volume":"9","author":"A Ivask","year":"2009","journal-title":"BMC Biotechnology"},{"key":"ref28","first-page":"536","article-title":"A bacterial reporter panel for the detection and classification of antibiotic substances","volume":"5","author":"S Melamed","year":"2012","journal-title":"Molecular Biotechnology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2199-8-80","article-title":"Construction and evaluation of multisite recombinatorial (gateway) cloning vectors for Gram-positive bacteria","volume":"8","author":"T Perehinec","year":"2007","journal-title":"BMC Molecular Biology"},{"issue":"16","key":"ref30","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1128\/JB.182.16.4394-4400.2000","article-title":"Identification and characterization of a membrane permease involved in iron-hydroxamate transport in <italic>Staphylococcus aureus<\/italic>","volume":"182","author":"M Sebulsky","year":"2000","journal-title":"Journal of Bacteriology"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11222-008-9110-y","article-title":"A tutorial on adaptive MCMC","volume":"18","author":"C Andrieu","year":"2008","journal-title":"Statistics and Computing"},{"key":"ref32","first-page":"505","article-title":"Nonparametric Bayesian inference from right censored survival data, using the Gibbs sampler","volume":"4","author":"E Arjas","year":"1994","journal-title":"Statistica sinica"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/biomet\/82.4.711","article-title":"Reversible jumple Markov chain Monte Carlo computation and Bayesian model determination","volume":"82","author":"P Green","year":"1995","journal-title":"Biometrika"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005731","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T19:53:11Z","timestamp":1659469991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005731"}},"subtitle":[],"editor":[{"given":"Jorg","family":"Stelling","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005731","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/117093","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}