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Pandemic Influenza Preparedness and Response: A WHO Guidance Document. 2010; p. 64."},{"key":"ref3","unstructured":"CDC. The 2009 H1N1 Pandemic: Summary Highlights, April 2009-April 2010. CDC; 2010. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/h1n1flu\/cdcresponse.htm\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/h1n1flu\/cdcresponse.htm<\/ext-link>."},{"issue":"21","key":"ref4","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1056\/NEJMra1002842","article-title":"Influenza Vaccines for the Future","volume":"363","author":"LC Lambert","year":"2010","journal-title":"New England Journal of Medicine"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/S0264-410X(03)00071-9","article-title":"The annual production cycle for influenza vaccine","volume":"21","author":"C Gerdil","year":"2003","journal-title":"Vaccine"},{"issue":"38","key":"ref6","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1016\/j.vaccine.2009.06.034","article-title":"Vaccine production capacity for seasonal and pandemic (H1N1) 2009 influenza","volume":"27","author":"N Collin","year":"2009","journal-title":"Vaccine"},{"key":"ref7","unstructured":"Homeland Security Council. Pandemic Influenza Implementation Plan. 2006;."},{"issue":"18","key":"ref8","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1056\/NEJMp058068","article-title":"Preparing for the Next Pandemic","volume":"352","author":"MT Osterholm","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"ref9","unstructured":"WHO. Global influenza surveillance and response system. 2013;."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.03883","article-title":"Improving pandemic influenza risk assessment","volume":"3","author":"CA Russell","year":"2014","journal-title":"eLife"},{"key":"ref11","unstructured":"FAO-OIE-WHO. GLEWS+ The Joint FAO-OIE-WHO Global Early Warning System for health threats and emerging risks at the human-animal-ecosystems interface. 2013;."},{"issue":"7403","key":"ref12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature10831","article-title":"Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA\/H1N1 virus in ferrets","volume":"486","author":"M Imai","year":"2012","journal-title":"Nature"},{"issue":"6088","key":"ref13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.1213362","article-title":"Airborne transmission of influenza A\/H5N1 virus between ferrets","volume":"336","author":"S Herfst","year":"2012","journal-title":"Science"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"e1001646","DOI":"10.1371\/journal.pmed.1001646","article-title":"Ethical alternatives to experiments with novel potential pandemic pathogens","volume":"11","author":"M Lipsitch","year":"2014","journal-title":"PLoS medicine"},{"issue":"5669","key":"ref15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/274334a0","article-title":"Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950","volume":"274","author":"K Nakajima","year":"1978","journal-title":"Nature"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"e01013","DOI":"10.1128\/mBio.01013-15","article-title":"The Reemergent 1977 H1N1 Strain and the Gain-of-Function Debate","volume":"6","author":"M Rozo","year":"2015","journal-title":"mBio"},{"article-title":"Influenza Epidemic of 1889-90","year":"1891","author":"HF Parsons","key":"ref17"},{"issue":"1245","key":"ref18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1126\/science.48.1245.451","article-title":"The Influenza Pneumonia Pandemic in the American Army Camps during September and October. 1918","volume":"48","author":"GA Soper","year":"1918","journal-title":"Science"},{"article-title":"Epidemic Influenza: A Survey","year":"1927","author":"EO Jordan","key":"ref19"},{"key":"ref20","unstructured":"Hong Kong Battling Influenza Epidemic. New York Times. 1957; p. 3."},{"key":"ref21","unstructured":"Bulletin of the World Health Organization; 1959."},{"issue":"3","key":"ref22","first-page":"345","article-title":"Origin and progress of the 1968-69 Hong Kong influenza epidemic","volume":"41","author":"WC Cockburn","year":"1969","journal-title":"Bull World Health Organ"},{"key":"ref23","first-page":"349","article-title":"National influenza experience in Hong Kong, 1968","volume":"41","author":"WK Chang","year":"1969","journal-title":"Bull World Health Organ"},{"key":"ref24","first-page":"790","article-title":"Where did the red flu come from?","author":"WIB Beveridge","year":"1978"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000436","article-title":"Characterizing the Epidemiology of the 2009 Influenza A\/H1N1 Pandemic in Mexico","volume":"8","author":"G Chowell","year":"2011","journal-title":"PLoS Medicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2334-14-480","article-title":"Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature","volume":"14","author":"M Biggerstaff","year":"2014","journal-title":"BMC infectious diseases"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1353\/bhm.2002.0022","article-title":"Updating the Accounts: Global Mortality of the 1918-1920 \u201cSpanish\u201d Influenza Pandemic","volume":"76","author":"NPAS Johnson","year":"2002","journal-title":"Bulletin of the History of Medicine"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3201\/eid1209.05-0979","article-title":"1918 Influenza: the Mother of All Pandemics","volume":"12","author":"JK Taubenberger","year":"2006","journal-title":"Emerging Infectious Diseases"},{"key":"ref29","unstructured":"WHO, CDC. National and Regional Level Outpatient Illness and Viral Surveillance; 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/gis.cdc.gov\/grasp\/fluview\/fluportaldashboard.html\" xlink:type=\"simple\">http:\/\/gis.cdc.gov\/grasp\/fluview\/fluportaldashboard.html<\/ext-link>."},{"key":"ref30","unstructured":"CDC. Update: Novel Influenza A (H1N1) Virus Infection\u2014Mexico, March\u2013May, 2009; 2009. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5821a2.htm\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5821a2.htm<\/ext-link>."},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"e1000316","DOI":"10.1371\/journal.pbio.1000316","article-title":"Absolute humidity and the seasonal onset of influenza in the continental United States","volume":"8","author":"J Shaman","year":"2010","journal-title":"PLoS biology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/aje\/kwq347","article-title":"Absolute humidity and pandemic versus epidemic influenza","volume":"173","author":"J Shaman","year":"2011","journal-title":"American journal of epidemiology"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"e1002205","DOI":"10.1371\/journal.pcbi.1002205","article-title":"Determinants of the Spatiotemporal Dynamics of the 2009 H1N1 Pandemic in Europe: Implications for Real-Time Modelling","volume":"7","author":"S Merler","year":"2011","journal-title":"PLoS Computational Biology"},{"key":"ref34","first-page":"1","article-title":"Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus","author":"M Worobey","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7250","key":"ref35","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature08182","article-title":"Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic","volume":"459","author":"GJD Smith","year":"2009","journal-title":"Nature"},{"issue":"28","key":"ref36","doi-asserted-by":"crossref","first-page":"11709","DOI":"10.1073\/pnas.0904991106","article-title":"Dating the emergence of pandemic influenza viruses","volume":"106","author":"GJD Smith","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref37","first-page":"1","article-title":"Capturing the dynamics of pathogens with many strains","author":"AJ Kucharski","year":"2015","journal-title":"Journal of mathematical biology"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7007-10-38","article-title":"Canalization of the evolutionary trajectory of the human influenza virus","volume":"10","author":"T Bedford","year":"2012","journal-title":"BMC biology"},{"issue":"1729","key":"ref39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1098\/rspb.2011.1168","article-title":"Influenza emergence in the face of evolutionary constraints","volume":"279","author":"A Kucharski","year":"2012","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"e1003104","DOI":"10.1371\/journal.ppat.1003104","article-title":"The roles of competition and mutation in shaping antigenic and genetic diversity in influenza","volume":"9","author":"D Zinder","year":"2013","journal-title":"PLoS pathogens"},{"issue":"7559","key":"ref41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature14460","article-title":"Global circulation patterns of seasonal influenza viruses vary with antigenic drift","volume":"523","author":"T Bedford","year":"2015","journal-title":"Nature"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/JB.89.1.170-174.1965","article-title":"Induction of Partial Specific Heterotypic Immunity in Mice By a Single Infection With Influenza a Virus","volume":"89","author":"JL Schulman","year":"1965","journal-title":"Journal of bacteriology"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.micinf.2008.07.002","article-title":"Heterosubtypic immunity to influenza A virus: where do we stand?","volume":"10","author":"KM Grebe","year":"2008","journal-title":"Microbes and Infection"},{"issue":"6930","key":"ref44","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature01509","article-title":"Ecological and immunological determinants of influenza evolution","volume":"422","author":"NM Ferguson","year":"2003","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/viro.1998.9521","article-title":"Heterosubtypic Immunity to Lethal Influenza A Virus Infection Is Associated with Virus-Specific CD8+ Cytotoxic T Lymphocyte Responses Induced in Mucosa-Associated Tissues","volume":"254","author":"HH Nguyen","year":"1999","journal-title":"Virology"},{"issue":"06","key":"ref46","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1017\/S0950268814001976","article-title":"Cross-immunity and age patterns of influenza A(H5N1) infection","volume":"143","author":"AJ Kucharski","year":"2015","journal-title":"Epidemiology and Infection"},{"key":"ref47","first-page":"1653","article-title":"Effector mechanisms and their longevity","volume":"152","author":"S Liang","year":"1994","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"key":"ref48","unstructured":"Gostic KM, Ambrose MR, Worobey M, Lloyd-Smith JO. Potent Protection against H5N1 and H7N9 Influenza via Childhood Hemagglutinin Imprinting; 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/061598\" xlink:type=\"simple\">http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/061598<\/ext-link>."},{"issue":"36","key":"ref49","doi-asserted-by":"crossref","first-page":"13133","DOI":"10.1073\/pnas.1414070111","article-title":"Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans","volume":"111","author":"AH Ellebedy","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"23","key":"ref50","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.1118979109","article-title":"Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells","volume":"109","author":"GM Li","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"198","key":"ref51","doi-asserted-by":"crossref","first-page":"198ra107","DOI":"10.1126\/scitranslmed.3006637","article-title":"Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis","volume":"5","author":"MS Miller","year":"2013","journal-title":"Science translational medicine"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1073\/pnas.1200039109","article-title":"Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses","volume":"109","author":"N Pica","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"14","key":"ref53","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1073\/pnas.1522376113","article-title":"Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity","volume":"113","author":"JR Hamilton","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"11","key":"ref54","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/infdis\/jiv260","article-title":"Interval Between Infections and Viral Hierarchy Are Determinants of Viral Interference Following Influenza Virus Infection in a Ferret Model","volume":"212","author":"KL Laurie","year":"2015","journal-title":"Journal of Infectious Diseases"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1086\/656188","article-title":"Multiple Infections with Seasonal Influenza A Virus Induce CrossProtective Immunity against A(H1N1) Pandemic Influenza Virus in a Ferret Model","volume":"202","author":"KL Laurie","year":"2010","journal-title":"The Journal of Infectious Diseases"},{"issue":"47","key":"ref56","first-page":"1","article-title":"Seasonal influenza vaccination and the risk of infection with pandemic influenza: a possible illustration of non-specific temporary immunity following infection","volume":"15","author":"H Kelly","year":"2010","journal-title":"Euro surveillance: European communicable disease bulletin"},{"issue":"17","key":"ref57","doi-asserted-by":"crossref","first-page":"9331","DOI":"10.1128\/JVI.00751-07","article-title":"Heterosubtypic Immunity to Influenza A Virus Infection Requires a Properly Diversified Antibody Repertoire","volume":"81","author":"HH Nguyen","year":"2007","journal-title":"Journal of Virology"},{"issue":"1410","key":"ref58","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1098\/rspb.1998.0537","article-title":"Population dynamic interference among childhood diseases","volume":"265","author":"P Rohani","year":"1998","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/infdis\/151.1.81","article-title":"Cross-subtype protection in humans during sequential, overlapping, and\/or concurrent epidemics caused by h3n2 and h1n1 influenza viruses","volume":"151","author":"T Sonoguchi","year":"1985","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1503\/cmaj.091807","article-title":"Estimated epidemiologic parameters and morbidity associated with pandemic H1N1 influenza","volume":"182","author":"AR Tuite","year":"2010","journal-title":"Canadian Medical Association Journal"},{"issue":"11","key":"ref61","first-page":"201415012","article-title":"Inference of seasonal and pandemic influenza transmission dynamics","volume":"3","author":"W Yang","year":"2015","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref62","unstructured":"NOAA. Gridded Climate Datasets; 2017. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.esrl.noaa.gov\/psd\/cgi-bin\/db_search\/DBListFiles.pl?did=59&tid=57631&vid=4277\" xlink:type=\"simple\">https:\/\/www.esrl.noaa.gov\/psd\/cgi-bin\/db_search\/DBListFiles.pl?did=59&amp;tid=57631&amp;vid=4277<\/ext-link>."},{"issue":"25","key":"ref63","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact Stochastic Simulation of Coupled Chemical Reactions","volume":"81","author":"DT Gillesple","year":"1977","journal-title":"The Journal of Physical Chemistry"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2105-13-76","article-title":"EpiFire: An open source C++ library and application for contact network epidemiology","volume":"13","author":"T Hladish","year":"2012","journal-title":"BMC bioinformatics"},{"issue":"16","key":"ref65","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1098\/rsif.2007.1100","article-title":"When individual behaviour matters: homogeneous and network models in epidemiology","volume":"4","author":"S Bansal","year":"2007","journal-title":"Journal of The Royal Society Interface"},{"issue":"6","key":"ref66","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/EDE.0b013e31826c2dda","article-title":"Improving the estimation of influenza-related mortality over a seasonal baseline","volume":"23","author":"E Goldstein","year":"2012","journal-title":"Epidemiology (Cambridge, Mass)"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00285-007-0116-4","article-title":"SIR dynamics in random networks with heterogeneous connectivity","volume":"56","author":"E Volz","year":"2008","journal-title":"Journal of Mathematical Biology"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00285-010-0337-9","article-title":"A note on a paper by Erik Volz: SIR dynamics in random networks","volume":"62","author":"JC Miller","year":"2011","journal-title":"Journal of mathematical biology"},{"key":"ref69","unstructured":"Carlson K. Mathematical Modeling of Infectious Diseases with Latency: Homogeneous Mixing and Contact Network [Masters of Science]. University of Central Florida; 2016."},{"issue":"9","key":"ref70","first-page":"1","article-title":"Solving Differential Equations in R: Package deSolve","volume":"33","author":"K Soetart","year":"2010","journal-title":"Journal of Statistical Software"},{"key":"ref71","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing; 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.R-project.org\/\" xlink:type=\"simple\">https:\/\/www.R-project.org\/<\/ext-link>."},{"issue":"1","key":"ref72","doi-asserted-by":"crossref","first-page":"010101","DOI":"10.1103\/PhysRevE.76.010101","article-title":"Epidemic size and probability in populations with heterogeneous infectivity and susceptibility","volume":"76","author":"JC Miller","year":"2007","journal-title":"Physical Review E"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1090\/S0273-0979-06-01148-7","article-title":"Contact Network Epidemiology: Bond Percolation Applied to Infectious Disease Prediction and Control","volume":"44","author":"LA Meyers","year":"2007","journal-title":"Bulletin of the American Mathematical Society"},{"issue":"1609","key":"ref74","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1098\/rspb.2006.3754","article-title":"How generation intervals shape the relationship between growth rates and reproductive numbers","volume":"274","author":"J Wallinga","year":"2007","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jtbi.2012.06.012","article-title":"The impact of past epidemics on future disease dynamics","volume":"309","author":"S Bansal","year":"2012","journal-title":"Journal of Theoretical Biology"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/BF01719674","article-title":"Source for influenza pandemics","volume":"10","author":"C Scholtissek","year":"1994","journal-title":"European Journal of Epidemiology"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1006\/viro.1993.1319","article-title":"Origin of the Pandemic 1957 H2 Influenza A Virus and the Persistence of Its Possible Progenitors in the Avian Reservoir","volume":"194","author":"JR Sch\u00e4ffr","year":"1993","journal-title":"Virology"},{"issue":"25","key":"ref78","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1056\/NEJMoa0903810","article-title":"Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans","volume":"360","author":"KK Teo","year":"2009","journal-title":"New England Journal of Medicine"},{"key":"ref79","first-page":"1","article-title":"Evolution and emergence of infectious diseases in theoretical and real-world networks","volume":"2","author":"GE Leventhal","year":"2015","journal-title":"Nature Communications"},{"issue":"10","key":"ref80","doi-asserted-by":"crossref","first-page":"108701","DOI":"10.1103\/PhysRevLett.95.108701","article-title":"Threshold Effects for Two Pathogens Spreading on a Network","volume":"95","author":"M Newman","year":"2005","journal-title":"Physical Review Letters"},{"issue":"1602","key":"ref81","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1098\/rspb.2006.3636","article-title":"Network frailty and the geometry of herd immunity","volume":"273","author":"MJ Ferrari","year":"2006","journal-title":"Proceedings of the Royal Society of London B: Biological Sciences"},{"issue":"7","key":"ref82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0101421","article-title":"Epidemics on networks with large initial conditions or changing structure","volume":"9","author":"JC Miller","year":"2014","journal-title":"PLoS ONE"},{"issue":"70","key":"ref83","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1098\/rsif.2011.0403","article-title":"Edge-based compartmental modelling for infectious disease spread","volume":"9","author":"JC Miller","year":"2012","journal-title":"Journal of The Royal Society Interface"},{"key":"ref84","first-page":"199","article-title":"Paleomicrobiology: Past Human Infections","author":"B Lina","year":"2008"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1086\/524065","article-title":"Epidemiologic characterization of the 1918 influenza pandemic summer wave in Copenhagen: implications for pandemic control strategies","volume":"197","author":"V Andreasen","year":"2008","journal-title":"The Journal of infectious diseases"},{"issue":"4","key":"ref86","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1086\/654897","article-title":"Mortality patterns associated with the 1918 influenza pandemic in Mexico: evidence for a spring herald wave and lack of preexisting immunity in older populations","volume":"202","author":"G Chowell","year":"2010","journal-title":"The Journal of infectious diseases"},{"issue":"33","key":"ref87","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.1073\/pnas.1303117110","article-title":"Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England","volume":"110","author":"I Dorigatti","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref88","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/JVI.01762-10","article-title":"Phylogeography of the spring and fall waves of the H1N1\/09 pandemic influenza virus in the United States","volume":"85","author":"MI Nelson","year":"2011","journal-title":"Journal of virology"},{"issue":"31","key":"ref89","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.0408290102","article-title":"Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York City","volume":"102","author":"DR Olson","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2\u20133","key":"ref90","first-page":"187","article-title":"Summary report on the Asian influenza epidemic in Japan, 1957","volume":"20","author":"H Fukumi","year":"1959","journal-title":"Bulletin of the World Health Organization"},{"issue":"1634","key":"ref91","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1098\/rspb.2007.1477","article-title":"The 1918-1919 influenza pandemic in England and Wales: spatial patterns in transmissibility and mortality impact","volume":"275","author":"G Chowell","year":"2008","journal-title":"Proceedings Biological sciences \/ The Royal Society"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/irv.12217","article-title":"The 1918 influenza pandemic in New York City: Age-specific timing, mortality, and transmission dynamics","volume":"8","author":"W Yang","year":"2014","journal-title":"Influenza and other Respiratory Viruses"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"RRN1209","DOI":"10.1371\/currents.RRN1209","article-title":"Prevalence and risk factors for swine influenza virus infection in the 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