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Chem"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(92)90324-D","article-title":"Calmodulin structure refined at 1.7 A resolution","volume":"228","author":"R Chattopadhyaya","year":"1992","journal-title":"J Mol Biol"},{"issue":"5057","key":"ref81","doi-asserted-by":"crossref","DOI":"10.1126\/science.1585175","article-title":"Solution structure of a calmodulin-target peptide complex by multidimensional NMR","volume":"256","author":"M Ikura","year":"1992","journal-title":"Science"},{"issue":"2","key":"ref82","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuroscience.2007.01.045","article-title":"Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain","volume":"146","author":"AC Conti","year":"2007","journal-title":"Neuroscience"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/syn.890140108","article-title":"Discrete expression of Ca2+\/calmodulin-sensitive and Ca2+-insensitive adenylyl cyclases in the rat brain","volume":"14","author":"N Mons","year":"1993","journal-title":"Synapse"},{"issue":"16","key":"ref84","doi-asserted-by":"crossref","first-page":"12190","DOI":"10.1016\/S0021-9258(17)32700-X","article-title":"Type VIII adenylyl cyclase: A Ca2+\/calmodulin-stimulated enzyme expressed in discrete regions of rat brain","volume":"269","author":"JJ Cali","year":"1994","journal-title":"J Biol Chem"},{"issue":"10","key":"ref85","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/bi00734a004","article-title":"Solubilization, stabilization, and partial purification of brain adenylate cyclase from rat","volume":"12","author":"NI Swislocki","year":"1973","journal-title":"Biochemistry"},{"issue":"1","key":"ref86","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1073\/pnas.72.1.64","article-title":"Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase","volume":"72","author":"CO Brostrom","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"ref87","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1074\/jbc.270.13.7573","article-title":"Identification of functional domains of adenylyl cyclase using in vivo chimeras","volume":"270","author":"LR Levin","year":"1995","journal-title":"J Biol Chem"},{"issue":"7","key":"ref88","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1074\/jbc.M807359200","article-title":"Distinct Mechanisms of Regulation by Ca(2+)\/Calmodulin of Type 1 and 8 Adenylyl Cyclases Support Their Different Physiological Roles","volume":"284","author":"N Masada","year":"2009","journal-title":"J Biol Chem"},{"issue":"12","key":"ref89","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1074\/jbc.274.12.8012","article-title":"Calmodulin-binding sites on adenylyl cyclase type VIII","volume":"274","author":"C Gu","year":"1999","journal-title":"J Biol Chem"},{"issue":"429","key":"ref90","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1007\/s00216-013-7358-3","article-title":"Structural insights into calmodulin\/adenylyl cyclase 8 interaction","volume":"405","author":"S Herbst","year":"2013","journal-title":"Anal Bioanal Chem"},{"issue":"1","key":"ref91","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2005.03.039","article-title":"Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers","volume":"134","author":"SM Lilly","year":"2005","journal-title":"Neuroscience"},{"issue":"3","key":"ref92","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0306-4522(96)00626-4","article-title":"Calcineurin in the adult rat hippocampus: Different distribution in CA1 and CA3 subfields","volume":"78","author":"M Morioka","year":"1997","journal-title":"Neuroscience"},{"issue":"12","key":"ref93","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1073\/pnas.76.12.6270","article-title":"Calcineurin: A calcium- and calmodulin-binding protein of the nervous system","volume":"76","author":"CB Klee","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"36","key":"ref94","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1021\/bi5004734","article-title":"Stoichiometry of the calcineurin regulatory domain-calmodulin complex","volume":"53","author":"TB Dunlap","year":"2014","journal-title":"Biochemistry"},{"issue":"2","key":"ref95","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tcb.2010.09.011","article-title":"Interaction of calcineurin with substrates and targeting proteins","volume":"21","author":"L Huiming","year":"2011","journal-title":"Trends Cell Biol"},{"issue":"9","key":"ref96","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/bi00550a016","article-title":"High levels of a heat-labile calmodulin-binding protein (CaM-BP80) in bovine neostriatum","volume":"19","author":"RW Wallace","year":"1980","journal-title":"Biochemistry"},{"issue":"15","key":"ref97","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1016\/S0021-9258(17)39454-1","article-title":"Distinct forebrain and cerebellar isozymes of type II calcium\/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction","volume":"260","author":"SG Miller","year":"1985","journal-title":"J Biol Chem"},{"issue":"4","key":"ref98","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0306-4522(92)90189-9","article-title":"Dendritic localization of type II calcium calmodulin-dependent protein kinase mRNA in normal and reinnervated rat hippocampus","volume":"46","author":"DL Benson","year":"1992","journal-title":"Neuroscience"},{"issue":"20","key":"ref99","doi-asserted-by":"crossref","first-page":"12735","DOI":"10.1016\/S0021-9258(17)44239-6","article-title":"Purification and characterization of a calmoduli-dependent protein kinase that is highly concentrated in brain","volume":"258","author":"MK Bennett","year":"1983","journal-title":"J Biol Chem"},{"issue":"10","key":"ref100","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1016\/S0021-9258(18)88990-6","article-title":"Mechanism of autophosphorylation of the multifunctional Ca2+\/calmodulin-dependent protein kinase","volume":"260","author":"J Kuret","year":"1985","journal-title":"J Biol Chem"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0167-4889(91)90063-4","article-title":"Calmodulin-dependent protein kinase II: Kinetic studies on the interaction with substrates and calmodulin","volume":"1091","author":"T Katoh","year":"1991","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"ref102","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1529\/biophysj.104.055319","article-title":"Two-photon cross-correlation analysis of intracellular reactions with variable stoichiometry","volume":"88","author":"SA Kim","year":"2005","journal-title":"Biophys J"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.bi.61.070192.003015","article-title":"Neuronal Ca2+\/calmodulin-dependent protein kinases","volume":"61","author":"PI Hanson","year":"1992","journal-title":"Annu Rev Biochem"},{"issue":"8","key":"ref104","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tins.2006.06.009","article-title":"alphaCaMKII autophosphorylation: A fast track to memory","volume":"29","author":"EE Irvine","year":"2006","journal-title":"Trends Neurosci"},{"issue":"5060","key":"ref105","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.256.5060.1199","article-title":"Calmodulin trapping by calcium-calmodulin-dependent protein kinase","volume":"256","author":"T Meyer","year":"1992","journal-title":"Science"},{"issue":"1","key":"ref106","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0169-328X(92)90006-W","article-title":"Myosin light chain kinase is expressed in neurons and glia: Immunoblotting and immunocytochemical studies","volume":"14","author":"AM Edelman","year":"1992","journal-title":"Mol Brain Res"},{"issue":"2","key":"ref107","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/bi00595a010","article-title":"Modulator protein as a component of the myosin light chain kinase from chicken gizzard","volume":"17","author":"R Dabrowska","year":"1978","journal-title":"Biochemistry"},{"issue":"6","key":"ref108","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1021\/bi00354a041","article-title":"Calmodulin binding domains: Characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase","volume":"25","author":"TJ Lukas","year":"1986","journal-title":"Biochemistry"},{"issue":"7","key":"ref109","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/S0021-9258(19)69586-4","article-title":"The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3':5' cAMP-dependent protein kinase","volume":"256","author":"MA Conti","year":"1981","journal-title":"J Biol Chem"},{"issue":"3","key":"ref110","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/geno.1995.9965","article-title":"The human myosin light chain kinase (MLCK) from hippocampus: Cloning, sequencing, expression, and localization to 3qcen-q21","volume":"29","author":"M-C Potier","year":"1995","journal-title":"Genomics"},{"issue":"1","key":"ref111","doi-asserted-by":"crossref","first-page":"C94","DOI":"10.1152\/ajpcell.00257.2001","article-title":"Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscle","volume":"51","author":"P Szymanski","year":"2002","journal-title":"Am J Physiol"},{"issue":"1","key":"ref112","first-page":"229","article-title":"Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17)","volume":"266","author":"J Baudier","year":"1991","journal-title":"J Biol Chem"},{"issue":"1","key":"ref113","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1042\/BJ20061483","article-title":"Neurogranin binds to phosphatidic acid and associates to cellular membranes","volume":"404","author":"I Dominguez-Gonzalez","year":"2007","journal-title":"Biochem J"},{"issue":"12","key":"ref114","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1523\/JNEUROSCI.10-12-03782.1990","article-title":"Neurogranin: Immunocytochemical localization of a brain-specific protein kinase C substrate","volume":"10","author":"A Represa","year":"1990","journal-title":"J Neurosci"},{"issue":"35","key":"ref115","doi-asserted-by":"crossref","first-page":"22420","DOI":"10.1016\/S0021-9258(17)31806-9","article-title":"Mutational and biophysical studies suggest RC3\/neurogranin regulates calmodulin availability","volume":"269","author":"DD Gerendasy","year":"1994","journal-title":"J Biol Chem"},{"issue":"2","key":"ref116","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1006\/abbi.1993.1463","article-title":"Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain","volume":"305","author":"K-P Huang","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"ref117","doi-asserted-by":"crossref","first-page":"e41275","DOI":"10.1371\/journal.pone.0041275","article-title":"Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation","volume":"7","author":"L Zhong","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref118","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2826.1996.tb00688.x","article-title":"Relationship of neuronal nitric oxide synthase immunoreactivity to GnRH neurons in the ovariectomized and intact female rat","volume":"8","author":"AE Herbison","year":"1996","journal-title":"J Neuroendocrinol"},{"issue":"20","key":"ref119","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.1523\/JNEUROSCI.22-20-08961.2002","article-title":"Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus","volume":"22","author":"A Burette","year":"2002","journal-title":"J Neurosci"},{"issue":"2","key":"ref120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0306-4522(96)00297-7","article-title":"Localization of neuronal and endothelial nitric oxide synthase isoforms in human hippocampus","volume":"76","author":"CA Doyle","year":"1997","journal-title":"Neuroscience"},{"issue":"2","key":"ref121","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1073\/pnas.87.2.682","article-title":"Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme","volume":"87","author":"DS Bredt","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"26","key":"ref122","doi-asserted-by":"crossref","first-page":"23349","DOI":"10.1074\/jbc.M100687200","article-title":"Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer","volume":"276","author":"K Panda","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"ref123","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bios.2009.06.039","article-title":"Monitoring the activation of neuronal nitric oxide synthase in brain tissue and cells with a potentiometric immunosensor","volume":"25","author":"WC Koh","year":"2009","journal-title":"Biosensors Bioelectron"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.01.030","article-title":"The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortext and striatum","volume":"1554","author":"CF Lourenco","year":"2014","journal-title":"Brain Res"},{"issue":"3","key":"ref125","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0896-6273(02)00573-1","article-title":"The life cycle of Ca2+ ions in dendritic spines","volume":"33","author":"BL Sabatini","year":"2002","journal-title":"Neuron"},{"issue":"21","key":"ref126","doi-asserted-by":"crossref","first-page":"11232","DOI":"10.1073\/pnas.210184697","article-title":"Involvement of neurogranin in the modulation of calcium\/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice","volume":"97","author":"JH Pak","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"ref127","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1523\/JNEUROSCI.22-13-05525.2002","article-title":"Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus","volume":"22","author":"T Krucker","year":"2002","journal-title":"J Neurosci"},{"issue":"1","key":"ref128","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.pone.0008449","article-title":"Ligand Depletion in vivo Modulates the Dynamic Range and Cooperativity of Signal Transduction","volume":"5","author":"SJ Edelstein","year":"2010","journal-title":"PLoS One"},{"issue":"17","key":"ref129","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1113\/JP270510","article-title":"Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes","volume":"593","author":"H Bazzazi","year":"2015","journal-title":"J Physiol"},{"issue":"43","key":"ref130","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1523\/JNEUROSCI.3326-12.2012","article-title":"AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors","volume":"32","author":"JL Sanderson","year":"2012","journal-title":"J Neurosci"},{"issue":"3","key":"ref131","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1073858410384740","article-title":"AKAP Signaling Complexes in Regulation of Excitatory Synaptic 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