{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:17:22Z","timestamp":1777695442894,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005958","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000}}],"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L023458\/1"],"award-info":[{"award-number":["BB\/L023458\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/ N010760\/1"],"award-info":[{"award-number":["MR\/ N010760\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005958","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T13:26:20Z","timestamp":1517837180000},"page":"e1005958","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":234,"title":["A phylogenetic method to perform genome-wide association studies in microbes that accounts for population structure and recombination"],"prefix":"10.1371","volume":"14","author":[{"given":"Caitlin","family":"Collins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-500X","authenticated-orcid":true,"given":"Xavier","family":"Didelot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"ref1","first-page":"72","article-title":"Global Health Indicators: Cause-specific mortality and morbidity","year":"2015"},{"issue":"46","key":"ref2","doi-asserted-by":"crossref","first-page":"19545","DOI":"10.1073\/pnas.0909285106","article-title":"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus","volume":"106","author":"BV Lowder","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/gbe\/evq031","article-title":"Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation","volume":"2","author":"CM Guinane","year":"2010","journal-title":"Genome Biol Evol"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.5858\/2004-128-1337-TOEAII","article-title":"The -omics era and its impact","volume":"128","author":"FL Kiechle","year":"2004","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1101\/gr.147710.112","article-title":"A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic","volume":"23","author":"MTG Holden","year":"2013","journal-title":"Genome Res"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ng1337","article-title":"The effects of human population structure on large genetic association studies","volume":"36","author":"J Marchini","year":"2004","journal-title":"Nat Genet"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/sj.ejhg.5201239","article-title":"Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin","volume":"12","author":"LA Weiss","year":"2004","journal-title":"Eur J Hum Genet"},{"issue":"5720","key":"ref8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"JL Haines","year":"2005","journal-title":"Science"},{"issue":"5720","key":"ref9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"RJ Klein","year":"2005","journal-title":"Science"},{"issue":"Database issue","key":"ref10","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","article-title":"The NHGRI GWAS Catalog, a curated resource of SNP-trait associations","volume":"42","author":"D Welter","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tim.2006.06.003","article-title":"Genome-wide association mapping in bacteria?","volume":"14","author":"D Falush","year":"2006","journal-title":"Trends Microbiol"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13073-014-0109-z","article-title":"Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology","volume":"6","author":"T Read","year":"2014","journal-title":"Genome Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mib.2015.03.002","article-title":"The advent of genome-wide association studies for bacteria","volume":"25","author":"PE Chen","year":"2015","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrg.2016.132","article-title":"Microbial genome-wide association studies: lessons from human GWAS","volume":"18","author":"RA Power","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1534\/genetics.110.120121","article-title":"Inference of homologous recombination in bacteria using whole-genome sequences","volume":"186","author":"X Didelot","year":"2010","journal-title":"Genetics"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tim.2010.04.002","article-title":"Impact of recombination on bacterial evolution","volume":"18","author":"X Didelot","year":"2010","journal-title":"Trends Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mib.2014.11.016","article-title":"Ten years of pan-genome analyses","volume":"23","author":"G Vernikos","year":"2015","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1534\/genetics.116.190496","article-title":"Bayesian Inference of the Evolution of a Phenotype Distribution on a Phylogenetic Tree","volume":"204","author":"MA Ansari","year":"2016","journal-title":"Genetics"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"issue":"303","key":"ref20","first-page":"690","article-title":"Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel-Haenszel Procedure","volume":"58","author":"N Mantel","year":"1963","journal-title":"J Am Stat Assoc"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/14786440109462720","article-title":"On lines and planes of closest fit to systems of points in space","volume":"2","author":"K Pearson","year":"1901","journal-title":"Philosophical Magazine Series 6"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2156-11-94","article-title":"Discriminant analysis of principal components: a new method for the analysis of genetically structured populations","volume":"11","author":"T Jombart","year":"2010","journal-title":"BMC Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1038\/ncomms7740","article-title":"Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis","volume":"6","author":"LA Weinert","year":"2015","journal-title":"Nat Commun"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"e1004547","DOI":"10.1371\/journal.pgen.1004547","article-title":"Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes","volume":"10","author":"C Chewapreecha","year":"2014","journal-title":"PLoS Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1186\/1471-2164-15-1179","article-title":"The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis","volume":"15","author":"KJ Howell","year":"2014","journal-title":"BMC Genomics"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"e0163746","DOI":"10.1371\/journal.pone.0163746","article-title":"Genome-Wide Association Study of HIV Whole Genome Sequences Validated using Drug Resistance","volume":"11","author":"RA Power","year":"2016","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"12797","DOI":"10.1038\/ncomms12797","article-title":"Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes","volume":"7","author":"JA Lees","year":"2016","journal-title":"Nat Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"16041","DOI":"10.1038\/nmicrobiol.2016.41","article-title":"Identifying lineage effects when controlling for population structure improves power in bacterial association studies","volume":"1","author":"SG Earle","year":"2016","journal-title":"Nat Microbiol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13059-016-1108-8","article-title":"Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary","volume":"17","author":"O Brynildsrud","year":"2016","journal-title":"Genome Biol"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13073-014-0101-7","article-title":"A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens","volume":"6","author":"M Farhat","year":"2014","journal-title":"Genome Med"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/ng.2747","article-title":"Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis","volume":"45","author":"MR Farhat","year":"2013","journal-title":"Nat Genet"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/mec.12162","article-title":"Progressive genome-wide introgression in agricultural Campylobacter coli","volume":"22","author":"SK Sheppard","year":"2013","journal-title":"Mol Ecol"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"e00101","DOI":"10.1128\/mSystems.00101-16","article-title":"From genomes to phenotypes: Traitar, the microbial trait analyzer","volume":"1","author":"A Weimann","year":"2016","journal-title":"mSystems"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1534\/genetics.106.063305","article-title":"Inference of bacterial microevolution using multilocus sequence data","volume":"175","author":"X Didelot","year":"2007","journal-title":"Genetics"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1371\/journal.pcbi.0010003","article-title":"Predicting functional gene links from phylogenetic-statistical analyses of whole genomes","volume":"1","author":"D Barker","year":"2005","journal-title":"PLoS Comput Biol"},{"issue":"18","key":"ref36","doi-asserted-by":"crossref","first-page":"i389","DOI":"10.1093\/bioinformatics\/bts396","article-title":"Uncovering the co-evolutionary network among prokaryotic genes","volume":"28","author":"O Cohen","year":"2012","journal-title":"Bioinformatics"},{"key":"ref37","first-page":"1409","article-title":"A statistical method for evaluating systematic relationships","volume":"38","author":"R Sokal","year":"1958","journal-title":"University of Kansas Science Bulletin"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/oxfordjournals.molbev.a025808","article-title":"BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data","volume":"14","author":"O Gascuel","year":"1997","journal-title":"Mol Biol Evol"},{"issue":"4","key":"ref39","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"N Saitou","year":"1987","journal-title":"Mol Biol Evol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2105-9-166","article-title":"Fast NJ-like algorithms to deal with incomplete distance matrices","volume":"9","author":"A Criscuolo","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01734359","article-title":"Evolutionary trees from DNA sequences: a maximum likelihood approach","volume":"17","author":"J Felsenstein","year":"1981","journal-title":"J Mol Evol"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"e1004041","DOI":"10.1371\/journal.pcbi.1004041","article-title":"ClonalFrameML: efficient inference of recombination in whole bacterial genomes","volume":"11","author":"X Didelot","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gku1196","article-title":"Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins","volume":"43","author":"NJ Croucher","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/sysbio\/20.4.406","article-title":"Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology","volume":"20","author":"WM Fitch","year":"1971","journal-title":"Syst Biol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0025-5564(87)90074-5","article-title":"Reconstructing ancestral character states under Wagner parsimony","volume":"87","author":"DL Swofford","year":"1987","journal-title":"Math Biosci"},{"issue":"1342","key":"ref46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1098\/rspb.1994.0006","article-title":"Detecting Correlated Evolution on Phylogenies: A General Method for the Comparative Analysis of Discrete Characters","volume":"255","author":"M Pagel","year":"1994","journal-title":"Proceedings of the Royal Society of London B: Biological Sciences"},{"issue":"5","key":"ref47","first-page":"471","article-title":"Maximum-likelihood estimation of evolutionary trees from continuous characters","volume":"25","author":"J Felsenstein","year":"1973","journal-title":"Am J Hum Genet"},{"issue":"29","key":"ref48","doi-asserted-by":"crossref","first-page":"11923","DOI":"10.1073\/pnas.1305559110","article-title":"Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter","volume":"110","author":"SK Sheppard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"12","key":"ref50","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"N Patterson","year":"2006","journal-title":"PLoS Genet"},{"issue":"4","key":"ref51","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"N Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"ref52","article-title":"Information Retrieval","author":"CJV Rijsbergen","year":"1979"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12862-015-0283-7","article-title":"Automatic selection of partitioning schemes for phylogenetic analyses using iterative k-means clustering of site rates","volume":"15","author":"PB Frandsen","year":"2015","journal-title":"BMC Evol Biol"},{"issue":"R2","key":"ref54","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1093\/hmg\/ddn268","article-title":"Accounting for ancestry: population substructure and genome-wide association studies","volume":"17","author":"C Tian","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1186\/1471-2105-11-595","article-title":"BIGSdb: Scalable analysis of bacterial genome variation at the population level","volume":"11","author":"KA Jolley","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ismej.2008.93","article-title":"A comparison of homologous recombination rates in bacteria and archaea","volume":"3","author":"M Vos","year":"2008","journal-title":"ISME J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4939-6673-8_8","article-title":"Reconstructing the Ancestral Relationships Between Bacterial Pathogen Genomes","volume":"1535","author":"C Collins","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"Suppl 1","key":"ref58","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1093\/clinids\/24.Supplement_1.S98","article-title":"Antibiotic resistance in Neisseria meningitidis","volume":"24","author":"BA Oppenheim","year":"1997","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/jb.176.2.333-337.1994","article-title":"Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation","volume":"176","author":"LD Bowler","year":"1994","journal-title":"J Bacteriol"},{"issue":"Suppl 1","key":"ref60","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1086\/514917","article-title":"Horizontal genetic exchange, evolution, and spread of antibiotic resistance in bacteria","volume":"27","author":"MC Maiden","year":"1998","journal-title":"Clin Infect Dis"},{"issue":"22","key":"ref61","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1073\/pnas.86.22.8988","article-title":"Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis","volume":"86","author":"BG Spratt","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref62","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1128\/AAC.34.8.1523","article-title":"Genetic diversity of penicillin-binding protein 2 genes of penicillin-resistant strains of Neisseria meningitidis revealed by fingerprinting of amplified DNA","volume":"34","author":"QY Zhang","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mib.2014.11.006","article-title":"Neisseria meningitidis: pathogenesis and immunity","volume":"23","author":"M Pizza","year":"2015","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"ref64","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2958.2004.04423.x","article-title":"Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells","volume":"55","author":"B Capecchi","year":"2005","journal-title":"Mol Microbiol"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1084\/jem.20020407","article-title":"NadA, a novel vaccine candidate of Neisseria meningitidis","volume":"195","author":"M Comanducci","year":"2002","journal-title":"J Exp Med"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/JB.06161-11","article-title":"In the NadR regulon, adhesins and diverse meningococcal functions are regulated in response to signals in human saliva","volume":"194","author":"L Fagnocchi","year":"2012","journal-title":"J Bacteriol"},{"issue":"2","key":"ref67","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.pgen.0030023","article-title":"Meningococcal Genetic Variation Mechanisms Viewed through Comparative Analysis of Serogroup C Strain FAM18","volume":"3","author":"SD Bentley","year":"2007","journal-title":"PLoS Genet"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1086\/599377","article-title":"Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence","volume":"200","author":"OB Harrison","year":"2009","journal-title":"J Infect Dis"},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2958.1995.tb02266.x","article-title":"The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence","volume":"15","author":"I Stojiljkovic","year":"1995","journal-title":"Mol Microbiol"},{"issue":"15","key":"ref70","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1128\/jb.178.15.4670-4678.1996","article-title":"HmbR outer membrane receptors of pathogenic Neisseria spp.: iron-regulated, hemoglobin-binding proteins with a high level of primary structure conservation","volume":"178","author":"I Stojiljkovic","year":"1996","journal-title":"J Bacteriol"},{"issue":"10","key":"ref71","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1128\/JB.183.10.3160-3168.2001","article-title":"ComE, a competence protein from Neisseria gonorrhoeae with DNA-binding activity","volume":"183","author":"I Chen","year":"2001","journal-title":"J Bacteriol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2164-10-70","article-title":"Comparative analysis of two Neisseria gonorrhoeae genome sequences reveals evidence of mobilization of Correia Repeat Enclosed Elements and their role in regulation","volume":"10","author":"LAS Snyder","year":"2009","journal-title":"BMC Genomics"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/CS20090513","article-title":"Cellular and molecular biology of Neisseria meningitidis colonization and invasive disease","volume":"118","author":"DJ Hill","year":"2010","journal-title":"Clin Sci"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01173-16","article-title":"Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization","volume":"7","author":"E Capel","year":"2016","journal-title":"MBio"},{"issue":"10","key":"ref75","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1128\/IAI.72.10.5955-5962.2004","article-title":"Distribution of surface protein variants among hyperinvasive meningococci: implications for vaccine design","volume":"72","author":"R Urwin","year":"2004","journal-title":"Infect Immun"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3201\/eid1004.030247","article-title":"PorA variable regions of Neisseria meningitidis","volume":"10","author":"JE Russell","year":"2004","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"ref77","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1128\/IAI.67.5.2406-2413.1999","article-title":"Structural and evolutionary inference from molecular variation in Neisseria porins","volume":"67","author":"JP Derrick","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"ref78","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2958.1994.tb01014.x","article-title":"The porA gene in serogroup A meningococci: evolutionary stability and mechanism of genetic variation","volume":"12","author":"J Suker","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/1471-2180-10-280","article-title":"The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells","volume":"10","author":"SA Tunio","year":"2010","journal-title":"BMC Microbiol"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005958","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T19:00:34Z","timestamp":1660417234000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005958"}},"subtitle":[],"editor":[{"given":"Alice Carolyn","family":"McHardy","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":79,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005958","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/140798","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]}}}