{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T16:05:32Z","timestamp":1775923532906,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1005966","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000}}],"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1005966","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T18:23:32Z","timestamp":1520274212000},"page":"e1005966","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["A computational model for how cells choose temporal or spatial sensing during chemotaxis"],"prefix":"10.1371","volume":"14","author":[{"given":"Rui Zhen","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keng-Hwee","family":"Chiam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"e1000735","DOI":"10.1371\/journal.pcbi.1000735","article-title":"Quantitative modeling of Escherichia coli chemotactic motion in environments varying in space and time","volume":"6","author":"L Jiang","year":"2010","journal-title":"PLoS Comput Biol"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1073\/pnas.72.8.3235","article-title":"Transient response to chemotactic stimuli in Escherichia coli","volume":"72","author":"HC Berg","year":"1975","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0962-8924(00)01841-9","article-title":"Leukocytes navigate by compass: roles of PI3K<italic>\u03b3<\/italic> and its lipid products","volume":"10","author":"P Rickert","year":"2000","journal-title":"Trends in cell biology"},{"issue":"5458","key":"ref4","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1126\/science.287.5458.1652","article-title":"An ultrasensitive bacterial motor revealed by monitoring signaling proteins in single cells","volume":"287","author":"P Cluzel","year":"2000","journal-title":"Science"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S1097-2765(01)00273-8","article-title":"Topological regulation of cell division in E. coli: spatiotemporal oscillation of MinD requires stimulation of its ATPase by MinE and phospholipid","volume":"7","author":"Z Hu","year":"2001","journal-title":"Molecular cell"},{"issue":"5102","key":"ref6","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.8456299","article-title":"Polar location of the chemoreceptor complex in the Escherichia coli cell","volume":"259","author":"L Shapiro","year":"1993","journal-title":"Science"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-3495(77)85544-6","article-title":"Physics of chemoreception","volume":"20","author":"HC Berg","year":"1977","journal-title":"Biophysical journal"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0006-3495(98)77936-6","article-title":"Spatial sensing of stimulus gradients can be superior to temporal sensing for free-swimming bacteria","volume":"74","author":"DB Dusenbery","year":"1998","journal-title":"Biophysical journal"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1073\/pnas.97.9.4649","article-title":"Robust perfect adaptation in bacterial chemotaxis through integral feedback control","volume":"97","author":"TM Yi","year":"2000","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6636","key":"ref10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/43199","article-title":"Robustness in simple biochemical networks","volume":"387","author":"N Barkal","year":"1997","journal-title":"Nature"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1529\/biophysj.104.045484","article-title":"Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI (3, 4, 5) P 3 response in Dictyostelium cells","volume":"87","author":"L Ma","year":"2004","journal-title":"Biophysical journal"},{"issue":"205","key":"ref12","doi-asserted-by":"crossref","first-page":"ra2","DOI":"10.1126\/scisignal.2002413","article-title":"Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway","volume":"5","author":"K Takeda","year":"2012","journal-title":"Science signaling"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-3495(02)75373-3","article-title":"Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils","volume":"82","author":"A Levchenko","year":"2002","journal-title":"Biophysical journal"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.cell.2009.06.013","article-title":"Defining network topologies that can achieve biochemical adaptation","volume":"138","author":"W Ma","year":"2009","journal-title":"Cell"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/JB.135.2.559-574.1978","article-title":"Dimensions of Escherichia coli at various growth rates: model for envelope growth","volume":"135","author":"O Pierucci","year":"1978","journal-title":"Journal of bacteriology"},{"issue":"20","key":"ref16","doi-asserted-by":"crossref","first-page":"12669","DOI":"10.1073\/pnas.192463199","article-title":"Binding of the Escherichia coli response regulator CheY to its target measured in vivo by fluorescence resonance energy transfer","volume":"99","author":"V Sourjik","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/msb.2008.77","article-title":"Dynamic map of protein interactions in the Escherichia coli chemotaxis pathway","volume":"5","author":"D Kentner","year":"2009","journal-title":"Molecular systems biology"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/10042","article-title":"Spatial control of actin polymerization during neutrophil chemotaxis","volume":"1","author":"OD Weiner","year":"1999","journal-title":"Nature cell biology"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033796","article-title":"Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii","volume":"7","author":"R Pontier-Bres","year":"2012","journal-title":"PloS one"},{"key":"ref20","article-title":"Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori","author":"E Aihara","year":"2014","journal-title":"Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1128\/AEM.67.7.3299-3303.2001","article-title":"True chemotaxis in oxygen gradients of the sulfur-oxidizing bacterium Thiovulum majus","volume":"67","author":"R Thar","year":"2001","journal-title":"Applied and environmental microbiology"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1348-0421.1995.tb03260.x","article-title":"The measurement of swimming velocity of Vibrio cholerae and Pseudomonas aeruginosa using the video tracking method","volume":"39","author":"M Shigematsu","year":"1995","journal-title":"Microbiology and immunology"},{"issue":"3","key":"ref23","first-page":"401","article-title":"Effects of Various Chemicals on the Behaviour of Paramecium caudatum (With 7 Text-figures and 2 Tables)","volume":"17","author":"I Nakatani","year":"1970","journal-title":"= JOURNAL OF THE FACULTY OF SCIENCE HOKKAIDO UNIVERSITY Series ZOOLOGY"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2307\/1541279","article-title":"Chemosensory responses to amino acids and certain amines by the ciliate Tetrahymena: a flat capillary assay","volume":"167","author":"M Levandowsky","year":"1984","journal-title":"The Biological Bulletin"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/JB.134.2.671-673.1978","article-title":"Chemoresponses of Chlamydomonas reinhardtii","volume":"134","author":"R Hirschberg","year":"1978","journal-title":"Journal of bacteriology"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1083\/jcb.201204024","article-title":"Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm","volume":"198","author":"ND Kashikar","year":"2012","journal-title":"The Journal of cell biology"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/humrep\/den409","article-title":"Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides","volume":"24","author":"A Gakamsky","year":"2009","journal-title":"Human reproduction"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1371\/journal.pbio.0030356","article-title":"Modeling T cell antigen discrimination based on feedback control of digital ERK responses","volume":"3","author":"G Altan-Bonnet","year":"2005","journal-title":"PLoS biology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0022-1759(83)90208-9","article-title":"Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle","volume":"63","author":"JG Monroe","year":"1983","journal-title":"Journal of immunological methods"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1142\/S2339547813500040","article-title":"Measuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood","volume":"1","author":"AN Hoang","year":"2013","journal-title":"Technology"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/jcs.99.2.419","article-title":"Migration of individual microvessel endothelial cells: stochastic model and parameter measurement","volume":"99","author":"CL Stokes","year":"1991","journal-title":"Journal of Cell Science"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4049\/jimmunol.1002358","article-title":"Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4","volume":"186","author":"BG Ricart","year":"2011","journal-title":"The Journal of Immunology"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2011.12.034","article-title":"Arp2\/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis","volume":"148","author":"C Wu","year":"2012","journal-title":"Cell"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1242\/bio.20136619","article-title":"Activation of Drosophila hemocyte motility by the ecdysone hormone","volume":"2","author":"CJ Sampson","year":"2013","journal-title":"Biology open"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.201010003","article-title":"Cell behaviors regulated by guidance cues in collective migration of border cells","volume":"192","author":"M Poukkula","year":"2011","journal-title":"The Journal of cell biology"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ejcb.2006.01.012","article-title":"Dictyostelium discoideum chemotaxis: threshold for directed motion","volume":"85","author":"L Song","year":"2006","journal-title":"European journal of cell biology"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1538484","article-title":"Variations in cell size during the development of the slime mold, Dictyostelium discoideum","volume":"104","author":"JT Bonner","year":"1953","journal-title":"The Biological Bulletin"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1529\/biophysj.107.123851","article-title":"Intracellular microrheology of motile Amoeba proteus","volume":"94","author":"SS Rogers","year":"2008","journal-title":"Biophysical journal"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1073\/pnas.1030795100","article-title":"Bacteria are not too small for spatial sensing of chemical gradients: an experimental evidence","volume":"100","author":"R Thar","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cm.970010208","article-title":"Chemotaxis in Tetrahymena thermophila","volume":"1","author":"M Almagor","year":"1981","journal-title":"Cell Motility"},{"issue":"21","key":"ref41","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.0911178107","article-title":"External and internal constraints on eukaryotic chemotaxis","volume":"107","author":"D Fuller","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"17","key":"ref42","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.112.17.2867","article-title":"Orientation of chemotactic cells and growth cones: models and mechanisms","volume":"112","author":"H Meinhardt","year":"1999","journal-title":"Journal of Cell Science"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0006-3495(02)73906-4","article-title":"Establishing direction during chemotaxis in eukaryotic cells","volume":"83","author":"WJ Rappel","year":"2002","journal-title":"Biophysical journal"},{"issue":"8","key":"ref44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1114\/1.1385805","article-title":"A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics","volume":"29","author":"A Narang","year":"2001","journal-title":"Annals of biomedical engineering"},{"key":"ref45","article-title":"Fold-change detection and scale invariance of cell\u2013cell signaling in social amoeba","author":"K Kamino","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref46","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6367","article-title":"Rectified directional sensing in long-range cell migration","volume":"5","author":"A Nakajima","year":"2014","journal-title":"Nature communications"},{"issue":"213","key":"ref47","first-page":"ra17","article-title":"Diverse sensitivity thresholds in dynamic signaling responses by social amoebae","volume":"5","author":"CJ Wang","year":"2012","journal-title":"Sci Signal"},{"issue":"1629","key":"ref48","doi-asserted-by":"crossref","first-page":"20130117","DOI":"10.1098\/rstb.2013.0117","article-title":"Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture","volume":"368","author":"H Chang","year":"2013","journal-title":"Phil Trans R Soc B"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"048104","DOI":"10.1103\/PhysRevLett.105.048104","article-title":"Physical limits on cellular sensing of spatial gradients","volume":"105","author":"B Hu","year":"2010","journal-title":"Physical review letters"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.1038\/srep05688","article-title":"Memory improves precision of cell sensing in fluctuating environments","volume":"4","author":"G Aquino","year":"2014","journal-title":"Scientific reports"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Ellison D, Mugler A, Brennan M, Lee SH, Huebner R, Shamir E, et al. Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis. arXiv preprint arXiv:150804692. 2015;.","DOI":"10.1101\/025346"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2012.08.040","article-title":"Designing synthetic regulatory networks capable of self-organizing cell polarization","volume":"151","author":"AH Chau","year":"2012","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1005966","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T07:38:36Z","timestamp":1660549116000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1005966"}},"subtitle":[],"editor":[{"given":"Lingchong","family":"You","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1005966","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1005966","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]}}}