{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:22:22Z","timestamp":1778307742939,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006022","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000}}],"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R00GM098371"],"award-info":[{"award-number":["R00GM098371"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006022","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T13:25:50Z","timestamp":1520515550000},"page":"e1006022","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Stoichiometric balance of protein copy numbers is measurable and functionally significant in a protein-protein interaction network for yeast endocytosis"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-6546","authenticated-orcid":true,"given":"David O.","family":"Holland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-291X","authenticated-orcid":true,"given":"Margaret E.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"issue":"6959","key":"ref1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature02046","article-title":"Global analysis of protein expression in yeast","volume":"425","author":"S Ghaemmaghami","year":"2003","journal-title":"Nature"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nmeth.2834","article-title":"Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells","volume":"11","author":"NA Kulak","year":"2014","journal-title":"Nat Methods"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tig.2008.05.005","article-title":"Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects","volume":"24","author":"RA Veitia","year":"2008","journal-title":"Trends in genetics: TIG"},{"issue":"37","key":"ref4","doi-asserted-by":"crossref","first-page":"14746","DOI":"10.1073\/pnas.1207726109","article-title":"Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines","volume":"109","author":"JA Birchler","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.tibs.2015.03.011","article-title":"Gene dosage imbalances: action, reaction, and models","volume":"40","author":"RA Veitia","year":"2015","journal-title":"Trends Biochem Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/msb.2009.9","article-title":"Complex topology rather than complex membership is a determinant of protein dosage sensitivity","volume":"5","author":"R Oberdorf","year":"2009","journal-title":"Molecular systems biology"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1093\/gbe\/evt154","article-title":"Evaluating the fitness cost of protein expression in Saccharomyces cerevisiae","volume":"5","author":"K Tomala","year":"2013","journal-title":"Genome Biol Evol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cell.2009.04.029","article-title":"Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity","volume":"138","author":"T Vavouri","year":"2009","journal-title":"Cell"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1101\/gr.146662.112","article-title":"Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method","volume":"23","author":"K Makanae","year":"2013","journal-title":"Genome Res"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.celrep.2012.09.036","article-title":"Cellular strategies for regulating functional and nonfunctional protein aggregation","volume":"2","author":"J Gsponer","year":"2012","journal-title":"Cell Rep"},{"issue":"5906","key":"ref11","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.1163581","article-title":"Tight regulation of unstructured proteins: from transcript synthesis to protein degradation","volume":"322","author":"J Gsponer","year":"2008","journal-title":"Science"},{"issue":"5991","key":"ref12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1188308","article-title":"Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells","volume":"329","author":"Y Taniguchi","year":"2010","journal-title":"Science"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ng.948","article-title":"Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster","volume":"43","author":"X Deng","year":"2011","journal-title":"Nat Genet"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4161\/fly.5.2.14934","article-title":"Drosophila dosage compensation: males are from Mars, females are from Venus","volume":"5","author":"P Georgiev","year":"2011","journal-title":"Fly (Austin)"},{"issue":"14","key":"ref15","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1073\/pnas.1116763109","article-title":"Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome","volume":"109","author":"E Pessia","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"ra109","DOI":"10.1126\/scisignal.2004560","article-title":"Integration of protein abundance and structure data reveals competition in the ErbB signaling network","volume":"6","author":"C Kiel","year":"2013","journal-title":"Sci Signal"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1038\/ncomms7203","article-title":"Undesired usage and the robust self-assembly of heterogeneous structures","volume":"6","author":"A Murugan","year":"2015","journal-title":"Nat Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.sbi.2014.06.001","article-title":"Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties","volume":"26","author":"O Matalon","year":"2014","journal-title":"Curr Opin Struct Biol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cell.2015.09.053","article-title":"A human interactome in three quantitative dimensions organized by stoichiometries and abundances","volume":"163","author":"MY Hein","year":"2015","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1003065","DOI":"10.1371\/journal.pcbi.1003065","article-title":"Interface-resolved network of protein-protein interactions","volume":"9","author":"ME Johnson","year":"2013","journal-title":"Plos Comput Biol"},{"issue":"22","key":"ref21","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1091\/mbc.E15-07-0512","article-title":"Quantitative nature of overexpression experiments","volume":"26","author":"H Moriya","year":"2015","journal-title":"Mol Biol Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/msb.2008.48","article-title":"Constraints imposed by non-functional protein-protein interactions on gene expression and proteome size","volume":"4","author":"J Zhang","year":"2008","journal-title":"Mol Syst Biol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1073\/pnas.1010954108","article-title":"Nonspecific binding limits the number of proteins in a cell and shapes their interaction networks","volume":"108","author":"ME Johnson","year":"2011","journal-title":"P Natl Acad Sci USA"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1073\/pnas.1009392108","article-title":"Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions","volume":"108","author":"M Heo","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"E831","DOI":"10.1073\/pnas.1117408109","article-title":"Protein misinteraction avoidance causes highly expressed proteins to evolve slowly","volume":"109","author":"J-R Yang","year":"2012","journal-title":"P Natl Acad Sci USA"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"20461","DOI":"10.1073\/pnas.1209312109","article-title":"Cellular crowding imposes global constraints on the chemistry and evolution of proteomes","volume":"109","author":"ED Levy","year":"2012","journal-title":"P Natl Acad Sci USA"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"13098","DOI":"10.1021\/jp402944e","article-title":"Evolutionary pressure on the topology of protein interface interaction networks","volume":"117","author":"ME Johnson","year":"2013","journal-title":"The journal of physical chemistry B"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.sbi.2010.10.007","article-title":"Protein dynamics and allostery: an NMR view","volume":"21","author":"SR Tzeng","year":"2011","journal-title":"Curr Opin Struct Biol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2010.02.108","article-title":"Ribonucleotide reductases: substrate specificity by allostery","volume":"396","author":"P Reichard","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.sbi.2010.10.002","article-title":"Protein binding specificity versus promiscuity","volume":"21","author":"G Schreiber","year":"2011","journal-title":"Curr Opin Struct Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature02178","article-title":"Optimization of specificity in a cellular protein interaction network by negative selection","volume":"426","author":"A Zarrinpar","year":"2003","journal-title":"Nature"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ng881","article-title":"Network motifs in the transcriptional regulation network of Escherichia coli","volume":"31","author":"SS Shen-Orr","year":"2002","journal-title":"Nat Genet"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1083\/jcb.200305145","article-title":"Clathrin-mediated endocytosis in AP-2-depleted cells","volume":"162","author":"A Motley","year":"2003","journal-title":"The Journal of cell biology"},{"issue":"25","key":"ref34","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0960-9822(98)00022-0","article-title":"Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation","volume":"8","author":"M Jost","year":"1998","journal-title":"Curr Biol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/ncb2478","article-title":"Reconstitution of clathrin-coated bud and vesicle formation with minimal components","volume":"14","author":"PN Dannhauser","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.molcel.2005.12.011","article-title":"Mapping pathways and phenotypes by systematic gene overexpression","volume":"21","author":"R Sopko","year":"2006","journal-title":"Mol Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/gbe\/evr023","article-title":"Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster","volume":"3","author":"J Zhou","year":"2011","journal-title":"Genome Biol Evol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.genom.9.081307.164217","article-title":"Copy number variation in human health, disease, and evolution","volume":"10","author":"F Zhang","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1177\/1352458512469696","article-title":"Copy number variation in pediatric multiple sclerosis","volume":"19","author":"JP McElroy","year":"2013","journal-title":"Multiple sclerosis (Houndmills, Basingstoke, England)"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1158\/0008-5472.CAN-03-3308","article-title":"An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays","volume":"64","author":"X Zhao","year":"2004","journal-title":"Cancer Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1038\/s41598-017-05686-2","article-title":"Protein-protein binding selectivity and network topology constrains global and local properties of interface binding networks","volume":"7","author":"DO Holland","year":"2017","journal-title":"Sci Rep"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.1070919","article-title":"Stochastic gene expression in a single cell","volume":"297","author":"MB Elowitz","year":"2002","journal-title":"Science"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ng1807","article-title":"Noise in protein expression scales with natural protein abundance","volume":"38","author":"A Bar-Even","year":"2006","journal-title":"Nat Genet"},{"issue":"13","key":"ref44","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.cub.2013.05.005","article-title":"Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches","volume":"23","author":"Q Chen","year":"2013","journal-title":"Curr Biol"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrm3609","article-title":"Functions of cofilin in cell locomotion and invasion","volume":"14","author":"JJ Bravo-Cordero","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1073\/pnas.97.11.5818","article-title":"Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties","volume":"97","author":"A Levchenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical reactions","volume":"81","author":"DT Gillespie","year":"1977","journal-title":"J Phys Chem"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nmeth.1546","article-title":"Efficient modeling, simulation and coarse-graining of biological complexity with NFsim","volume":"8","author":"MW Sneddon","year":"2011","journal-title":"Nature methods"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.cell.2015.04.051","article-title":"Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis","volume":"161","author":"YT Chong","year":"2015","journal-title":"Cell"},{"issue":"7095","key":"ref50","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature04785","article-title":"Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise","volume":"441","author":"JR Newman","year":"2006","journal-title":"Nature"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1074\/mcp.M113.037309","article-title":"A "proteomic ruler" for protein copy number and concentration estimation without spike-in standards","volume":"13","author":"JR Wisniewski","year":"2014","journal-title":"Mol Cell Proteomics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/msb.2011.81","article-title":"Deep proteome and transcriptome mapping of a human cancer cell line","volume":"7","author":"N Nagaraj","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/msb.2011.82","article-title":"The quantitative proteome of a human cell line","volume":"7","author":"M Beck","year":"2011","journal-title":"Mol Syst Biol"},{"issue":"8","key":"ref54","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"HT McMahon","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"18","key":"ref55","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1093\/emboj\/cdf487","article-title":"Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor","volume":"21","author":"SK Mishra","year":"2002","journal-title":"The EMBO journal"},{"issue":"6195","key":"ref56","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.1254836","article-title":"Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch","volume":"345","author":"BT Kelly","year":"2014","journal-title":"Science"},{"issue":"5580","key":"ref57","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.1070850","article-title":"Systematic identification of pathways that couple cell growth and division in yeast","volume":"297","author":"P Jorgensen","year":"2002","journal-title":"Science"},{"key":"ref58","volume":"1","author":"B Alberts","year":"2015"},{"key":"ref59","article-title":"Cytoplasmic proteins can exploit membrane localization to trigger functional assembly","author":"ON Yogurtcu","year":"2018","journal-title":"PLoS Comp Biol"},{"issue":"19","key":"ref60","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1093\/emboj\/cdg511","article-title":"Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation","volume":"22","author":"DE Wakeham","year":"2003","journal-title":"The EMBO journal"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nsmb736","article-title":"Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller","volume":"11","author":"AE Miele","year":"2004","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jmb.2010.09.044","article-title":"Dynamic interactions between clathrin and locally structured elements in a disordered protein mediate clathrin lattice assembly","volume":"404","author":"Y Zhuo","year":"2010","journal-title":"J Mol Biol"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/80924","article-title":"Molecular mechanism of NPF recognition by EH domains","volume":"7","author":"T de Beer","year":"2000","journal-title":"Nat Struct Biol"},{"issue":"35","key":"ref64","doi-asserted-by":"crossref","first-page":"33583","DOI":"10.1074\/jbc.M304346200","article-title":"Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling","volume":"278","author":"JR Morgan","year":"2003","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"756","DOI":"10.15252\/msb.20145422","article-title":"Quantification of cytosolic interactions identifies Ede1 oligomers as key organizers of endocytosis","volume":"10","author":"D Boeke","year":"2014","journal-title":"Mol Syst Biol"},{"issue":"8","key":"ref66","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/j.1460-2075.1983.tb01597.x","article-title":"Clathrin heavy chain, light chain interactions","volume":"2","author":"FK Winkler","year":"1983","journal-title":"EMBO J"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1083\/jcb.200106089","article-title":"The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro","volume":"154","author":"AE Engqvist-Goldstein","year":"2001","journal-title":"J Cell Biol"},{"issue":"47","key":"ref68","doi-asserted-by":"crossref","first-page":"32870","DOI":"10.1074\/jbc.M802863200","article-title":"Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain","volume":"283","author":"JD Wilbur","year":"2008","journal-title":"J Biol Chem"},{"issue":"7","key":"ref69","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.str.2007.05.002","article-title":"Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature","volume":"15","author":"WM Henne","year":"2007","journal-title":"Structure"},{"issue":"31","key":"ref70","doi-asserted-by":"crossref","first-page":"28993","DOI":"10.1074\/jbc.M302865200","article-title":"Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains","volume":"278","author":"RV Stahelin","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.str.2014.12.009","article-title":"Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site","volume":"23","author":"K Moravcevic","year":"2015","journal-title":"Structure"},{"issue":"11","key":"ref72","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nchem.1163","article-title":"In situ quantitative imaging of cellular lipids using molecular sensors","volume":"3","author":"Y Yoon","year":"2011","journal-title":"Nat Chem"},{"issue":"7357","key":"ref73","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nature10183","article-title":"Transforming binding affinities from three dimensions to two with application to cadherin clustering","volume":"475","author":"Y Wu","year":"2011","journal-title":"Nature"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1371\/journal.pbio.1000057","article-title":"Cargo and dynamin regulate clathrin-coated pit maturation","volume":"7","author":"D Loerke","year":"2009","journal-title":"Plos Biol"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tcb.2011.09.001","article-title":"Clathrin-mediated endocytosis in budding yeast","volume":"22","author":"J Weinberg","year":"2012","journal-title":"Trends Cell Biol"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2403","article-title":"Lessons from yeast for clathrin-mediated endocytosis","volume":"14","author":"DR Boettner","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nmeth.2289","article-title":"Interactome3D: adding structural details to protein networks","volume":"10","author":"R Mosca","year":"2013","journal-title":"Nat Methods"},{"issue":"2","key":"ref78","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nbt.2106","article-title":"Three-dimensional reconstruction of protein networks provides insight into human genetic disease","volume":"30","author":"X Wang","year":"2012","journal-title":"Nature biotechnology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature01771","article-title":"Dosage sensitivity and the evolution of gene families in yeast","volume":"424","author":"B Papp","year":"2003","journal-title":"Nature"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tibtech.2011.08.002","article-title":"Imaging proteins inside cells with fluorescent tags","volume":"30","author":"G Crivat","year":"2012","journal-title":"Trends Biotechnol"},{"issue":"8","key":"ref81","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1534\/g3.113.005777","article-title":"The genomic and transcriptomic landscape of a HeLa cell line","volume":"3","author":"JJ Landry","year":"2013","journal-title":"G3 (Bethesda)"},{"issue":"8","key":"ref82","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1242\/jcs.182303","article-title":"Clathrin-mediated endocytosis in budding yeast at a glance","volume":"129","author":"R Lu","year":"2016","journal-title":"J Cell Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"7875","DOI":"10.1038\/ncomms8875","article-title":"Intrinsically disordered proteins drive membrane curvature","volume":"6","author":"DJ Busch","year":"2015","journal-title":"Nat Commun"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1145\/641876.641880","article-title":"Object-oriented software for quadratic programming","volume":"29","author":"EM Gertz","year":"2003","journal-title":"ACM Transactions on Mathematical Software"},{"key":"ref85","first-page":"278207","article-title":"Universal behavior of load distribution in scale-free networks","volume":"87","author":"K-I Goh","year":"2001","journal-title":"Phys Rev Lett"},{"issue":"11","key":"ref86","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"Suppl 8","key":"ref87","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2105-13-S8-S3","article-title":"RuleBender: integrated modeling, simulation and visualization for rule-based intracellular biochemistry","volume":"13","author":"AM Smith","year":"2012","journal-title":"Bmc Bioinformatics"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006022","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:28:41Z","timestamp":1588984121000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006022"}},"subtitle":[],"editor":[{"given":"Martin","family":"Meier-Schellersheim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":87,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006022","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/205674","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]}}}