{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:17:52Z","timestamp":1767179872045,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006026","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000}}],"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006026","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T13:54:11Z","timestamp":1519307651000},"page":"e1006026","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between expression of random gene sets and survival is evident in multiple cancer types and may be explained by sub-classification"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-4207","authenticated-orcid":true,"given":"Yishai","family":"Shimoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"issue":"19","key":"ref1","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"T S\u00f8rlie","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6871","key":"ref2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","article-title":"Gene expression profiling predicts clinical outcome of breast cancer","volume":"415","author":"LJ Van\u2019t Veer","year":"2002","journal-title":"nature"},{"issue":"25","key":"ref3","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMoa021967","article-title":"A gene-expression signature as a predictor of survival in breast cancer","volume":"347","author":"MJ Van De Vijver","year":"2002","journal-title":"New England Journal of Medicine"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/sj.onc.1209920","article-title":"A gene-expression signature to predict survival in breast cancer across independent data sets","volume":"26","author":"A Naderi","year":"2007","journal-title":"Oncogene"},{"key":"ref5","first-page":"JCO","article-title":"Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer","author":"R Salazar","year":"2010","journal-title":"Journal of clinical oncology"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng.3225","article-title":"Stromal gene expression defines poor-prognosis subtypes in colorectal cancer","volume":"47","author":"A Calon","year":"2015","journal-title":"Nature genetics"},{"issue":"7633","key":"ref7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature20598","article-title":"A 17-gene stemness score for rapid determination of risk in acute leukaemia","volume":"540","author":"SW Ng","year":"2016","journal-title":"Nature"},{"key":"ref8","article-title":"Breast cancer: Genetic signature might spare 100,000 women annually from chemotherapy","author":"D Killock","year":"2016","journal-title":"Nature Reviews Clinical Oncology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ncomms1033","article-title":"Identification of high-quality cancer prognostic markers and metastasis network modules","volume":"1","author":"J Li","year":"2010","journal-title":"Nature communications"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/bioinformatics\/bth469","article-title":"Outcome signature genes in breast cancer: is there a unique set?","volume":"21","author":"L Ein-Dor","year":"2005","journal-title":"Bioinformatics"},{"issue":"17","key":"ref11","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1158\/0008-5472.CAN-13-3338","article-title":"Using high-throughput transcriptomic data for prognosis: a critical overview and perspectives","volume":"74","author":"E Domany","year":"2014","journal-title":"Cancer research"},{"issue":"16","key":"ref12","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1093\/nar\/gkv810","article-title":"Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets","volume":"43","author":"D Amar","year":"2015","journal-title":"Nucleic acids research"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/msb.2010.31","article-title":"A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers","volume":"6","author":"C Lefebvre","year":"2010","journal-title":"Molecular systems biology"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"i311","DOI":"10.1093\/bioinformatics\/btv255","article-title":"FERAL: network-based classifier with application to breast cancer outcome prediction","volume":"31","author":"A Allahyar","year":"2015","journal-title":"Bioinformatics"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.3593","article-title":"Network-based inference of protein activity helps functionalize the genetic landscape of cancer","volume":"48","author":"MJ Alvarez","year":"2016","journal-title":"Nature genetics"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"e1002240","DOI":"10.1371\/journal.pcbi.1002240","article-title":"Most random gene expression signatures are significantly associated with breast cancer outcome","volume":"7","author":"D Venet","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref17","first-page":"btv677","article-title":"TCGA2STAT: simple TCGA data access for integrated statistical analysis in R","author":"YW Wan","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2015.05.047","article-title":"Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis","volume":"162","author":"JH Levine","year":"2015","journal-title":"Cell"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"P10008","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"2008","author":"VD Blondel","year":"2008","journal-title":"Journal of statistical mechanics: theory and experiment"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"056117","DOI":"10.1103\/PhysRevE.80.056117","article-title":"Community detection algorithms: a comparative analysis","volume":"80","author":"A Lancichinetti","year":"2009","journal-title":"Physical review E"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"D Hanahan","year":"2000","journal-title":"cell"},{"issue":"7407","key":"ref22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"CGA Network","year":"2012","journal-title":"Nature"},{"issue":"6797","key":"ref23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"CM Perou","year":"2000","journal-title":"Nature"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1158\/1078-0432.CCR-10-1282","article-title":"A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor\u2013positive breast cancer","volume":"16","author":"TO Nielsen","year":"2010","journal-title":"Clinical Cancer Research"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1172\/JCI45014","article-title":"Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies","volume":"121","author":"BD Lehmann","year":"2011","journal-title":"The Journal of clinical investigation"},{"key":"ref26","article-title":"Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer","author":"MD Burstein","year":"2014","journal-title":"Clinical Cancer Research"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"e0157368","DOI":"10.1371\/journal.pone.0157368","article-title":"Refinement of triple-negative breast cancer molecular subtypes: implications for neoadjuvant chemotherapy selection","volume":"11","author":"BD Lehmann","year":"2016","journal-title":"PLoS One"},{"issue":"7403","key":"ref28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"C Curtis","year":"2012","journal-title":"Nature"},{"key":"ref29","article-title":"Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features","author":"D Sia","year":"2017","journal-title":"Gastroenterology"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"e1001453","DOI":"10.1371\/journal.pmed.1001453","article-title":"Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value","volume":"10","author":"L Marisa","year":"2013","journal-title":"PLoS medicine"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006026","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:14:23Z","timestamp":1588958063000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006026"}},"subtitle":[],"editor":[{"given":"Bing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006026","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,22]]}}}