{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:06:43Z","timestamp":1777086403351,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006046","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/K026550"],"award-info":[{"award-number":["EP\/K026550"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT130100254"],"award-info":[{"award-number":["FT130100254"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006046","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T17:25:31Z","timestamp":1522085131000},"page":"e1006046","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Scabies in residential care homes: Modelling, inference and interventions for well-connected population sub-units"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-4946","authenticated-orcid":true,"given":"Timothy","family":"Kinyanjui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"G\u00fcttel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Cassell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-8062","authenticated-orcid":true,"given":"Thomas","family":"House","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0140-6736(05)63020-6","article-title":"Deaths associated with ivermectin treatment of scabies","volume":"349","author":"R Barkwell","year":"1997","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0025-5564(98)10060-3","article-title":"Stochastic and deterministic models for SIS epidemics among a population partitioned into households","volume":"156","author":"F Ball","year":"1999","journal-title":"Mathematical Biosciences"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1214\/aoap\/1034625252","article-title":"Epidemics with two levels of mixing","volume":"7","author":"F Ball","year":"1997","journal-title":"The Annals of Applied Probability"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1017\/S0950268808001416","article-title":"Household structure and infectious disease transmission","volume":"137","author":"T House","year":"2009","journal-title":"Epidemiol Infect"},{"key":"ref5","article-title":"Epidemiological consequences of household-based antiviral prophylaxis for pandemic influenza","volume":"10","author":"AJ Black","year":"2012","journal-title":"Journal of The Royal Society Interface"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMoa0911530","article-title":"Comparative epidemiology of pandemic and seasonal influenza A in households","volume":"362","author":"BJ Cowling","year":"2010","journal-title":"The New England journal of medicine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/infdis\/jit828","article-title":"The source of respiratory syncytial virus infection in infants: A household cohort study in rural Kenya","volume":"209","author":"PK Munywoki","year":"2014","journal-title":"J Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1017\/S0950268813001623","article-title":"Optimal design of studies of influenza transmission in households II: comparison between cohort and case-ascertained studies","volume":"142","author":"B Klick","year":"2014","journal-title":"Epidemiol Infect"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1098\/rsif.2007.1106","article-title":"On methods for studying stochastic disease dynamics","volume":"5","author":"MJ Keeling","year":"2008","journal-title":"J R Soc Interface"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.epidem.2016.03.002","article-title":"Information content of household-stratified epidemics","volume":"16","author":"TM Kinyanjui","year":"2016","journal-title":"Epidemics"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198545996.001.0001","article-title":"Infectious diseases of humans: dynamics and control","author":"RM Anderson","year":"1991"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e0138018","DOI":"10.1371\/journal.pone.0138018","article-title":"Vaccine induced herd immunity for control of respiratory syncytial virus disease in a low-income country setting","volume":"10","author":"TM Kinyanjui","year":"2015","journal-title":"PLOS ONE"},{"key":"ref13","first-page":"366","article-title":"Modeling Infectious Diseases in Humans and Animals","author":"MJ Keeling","year":"2007"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e1001021","DOI":"10.1371\/journal.pcbi.1001021","article-title":"Little Italy: an agent-based approach to the estimation of contact patterns- fitting predicted matrices to serological data","volume":"6","author":"F Iozzi","year":"2010","journal-title":"PLOS Computational Biology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical reactions","volume":"81","author":"DT Gillespie","year":"1977","journal-title":"The Journal of Physical Chemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/1467-985X.00125","article-title":"Bayesian inference for partially observed stochastic epidemics","volume":"162","author":"PD O\u2019Neill","year":"1999","journal-title":"Journal of the Royal Statistical Society A"},{"key":"ref17","article-title":"The Mathematical Theory of Epidemics","author":"NTJ Bailey","year":"1957"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mbs.2008.01.011","article-title":"Deterministic epidemic models with explicit household structure","volume":"213","author":"T House","year":"2008","journal-title":"Math Biosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e73420","DOI":"10.1371\/journal.pone.0073420","article-title":"Estimating a Markovian epidemic model using household serial interval data from the early phase of an epidemic","volume":"8","author":"AJ Black","year":"2013","journal-title":"PlOS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1137\/S00361445024180","article-title":"Nineteen dubious ways to compute the exponential of a matrix, twenty-five years later","volume":"45","author":"C Moler","year":"2003","journal-title":"SIAM Review"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1137\/100788860","article-title":"Computing the action of the matrix exponential, with an application to exponential integrators","volume":"33","author":"AH Al-Mohy","year":"2011","journal-title":"SIAM Journal on Scientific Computing"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1137\/15M1027553","article-title":"Scaled and Squared Subdiagonal Pad\u00e9 Approximation for the Matrix Exponential","volume":"37","author":"S G\u00fcttel","year":"2016","journal-title":"SIAM Journal on Matrix Analysis and Applications"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/QCO.0b013e32835eb851","article-title":"Epidemiology of scabies","volume":"26","author":"LC Fuller","year":"2013","journal-title":"Current opinion in infectious diseases"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"T Vos","year":"2016","journal-title":"The Lancet"},{"key":"ref25","article-title":"The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015","author":"C Karimkhani","year":"2017","journal-title":"The Lancet Infectious Diseases"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S1473-3099(15)00132-2","article-title":"Prevalence of scabies and impetigo worldwide: A systematic review","volume":"15","author":"L Romani","year":"2015","journal-title":"The Lancet Infectious Diseases"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1473-3099(06)70654-5","article-title":"Scabies: a ubiquitous neglected skin disease","volume":"6","author":"UR Hengge","year":"2006","journal-title":"Lancet Infectious Diseases"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1017\/S0950268814002143","article-title":"Scabies outbreaks in residential care homes: factors associated with late recognition, burden and impact. a mixed methods study in England","volume":"143","author":"KA Hewitt","year":"2015","journal-title":"Epidemiology and Infection"},{"key":"ref29","first-page":"1","article-title":"Retrospective analysis of institutional scabies outbreaks from 1984 to 2013: lessons learned and moving forward","volume":"11","author":"KE Mounsey","year":"2016","journal-title":"Epidemiology and Infection"},{"key":"ref30","first-page":"32","article-title":"Scabies in 1976","volume":"97","author":"K Mellanby","year":"1977","journal-title":"The Journal of the Royal Society for the Promotion of Health"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-3024.2010.01218.x","article-title":"The immunology of susceptibility and resistance to scabies","volume":"32","author":"SF Walton","year":"2010","journal-title":"Parasite Immunology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/oxfordjournals.epirev.a036033","article-title":"Epidemiology of scabies","volume":"11","author":"MS Green","year":"1989","journal-title":"Epidemiologic Reviews"},{"key":"ref33","first-page":"219","article-title":"Scabies in urban bangladesh","volume":"90","author":"B Stanton","year":"1987","journal-title":"The Journal of tropical medicine and hygiene"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1017\/S0950268816001746","article-title":"The management of scabies outbreaks in residential care facilities for the elderly in England: a review of current health protection guidelines","volume":"144","author":"LCJ White","year":"2016","journal-title":"Epidemiology and Infection"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/CMR.00042-06","article-title":"Problems in diagnosing scabies, a global disease in human and animal populations","volume":"20","author":"SF Walton","year":"2007","journal-title":"Clinical Microbiology Reviews"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jtbi.2014.11.029","article-title":"Computation of epidemic final size distributions","volume":"367","author":"AJ Black","year":"2014","journal-title":"Journal of theoretical biology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e36160","DOI":"10.1371\/journal.pone.0036160","article-title":"Numerical integration of the master equation in some models of stochastic epidemiology","volume":"7","author":"G Jenkinson","year":"2012","journal-title":"PlOS ONE"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00285-015-0872-5","article-title":"Estimating the within-household infection rate in emerging SIR epidemics among a community of households","volume":"71","author":"F Ball","year":"2015","journal-title":"Journal of Mathematical Biology"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1137\/1.9780898717778","article-title":"Functions of Matrices: Theory and Computation","author":"NJ Higham","year":"2008"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1137\/04061101X","article-title":"The scaling and squaring method for the matrix exponential revisited","volume":"26","author":"NJ Higham","year":"2005","journal-title":"SIAM Journal on Matrix Analysis and Applications"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1137\/09074721X","article-title":"A new scaling and squaring algorithm for the matrix exponential","volume":"31","author":"AH Al-Mohy","year":"2009","journal-title":"SIAM Journal on Matrix Analysis and Applications"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0041-5553(89)80020-5","article-title":"Two polynomial methods of calculating functions of symmetric matrices","volume":"29","author":"VL Druskin","year":"1989","journal-title":"USSR Computational Mathematics and Mathematical Physics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF01060992","article-title":"A method for exponential propagation of large systems of stiff nonlinear differential equations","volume":"4","author":"RA Friesner","year":"1989","journal-title":"Journal of Scientific Computing"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1137\/0729014","article-title":"Analysis of some Krylov subspace approximations to the matrix exponential operator","volume":"29","author":"Y Saad","year":"1992","journal-title":"SIAM Journal on Numerical Analysis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1137\/050633846","article-title":"A restarted Krylov subspace method for the evaluation of matrix functions","volume":"44","author":"M Eiermann","year":"2006","journal-title":"SIAM Journal on Numerical Analysis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1137\/13093491X","article-title":"Efficient and stable Arnoldi restarts for matrix functions based on quadrature","volume":"35","author":"A Frommer","year":"2014","journal-title":"SIAM Journal on Matrix Analysis and Applications"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1145\/285861.285868","article-title":"Expokit: A software package for computing matrix exponentials","volume":"24","author":"RB Sidje","year":"1998","journal-title":"ACM Trans Math Softw"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1023\/B:BITN.0000046805.27551.3b","article-title":"RD-rational approximations of the matrix exponential","volume":"44","author":"I Moret","year":"2004","journal-title":"BIT Numerical Mathematics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1137\/040605461","article-title":"Preconditioning Lanczos approximations to the matrix exponential","volume":"27","author":"J van den Eshof","year":"2006","journal-title":"SIAM Journal on Scientific Computing"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/gamm.201310002","article-title":"Rational Krylov approximation of matrix functions: Numerical methods and optimal pole selection","volume":"36","author":"S G\u00fcttel","year":"2013","journal-title":"GAMM-Mitt"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.1201\/b14835","article-title":"Markov Chain Monte Carlo in Practice","author":"WR Gilks","year":"1995"},{"key":"ref52","doi-asserted-by":"crossref","DOI":"10.1201\/b10905","article-title":"Handbook of Markov Chain Monte Carlo","author":"S Brooks","year":"2011"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2307\/3212797","article-title":"The cost of a general stochastic epidemic","volume":"9","author":"J Gani","year":"1972","journal-title":"J Appl Prob"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1056\/NEJMct0910329","article-title":"Permethrin and ivermectin for scabies","volume":"362","author":"BJ Currie","year":"2010","journal-title":"The New England journal of medicine"},{"key":"ref55","first-page":"189","article-title":"The efficacy of permethrin 5% vs oral ivermectin for the treatment of scabies","volume":"59","author":"M Ranjkesh","year":"2013","journal-title":"Annals of parasitology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(05)62377-X","article-title":"Deaths associated with ivermectin for scabies","volume":"350","author":"R Reintjes","year":"1997","journal-title":"The Lancet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(05)62378-1","article-title":"Deaths associated with ivermectin for scabies","volume":"350","author":"PE Coyne","year":"1997","journal-title":"The Lancet"},{"key":"ref58","unstructured":"Mathworks Inc (2017). MATLAB R2017a. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.mathworks.co.uk\/\" xlink:type=\"simple\">http:\/\/www.mathworks.co.uk\/<\/ext-link>."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e9666","DOI":"10.1371\/journal.pone.0009666","article-title":"Calculation of Disease Dynamics in a Population of Households","volume":"5","author":"JV Ross","year":"2010","journal-title":"PLoS ONE"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(05)62379-3","article-title":"Deaths associated with ivermectin for scabies","volume":"350","author":"R Barkwell","year":"1997","journal-title":"The Lancet"},{"key":"ref61","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.140216","article-title":"An investigation of the false discovery rate and the misinterpretation of p-values","volume":"1","author":"D Colquhoun","year":"2014","journal-title":"Royal Society Open Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1346-8138.2011.01324.x","article-title":"A 35-month prospective study on onset of scabies in a psychiatric hospital: Discussion on patient transfer and incubation period","volume":"39","author":"K Makigami","year":"2012","journal-title":"Journal of Dermatology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e2167","DOI":"10.1371\/journal.pntd.0002167","article-title":"Toward the global control of human scabies: Introducing the international alliance for the control of scabies","volume":"7","author":"D Engelman","year":"2013","journal-title":"PLOS Neglected Tropical Diseases"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006046","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T09:55:36Z","timestamp":1719914136000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006046"}},"subtitle":[],"editor":[{"given":"Samuel","family":"Alizon","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006046","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006046","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]}}}